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The map label for this gene is pccA [H]

Identifier: 197104744

GI number: 197104744

Start: 1454632

End: 1456605

Strand: Direct

Name: pccA [H]

Synonym: PHZ_c1278

Alternate gene names: 197104744

Gene position: 1454632-1456605 (Clockwise)

Preceding gene: 197104741

Following gene: 197104745

Centisome position: 36.4

GC content: 68.79

Gene sequence:

>1974_bases
ATGTTTTCGAAGATCCTGATTGCGAACCGGGGCGAGATCGCCGTCCGGATCATCAAGACCTGCCGGCGGATGGGGATCGC
CACGGTGGTCGTCTACTCCGAGGCCGACGCCGATTCGATGGCGGTGGAGATGGCGGATGAGGCGGTCTTCATCGGCCCGC
CCCCGGCGGCCCAGAGCTATCTGCTGCAGGACAAGATCGTGGAGGCGGTGCGCCAGACGGGCGCCGAGGCCGTCCACCCG
GGATTCGGCTTCCTGTCCGAGAACGCGTCCTTCGCCCGCCGGCTGGCCGCCGAGAACATCGTCTTCATCGGCCCCAATCC
CCAGGCCATCGAGGCCATGGGCGACAAGATCGAGTCCAAGAAGTTCGCCGCCAAGGCCGGCGTCTCGACGGTGCCGGGCC
ACGTGGGCGAGATCGACGACACGGGCCACGCCATCCGCATCTCCGAGGAGATCGGCTATCCGGTGATGATCAAGGCCTCG
GCCGGGGGCGGGGGCAAGGGCATCCGCGTCGCCTGGAGCCGGCAGGACGTGGAGGAAGGATTTCCCGCCGTCCGCGCCGA
GGCCAAGGCCAGCTTCGGCGACGACCGCATCTTCATCGAGAAGTTCATCGAGAGCCCGCGCCACGTCGAGATCCAGGTGC
TGGGGGACAAGCACGGCAACGTCGTCCACCTGTTCGAGCGCGAGTGCTCGATCCAGCGCCGCAACCAGAAGGTCGTCGAG
GAGGCTCCCAGCCCGCTGCTGGACGAGAAGACCCGCAAGGCGATGGGCGACCAGGCCGTCGCCCTGGCCAAGGCCGTAGG
CTACGACAGCGCCGGCACCGTCGAGTTCGTGGCGGGCCAGGACCGCAGCTTCTTTTTCCTCGAGATGAACACCCGCCTGC
AGGTGGAGCATCCGGTGACCGAGCTGATCACCGGGGTGGACCTGGTCGAGCAGATGATCCGCGTGGCCGCCGGCGAGACG
CTGCCCTTCGCCCAGGACGACCTGAAGATCGACGGCTGGGCCATGGAAAGCCGGATTTACGCCGAGGACCCGTACCGCGG
CTTCCTGCCCTCGATCGGCCGTCTCGTCCGCTACGACCCGCCGACCGAGGGGCCGGTGAAGGAGGGGATCGTCCGCAACG
ACGCCGGCGTGCGCGAGGGGGACGAGATCTCGATGTTCTACGATCCGATGATCTCGAAGCTGTCCACTTGGGGGAAGACC
CGCGACGCGGCCATCGACGCCATGGGTCGGGCCCTCGAGGACTTCCACATCGAGGGCCTGGGCCACAACATCCCGTTCCT
GGCGGCGGTGATGGACCAGGACCGCTTCCGGTCGGGCAAGCTGTCGACGAACTACATCAAGGACGAGTTCCCGGACGGCT
TCCACGGACTCGAGCCCACGGAGGCCCAGCGCGACCTCATGGGGGCCGTGGCCGTCGCCATGCACCGCACGCTGGTGGCC
CGGCAGGCGCCCGCGCTCGCCCGCGACGAGTGGATCGAGGTGGTCGGACACGAGAAGCGCCCCGTGCGGGTGCGCTCCGA
GAGCGAGGCCCTCGTGGTCGAGAGGCCGGGACGCGACACCCGGCTGACAGACATCGACTGGCGGCCGGGCCGACCGCTGT
TCCGCGGCAAGGTGGACGGCGAGCCCTTCACCGCGACGGTCAAGCCGGCCGCCGAGGGCTTCGTGATCCGCCACCGCGCC
GCCCAGGCCCACGTGCTGGTGCTGACGCCGCGCTCGGCCGAGCTGCACGAGAAGCTGCCGCCGAAGAAGGCGGCCGACAC
CTCCAAGATGGTGCTCTCGCCGATGCCGGGTCTGGTCGTCTCGATCGACGTGGCGACCGGCCAGGAGGTCAAGACCGGCG
AGGTCGTCGCCGTCCTCGAGGCCATGAAGATGCAGAACATCATCCGCGCCGAGCGCGACGGGGTGGTGAAGGCGGTCGGC
GCCAAGCCGGGCGACAGCGTCGCGGCCGACGAGGTTCTGGTAGAGTTCGCCTAA

Upstream 100 bases:

>100_bases
ATGGACGCCAATCTAAGGTCGCCCCTTCGCGAGCGGAAGACGCGGGAGGCCGATTGCGCCTCCTTTGGCGGCCTGTGGGC
TGTAGGGCGTAAGGGACGGA

Downstream 100 bases:

>100_bases
GGGAATCGCCAGGCGGGGGCGCCATGAACGGCCAGACGGGCTTCGGGGAGCTTTTCCTCTCGGCGAACGGGCGGGCGTCG
CGCCTGCCGTCGACCCTGGC

Product: propionyl-CoA carboxylase, alpha subunit

Products: NA

Alternate protein names: Pyruvic carboxylase A [H]

Number of amino acids: Translated: 657; Mature: 657

Protein sequence:

>657_residues
MFSKILIANRGEIAVRIIKTCRRMGIATVVVYSEADADSMAVEMADEAVFIGPPPAAQSYLLQDKIVEAVRQTGAEAVHP
GFGFLSENASFARRLAAENIVFIGPNPQAIEAMGDKIESKKFAAKAGVSTVPGHVGEIDDTGHAIRISEEIGYPVMIKAS
AGGGGKGIRVAWSRQDVEEGFPAVRAEAKASFGDDRIFIEKFIESPRHVEIQVLGDKHGNVVHLFERECSIQRRNQKVVE
EAPSPLLDEKTRKAMGDQAVALAKAVGYDSAGTVEFVAGQDRSFFFLEMNTRLQVEHPVTELITGVDLVEQMIRVAAGET
LPFAQDDLKIDGWAMESRIYAEDPYRGFLPSIGRLVRYDPPTEGPVKEGIVRNDAGVREGDEISMFYDPMISKLSTWGKT
RDAAIDAMGRALEDFHIEGLGHNIPFLAAVMDQDRFRSGKLSTNYIKDEFPDGFHGLEPTEAQRDLMGAVAVAMHRTLVA
RQAPALARDEWIEVVGHEKRPVRVRSESEALVVERPGRDTRLTDIDWRPGRPLFRGKVDGEPFTATVKPAAEGFVIRHRA
AQAHVLVLTPRSAELHEKLPPKKAADTSKMVLSPMPGLVVSIDVATGQEVKTGEVVAVLEAMKMQNIIRAERDGVVKAVG
AKPGDSVAADEVLVEFA

Sequences:

>Translated_657_residues
MFSKILIANRGEIAVRIIKTCRRMGIATVVVYSEADADSMAVEMADEAVFIGPPPAAQSYLLQDKIVEAVRQTGAEAVHP
GFGFLSENASFARRLAAENIVFIGPNPQAIEAMGDKIESKKFAAKAGVSTVPGHVGEIDDTGHAIRISEEIGYPVMIKAS
AGGGGKGIRVAWSRQDVEEGFPAVRAEAKASFGDDRIFIEKFIESPRHVEIQVLGDKHGNVVHLFERECSIQRRNQKVVE
EAPSPLLDEKTRKAMGDQAVALAKAVGYDSAGTVEFVAGQDRSFFFLEMNTRLQVEHPVTELITGVDLVEQMIRVAAGET
LPFAQDDLKIDGWAMESRIYAEDPYRGFLPSIGRLVRYDPPTEGPVKEGIVRNDAGVREGDEISMFYDPMISKLSTWGKT
RDAAIDAMGRALEDFHIEGLGHNIPFLAAVMDQDRFRSGKLSTNYIKDEFPDGFHGLEPTEAQRDLMGAVAVAMHRTLVA
RQAPALARDEWIEVVGHEKRPVRVRSESEALVVERPGRDTRLTDIDWRPGRPLFRGKVDGEPFTATVKPAAEGFVIRHRA
AQAHVLVLTPRSAELHEKLPPKKAADTSKMVLSPMPGLVVSIDVATGQEVKTGEVVAVLEAMKMQNIIRAERDGVVKAVG
AKPGDSVAADEVLVEFA
>Mature_657_residues
MFSKILIANRGEIAVRIIKTCRRMGIATVVVYSEADADSMAVEMADEAVFIGPPPAAQSYLLQDKIVEAVRQTGAEAVHP
GFGFLSENASFARRLAAENIVFIGPNPQAIEAMGDKIESKKFAAKAGVSTVPGHVGEIDDTGHAIRISEEIGYPVMIKAS
AGGGGKGIRVAWSRQDVEEGFPAVRAEAKASFGDDRIFIEKFIESPRHVEIQVLGDKHGNVVHLFERECSIQRRNQKVVE
EAPSPLLDEKTRKAMGDQAVALAKAVGYDSAGTVEFVAGQDRSFFFLEMNTRLQVEHPVTELITGVDLVEQMIRVAAGET
LPFAQDDLKIDGWAMESRIYAEDPYRGFLPSIGRLVRYDPPTEGPVKEGIVRNDAGVREGDEISMFYDPMISKLSTWGKT
RDAAIDAMGRALEDFHIEGLGHNIPFLAAVMDQDRFRSGKLSTNYIKDEFPDGFHGLEPTEAQRDLMGAVAVAMHRTLVA
RQAPALARDEWIEVVGHEKRPVRVRSESEALVVERPGRDTRLTDIDWRPGRPLFRGKVDGEPFTATVKPAAEGFVIRHRA
AQAHVLVLTPRSAELHEKLPPKKAADTSKMVLSPMPGLVVSIDVATGQEVKTGEVVAVLEAMKMQNIIRAERDGVVKAVG
AKPGDSVAADEVLVEFA

Specific function: Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second [H]

COG id: COG4770

COG function: function code I; Acetyl/propionyl-CoA carboxylase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI65506442, Length=670, Percent_Identity=51.044776119403, Blast_Score=640, Evalue=0.0,
Organism=Homo sapiens, GI189095269, Length=670, Percent_Identity=51.044776119403, Blast_Score=639, Evalue=0.0,
Organism=Homo sapiens, GI295821183, Length=668, Percent_Identity=49.1017964071856, Blast_Score=593, Evalue=1e-169,
Organism=Homo sapiens, GI116805327, Length=674, Percent_Identity=40.0593471810089, Blast_Score=489, Evalue=1e-138,
Organism=Homo sapiens, GI106049528, Length=477, Percent_Identity=43.8155136268344, Blast_Score=374, Evalue=1e-103,
Organism=Homo sapiens, GI106049295, Length=477, Percent_Identity=43.8155136268344, Blast_Score=374, Evalue=1e-103,
Organism=Homo sapiens, GI106049292, Length=477, Percent_Identity=43.8155136268344, Blast_Score=374, Evalue=1e-103,
Organism=Homo sapiens, GI38679971, Length=745, Percent_Identity=29.3959731543624, Blast_Score=251, Evalue=1e-66,
Organism=Homo sapiens, GI38679974, Length=543, Percent_Identity=32.5966850828729, Blast_Score=251, Evalue=1e-66,
Organism=Homo sapiens, GI38679960, Length=543, Percent_Identity=32.5966850828729, Blast_Score=251, Evalue=2e-66,
Organism=Homo sapiens, GI38679977, Length=543, Percent_Identity=32.5966850828729, Blast_Score=251, Evalue=2e-66,
Organism=Homo sapiens, GI38679967, Length=543, Percent_Identity=32.5966850828729, Blast_Score=251, Evalue=2e-66,
Organism=Homo sapiens, GI134142062, Length=727, Percent_Identity=28.748280605227, Blast_Score=240, Evalue=2e-63,
Organism=Escherichia coli, GI1789654, Length=452, Percent_Identity=45.575221238938, Blast_Score=385, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI17567343, Length=680, Percent_Identity=49.1176470588235, Blast_Score=610, Evalue=1e-175,
Organism=Caenorhabditis elegans, GI71987519, Length=666, Percent_Identity=42.7927927927928, Blast_Score=487, Evalue=1e-138,
Organism=Caenorhabditis elegans, GI17562816, Length=480, Percent_Identity=43.125, Blast_Score=362, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI133931226, Length=688, Percent_Identity=28.343023255814, Blast_Score=226, Evalue=3e-59,
Organism=Caenorhabditis elegans, GI71997163, Length=512, Percent_Identity=30.46875, Blast_Score=224, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI71997168, Length=512, Percent_Identity=30.46875, Blast_Score=223, Evalue=2e-58,
Organism=Saccharomyces cerevisiae, GI6319685, Length=470, Percent_Identity=44.2553191489362, Blast_Score=390, Evalue=1e-109,
Organism=Saccharomyces cerevisiae, GI6319695, Length=477, Percent_Identity=40.8805031446541, Blast_Score=342, Evalue=8e-95,
Organism=Saccharomyces cerevisiae, GI6321376, Length=477, Percent_Identity=41.0901467505241, Blast_Score=331, Evalue=2e-91,
Organism=Saccharomyces cerevisiae, GI6323863, Length=683, Percent_Identity=28.4040995607613, Blast_Score=236, Evalue=1e-62,
Organism=Saccharomyces cerevisiae, GI6324343, Length=732, Percent_Identity=27.3224043715847, Blast_Score=234, Evalue=3e-62,
Organism=Drosophila melanogaster, GI24651757, Length=674, Percent_Identity=38.2789317507418, Blast_Score=460, Evalue=1e-129,
Organism=Drosophila melanogaster, GI24651759, Length=636, Percent_Identity=37.1069182389937, Blast_Score=414, Evalue=1e-116,
Organism=Drosophila melanogaster, GI24652212, Length=520, Percent_Identity=43.0769230769231, Blast_Score=376, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652210, Length=520, Percent_Identity=43.0769230769231, Blast_Score=376, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652214, Length=520, Percent_Identity=43.0769230769231, Blast_Score=376, Evalue=1e-104,
Organism=Drosophila melanogaster, GI19921944, Length=520, Percent_Identity=43.0769230769231, Blast_Score=376, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652216, Length=520, Percent_Identity=43.0769230769231, Blast_Score=376, Evalue=1e-104,
Organism=Drosophila melanogaster, GI281363050, Length=528, Percent_Identity=42.0454545454545, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652224, Length=528, Percent_Identity=42.0454545454545, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652222, Length=528, Percent_Identity=42.0454545454545, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652220, Length=528, Percent_Identity=42.0454545454545, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652218, Length=528, Percent_Identity=42.0454545454545, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI161076407, Length=503, Percent_Identity=32.20675944334, Blast_Score=232, Evalue=6e-61,
Organism=Drosophila melanogaster, GI24586460, Length=503, Percent_Identity=32.20675944334, Blast_Score=232, Evalue=6e-61,
Organism=Drosophila melanogaster, GI161076409, Length=503, Percent_Identity=32.20675944334, Blast_Score=232, Evalue=7e-61,
Organism=Drosophila melanogaster, GI24586458, Length=503, Percent_Identity=32.20675944334, Blast_Score=232, Evalue=8e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.4.1.1 [H]

Molecular weight: Translated: 71754; Mature: 71754

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC ; PS50968 BIOTINYL_LIPOYL ; PS00188 BIOTIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSKILIANRGEIAVRIIKTCRRMGIATVVVYSEADADSMAVEMADEAVFIGPPPAAQSY
CCCEEEEECCCCHHHHHHHHHHHCCEEEEEEEECCCCCHHEEEECCCEEEECCCCCHHHH
LLQDKIVEAVRQTGAEAVHPGFGFLSENASFARRLAAENIVFIGPNPQAIEAMGDKIESK
HHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHH
KFAAKAGVSTVPGHVGEIDDTGHAIRISEEIGYPVMIKASAGGGGKGIRVAWSRQDVEEG
HHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCCEEEEECCCCCCCCEEEEECCCCHHHC
FPAVRAEAKASFGDDRIFIEKFIESPRHVEIQVLGDKHGNVVHLFERECSIQRRNQKVVE
CCHHHHHHHCCCCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEEECHHHHHHHHHHHHHH
EAPSPLLDEKTRKAMGDQAVALAKAVGYDSAGTVEFVAGQDRSFFFLEMNTRLQVEHPVT
HCCCCHHHHHHHHHHCHHHHHHHHHHCCCCCCCEEEEECCCCEEEEEEECCEEEECCCHH
ELITGVDLVEQMIRVAAGETLPFAQDDLKIDGWAMESRIYAEDPYRGFLPSIGRLVRYDP
HHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCEEECCEEEECCCCCCHHHHHCCEEECCC
PTEGPVKEGIVRNDAGVREGDEISMFYDPMISKLSTWGKTRDAAIDAMGRALEDFHIEGL
CCCCCHHHCCEECCCCCCCCCCEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHEECCC
GHNIPFLAAVMDQDRFRSGKLSTNYIKDEFPDGFHGLEPTEAQRDLMGAVAVAMHRTLVA
CCCCCHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
RQAPALARDEWIEVVGHEKRPVRVRSESEALVVERPGRDTRLTDIDWRPGRPLFRGKVDG
HCCCCHHHHHHHHHHCCCCCCEEEECCCCEEEEECCCCCCEEEECCCCCCCCCEECCCCC
EPFTATVKPAAEGFVIRHRAAQAHVLVLTPRSAELHEKLPPKKAADTSKMVLSPMPGLVV
CCEEEEECCCCCCEEEEEECCCEEEEEECCCCHHHHHCCCCCCCCCCCCEEECCCCCEEE
SIDVATGQEVKTGEVVAVLEAMKMQNIIRAERDGVVKAVGAKPGDSVAADEVLVEFA
EEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHEEEECC
>Mature Secondary Structure
MFSKILIANRGEIAVRIIKTCRRMGIATVVVYSEADADSMAVEMADEAVFIGPPPAAQSY
CCCEEEEECCCCHHHHHHHHHHHCCEEEEEEEECCCCCHHEEEECCCEEEECCCCCHHHH
LLQDKIVEAVRQTGAEAVHPGFGFLSENASFARRLAAENIVFIGPNPQAIEAMGDKIESK
HHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHH
KFAAKAGVSTVPGHVGEIDDTGHAIRISEEIGYPVMIKASAGGGGKGIRVAWSRQDVEEG
HHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCCEEEEECCCCCCCCEEEEECCCCHHHC
FPAVRAEAKASFGDDRIFIEKFIESPRHVEIQVLGDKHGNVVHLFERECSIQRRNQKVVE
CCHHHHHHHCCCCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEEECHHHHHHHHHHHHHH
EAPSPLLDEKTRKAMGDQAVALAKAVGYDSAGTVEFVAGQDRSFFFLEMNTRLQVEHPVT
HCCCCHHHHHHHHHHCHHHHHHHHHHCCCCCCCEEEEECCCCEEEEEEECCEEEECCCHH
ELITGVDLVEQMIRVAAGETLPFAQDDLKIDGWAMESRIYAEDPYRGFLPSIGRLVRYDP
HHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCEEECCEEEECCCCCCHHHHHCCEEECCC
PTEGPVKEGIVRNDAGVREGDEISMFYDPMISKLSTWGKTRDAAIDAMGRALEDFHIEGL
CCCCCHHHCCEECCCCCCCCCCEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHEECCC
GHNIPFLAAVMDQDRFRSGKLSTNYIKDEFPDGFHGLEPTEAQRDLMGAVAVAMHRTLVA
CCCCCHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
RQAPALARDEWIEVVGHEKRPVRVRSESEALVVERPGRDTRLTDIDWRPGRPLFRGKVDG
HCCCCHHHHHHHHHHCCCCCCEEEECCCCEEEEECCCCCCEEEECCCCCCCCCEECCCCC
EPFTATVKPAAEGFVIRHRAAQAHVLVLTPRSAELHEKLPPKKAADTSKMVLSPMPGLVV
CCEEEEECCCCCCEEEEEECCCEEEEEECCCCHHHHHCCCCCCCCCCCCEEECCCCCEEE
SIDVATGQEVKTGEVVAVLEAMKMQNIIRAERDGVVKAVGAKPGDSVAADEVLVEFA
EEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087; 11195096 [H]