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The map label for this gene is lctD [H]

Identifier: 197104607

GI number: 197104607

Start: 1306513

End: 1307652

Strand: Direct

Name: lctD [H]

Synonym: PHZ_c1141

Alternate gene names: 197104607

Gene position: 1306513-1307652 (Clockwise)

Preceding gene: 197104606

Following gene: 197104609

Centisome position: 32.69

GC content: 71.58

Gene sequence:

>1140_bases
ATGCGTGCAGCTTCGGTTTCTGACTTCCGCGAACTCGCGCGGCGCAGGCTTCCGAAGATCTTCTTTGAGTACATCGACGG
CGGCTCCTACGCCGAGGTGACGCTGAAGCGGAACGTCGAGGACCTGGAGGCTATCGCCCTGCGCCAGCGGGTCATGAAGG
ACATGACCGAGCTGTCTATGACGGTGGAAACGCTGGGCCAGACCCTGGCCATGCCCGTGGGCCTCGCGCCGGTCGGCATG
GCGGGGATGTACGGCCGGCGCGGGGAGACCCAGGCGGCGCGCGCGGCGGCGGCGGCCGGCGTGCCGTTCTGCCTGTCGAC
CGTGGGCGTCTGCTCGGTGGAGGAGGTGGCCAGGACCGGCACGCCCCCCTGGTTCCAGCTCTACATGCTGAAGGACCGCG
GCTACATGCGCGAGCTGCTGGCCCGCGCCCACGAGCTGGGCTCGCCCGTGCTGGTGTTCACCGTCGACCTGCCGATCCCC
GGCGCCCGCTACCGCGACGTCCGCTCGGGCTTCACCGGCGCCGGCAAGCTGGAGGCGGTGCTGAACCAGGCCTGGGACGG
GATCACCCATCCGGCCTGGACCTGGGACGTGTTCGTCCACGGCCGGCCCCACACGTTGGGCTCGGTCGCCGGGGCCGTGC
AGGAGGGCCGCCGGGTGACCGACTTCCTGGTCTGGATCGCCCGCAACTTCGACCGCTCGGTCACCTGGAAGGACCTCGAC
TGGGTGCGCGAGAACTGGGACCGGCCGATCGTGGTCAAGGGCGTGCTCGACGTGGAGGACGCGCGCGACGCGGTCCGGGC
CGGGGCGCAGGGCGTGGTGGTCTCGAACCACGGCGGCCGCCAGCTCGACGGGGTGAAGTCCTCCATCGCCTCGCTTCCCC
GGATCGCCGACGCCGTGGGCGGCGAGCTGGAGGTGTTCATGGACGGCGGCGTGCGCTCGGGCCTGGACGTGCTGAAGGCG
CTGGCCCTGGGTGCCAAGGCCTGTTTCGTCGGCCGCCCGTGGGCCTATGCGCTCGGCGCGGGCGGCGAGGCGGCGATCGG
CAAGATGCTGGGCCTCATGCGCTCCGAGCTGGCCGTGGCCATGATCCTGACCGGCTGCAACGACGTGCGGCGGGCCGGGC
GCGAGCTGCTGGACATCTAG

Upstream 100 bases:

>100_bases
CCCGCCCCGATGAAGGCCGCCGCCGAGGCCTGACCCATCCGCCGGGACCTTGCGCCCGGCGGGCGCAGGCTTCACCTTCC
CGCGCCCAGGGAGGGACGGC

Downstream 100 bases:

>100_bases
CGCGCCGTCATCTCGCGCGGGGTCTGGGCGGCCACGCCGCTCGGCCGATGGGCGCCGAGGCCGGTGCGGAACAGCTTCAT
CATCGGCTTCTCGGCCAGGT

Product: L-lactate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MRAASVSDFRELARRRLPKIFFEYIDGGSYAEVTLKRNVEDLEAIALRQRVMKDMTELSMTVETLGQTLAMPVGLAPVGM
AGMYGRRGETQAARAAAAAGVPFCLSTVGVCSVEEVARTGTPPWFQLYMLKDRGYMRELLARAHELGSPVLVFTVDLPIP
GARYRDVRSGFTGAGKLEAVLNQAWDGITHPAWTWDVFVHGRPHTLGSVAGAVQEGRRVTDFLVWIARNFDRSVTWKDLD
WVRENWDRPIVVKGVLDVEDARDAVRAGAQGVVVSNHGGRQLDGVKSSIASLPRIADAVGGELEVFMDGGVRSGLDVLKA
LALGAKACFVGRPWAYALGAGGEAAIGKMLGLMRSELAVAMILTGCNDVRRAGRELLDI

Sequences:

>Translated_379_residues
MRAASVSDFRELARRRLPKIFFEYIDGGSYAEVTLKRNVEDLEAIALRQRVMKDMTELSMTVETLGQTLAMPVGLAPVGM
AGMYGRRGETQAARAAAAAGVPFCLSTVGVCSVEEVARTGTPPWFQLYMLKDRGYMRELLARAHELGSPVLVFTVDLPIP
GARYRDVRSGFTGAGKLEAVLNQAWDGITHPAWTWDVFVHGRPHTLGSVAGAVQEGRRVTDFLVWIARNFDRSVTWKDLD
WVRENWDRPIVVKGVLDVEDARDAVRAGAQGVVVSNHGGRQLDGVKSSIASLPRIADAVGGELEVFMDGGVRSGLDVLKA
LALGAKACFVGRPWAYALGAGGEAAIGKMLGLMRSELAVAMILTGCNDVRRAGRELLDI
>Mature_379_residues
MRAASVSDFRELARRRLPKIFFEYIDGGSYAEVTLKRNVEDLEAIALRQRVMKDMTELSMTVETLGQTLAMPVGLAPVGM
AGMYGRRGETQAARAAAAAGVPFCLSTVGVCSVEEVARTGTPPWFQLYMLKDRGYMRELLARAHELGSPVLVFTVDLPIP
GARYRDVRSGFTGAGKLEAVLNQAWDGITHPAWTWDVFVHGRPHTLGSVAGAVQEGRRVTDFLVWIARNFDRSVTWKDLD
WVRENWDRPIVVKGVLDVEDARDAVRAGAQGVVVSNHGGRQLDGVKSSIASLPRIADAVGGELEVFMDGGVRSGLDVLKA
LALGAKACFVGRPWAYALGAGGEAAIGKMLGLMRSELAVAMILTGCNDVRRAGRELLDI

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI11068137, Length=378, Percent_Identity=35.4497354497354, Blast_Score=237, Evalue=2e-62,
Organism=Homo sapiens, GI54234014, Length=380, Percent_Identity=34.7368421052632, Blast_Score=226, Evalue=2e-59,
Organism=Homo sapiens, GI7705393, Length=380, Percent_Identity=34.7368421052632, Blast_Score=226, Evalue=2e-59,
Organism=Escherichia coli, GI1790033, Length=378, Percent_Identity=51.8518518518518, Blast_Score=416, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI193208036, Length=372, Percent_Identity=33.3333333333333, Blast_Score=218, Evalue=4e-57,
Organism=Caenorhabditis elegans, GI32566217, Length=291, Percent_Identity=29.553264604811, Blast_Score=147, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6323587, Length=387, Percent_Identity=29.7157622739018, Blast_Score=169, Evalue=6e-43,
Organism=Drosophila melanogaster, GI78707188, Length=372, Percent_Identity=36.5591397849462, Blast_Score=218, Evalue=4e-57,
Organism=Drosophila melanogaster, GI281363140, Length=372, Percent_Identity=36.5591397849462, Blast_Score=218, Evalue=5e-57,
Organism=Drosophila melanogaster, GI78707190, Length=372, Percent_Identity=36.5591397849462, Blast_Score=218, Evalue=5e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259
- InterPro:   IPR020920 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.1.2.3 [H]

Molecular weight: Translated: 41098; Mature: 41098

Theoretical pI: Translated: 8.32; Mature: 8.32

Prosite motif: PS00557 FMN_HYDROXY_ACID_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAASVSDFRELARRRLPKIFFEYIDGGSYAEVTLKRNVEDLEAIALRQRVMKDMTELSM
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
TVETLGQTLAMPVGLAPVGMAGMYGRRGETQAARAAAAAGVPFCLSTVGVCSVEEVARTG
HHHHHHHHHHCCCCCCCCCHHHCCCCCCCHHHHHHHHHCCCHHHHHHHCCCCHHHHHHCC
TPPWFQLYMLKDRGYMRELLARAHELGSPVLVFTVDLPIPGARYRDVRSGFTGAGKLEAV
CCCCEEEEEECCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHCCCCCCHHHHHH
LNQAWDGITHPAWTWDVFVHGRPHTLGSVAGAVQEGRRVTDFLVWIARNFDRSVTWKDLD
HHHHHCCCCCCCEEEEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCHHHHH
WVRENWDRPIVVKGVLDVEDARDAVRAGAQGVVVSNHGGRQLDGVKSSIASLPRIADAVG
HHHHCCCCCEEEEEECCHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCC
GELEVFMDGGVRSGLDVLKALALGAKACFVGRPWAYALGAGGEAAIGKMLGLMRSELAVA
CCEEEEECCCCHHHHHHHHHHHHCCHHHCCCCCHHEEECCCCHHHHHHHHHHHHHHHHHH
MILTGCNDVRRAGRELLDI
HHHHCCHHHHHHHHHHHCC
>Mature Secondary Structure
MRAASVSDFRELARRRLPKIFFEYIDGGSYAEVTLKRNVEDLEAIALRQRVMKDMTELSM
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
TVETLGQTLAMPVGLAPVGMAGMYGRRGETQAARAAAAAGVPFCLSTVGVCSVEEVARTG
HHHHHHHHHHCCCCCCCCCHHHCCCCCCCHHHHHHHHHCCCHHHHHHHCCCCHHHHHHCC
TPPWFQLYMLKDRGYMRELLARAHELGSPVLVFTVDLPIPGARYRDVRSGFTGAGKLEAV
CCCCEEEEEECCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHCCCCCCHHHHHH
LNQAWDGITHPAWTWDVFVHGRPHTLGSVAGAVQEGRRVTDFLVWIARNFDRSVTWKDLD
HHHHHCCCCCCCEEEEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCHHHHH
WVRENWDRPIVVKGVLDVEDARDAVRAGAQGVVVSNHGGRQLDGVKSSIASLPRIADAVG
HHHHCCCCCEEEEEECCHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCC
GELEVFMDGGVRSGLDVLKALALGAKACFVGRPWAYALGAGGEAAIGKMLGLMRSELAVA
CCEEEEECCCCHHHHHHHHHHHHCCHHHCCCCCHHEEECCCCHHHHHHHHHHHHHHHHHH
MILTGCNDVRRAGRELLDI
HHHHCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA