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The map label for this gene is acdA [H]

Identifier: 197104663

GI number: 197104663

Start: 1379032

End: 1380198

Strand: Direct

Name: acdA [H]

Synonym: PHZ_c1197

Alternate gene names: 197104663

Gene position: 1379032-1380198 (Clockwise)

Preceding gene: 197104662

Following gene: 197104664

Centisome position: 34.51

GC content: 72.24

Gene sequence:

>1167_bases
GTGGGGGGTGGCGACGACGCCGCGTTCCTCGAAGACATTCGGGCTTTCCTGGCGCGTGAGCTGACCCCTGATCTCCGGGA
AGCGTCGCGGCGGACCGTGGGCGTCTACACGGACGTGGCGAGCGGCTTGGTCTGGCATCGCCGCCTGCACGCCCGAGGCT
GGATCGCGCCGGCGTGGCCGGCGCAATGGGGCGGCGCGGGCTGGAGCGCGCGCCAGCGCTACCTATGGGACCGCGAGTGC
GCGCTGAACGACGCCCCGGTGCTCTTCGCGGCCGGAGTCCGCAGCCTGGGGCCGTTGCTGATCGAGGCCGGAACGGCCGC
ACAGCGGGCGGAGCACCTGCCGCGGATCCTCAGCGGCGAAGCCCTGTGGTGCCAGGGGTTCTCCGAGACGGGCGCCGGGT
CGGACCTGGCCGGCGTCGCCACGCGCGCGGCGCAGGACGGAGACGACTATCTGGTGACGGGGGCGAAGGTCTGGACGACC
GGCGCGCACCTCTCGAACTGGATGTTCGCCCTGGTGCGCACCGCGGACGGCGACCGCAAGCAGGCCGGCCTGACGTTCCT
GCTGATCGACATGGCGAGCGCCGGGATTTCGGTCTCGCCGATCCGAGACATCTCGGGCGAGCACGAGCTGAACCAGGTCT
TCTTCGACGCCGTGCGGGTTCCCGTCGCCAACCGCGTGGGCGCCGAGAACGATGGCTGGGTCGTCGCCAAGCGGCTGATG
CAGCTCGCCAGGTCGAACAACACGCCGGCGGCGCTGGTCCGCCGCTCCCTGAACCGCGTCCGCCGCGTCGTGACTGAAGA
CGCGGCGGCGGACCCCGCCCTGCGGCGTCGCCTCGCCGAGCTGGAGATCGAGCTGGAGGCCTTCACGGCGCTGGAGCTGG
CGGCGCTCCCGGAGGGACGACCCGAGGCGTCGGCCGTCAGCGCCCCCTCGATGGTCAAGCTGGTCGGCACTGAGCTGCAT
CAGAAGGTGCACGCGCTCGGCGTCGATGTCGCCTGCGCCGCCGGGGCCCCGCACCTGGCCGCCGGGGAGTTCGGCGATCC
TGAACTCGACGCGGCGCAGCTCTTCATGGCCAAGCACCTGGCGGGGCGCGCGTCGACGATCTACTCCGGGAGCAGCGAGA
CCCAGAGGAATGTGATCTTCCGAGGCCGGCTCGGCTCGCGGCCGTGA

Upstream 100 bases:

>100_bases
CGGCCGCCCTGCGGCCCCCCATGGGTCCTCCCGCCCGGCGGGCCCTCGGCCCGGTGCGGGACGCCCCGACAGGGAAGGTC
CGCGTCCGCCGGCGGCTTTC

Downstream 100 bases:

>100_bases
CCGTGGACGCTCGCCGCCGCCTTACGGCCGGCGTCGGCGCAGCCCGGCTGATCGAGGCCCGGCGTCGAGCCGCGACATGA
CGGCCGCGCCGGCGCGCCCC

Product: acyl-CoA dehydrogenase

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 387

Protein sequence:

>388_residues
MGGGDDAAFLEDIRAFLARELTPDLREASRRTVGVYTDVASGLVWHRRLHARGWIAPAWPAQWGGAGWSARQRYLWDREC
ALNDAPVLFAAGVRSLGPLLIEAGTAAQRAEHLPRILSGEALWCQGFSETGAGSDLAGVATRAAQDGDDYLVTGAKVWTT
GAHLSNWMFALVRTADGDRKQAGLTFLLIDMASAGISVSPIRDISGEHELNQVFFDAVRVPVANRVGAENDGWVVAKRLM
QLARSNNTPAALVRRSLNRVRRVVTEDAAADPALRRRLAELEIELEAFTALELAALPEGRPEASAVSAPSMVKLVGTELH
QKVHALGVDVACAAGAPHLAAGEFGDPELDAAQLFMAKHLAGRASTIYSGSSETQRNVIFRGRLGSRP

Sequences:

>Translated_388_residues
MGGGDDAAFLEDIRAFLARELTPDLREASRRTVGVYTDVASGLVWHRRLHARGWIAPAWPAQWGGAGWSARQRYLWDREC
ALNDAPVLFAAGVRSLGPLLIEAGTAAQRAEHLPRILSGEALWCQGFSETGAGSDLAGVATRAAQDGDDYLVTGAKVWTT
GAHLSNWMFALVRTADGDRKQAGLTFLLIDMASAGISVSPIRDISGEHELNQVFFDAVRVPVANRVGAENDGWVVAKRLM
QLARSNNTPAALVRRSLNRVRRVVTEDAAADPALRRRLAELEIELEAFTALELAALPEGRPEASAVSAPSMVKLVGTELH
QKVHALGVDVACAAGAPHLAAGEFGDPELDAAQLFMAKHLAGRASTIYSGSSETQRNVIFRGRLGSRP
>Mature_387_residues
GGGDDAAFLEDIRAFLARELTPDLREASRRTVGVYTDVASGLVWHRRLHARGWIAPAWPAQWGGAGWSARQRYLWDRECA
LNDAPVLFAAGVRSLGPLLIEAGTAAQRAEHLPRILSGEALWCQGFSETGAGSDLAGVATRAAQDGDDYLVTGAKVWTTG
AHLSNWMFALVRTADGDRKQAGLTFLLIDMASAGISVSPIRDISGEHELNQVFFDAVRVPVANRVGAENDGWVVAKRLMQ
LARSNNTPAALVRRSLNRVRRVVTEDAAADPALRRRLAELEIELEAFTALELAALPEGRPEASAVSAPSMVKLVGTELHQ
KVHALGVDVACAAGAPHLAAGEFGDPELDAAQLFMAKHLAGRASTIYSGSSETQRNVIFRGRLGSRP

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI21361497, Length=250, Percent_Identity=26.4, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI7656849, Length=318, Percent_Identity=26.1006289308176, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI4557231, Length=261, Percent_Identity=28.3524904214559, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI187960098, Length=261, Percent_Identity=28.3524904214559, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI226958412, Length=239, Percent_Identity=25.1046025104602, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI226958414, Length=203, Percent_Identity=26.6009852216749, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI4501859, Length=192, Percent_Identity=28.6458333333333, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI76496475, Length=196, Percent_Identity=28.5714285714286, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI4557235, Length=196, Percent_Identity=28.5714285714286, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI4557233, Length=393, Percent_Identity=23.9185750636132, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17570075, Length=408, Percent_Identity=26.9607843137255, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17508101, Length=244, Percent_Identity=28.6885245901639, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17506239, Length=245, Percent_Identity=27.3469387755102, Blast_Score=92, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17534899, Length=355, Percent_Identity=26.4788732394366, Blast_Score=91, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI17569725, Length=349, Percent_Identity=25.7879656160458, Blast_Score=89, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI32563615, Length=190, Percent_Identity=31.0526315789474, Blast_Score=88, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI71990804, Length=197, Percent_Identity=27.9187817258883, Blast_Score=81, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17538396, Length=242, Percent_Identity=25.2066115702479, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71985192, Length=154, Percent_Identity=29.2207792207792, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71985184, Length=154, Percent_Identity=29.2207792207792, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17505929, Length=179, Percent_Identity=26.8156424581006, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17551932, Length=186, Percent_Identity=26.8817204301075, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI21355753, Length=226, Percent_Identity=28.3185840707965, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24660351, Length=346, Percent_Identity=26.0115606936416, Blast_Score=78, Evalue=8e-15,
Organism=Drosophila melanogaster, GI281363737, Length=198, Percent_Identity=25.7575757575758, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24666513, Length=204, Percent_Identity=26.9607843137255, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24646207, Length=391, Percent_Identity=26.0869565217391, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI21356377, Length=354, Percent_Identity=24.0112994350282, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 41624; Mature: 41492

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGGGDDAAFLEDIRAFLARELTPDLREASRRTVGVYTDVASGLVWHRRLHARGWIAPAWP
CCCCCHHHHHHHHHHHHHHHCCHHHHHHCCCEEEEHHHHHHHHHHHHHHHHCCCCCCCCC
AQWGGAGWSARQRYLWDRECALNDAPVLFAAGVRSLGPLLIEAGTAAQRAEHLPRILSGE
CCCCCCCCHHHHHHCCCHHHCCCCCCCHHHHHHHHHCHHEEECCCHHHHHHHHHHHHCCC
ALWCQGFSETGAGSDLAGVATRAAQDGDDYLVTGAKVWTTGAHLSNWMFALVRTADGDRK
EEEECCCCCCCCCCCHHHHHHHHCCCCCCEEEECCEEEECCHHHHHHHHHHHHCCCCCCH
QAGLTFLLIDMASAGISVSPIRDISGEHELNQVFFDAVRVPVANRVGAENDGWVVAKRLM
HCCCEEEEEEHHCCCCCCCCHHHCCCCHHHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHH
QLARSNNTPAALVRRSLNRVRRVVTEDAAADPALRRRLAELEIELEAFTALELAALPEGR
HHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PEASAVSAPSMVKLVGTELHQKVHALGVDVACAAGAPHLAAGEFGDPELDAAQLFMAKHL
CCCHHCCCCHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHH
AGRASTIYSGSSETQRNVIFRGRLGSRP
CCCCCEEECCCCCCCCCEEEECCCCCCC
>Mature Secondary Structure 
GGGDDAAFLEDIRAFLARELTPDLREASRRTVGVYTDVASGLVWHRRLHARGWIAPAWP
CCCCHHHHHHHHHHHHHHHCCHHHHHHCCCEEEEHHHHHHHHHHHHHHHHCCCCCCCCC
AQWGGAGWSARQRYLWDRECALNDAPVLFAAGVRSLGPLLIEAGTAAQRAEHLPRILSGE
CCCCCCCCHHHHHHCCCHHHCCCCCCCHHHHHHHHHCHHEEECCCHHHHHHHHHHHHCCC
ALWCQGFSETGAGSDLAGVATRAAQDGDDYLVTGAKVWTTGAHLSNWMFALVRTADGDRK
EEEECCCCCCCCCCCHHHHHHHHCCCCCCEEEECCEEEECCHHHHHHHHHHHHCCCCCCH
QAGLTFLLIDMASAGISVSPIRDISGEHELNQVFFDAVRVPVANRVGAENDGWVVAKRLM
HCCCEEEEEEHHCCCCCCCCHHHCCCCHHHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHH
QLARSNNTPAALVRRSLNRVRRVVTEDAAADPALRRRLAELEIELEAFTALELAALPEGR
HHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PEASAVSAPSMVKLVGTELHQKVHALGVDVACAAGAPHLAAGEFGDPELDAAQLFMAKHL
CCCHHCCCCHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHH
AGRASTIYSGSSETQRNVIFRGRLGSRP
CCCCCEEECCCCCCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]