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The map label for this gene is metC [H]

Identifier: 197104927

GI number: 197104927

Start: 1660993

End: 1662189

Strand: Reverse

Name: metC [H]

Synonym: PHZ_c1462

Alternate gene names: 197104927

Gene position: 1662189-1660993 (Counterclockwise)

Preceding gene: 197104929

Following gene: 197104926

Centisome position: 41.59

GC content: 72.01

Gene sequence:

>1197_bases
ATGCGCGACCCCACACTCTGCCTGACGCCGGGGGACGGCCTCGGAGGCGCGTTCGAGAGCCTTGCGGTGCCCGTGCACCG
GGCGTCCACCGTGGTCTTCCCGACCGTGGCCGCCTACCAGGGCCGTCGGGACGAGATCTACGACGGCTTCTCCTATGGCC
TCTACGGCACGCCCACGTCCCGCGAACTCGAGACACGGCTGGCGCGCCTGGAAGGCGCGGCGCGGACGCTGGCCCTGCCT
TCCGGCTTCGCGGCCATCGCGATGACGACCCTCGCGGCGGTCCGCCCGGGAGAAGAGGTGCTGTTCCCCGACACAACATA
CGACACCGTGCGACCGTTCGCCGAACGGTTCCTCGCCGGCCTCGGCATCGGCTCGCGCTACTACGATCCGATGATCGGCG
CCGGCCTGGCCGAGGTGCTCGACGGGGGGACCCGCCTGGTGTGGGTGGAGTCGCCCGGCTCCATGACCATGGAGGTGCAG
GACGTTCCCGCCATCGCCGCCGCGGCCCACGCCCGTGGGGCCATGGTGGCGGCCGACAACACCTGGGCGACGCCGCTGCG
GTTCAAGGCGCTGGCGCACGGCGTCGACTTCTCCGTCTGCGCCCTGTCGAAGTACGTGGCGGGGCATTCGGACGTGATGA
TGGGCTCGGTGTCGGTGAACGATGTCGGGCTCTACCGCAAGCTCAAGGACTACAGCCGCTTCCTCGGGCTGGGGGTCTCG
GCGGACGAAAGCAGCCTCGTGCTCCGCGGCCTGGAGACGCTGGCGATCCGCATGGACCGCGCCGAACAGTCCGCGCGGCG
ACTGGTGGACTGGGTCGTCGCCCAGCCCGGCGTCGCCGAGGTGCGCTTCCCGCAGTTGGCCACGTCCCCCGGCCACGCCC
TGTGGCGGCGCGATTTCACCGGCGGGGCGGGTCTGTTCTCGGTCTTCCTGGAGGATTGGACCCGTCCGGCGCTCGCCGAA
GCCGTGGAGTCGCTGCAGCTGTTCGCCATCGGCGCCAGCTGGGGCGGCACGCGCAGCCTCGTGGCGGTGCTCGACCGGCC
GCCGCTGCGCACCGTGGCGCCGCCGGCCCACACCGGGCCCGTAGTCCGTTTCAGCATCGGACTGGAGGATCCCGAGGATC
TTCTGCAGGACCTTGCCCGTGGCTTCGCCCGCCTCGCCGCCCCTGACCAGGGCGGCGGCGCCCAGCGACGGGCCTAG

Upstream 100 bases:

>100_bases
TTCATGGCCGCATCATAACCTCGGCGCATGAATTCGCCGCAACTATGAATTTGAACGAGTTCCAGGGCCGGGCTACGCCG
GGTCCCGAAGGGAGTACAGC

Downstream 100 bases:

>100_bases
GCCATGCAAGGCAGCTCGGTCCAGGCGGCGCCGGACACACGCCCCGCCGCCCGCACATCCGCCCTTGCCAGGCTCGGGGC
GGCGAGACGGCGGCTGGCCG

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase; ORF5 [H]

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MRDPTLCLTPGDGLGGAFESLAVPVHRASTVVFPTVAAYQGRRDEIYDGFSYGLYGTPTSRELETRLARLEGAARTLALP
SGFAAIAMTTLAAVRPGEEVLFPDTTYDTVRPFAERFLAGLGIGSRYYDPMIGAGLAEVLDGGTRLVWVESPGSMTMEVQ
DVPAIAAAAHARGAMVAADNTWATPLRFKALAHGVDFSVCALSKYVAGHSDVMMGSVSVNDVGLYRKLKDYSRFLGLGVS
ADESSLVLRGLETLAIRMDRAEQSARRLVDWVVAQPGVAEVRFPQLATSPGHALWRRDFTGGAGLFSVFLEDWTRPALAE
AVESLQLFAIGASWGGTRSLVAVLDRPPLRTVAPPAHTGPVVRFSIGLEDPEDLLQDLARGFARLAAPDQGGGAQRRA

Sequences:

>Translated_398_residues
MRDPTLCLTPGDGLGGAFESLAVPVHRASTVVFPTVAAYQGRRDEIYDGFSYGLYGTPTSRELETRLARLEGAARTLALP
SGFAAIAMTTLAAVRPGEEVLFPDTTYDTVRPFAERFLAGLGIGSRYYDPMIGAGLAEVLDGGTRLVWVESPGSMTMEVQ
DVPAIAAAAHARGAMVAADNTWATPLRFKALAHGVDFSVCALSKYVAGHSDVMMGSVSVNDVGLYRKLKDYSRFLGLGVS
ADESSLVLRGLETLAIRMDRAEQSARRLVDWVVAQPGVAEVRFPQLATSPGHALWRRDFTGGAGLFSVFLEDWTRPALAE
AVESLQLFAIGASWGGTRSLVAVLDRPPLRTVAPPAHTGPVVRFSIGLEDPEDLLQDLARGFARLAAPDQGGGAQRRA
>Mature_398_residues
MRDPTLCLTPGDGLGGAFESLAVPVHRASTVVFPTVAAYQGRRDEIYDGFSYGLYGTPTSRELETRLARLEGAARTLALP
SGFAAIAMTTLAAVRPGEEVLFPDTTYDTVRPFAERFLAGLGIGSRYYDPMIGAGLAEVLDGGTRLVWVESPGSMTMEVQ
DVPAIAAAAHARGAMVAADNTWATPLRFKALAHGVDFSVCALSKYVAGHSDVMMGSVSVNDVGLYRKLKDYSRFLGLGVS
ADESSLVLRGLETLAIRMDRAEQSARRLVDWVVAQPGVAEVRFPQLATSPGHALWRRDFTGGAGLFSVFLEDWTRPALAE
AVESLQLFAIGASWGGTRSLVAVLDRPPLRTVAPPAHTGPVVRFSIGLEDPEDLLQDLARGFARLAAPDQGGGAQRRA

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=295, Percent_Identity=31.5254237288136, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI299473759, Length=295, Percent_Identity=29.4915254237288, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI25453487, Length=294, Percent_Identity=28.5714285714286, Blast_Score=108, Evalue=7e-24,
Organism=Escherichia coli, GI1789383, Length=368, Percent_Identity=38.0434782608696, Blast_Score=262, Evalue=3e-71,
Organism=Escherichia coli, GI1790375, Length=378, Percent_Identity=30.1587301587302, Blast_Score=142, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI71980708, Length=374, Percent_Identity=28.3422459893048, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17560056, Length=328, Percent_Identity=28.3536585365854, Blast_Score=131, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI17538055, Length=336, Percent_Identity=28.2738095238095, Blast_Score=123, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6321170, Length=314, Percent_Identity=36.624203821656, Blast_Score=218, Evalue=1e-57,
Organism=Saccharomyces cerevisiae, GI6319307, Length=351, Percent_Identity=28.7749287749288, Blast_Score=133, Evalue=6e-32,
Organism=Saccharomyces cerevisiae, GI6321904, Length=397, Percent_Identity=25.9445843828715, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6323333, Length=436, Percent_Identity=24.5412844036697, Blast_Score=87, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6321254, Length=249, Percent_Identity=24.8995983935743, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI19922554, Length=346, Percent_Identity=30.3468208092486, Blast_Score=163, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 42478; Mature: 42478

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDPTLCLTPGDGLGGAFESLAVPVHRASTVVFPTVAAYQGRRDEIYDGFSYGLYGTPTS
CCCCCEEEECCCCCCHHHHHHHCCHHHCCEEEEEHHHHHCCCCHHHCCCCCCCCCCCCCC
RELETRLARLEGAARTLALPSGFAAIAMTTLAAVRPGEEVLFPDTTYDTVRPFAERFLAG
HHHHHHHHHHHCCHHEEECCCCHHHHHHHHHHHCCCCCCEECCCCCHHHHHHHHHHHHHH
LGIGSRYYDPMIGAGLAEVLDGGTRLVWVESPGSMTMEVQDVPAIAAAAHARGAMVAADN
CCCCCHHCCHHHHCCHHHHHCCCCEEEEEECCCCEEEEECCCCHHHHHHHHCCCEEEECC
TWATPLRFKALAHGVDFSVCALSKYVAGHSDVMMGSVSVNDVGLYRKLKDYSRFLGLGVS
CCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCC
ADESSLVLRGLETLAIRMDRAEQSARRLVDWVVAQPGVAEVRFPQLATSPGHALWRRDFT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCHHHHHCCCC
GGAGLFSVFLEDWTRPALAEAVESLQLFAIGASWGGTRSLVAVLDRPPLRTVAPPAHTGP
CCHHHHHHHHHHCCCHHHHHHHHHEEEEEEECCCCCHHHHHHHHCCCCCCCCCCCCCCCC
VVRFSIGLEDPEDLLQDLARGFARLAAPDQGGGAQRRA
EEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MRDPTLCLTPGDGLGGAFESLAVPVHRASTVVFPTVAAYQGRRDEIYDGFSYGLYGTPTS
CCCCCEEEECCCCCCHHHHHHHCCHHHCCEEEEEHHHHHCCCCHHHCCCCCCCCCCCCCC
RELETRLARLEGAARTLALPSGFAAIAMTTLAAVRPGEEVLFPDTTYDTVRPFAERFLAG
HHHHHHHHHHHCCHHEEECCCCHHHHHHHHHHHCCCCCCEECCCCCHHHHHHHHHHHHHH
LGIGSRYYDPMIGAGLAEVLDGGTRLVWVESPGSMTMEVQDVPAIAAAAHARGAMVAADN
CCCCCHHCCHHHHCCHHHHHCCCCEEEEEECCCCEEEEECCCCHHHHHHHHCCCEEEECC
TWATPLRFKALAHGVDFSVCALSKYVAGHSDVMMGSVSVNDVGLYRKLKDYSRFLGLGVS
CCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCC
ADESSLVLRGLETLAIRMDRAEQSARRLVDWVVAQPGVAEVRFPQLATSPGHALWRRDFT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCHHHHHCCCC
GGAGLFSVFLEDWTRPALAEAVESLQLFAIGASWGGTRSLVAVLDRPPLRTVAPPAHTGP
CCHHHHHHHHHHCCCHHHHHHHHHEEEEEEECCCCCHHHHHHHHCCCCCCCCCCCCCCCC
VVRFSIGLEDPEDLLQDLARGFARLAAPDQGGGAQRRA
EEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8898392 [H]