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The map label for this gene is glpK [H]

Identifier: 197104648

GI number: 197104648

Start: 1356126

End: 1357622

Strand: Direct

Name: glpK [H]

Synonym: PHZ_c1182

Alternate gene names: 197104648

Gene position: 1356126-1357622 (Clockwise)

Preceding gene: 197104644

Following gene: 197104650

Centisome position: 33.93

GC content: 74.82

Gene sequence:

>1497_bases
ATGGCCGCACCGCTGATCCTCGCCCTGGACCAAGGCACGACCAGCACGCGTGCGATCCTGTTCGAAGCGGATGGGGCGCC
CCTGGCCGAGGCCGGGCGGCCGCTGCGGCAGCACTATCCCCGCGACGGCTGGGTCGAGCACGACGCCGAGGAGATCTTCG
AGGCCTCGGTGGCCGTGCTGCGCGAGGCGGTCGAGCGGGCGGGACGCGACCTCGGCGAGGTCCGCGCCATCGGCATCACC
AACCAGCGGGAGACGGCGGTCATCTGGGACCGCCGGACGGGCAAGCCGATCCACCGGGCGATCGTCTGGCAGGACCGCCG
CACCGAGCCGCTCTGCCAGTCGCTGCGGGAGGCCGGCCGCGAGCCGCGGGTGACCGAGGTCACCGGCCTGCTGCTCGACC
CCTACTTCTCGGGCACGAAGTTCGCCTGGCTGCTCGACAACGTGGCCGGGGCGCGGAGCGCGGCCGAGGCGGGGCATCTG
CTCGCCGGCACCATCGACGCCTGGCTGGTCTGGAAGCTGACCGGCGGCAGGCTGCACGCCACCGACGCCACCAACGCCTC
GCGCACCCTGCTCTACGATATCGGCCGGGGCGAATGGTCGGCCGAGATGGGCGAGATGCTGGGCGTGCCGATCGGCATGA
TGCCGGACGTCCTCGACTGCAACGGCGACTTCGGCGAGACCGAGCCGGGGCTGCTGGGCCGCCCGATCCCGATCCGCGGC
GTGGCGGGCGACCAGCAGGCGGCGCTGATGGGCCAGGGCTGCATCCATCCCGGGGAGATGAAGGCCACGTACGGCACCGG
CTGCTTCATGCTGGTGAACACCGGCGAGACGCGCGCGCCGTCCCGCTCGCGTCTGCTGACCACCGTGGCGGCCCGGGTGG
ACGGACGCACGACCTACGCCCTGGAGGGCGCGATCTTCATCGCCGGCGCGGCGATCCAGTGGCTGGGCGAGGGGCTGGGC
GTGCAGGGCGGGCCGCAGGCCGCGGAGGCGCTGGCGGCCGGCGCGCGGCCGGATCACGGCGTGGTGCTGGTGCCGGCGTT
CACGGGCCTGGGCGCGCCCTGGTGGGACGCCGGCGCCCGCGGGGCGATCTTCGGCCTGACCCGCGACGCCGGCCTCGCCG
AGATCGCCCAGGCCGCTTTCGACGCGAGCGCGCTGCAGACCCGGGACCTGATCGAGGCGATGCGGGCCGACGCGCCGCGC
GCCTTCGCCGGCGAGGTCGAGATGCGGATCGACGGGGGCATGTCGAAGAGCGCCTGGTTCAGCCAGCGGCTCGCCGACCT
GACCGGCATCCAGGTCTGCCGCGCCACCTACCAGGAGACTACGGCTCTCGGGGCCGCGCTGTTCGCGGGCGTCGGCGCGG
GCGTCTACCGCGACGTCGCCGAGGCGGCCGCCTCCCGCCCGCGGACCGAAGGCTACCGGCCGCAGCTGGCGGACGAGCCG
CGCGAGCTGGCCTACGCCCGCTGGCTGGACGCCGTCGCGCGGGTGCGCTCGAGCTAG

Upstream 100 bases:

>100_bases
AAACCGAACGCGGCTGTAAGCCATCCTGTAGGGCGCGGATGAAAACATGCTTAAGGAGCCTGCCCGCGCGCAGAACGGGC
TCCGGGAGGACGAAGACCCC

Downstream 100 bases:

>100_bases
ACGATCCGGACTTCCGGCGGGCCGTCCGCAATCCGGCCGACCACGCGCGCCGAGTCGAAGCCGCGCTCGCGGGCCAGCGA
GAGCACCCGGTCGGCGGCCG

Product: glycerol kinase

Products: NA

Alternate protein names: ATP:glycerol 3-phosphotransferase; Glycerokinase; GK [H]

Number of amino acids: Translated: 498; Mature: 497

Protein sequence:

>498_residues
MAAPLILALDQGTTSTRAILFEADGAPLAEAGRPLRQHYPRDGWVEHDAEEIFEASVAVLREAVERAGRDLGEVRAIGIT
NQRETAVIWDRRTGKPIHRAIVWQDRRTEPLCQSLREAGREPRVTEVTGLLLDPYFSGTKFAWLLDNVAGARSAAEAGHL
LAGTIDAWLVWKLTGGRLHATDATNASRTLLYDIGRGEWSAEMGEMLGVPIGMMPDVLDCNGDFGETEPGLLGRPIPIRG
VAGDQQAALMGQGCIHPGEMKATYGTGCFMLVNTGETRAPSRSRLLTTVAARVDGRTTYALEGAIFIAGAAIQWLGEGLG
VQGGPQAAEALAAGARPDHGVVLVPAFTGLGAPWWDAGARGAIFGLTRDAGLAEIAQAAFDASALQTRDLIEAMRADAPR
AFAGEVEMRIDGGMSKSAWFSQRLADLTGIQVCRATYQETTALGAALFAGVGAGVYRDVAEAAASRPRTEGYRPQLADEP
RELAYARWLDAVARVRSS

Sequences:

>Translated_498_residues
MAAPLILALDQGTTSTRAILFEADGAPLAEAGRPLRQHYPRDGWVEHDAEEIFEASVAVLREAVERAGRDLGEVRAIGIT
NQRETAVIWDRRTGKPIHRAIVWQDRRTEPLCQSLREAGREPRVTEVTGLLLDPYFSGTKFAWLLDNVAGARSAAEAGHL
LAGTIDAWLVWKLTGGRLHATDATNASRTLLYDIGRGEWSAEMGEMLGVPIGMMPDVLDCNGDFGETEPGLLGRPIPIRG
VAGDQQAALMGQGCIHPGEMKATYGTGCFMLVNTGETRAPSRSRLLTTVAARVDGRTTYALEGAIFIAGAAIQWLGEGLG
VQGGPQAAEALAAGARPDHGVVLVPAFTGLGAPWWDAGARGAIFGLTRDAGLAEIAQAAFDASALQTRDLIEAMRADAPR
AFAGEVEMRIDGGMSKSAWFSQRLADLTGIQVCRATYQETTALGAALFAGVGAGVYRDVAEAAASRPRTEGYRPQLADEP
RELAYARWLDAVARVRSS
>Mature_497_residues
AAPLILALDQGTTSTRAILFEADGAPLAEAGRPLRQHYPRDGWVEHDAEEIFEASVAVLREAVERAGRDLGEVRAIGITN
QRETAVIWDRRTGKPIHRAIVWQDRRTEPLCQSLREAGREPRVTEVTGLLLDPYFSGTKFAWLLDNVAGARSAAEAGHLL
AGTIDAWLVWKLTGGRLHATDATNASRTLLYDIGRGEWSAEMGEMLGVPIGMMPDVLDCNGDFGETEPGLLGRPIPIRGV
AGDQQAALMGQGCIHPGEMKATYGTGCFMLVNTGETRAPSRSRLLTTVAARVDGRTTYALEGAIFIAGAAIQWLGEGLGV
QGGPQAAEALAAGARPDHGVVLVPAFTGLGAPWWDAGARGAIFGLTRDAGLAEIAQAAFDASALQTRDLIEAMRADAPRA
FAGEVEMRIDGGMSKSAWFSQRLADLTGIQVCRATYQETTALGAALFAGVGAGVYRDVAEAAASRPRTEGYRPQLADEPR
ELAYARWLDAVARVRSS

Specific function: Key enzyme in the regulation of glycerol uptake and metabolism [H]

COG id: COG0554

COG function: function code C; Glycerol kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI189409120, Length=503, Percent_Identity=41.5506958250497, Blast_Score=367, Evalue=1e-101,
Organism=Homo sapiens, GI4504007, Length=503, Percent_Identity=41.5506958250497, Blast_Score=367, Evalue=1e-101,
Organism=Homo sapiens, GI42794763, Length=509, Percent_Identity=41.0609037328094, Blast_Score=361, Evalue=1e-100,
Organism=Homo sapiens, GI41393575, Length=503, Percent_Identity=40.9542743538767, Blast_Score=354, Evalue=1e-97,
Organism=Homo sapiens, GI88196792, Length=506, Percent_Identity=28.4584980237154, Blast_Score=254, Evalue=2e-67,
Organism=Escherichia coli, GI1790361, Length=490, Percent_Identity=46.3265306122449, Blast_Score=443, Evalue=1e-125,
Organism=Escherichia coli, GI1789987, Length=491, Percent_Identity=24.0325865580448, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1790005, Length=463, Percent_Identity=23.3261339092873, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1787789, Length=486, Percent_Identity=25.1028806584362, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1789168, Length=499, Percent_Identity=22.2444889779559, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17535599, Length=501, Percent_Identity=36.7265469061876, Blast_Score=314, Evalue=7e-86,
Organism=Caenorhabditis elegans, GI71986140, Length=481, Percent_Identity=24.1164241164241, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI71986147, Length=257, Percent_Identity=27.6264591439689, Blast_Score=102, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6321755, Length=488, Percent_Identity=34.2213114754098, Blast_Score=249, Evalue=5e-67,
Organism=Drosophila melanogaster, GI17864214, Length=509, Percent_Identity=38.5068762278978, Blast_Score=337, Evalue=1e-92,
Organism=Drosophila melanogaster, GI24654573, Length=439, Percent_Identity=40.7744874715262, Blast_Score=315, Evalue=5e-86,
Organism=Drosophila melanogaster, GI24655555, Length=502, Percent_Identity=36.0557768924303, Blast_Score=299, Evalue=3e-81,
Organism=Drosophila melanogaster, GI24655560, Length=502, Percent_Identity=36.0557768924303, Blast_Score=299, Evalue=3e-81,
Organism=Drosophila melanogaster, GI24655570, Length=502, Percent_Identity=36.0557768924303, Blast_Score=299, Evalue=3e-81,
Organism=Drosophila melanogaster, GI24655574, Length=502, Percent_Identity=36.0557768924303, Blast_Score=299, Evalue=3e-81,
Organism=Drosophila melanogaster, GI24655565, Length=502, Percent_Identity=36.0557768924303, Blast_Score=299, Evalue=3e-81,
Organism=Drosophila melanogaster, GI19922058, Length=526, Percent_Identity=30.4182509505703, Blast_Score=253, Evalue=2e-67,
Organism=Drosophila melanogaster, GI24652871, Length=492, Percent_Identity=30.4878048780488, Blast_Score=240, Evalue=2e-63,
Organism=Drosophila melanogaster, GI24656367, Length=501, Percent_Identity=27.3453093812375, Blast_Score=177, Evalue=2e-44,
Organism=Drosophila melanogaster, GI21357867, Length=512, Percent_Identity=26.3671875, Blast_Score=175, Evalue=6e-44,
Organism=Drosophila melanogaster, GI24656372, Length=336, Percent_Identity=29.1666666666667, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI45552909, Length=247, Percent_Identity=29.1497975708502, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484
- InterPro:   IPR005999 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.30 [H]

Molecular weight: Translated: 53097; Mature: 52965

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS00933 FGGY_KINASES_1 ; PS00445 FGGY_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAPLILALDQGTTSTRAILFEADGAPLAEAGRPLRQHYPRDGWVEHDAEEIFEASVAVL
CCCCEEEEECCCCCCCEEEEEECCCCCHHHCCCHHHHCCCCCCCCCCCHHHHHHHHHHHH
REAVERAGRDLGEVRAIGITNQRETAVIWDRRTGKPIHRAIVWQDRRTEPLCQSLREAGR
HHHHHHHCCCHHHEEEEECCCCCCEEEEEECCCCCCHHHHEEECCCCCCHHHHHHHHCCC
EPRVTEVTGLLLDPYFSGTKFAWLLDNVAGARSAAEAGHLLAGTIDAWLVWKLTGGRLHA
CCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCEEEEEEEECCEEEE
TDATNASRTLLYDIGRGEWSAEMGEMLGVPIGMMPDVLDCNGDFGETEPGLLGRPIPIRG
CCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
VAGDQQAALMGQGCIHPGEMKATYGTGCFMLVNTGETRAPSRSRLLTTVAARVDGRTTYA
CCCCCHHHHHCCCCCCCCCCCEEECCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEE
LEGAIFIAGAAIQWLGEGLGVQGGPQAAEALAAGARPDHGVVLVPAFTGLGAPWWDAGAR
ECCEEEEHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCC
GAIFGLTRDAGLAEIAQAAFDASALQTRDLIEAMRADAPRAFAGEVEMRIDGGMSKSAWF
CEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCHHHHH
SQRLADLTGIQVCRATYQETTALGAALFAGVGAGVYRDVAEAAASRPRTEGYRPQLADEP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCH
RELAYARWLDAVARVRSS
HHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AAPLILALDQGTTSTRAILFEADGAPLAEAGRPLRQHYPRDGWVEHDAEEIFEASVAVL
CCCEEEEECCCCCCCEEEEEECCCCCHHHCCCHHHHCCCCCCCCCCCHHHHHHHHHHHH
REAVERAGRDLGEVRAIGITNQRETAVIWDRRTGKPIHRAIVWQDRRTEPLCQSLREAGR
HHHHHHHCCCHHHEEEEECCCCCCEEEEEECCCCCCHHHHEEECCCCCCHHHHHHHHCCC
EPRVTEVTGLLLDPYFSGTKFAWLLDNVAGARSAAEAGHLLAGTIDAWLVWKLTGGRLHA
CCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCEEEEEEEECCEEEE
TDATNASRTLLYDIGRGEWSAEMGEMLGVPIGMMPDVLDCNGDFGETEPGLLGRPIPIRG
CCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
VAGDQQAALMGQGCIHPGEMKATYGTGCFMLVNTGETRAPSRSRLLTTVAARVDGRTTYA
CCCCCHHHHHCCCCCCCCCCCEEECCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEE
LEGAIFIAGAAIQWLGEGLGVQGGPQAAEALAAGARPDHGVVLVPAFTGLGAPWWDAGAR
ECCEEEEHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCC
GAIFGLTRDAGLAEIAQAAFDASALQTRDLIEAMRADAPRAFAGEVEMRIDGGMSKSAWF
CEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCHHHHH
SQRLADLTGIQVCRATYQETTALGAALFAGVGAGVYRDVAEAAASRPRTEGYRPQLADEP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCH
RELAYARWLDAVARVRSS
HHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA