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The map label for this gene is cysB [H]

Identifier: 197105091

GI number: 197105091

Start: 1835879

End: 1836880

Strand: Direct

Name: cysB [H]

Synonym: PHZ_c1628

Alternate gene names: 197105091

Gene position: 1835879-1836880 (Clockwise)

Preceding gene: 197105090

Following gene: 197105092

Centisome position: 45.94

GC content: 67.76

Gene sequence:

>1002_bases
ATGCAAGTCGCCCAAAGCGTCCTCGACCTGATCGGGAACACGCCCCTCCTCCGCCTTCGCCGCGCCAGCGAGCTGACCGG
CTGCGAAATCCTGGCCAAGGCCGAGTTCATGAACCCCGGCCAGTCCGTGAAGGATCGGGCCGCGCTCCACATCATCCGCG
ACGCCGAGCGTAAAGGCCTGTTGCGGCCCGGCGGGCGCATCGTGGAGGGCACCGCCGGCAACACCGGCATCGGCCTGGCG
ATGGTCGGCAAGGCGCTGGGCTACAAGTGCACCATCGTCATCCCGCGCACCCAGAGCCAGGAGAAGAAGGACGCCATCCG
GCTCTACGGCGCCGAGCTGGTGGAGGTGGACGCGGTCCCCTACTCCAACGAGAACAACTATGTGAAGTATTCCGGGCGCT
TGGCGGCGGAGCTTAACGAGAAGGAGCCCGCCGGCGCGGTCTGGGCCAACCAGTTCGACAACGTCGCGAACCGCGAGGCG
CACGTGCATGGCACCGGCCCCGAGATCTGGCGCCAGACCGACGGCAAGGTCGACGGCTTCATCTGCGCCGTGGGATCGGG
CGGCACCCTGGCCGGGGTCGCCCAGGCGCTGCGGGAGAAGAAGCCGGACGTGACGATCGGCCTCGCCGATCCCCACGGTG
CAGCGCTCTACAAATATTACACGGACGGCGAACTGGCCGCCGAGGGGACCTCGATCAGCGAAGGCATCGGCCAGGGGCGG
ATCACCGCCAATCTCGAAGGGCTCAAGGTGGACCGCGCCTATCGCATCTCGGACGAGGAGATGCTGCTGGCGATCTACGA
CCTCATGGAGTTCGAGGGCCTGGTGATGGGCGGCTCGACGGGGATCAACGTGGCGGGCGCGATCCGCCTGGCCAGGGACC
TGGGGCCGGGCCACACCGTCGTGACGGTGCTGTGCGACCACGGCCAGCGCTATCAGTCCAAGATCTTCAACCCCGCGTTC
CTGCGCGAGAAGGGCCTGCCCTGCCCGCCCTGGATGGAGTAG

Upstream 100 bases:

>100_bases
GGCTTCCGCACCGCGCGGACCGACGTCGTTCAGCTCAGCTTGGCGCGGACTTAGAAATCCGCCCCTGTCGCAACCGGCCC
GGCTTGCCTAATTAGCGACC

Downstream 100 bases:

>100_bases
CCGCCATGGATCCTCTGGTTTCCACCGACTGGCTCGACGAACGCCTGCACGACCCGGCGGTCCAGGTGGCGGACGCGACC
TGGTACATGCCCGGCGAGGG

Product: cysteine synthase A

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MQVAQSVLDLIGNTPLLRLRRASELTGCEILAKAEFMNPGQSVKDRAALHIIRDAERKGLLRPGGRIVEGTAGNTGIGLA
MVGKALGYKCTIVIPRTQSQEKKDAIRLYGAELVEVDAVPYSNENNYVKYSGRLAAELNEKEPAGAVWANQFDNVANREA
HVHGTGPEIWRQTDGKVDGFICAVGSGGTLAGVAQALREKKPDVTIGLADPHGAALYKYYTDGELAAEGTSISEGIGQGR
ITANLEGLKVDRAYRISDEEMLLAIYDLMEFEGLVMGGSTGINVAGAIRLARDLGPGHTVVTVLCDHGQRYQSKIFNPAF
LREKGLPCPPWME

Sequences:

>Translated_333_residues
MQVAQSVLDLIGNTPLLRLRRASELTGCEILAKAEFMNPGQSVKDRAALHIIRDAERKGLLRPGGRIVEGTAGNTGIGLA
MVGKALGYKCTIVIPRTQSQEKKDAIRLYGAELVEVDAVPYSNENNYVKYSGRLAAELNEKEPAGAVWANQFDNVANREA
HVHGTGPEIWRQTDGKVDGFICAVGSGGTLAGVAQALREKKPDVTIGLADPHGAALYKYYTDGELAAEGTSISEGIGQGR
ITANLEGLKVDRAYRISDEEMLLAIYDLMEFEGLVMGGSTGINVAGAIRLARDLGPGHTVVTVLCDHGQRYQSKIFNPAF
LREKGLPCPPWME
>Mature_333_residues
MQVAQSVLDLIGNTPLLRLRRASELTGCEILAKAEFMNPGQSVKDRAALHIIRDAERKGLLRPGGRIVEGTAGNTGIGLA
MVGKALGYKCTIVIPRTQSQEKKDAIRLYGAELVEVDAVPYSNENNYVKYSGRLAAELNEKEPAGAVWANQFDNVANREA
HVHGTGPEIWRQTDGKVDGFICAVGSGGTLAGVAQALREKKPDVTIGLADPHGAALYKYYTDGELAAEGTSISEGIGQGR
ITANLEGLKVDRAYRISDEEMLLAIYDLMEFEGLVMGGSTGINVAGAIRLARDLGPGHTVVTVLCDHGQRYQSKIFNPAF
LREKGLPCPPWME

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=328, Percent_Identity=37.8048780487805, Blast_Score=208, Evalue=5e-54,
Organism=Homo sapiens, GI295821200, Length=328, Percent_Identity=37.8048780487805, Blast_Score=208, Evalue=5e-54,
Organism=Homo sapiens, GI4557415, Length=328, Percent_Identity=37.8048780487805, Blast_Score=208, Evalue=5e-54,
Organism=Homo sapiens, GI11345492, Length=296, Percent_Identity=28.3783783783784, Blast_Score=85, Evalue=8e-17,
Organism=Escherichia coli, GI2367138, Length=310, Percent_Identity=37.0967741935484, Blast_Score=172, Evalue=2e-44,
Organism=Escherichia coli, GI1788754, Length=319, Percent_Identity=38.871473354232, Blast_Score=170, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17535051, Length=307, Percent_Identity=39.0879478827362, Blast_Score=185, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17562970, Length=305, Percent_Identity=37.3770491803279, Blast_Score=178, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI32566674, Length=305, Percent_Identity=37.3770491803279, Blast_Score=178, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI115535073, Length=315, Percent_Identity=35.8730158730159, Blast_Score=155, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17561720, Length=317, Percent_Identity=35.3312302839117, Blast_Score=153, Evalue=9e-38,
Organism=Caenorhabditis elegans, GI17534315, Length=334, Percent_Identity=32.9341317365269, Blast_Score=148, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI25147552, Length=332, Percent_Identity=31.6265060240964, Blast_Score=136, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI32566672, Length=219, Percent_Identity=32.8767123287671, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71996324, Length=366, Percent_Identity=25.9562841530055, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17508781, Length=220, Percent_Identity=25.4545454545455, Blast_Score=65, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6321449, Length=333, Percent_Identity=40.2402402402402, Blast_Score=192, Evalue=6e-50,
Organism=Saccharomyces cerevisiae, GI6321594, Length=334, Percent_Identity=31.1377245508982, Blast_Score=164, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24643623, Length=331, Percent_Identity=34.7432024169184, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI20129101, Length=331, Percent_Identity=34.7432024169184, Blast_Score=173, Evalue=2e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 35832; Mature: 35832

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVAQSVLDLIGNTPLLRLRRASELTGCEILAKAEFMNPGQSVKDRAALHIIRDAERKGL
CCHHHHHHHHHCCCCEEEEHHHCCCCCCEEEEEHHCCCCCCCHHHHHHHHHHHHHHHCCC
LRPGGRIVEGTAGNTGIGLAMVGKALGYKCTIVIPRTQSQEKKDAIRLYGAELVEVDAVP
CCCCCEEEECCCCCCCCHHHHHHHHHCEEEEEEEECCCCCHHHHHHHHCCCEEEEEECCC
YSNENNYVKYSGRLAAELNEKEPAGAVWANQFDNVANREAHVHGTGPEIWRQTDGKVDGF
CCCCCCEEEECCEEEEECCCCCCCCCHHHHHHHHHCCCCEEEECCCHHHHHCCCCCCCEE
ICAVGSGGTLAGVAQALREKKPDVTIGLADPHGAALYKYYTDGELAAEGTSISEGIGQGR
EEEECCCCCHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEECCEEEECCCCHHHCCCCCE
ITANLEGLKVDRAYRISDEEMLLAIYDLMEFEGLVMGGSTGINVAGAIRLARDLGPGHTV
EEEECCCEEECCEEEECCHHHHHHHHHHHHHCCEEECCCCCCCHHHHHHHHHHCCCCCEE
VTVLCDHGQRYQSKIFNPAFLREKGLPCPPWME
EEEEECCCCHHHHHCCCHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MQVAQSVLDLIGNTPLLRLRRASELTGCEILAKAEFMNPGQSVKDRAALHIIRDAERKGL
CCHHHHHHHHHCCCCEEEEHHHCCCCCCEEEEEHHCCCCCCCHHHHHHHHHHHHHHHCCC
LRPGGRIVEGTAGNTGIGLAMVGKALGYKCTIVIPRTQSQEKKDAIRLYGAELVEVDAVP
CCCCCEEEECCCCCCCCHHHHHHHHHCEEEEEEEECCCCCHHHHHHHHCCCEEEEEECCC
YSNENNYVKYSGRLAAELNEKEPAGAVWANQFDNVANREAHVHGTGPEIWRQTDGKVDGF
CCCCCCEEEECCEEEEECCCCCCCCCHHHHHHHHHCCCCEEEECCCHHHHHCCCCCCCEE
ICAVGSGGTLAGVAQALREKKPDVTIGLADPHGAALYKYYTDGELAAEGTSISEGIGQGR
EEEECCCCCHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEECCEEEECCCCHHHCCCCCE
ITANLEGLKVDRAYRISDEEMLLAIYDLMEFEGLVMGGSTGINVAGAIRLARDLGPGHTV
EEEECCCEEECCEEEECCHHHHHHHHHHHHHCCEEECCCCCCCHHHHHHHHHHCCCCCEE
VTVLCDHGQRYQSKIFNPAFLREKGLPCPPWME
EEEEECCCCHHHHHCCCHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA