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The map label for this gene is thrA [C]

Identifier: 197104805

GI number: 197104805

Start: 1517000

End: 1518436

Strand: Direct

Name: thrA [C]

Synonym: PHZ_c1339

Alternate gene names: 197104805

Gene position: 1517000-1518436 (Clockwise)

Preceding gene: 197104804

Following gene: 197104806

Centisome position: 37.96

GC content: 71.96

Gene sequence:

>1437_bases
ATGGGCGTGCATACCGTCGAGAAGATCGGCGGCACCTCCATCTCGGACACGCGCGCGGTCCTGGACAACATCCTGATCGG
CGCGCGGACGGGGGCCGAGCTGTACAACCGGATCTTCGTGGTCTCGGCCTACGCCGGCGTTACGGACAGGCTGCTCGAGC
ACAAGAAGACCGGCCGGCCGGGGGTGTACGCCCTGTTCGCCGCCGCGGCGTCGGGCGAGGGCGAGGCCTGGCGCACGGCG
ATCGACGACCTGCTGACGCACCTGCGGGCGCTGAACGCCGAGCGGTTCACCGACCCGGCGGACCTGGCGGCGGCCGACGC
CTTCGTGGAGCAGCGGGTCGAGACCGCGCGCTCGTGCCTGGGCGACCTGCAGCGCCTCTGCGCCCAGGGCCACTTCCGGC
TGGACGCCCAGCTCGGGGCCGTGCGCGAGATGCTGGCCTCGATCGGCGAGGCCCAGAGCGCCCACAACCTCACGCTCGAG
CTGCGCCGCCGCGGCGTCAACGCCCGGATGGTCGACCTGACCGGCTGGGACGAGCCGGACGCCGTCGAGCTCGACGAGCT
CCTGGCGCGCGCCTTCGCCGACGTGGACCTGGCGAGCGAGCTGCCCATCGCCACCGGCTACGCCAAGGCGGGCAAGGGCC
TGATGGCCGAATACGGCCGCGGCTACAGCGAGGTGGTGTTCAGCCGCACGGCGGTGGTGACGGGGGCCCGCGAGGCCACG
ATCCACAAGGAGTTCCACCTCTCGAGCGCCGATCCCAAGCTGGTCGGGCCCGGGGCCGTGCGGAAGGTCGGGCGGACGAA
CTACGACGTCGCCGACCAACTGGCGAACCTCGGCATGGAGGCGATCCACCCACGGGCGGCGCGCGGCCTGCGCCAGGCCG
GCATCCCCCTCTGCGTGCGCAACACCTTCGATCCCGAGGATCGGGGCACGACCATCTGGTCGGACTTCGTCTCGGAGCAG
CCGCGGGTGGAGATCATCTGCGGCCTCACGGGCCTGACGGCGCTGGAGCTCTTCGAGCCCGACATGGTGGGGGTGAAGGG
CTATGACGCCGGCATCCTGGCGGTGCTCACCCGGCACGCGGCGCGGATCGTCTCGAAGGCGTCGAACGCCAACACGATCA
GCCACTACCTCGACGCCACGCCCAAGCAGGTGAAGCGGGTGATCGCCGACCTGGAACGCGAGTTCCCGAACGCCACGGTG
ACGACTCAGCAGGTCGCGGTGGTGGCGGTGATCGGCAGCGACCTGAACATCCCCGGGCTCACCGCCGCGGCGGCGCAGGC
GCTGGCGGACGCCGGAGTCGAGATCCTGGGCATCCAGCAGCTCACCCGCCGGGTGGATCTGCAGTTCGTGGTCCGGGAGC
GGGACTACGCCGCGAGCGTCCAGGCCCTGCACGCGCGCCTGGTATGCGGGGGCGGGCGGCTGCGCTCGGCGGCCTGA

Upstream 100 bases:

>100_bases
TCGGCGGGCGCGCCCCGCGGCCCGAGTTCATCGCCACCCGCGAGGGCTTCGAGCCGCTCACGGCGATGGGCGGCGACCTC
GCCGAGGGGAGGGCGGCCTG

Downstream 100 bases:

>100_bases
GGCGTCGACGCCGGATCGAAGTGGGGGCTGACATGACGATGGAACAGGACGGCCGGGGCCCTGCGGCGCCGGCCGAGGCG
GCCGCCGTCCGCCGGGCGGT

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 478; Mature: 477

Protein sequence:

>478_residues
MGVHTVEKIGGTSISDTRAVLDNILIGARTGAELYNRIFVVSAYAGVTDRLLEHKKTGRPGVYALFAAAASGEGEAWRTA
IDDLLTHLRALNAERFTDPADLAAADAFVEQRVETARSCLGDLQRLCAQGHFRLDAQLGAVREMLASIGEAQSAHNLTLE
LRRRGVNARMVDLTGWDEPDAVELDELLARAFADVDLASELPIATGYAKAGKGLMAEYGRGYSEVVFSRTAVVTGAREAT
IHKEFHLSSADPKLVGPGAVRKVGRTNYDVADQLANLGMEAIHPRAARGLRQAGIPLCVRNTFDPEDRGTTIWSDFVSEQ
PRVEIICGLTGLTALELFEPDMVGVKGYDAGILAVLTRHAARIVSKASNANTISHYLDATPKQVKRVIADLEREFPNATV
TTQQVAVVAVIGSDLNIPGLTAAAAQALADAGVEILGIQQLTRRVDLQFVVRERDYAASVQALHARLVCGGGRLRSAA

Sequences:

>Translated_478_residues
MGVHTVEKIGGTSISDTRAVLDNILIGARTGAELYNRIFVVSAYAGVTDRLLEHKKTGRPGVYALFAAAASGEGEAWRTA
IDDLLTHLRALNAERFTDPADLAAADAFVEQRVETARSCLGDLQRLCAQGHFRLDAQLGAVREMLASIGEAQSAHNLTLE
LRRRGVNARMVDLTGWDEPDAVELDELLARAFADVDLASELPIATGYAKAGKGLMAEYGRGYSEVVFSRTAVVTGAREAT
IHKEFHLSSADPKLVGPGAVRKVGRTNYDVADQLANLGMEAIHPRAARGLRQAGIPLCVRNTFDPEDRGTTIWSDFVSEQ
PRVEIICGLTGLTALELFEPDMVGVKGYDAGILAVLTRHAARIVSKASNANTISHYLDATPKQVKRVIADLEREFPNATV
TTQQVAVVAVIGSDLNIPGLTAAAAQALADAGVEILGIQQLTRRVDLQFVVRERDYAASVQALHARLVCGGGRLRSAA
>Mature_477_residues
GVHTVEKIGGTSISDTRAVLDNILIGARTGAELYNRIFVVSAYAGVTDRLLEHKKTGRPGVYALFAAAASGEGEAWRTAI
DDLLTHLRALNAERFTDPADLAAADAFVEQRVETARSCLGDLQRLCAQGHFRLDAQLGAVREMLASIGEAQSAHNLTLEL
RRRGVNARMVDLTGWDEPDAVELDELLARAFADVDLASELPIATGYAKAGKGLMAEYGRGYSEVVFSRTAVVTGAREATI
HKEFHLSSADPKLVGPGAVRKVGRTNYDVADQLANLGMEAIHPRAARGLRQAGIPLCVRNTFDPEDRGTTIWSDFVSEQP
RVEIICGLTGLTALELFEPDMVGVKGYDAGILAVLTRHAARIVSKASNANTISHYLDATPKQVKRVIADLEREFPNATVT
TQQVAVVAVIGSDLNIPGLTAAAAQALADAGVEILGIQQLTRRVDLQFVVRERDYAASVQALHARLVCGGGRLRSAA

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=230, Percent_Identity=25.6521739130435, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320893, Length=375, Percent_Identity=23.7333333333333, Blast_Score=77, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 51238; Mature: 51107

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVHTVEKIGGTSISDTRAVLDNILIGARTGAELYNRIFVVSAYAGVTDRLLEHKKTGRP
CCCCCHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHEEEEEEHHHHHHHHHHHHCCCCC
GVYALFAAAASGEGEAWRTAIDDLLTHLRALNAERFTDPADLAAADAFVEQRVETARSCL
CCEEHEEHHCCCCCHHHHHHHHHHHHHHHHHCHHHCCCHHHHHHHHHHHHHHHHHHHHHH
GDLQRLCAQGHFRLDAQLGAVREMLASIGEAQSAHNLTLELRRRGVNARMVDLTGWDEPD
HHHHHHHHCCCEEEHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCEEEEEECCCCCCC
AVELDELLARAFADVDLASELPIATGYAKAGKGLMAEYGRGYSEVVFSRTAVVTGAREAT
CCCHHHHHHHHHHCCCHHHCCCCCCCHHHHCCCHHHHHCCCHHHHHHHHHHHEECCHHHH
IHKEFHLSSADPKLVGPGAVRKVGRTNYDVADQLANLGMEAIHPRAARGLRQAGIPLCVR
HHHHEECCCCCCCCCCCHHHHHHCCCCCHHHHHHHHCCHHHCCHHHHHHHHHCCCCEEEC
NTFDPEDRGTTIWSDFVSEQPRVEIICGLTGLTALELFEPDMVGVKGYDAGILAVLTRHA
CCCCCCCCCCCHHHHHHCCCCCEEEEECCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHH
ARIVSKASNANTISHYLDATPKQVKRVIADLEREFPNATVTTQQVAVVAVIGSDLNIPGL
HHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEHHHEEEEEEECCCCCCCCH
TAAAAQALADAGVEILGIQQLTRRVDLQFVVRERDYAASVQALHARLVCGGGRLRSAA
HHHHHHHHHHCCCCEEEHHHHHHHHCHHHEEEHHHHHHHHHHHHHHHEECCCCCCCCC
>Mature Secondary Structure 
GVHTVEKIGGTSISDTRAVLDNILIGARTGAELYNRIFVVSAYAGVTDRLLEHKKTGRP
CCCCHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHEEEEEEHHHHHHHHHHHHCCCCC
GVYALFAAAASGEGEAWRTAIDDLLTHLRALNAERFTDPADLAAADAFVEQRVETARSCL
CCEEHEEHHCCCCCHHHHHHHHHHHHHHHHHCHHHCCCHHHHHHHHHHHHHHHHHHHHHH
GDLQRLCAQGHFRLDAQLGAVREMLASIGEAQSAHNLTLELRRRGVNARMVDLTGWDEPD
HHHHHHHHCCCEEEHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCEEEEEECCCCCCC
AVELDELLARAFADVDLASELPIATGYAKAGKGLMAEYGRGYSEVVFSRTAVVTGAREAT
CCCHHHHHHHHHHCCCHHHCCCCCCCHHHHCCCHHHHHCCCHHHHHHHHHHHEECCHHHH
IHKEFHLSSADPKLVGPGAVRKVGRTNYDVADQLANLGMEAIHPRAARGLRQAGIPLCVR
HHHHEECCCCCCCCCCCHHHHHHCCCCCHHHHHHHHCCHHHCCHHHHHHHHHCCCCEEEC
NTFDPEDRGTTIWSDFVSEQPRVEIICGLTGLTALELFEPDMVGVKGYDAGILAVLTRHA
CCCCCCCCCCCHHHHHHCCCCCEEEEECCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHH
ARIVSKASNANTISHYLDATPKQVKRVIADLEREFPNATVTTQQVAVVAVIGSDLNIPGL
HHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEHHHEEEEEEECCCCCCCCH
TAAAAQALADAGVEILGIQQLTRRVDLQFVVRERDYAASVQALHARLVCGGGRLRSAA
HHHHHHHHHHCCCCEEEHHHHHHHHCHHHEEEHHHHHHHHHHHHHHHEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]