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The map label for this gene is ivd [H]

Identifier: 197104750

GI number: 197104750

Start: 1461261

End: 1462427

Strand: Direct

Name: ivd [H]

Synonym: PHZ_c1284

Alternate gene names: 197104750

Gene position: 1461261-1462427 (Clockwise)

Preceding gene: 197104749

Following gene: 197104751

Centisome position: 36.57

GC content: 68.04

Gene sequence:

>1167_bases
ATGATCCCGAACCACGGACCCACCCTCGAATTCGGCCTCGGCGAGAGCGCGGACATGATCCGCGAGACGACGGCCCGCTT
CGCCCAGGATAGGATCGCGCCGCTCGCGGCCGAGATCGACCAGACCAACAGCTTCCCGCGCGAGCTCTGGCCTCAGATGG
GCGAGCTCGGCCTGCATGGGATCACCGTCGAGGAGGAATTCGGCGGCCTCGGCCTGGGCTACCTCGAGCACGTGGTGGCG
ATGGAGGAGGTCTCCCGCGCCTCGGCGTCGATCGGCCTGTCCTACGGCGCGCATTCGAACCTGTGCGTGAACCAGCTGCG
CCGCTGGGGCACCGAGGAGCAGAAGCGCCGCTACCTGCCCAAGCTGATCTCGGGCGAGCATGTGGGCGCGCTCGCCATGA
GCGAGGCCGGCTCGGGCTCGGACGTGGTCTCGATGCGCCTGCGCGCCGAGAAGAAGGGCGACCGCTACGTCCTGAACGGC
ACGAAGTTCTGGATCACCAACGCGCCCCACGCCGACACCCTGGTGGTCTACGCCAAGACCGACCCGGACGCCGACAGCCG
CGGCATCACCGCCTTCCTGATCGAGAAGGACTTCAAGGGGTTCCGCGTCTCGCAGAAGCTGGACAAGATGGGCATGCGAG
GCTCCGACACCGGCGAGCTGGTGTTCGAGGACTGCGAGGTCCCGGAAGAGAACGTCATGGGCCCGCTGAACGGCGGCGTG
GGCGTGCTGATGAGCGGCCTCGACTACGAGCGCGCGGTGCTCGCCGCCGGGCCGCTGGGCATTATGCAGGCCTGCATGGA
CGTGGTCCTGCCGTACGTCCGCGAGCGCAAGCAGTTCGGCAAGCCGATCGGCTCGTTCCAGCTGATGCAGGGCAAGATCG
CCGACATGTACGTCGCGCTCAATTCGGCGCGGGCCTACGTCTATGCGGTGGCCAAAGCGTGCGACGCCGGCATGACCACC
CGTTTCGACGCCGCGGGCGCGATCCTGATGGCCAGCGAGAACGCGGTGAAGGTGGCCCTGGAGGCCATCCAGGCCCTGGG
CGGGGCGGGCTACACTAAGGAGTACCCCGTCGAGCGCATGCTCCGTGACGCCAAGCTGTACGACATCGGCGCCGGCACCA
ACGAGATCCGCCGGTTCCTGATCGGGCGGGAGCTGCTGGGCGGATGA

Upstream 100 bases:

>100_bases
CGTGGTCGCCGTCTACCGCCTGCTGGAGCGCCTGGGCCGCCTGACCGAGCGGGACTAGCCGCTCTCGCACCCTTGGGCGA
CGCATGGTAACGCATCGCCC

Downstream 100 bases:

>100_bases
GGACGGCGGGAGTCCTGTTGGCGCTGGGGCTGGGGCTGGCGGGCTGCGCCACCGCGCCGCCGCCCGCCTGCCCGCCGGGC
CAGGAGCACCTGCGCACCGC

Product: isovaleryl-CoA dehydrogenase

Products: 3-methylbut-2-enoyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MIPNHGPTLEFGLGESADMIRETTARFAQDRIAPLAAEIDQTNSFPRELWPQMGELGLHGITVEEEFGGLGLGYLEHVVA
MEEVSRASASIGLSYGAHSNLCVNQLRRWGTEEQKRRYLPKLISGEHVGALAMSEAGSGSDVVSMRLRAEKKGDRYVLNG
TKFWITNAPHADTLVVYAKTDPDADSRGITAFLIEKDFKGFRVSQKLDKMGMRGSDTGELVFEDCEVPEENVMGPLNGGV
GVLMSGLDYERAVLAAGPLGIMQACMDVVLPYVRERKQFGKPIGSFQLMQGKIADMYVALNSARAYVYAVAKACDAGMTT
RFDAAGAILMASENAVKVALEAIQALGGAGYTKEYPVERMLRDAKLYDIGAGTNEIRRFLIGRELLGG

Sequences:

>Translated_388_residues
MIPNHGPTLEFGLGESADMIRETTARFAQDRIAPLAAEIDQTNSFPRELWPQMGELGLHGITVEEEFGGLGLGYLEHVVA
MEEVSRASASIGLSYGAHSNLCVNQLRRWGTEEQKRRYLPKLISGEHVGALAMSEAGSGSDVVSMRLRAEKKGDRYVLNG
TKFWITNAPHADTLVVYAKTDPDADSRGITAFLIEKDFKGFRVSQKLDKMGMRGSDTGELVFEDCEVPEENVMGPLNGGV
GVLMSGLDYERAVLAAGPLGIMQACMDVVLPYVRERKQFGKPIGSFQLMQGKIADMYVALNSARAYVYAVAKACDAGMTT
RFDAAGAILMASENAVKVALEAIQALGGAGYTKEYPVERMLRDAKLYDIGAGTNEIRRFLIGRELLGG
>Mature_388_residues
MIPNHGPTLEFGLGESADMIRETTARFAQDRIAPLAAEIDQTNSFPRELWPQMGELGLHGITVEEEFGGLGLGYLEHVVA
MEEVSRASASIGLSYGAHSNLCVNQLRRWGTEEQKRRYLPKLISGEHVGALAMSEAGSGSDVVSMRLRAEKKGDRYVLNG
TKFWITNAPHADTLVVYAKTDPDADSRGITAFLIEKDFKGFRVSQKLDKMGMRGSDTGELVFEDCEVPEENVMGPLNGGV
GVLMSGLDYERAVLAAGPLGIMQACMDVVLPYVRERKQFGKPIGSFQLMQGKIADMYVALNSARAYVYAVAKACDAGMTT
RFDAAGAILMASENAVKVALEAIQALGGAGYTKEYPVERMLRDAKLYDIGAGTNEIRRFLIGRELLGG

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=376, Percent_Identity=61.968085106383, Blast_Score=481, Evalue=1e-136,
Organism=Homo sapiens, GI226958414, Length=370, Percent_Identity=60.2702702702703, Blast_Score=452, Evalue=1e-127,
Organism=Homo sapiens, GI4557233, Length=374, Percent_Identity=40.6417112299465, Blast_Score=286, Evalue=3e-77,
Organism=Homo sapiens, GI4501859, Length=367, Percent_Identity=38.4196185286104, Blast_Score=278, Evalue=7e-75,
Organism=Homo sapiens, GI187960098, Length=385, Percent_Identity=36.1038961038961, Blast_Score=240, Evalue=1e-63,
Organism=Homo sapiens, GI4557231, Length=385, Percent_Identity=36.1038961038961, Blast_Score=240, Evalue=2e-63,
Organism=Homo sapiens, GI21361497, Length=359, Percent_Identity=38.7186629526462, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI4501857, Length=374, Percent_Identity=33.6898395721925, Blast_Score=229, Evalue=4e-60,
Organism=Homo sapiens, GI76496475, Length=395, Percent_Identity=34.6835443037975, Blast_Score=215, Evalue=7e-56,
Organism=Homo sapiens, GI4557235, Length=395, Percent_Identity=34.6835443037975, Blast_Score=214, Evalue=8e-56,
Organism=Homo sapiens, GI7656849, Length=379, Percent_Identity=33.245382585752, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI4503943, Length=387, Percent_Identity=32.2997416020672, Blast_Score=182, Evalue=5e-46,
Organism=Homo sapiens, GI7669494, Length=360, Percent_Identity=33.0555555555556, Blast_Score=172, Evalue=5e-43,
Organism=Homo sapiens, GI48976061, Length=287, Percent_Identity=29.2682926829268, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI211971008, Length=287, Percent_Identity=29.2682926829268, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI38505218, Length=282, Percent_Identity=23.758865248227, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI87081958, Length=385, Percent_Identity=31.1688311688312, Blast_Score=174, Evalue=9e-45,
Organism=Escherichia coli, GI1786223, Length=382, Percent_Identity=28.0104712041885, Blast_Score=165, Evalue=5e-42,
Organism=Escherichia coli, GI87082384, Length=283, Percent_Identity=25.7950530035336, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI87081702, Length=295, Percent_Identity=25.7627118644068, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17538396, Length=377, Percent_Identity=59.6816976127321, Blast_Score=473, Evalue=1e-134,
Organism=Caenorhabditis elegans, GI17569725, Length=390, Percent_Identity=36.9230769230769, Blast_Score=259, Evalue=2e-69,
Organism=Caenorhabditis elegans, GI17534899, Length=385, Percent_Identity=35.3246753246753, Blast_Score=251, Evalue=5e-67,
Organism=Caenorhabditis elegans, GI17508101, Length=382, Percent_Identity=35.0785340314136, Blast_Score=248, Evalue=4e-66,
Organism=Caenorhabditis elegans, GI17570075, Length=381, Percent_Identity=35.9580052493438, Blast_Score=245, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI17506239, Length=371, Percent_Identity=33.4231805929919, Blast_Score=243, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI17533517, Length=377, Percent_Identity=34.2175066312997, Blast_Score=213, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI71990804, Length=310, Percent_Identity=37.0967741935484, Blast_Score=206, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI71985184, Length=349, Percent_Identity=34.3839541547278, Blast_Score=202, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI71982178, Length=274, Percent_Identity=34.3065693430657, Blast_Score=184, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI17534353, Length=363, Percent_Identity=28.9256198347107, Blast_Score=173, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI32563615, Length=230, Percent_Identity=34.3478260869565, Blast_Score=173, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17505929, Length=372, Percent_Identity=30.3763440860215, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17551932, Length=360, Percent_Identity=30, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI71985192, Length=285, Percent_Identity=33.3333333333333, Blast_Score=162, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17531909, Length=239, Percent_Identity=30.1255230125523, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI86563381, Length=268, Percent_Identity=26.4925373134328, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI86563383, Length=268, Percent_Identity=26.4925373134328, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI21355753, Length=379, Percent_Identity=60.9498680738786, Blast_Score=467, Evalue=1e-132,
Organism=Drosophila melanogaster, GI21356377, Length=374, Percent_Identity=40.6417112299465, Blast_Score=288, Evalue=6e-78,
Organism=Drosophila melanogaster, GI24646207, Length=383, Percent_Identity=38.3812010443864, Blast_Score=265, Evalue=4e-71,
Organism=Drosophila melanogaster, GI24666513, Length=377, Percent_Identity=35.0132625994695, Blast_Score=253, Evalue=2e-67,
Organism=Drosophila melanogaster, GI24660351, Length=378, Percent_Identity=36.7724867724868, Blast_Score=246, Evalue=2e-65,
Organism=Drosophila melanogaster, GI281363737, Length=353, Percent_Identity=36.5439093484419, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI19920834, Length=384, Percent_Identity=29.4270833333333, Blast_Score=171, Evalue=1e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.10

Molecular weight: Translated: 42158; Mature: 42158

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPNHGPTLEFGLGESADMIRETTARFAQDRIAPLAAEIDQTNSFPRELWPQMGELGLHG
CCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCC
ITVEEEFGGLGLGYLEHVVAMEEVSRASASIGLSYGAHSNLCVNQLRRWGTEEQKRRYLP
EEEECCCCCCCHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHCCCHHHHHHHHH
KLISGEHVGALAMSEAGSGSDVVSMRLRAEKKGDRYVLNGTKFWITNAPHADTLVVYAKT
HHHCCCCCCEEEECCCCCCCHHEEEEEHHCCCCCEEEECCEEEEEECCCCCCEEEEEEEC
DPDADSRGITAFLIEKDFKGFRVSQKLDKMGMRGSDTGELVFEDCEVPEENVMGPLNGGV
CCCCCCCCCEEEEEECCCCCCCHHHHHHHCCCCCCCCCCEEEECCCCCHHHCCCCCCCCH
GVLMSGLDYERAVLAAGPLGIMQACMDVVLPYVRERKQFGKPIGSFQLMQGKIADMYVAL
HHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCHHHHHEEEH
NSARAYVYAVAKACDAGMTTRFDAAGAILMASENAVKVALEAIQALGGAGYTKEYPVERM
HCCHHHHHHHHHHHCCCCCEEECCCCEEEEECCCHHHHHHHHHHHHCCCCCCCCCCHHHH
LRDAKLYDIGAGTNEIRRFLIGRELLGG
HHHCCEEECCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIPNHGPTLEFGLGESADMIRETTARFAQDRIAPLAAEIDQTNSFPRELWPQMGELGLHG
CCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCC
ITVEEEFGGLGLGYLEHVVAMEEVSRASASIGLSYGAHSNLCVNQLRRWGTEEQKRRYLP
EEEECCCCCCCHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHCCCHHHHHHHHH
KLISGEHVGALAMSEAGSGSDVVSMRLRAEKKGDRYVLNGTKFWITNAPHADTLVVYAKT
HHHCCCCCCEEEECCCCCCCHHEEEEEHHCCCCCEEEECCEEEEEECCCCCCEEEEEEEC
DPDADSRGITAFLIEKDFKGFRVSQKLDKMGMRGSDTGELVFEDCEVPEENVMGPLNGGV
CCCCCCCCCEEEEEECCCCCCCHHHHHHHCCCCCCCCCCEEEECCCCCHHHCCCCCCCCH
GVLMSGLDYERAVLAAGPLGIMQACMDVVLPYVRERKQFGKPIGSFQLMQGKIADMYVAL
HHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCHHHHHEEEH
NSARAYVYAVAKACDAGMTTRFDAAGAILMASENAVKVALEAIQALGGAGYTKEYPVERM
HCCHHHHHHHHHHHCCCCCEEECCCCEEEEECCCHHHHHHHHHHHHCCCCCCCCCCHHHH
LRDAKLYDIGAGTNEIRRFLIGRELLGG
HHHCCEEECCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3-methylbutanoyl-CoA; acceptor

Specific reaction: 3-methylbutanoyl-CoA + acceptor = 3-methylbut-2-enoyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]