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The map label for this gene is betA [H]

Identifier: 197104576

GI number: 197104576

Start: 1264871

End: 1266523

Strand: Direct

Name: betA [H]

Synonym: PHZ_c1110

Alternate gene names: 197104576

Gene position: 1264871-1266523 (Clockwise)

Preceding gene: 197104575

Following gene: 197104579

Centisome position: 31.65

GC content: 70.6

Gene sequence:

>1653_bases
GTGGAGCGGTACGACTACATCATCATCGGCGCGGGCTCGGCCGGCTGCGTCCTGGCCAACCGCCTGAGCGAGGACCCGCA
GACGAAGGTGCTGCTGCTGGAGGCGGGCGGCAAGGACGCCTCGCTGCTGGTGCGGATGCCCGCGGGCGTCGGCGCCCTGA
TCGGCAAGCAGGGCCCCTACAACTGGGGCTTCTGGACCGAACCCGAGCCGCACCTCGACGGCCGCCGCCTGTGGTGGCCC
AGAGGCAAGGGCTGGGGCGGCTCGTCCTCGATCAACGGCATGATCTACATCCGCGGCCACGCGCGCGACTACGACCAGTG
GCGGCAGATGGGCCTGACCGGCTGGGGCTACGCCGACGTCCTGCCGTACTTCAAGCGCTCGGAGACCTTCGAGGGCGGGG
CCGATTCCTGGCACGGCGACGAGGGGCCGCTGCACGTCTCGAAGGCCGCCTCGCCCAATCCGATCTACCGCGCCGCGGTG
GAGGCGGGGGCCCAGGCCGGCCATCCGGTGACCAGCGACTTCAACGGCTACCAGCAGGAAGGCTGGGGGCCGTACCAGAT
GACCATCAAGGACGGGCAGCGCTGGAGCGCGGCGCGCGGCTACCTGCACCCCGTCCTGAACCGTCCGAACCTGACCTGCC
TGACCGGCGCGCGGACCACGCGGGTGCTCCTCGAGAACGGCCGCGCCGTCGGCGTCGAGATCGTCGAGGGCAAGAACCCG
GCGCGCGCGGTCTATGCCGACGCCGAGGTCATCGTGGCGGCGGGCGCCGTGCAGTCGCCGCACATCCTGCAGCTGTCCGG
CATCGGCGACGGCGAGGACCTGGGCAAGCACGGGATCAAGGCCGTCCACGAGCTGAAGGGCGTGGGCGCCAACCTGCAGG
ACCACCTCGACGCGTGCCTGTCGTGGGAGTGCCCGCAGCCGATCACGATCTATTCGATGCGCAAGGGCGTGAAGCAGCTC
TTCGTCGGGCTGAACTACATGCTGTTCAACAAGGGCATCGGCCGGGAGAACTTCCTGGAGAGCGGCGCCTTCCTGCGCTC
GCGGCCCGACCTGGACCGGCCCGACCTGCAGATCCACACCGTGCTGGCCATCATGCAGGACCACGGCAAGGTGTCGGTGA
ACAAGGACGGCTTCACCTTCCACGTCTGCCAGCTGCGGCCCGAGAGCCGCGGCAAGGTCGGGCTGAAGTCGGCCGACCCG
ATGGCCGACCCCGCGATCTTCGCCAACTACCTCGCCGCCGAGGAGGACCGCCGCGCCATGCGCGAGGGGGTGAAGATGAT
GCGCGACGTGGCCGCCCAGGCCGCGCTCGATCCCTATCGCGGCGCCGAATACTCGCCGGGCAAGGACGTGCGGACCGACG
CCGAGATCGACGCGTGGATCCGCCGCGCGGCCGAGACGATCTACCACCCGGTCGGCACCTGCCGCATGGGCGTGGCCGGC
GATGCGATGGCGGTGGTGGACGGCGAATGCCGGGTGCAGGGCCTGTCGGGCCTGCGCGTGGTGGACGCCTCGGTGATGCC
GACGCTGGTCGGCGGGAACACCAACGCCCCGACCATCATGATCGCCGAGAAGATCTCGGACGCGATCCGCGGCAAGGCCT
TCCTGCCGGCCGAGGACGCGCCGGTCTACGGCGACGAGAAGGCCGCCGCCTAG

Upstream 100 bases:

>100_bases
TGCTTTCGGCCTGACGCCGGCTGACGCTGGGGCGGCCTTGCAGAAACGTGACGCCTGCGTCACGTTTGCGCCAACTGAAC
AAGGTTAGGGAAGAAGCGCC

Downstream 100 bases:

>100_bases
GAGCCCGGCCGCTCCAGGCGCATGACCAGGCAGTCGTCCTCGCCGAACCGGCGGGGACCGACGGCCCGGAAGCCCAGCCG
CTCGTAGAAGCGGATCGCCC

Product: choline dehydrogenase

Products: NA

Alternate protein names: CDH; CHD [H]

Number of amino acids: Translated: 550; Mature: 550

Protein sequence:

>550_residues
MERYDYIIIGAGSAGCVLANRLSEDPQTKVLLLEAGGKDASLLVRMPAGVGALIGKQGPYNWGFWTEPEPHLDGRRLWWP
RGKGWGGSSSINGMIYIRGHARDYDQWRQMGLTGWGYADVLPYFKRSETFEGGADSWHGDEGPLHVSKAASPNPIYRAAV
EAGAQAGHPVTSDFNGYQQEGWGPYQMTIKDGQRWSAARGYLHPVLNRPNLTCLTGARTTRVLLENGRAVGVEIVEGKNP
ARAVYADAEVIVAAGAVQSPHILQLSGIGDGEDLGKHGIKAVHELKGVGANLQDHLDACLSWECPQPITIYSMRKGVKQL
FVGLNYMLFNKGIGRENFLESGAFLRSRPDLDRPDLQIHTVLAIMQDHGKVSVNKDGFTFHVCQLRPESRGKVGLKSADP
MADPAIFANYLAAEEDRRAMREGVKMMRDVAAQAALDPYRGAEYSPGKDVRTDAEIDAWIRRAAETIYHPVGTCRMGVAG
DAMAVVDGECRVQGLSGLRVVDASVMPTLVGGNTNAPTIMIAEKISDAIRGKAFLPAEDAPVYGDEKAAA

Sequences:

>Translated_550_residues
MERYDYIIIGAGSAGCVLANRLSEDPQTKVLLLEAGGKDASLLVRMPAGVGALIGKQGPYNWGFWTEPEPHLDGRRLWWP
RGKGWGGSSSINGMIYIRGHARDYDQWRQMGLTGWGYADVLPYFKRSETFEGGADSWHGDEGPLHVSKAASPNPIYRAAV
EAGAQAGHPVTSDFNGYQQEGWGPYQMTIKDGQRWSAARGYLHPVLNRPNLTCLTGARTTRVLLENGRAVGVEIVEGKNP
ARAVYADAEVIVAAGAVQSPHILQLSGIGDGEDLGKHGIKAVHELKGVGANLQDHLDACLSWECPQPITIYSMRKGVKQL
FVGLNYMLFNKGIGRENFLESGAFLRSRPDLDRPDLQIHTVLAIMQDHGKVSVNKDGFTFHVCQLRPESRGKVGLKSADP
MADPAIFANYLAAEEDRRAMREGVKMMRDVAAQAALDPYRGAEYSPGKDVRTDAEIDAWIRRAAETIYHPVGTCRMGVAG
DAMAVVDGECRVQGLSGLRVVDASVMPTLVGGNTNAPTIMIAEKISDAIRGKAFLPAEDAPVYGDEKAAA
>Mature_550_residues
MERYDYIIIGAGSAGCVLANRLSEDPQTKVLLLEAGGKDASLLVRMPAGVGALIGKQGPYNWGFWTEPEPHLDGRRLWWP
RGKGWGGSSSINGMIYIRGHARDYDQWRQMGLTGWGYADVLPYFKRSETFEGGADSWHGDEGPLHVSKAASPNPIYRAAV
EAGAQAGHPVTSDFNGYQQEGWGPYQMTIKDGQRWSAARGYLHPVLNRPNLTCLTGARTTRVLLENGRAVGVEIVEGKNP
ARAVYADAEVIVAAGAVQSPHILQLSGIGDGEDLGKHGIKAVHELKGVGANLQDHLDACLSWECPQPITIYSMRKGVKQL
FVGLNYMLFNKGIGRENFLESGAFLRSRPDLDRPDLQIHTVLAIMQDHGKVSVNKDGFTFHVCQLRPESRGKVGLKSADP
MADPAIFANYLAAEEDRRAMREGVKMMRDVAAQAALDPYRGAEYSPGKDVRTDAEIDAWIRRAAETIYHPVGTCRMGVAG
DAMAVVDGECRVQGLSGLRVVDASVMPTLVGGNTNAPTIMIAEKISDAIRGKAFLPAEDAPVYGDEKAAA

Specific function: Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine [H]

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Membrane-Bound [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI217272839, Length=549, Percent_Identity=48.0874316939891, Blast_Score=520, Evalue=1e-147,
Organism=Escherichia coli, GI1786503, Length=546, Percent_Identity=49.2673992673993, Blast_Score=506, Evalue=1e-144,
Organism=Caenorhabditis elegans, GI17532301, Length=560, Percent_Identity=41.4285714285714, Blast_Score=451, Evalue=1e-127,
Organism=Drosophila melanogaster, GI24642048, Length=582, Percent_Identity=38.1443298969072, Blast_Score=337, Evalue=9e-93,
Organism=Drosophila melanogaster, GI24642055, Length=586, Percent_Identity=37.0307167235495, Blast_Score=335, Evalue=6e-92,
Organism=Drosophila melanogaster, GI24642059, Length=570, Percent_Identity=38.4210526315789, Blast_Score=326, Evalue=3e-89,
Organism=Drosophila melanogaster, GI45549471, Length=570, Percent_Identity=37.1929824561403, Blast_Score=322, Evalue=3e-88,
Organism=Drosophila melanogaster, GI45551458, Length=570, Percent_Identity=37.1929824561403, Blast_Score=322, Evalue=5e-88,
Organism=Drosophila melanogaster, GI24642042, Length=566, Percent_Identity=38.6925795053004, Blast_Score=321, Evalue=9e-88,
Organism=Drosophila melanogaster, GI17137792, Length=548, Percent_Identity=37.5912408759124, Blast_Score=320, Evalue=2e-87,
Organism=Drosophila melanogaster, GI24650267, Length=587, Percent_Identity=34.5826235093697, Blast_Score=303, Evalue=3e-82,
Organism=Drosophila melanogaster, GI24642039, Length=566, Percent_Identity=34.982332155477, Blast_Score=284, Evalue=1e-76,
Organism=Drosophila melanogaster, GI18859995, Length=569, Percent_Identity=34.9736379613357, Blast_Score=281, Evalue=7e-76,
Organism=Drosophila melanogaster, GI24642035, Length=574, Percent_Identity=35.191637630662, Blast_Score=264, Evalue=1e-70,
Organism=Drosophila melanogaster, GI24642037, Length=570, Percent_Identity=34.2105263157895, Blast_Score=263, Evalue=2e-70,
Organism=Drosophila melanogaster, GI18859993, Length=566, Percent_Identity=33.2155477031802, Blast_Score=256, Evalue=3e-68,
Organism=Drosophila melanogaster, GI24642051, Length=568, Percent_Identity=31.5140845070423, Blast_Score=256, Evalue=4e-68,
Organism=Drosophila melanogaster, GI24645930, Length=574, Percent_Identity=30.3135888501742, Blast_Score=177, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24642057, Length=584, Percent_Identity=31.1643835616438, Blast_Score=151, Evalue=9e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011533
- InterPro:   IPR012132
- InterPro:   IPR000172
- InterPro:   IPR007867 [H]

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N [H]

EC number: =1.1.99.1 [H]

Molecular weight: Translated: 59664; Mature: 59664

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00623 GMC_OXRED_1 ; PS00624 GMC_OXRED_2 ; PS00687 ALDEHYDE_DEHYDR_GLU ; PS00496 PII_GLNB_UMP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERYDYIIIGAGSAGCVLANRLSEDPQTKVLLLEAGGKDASLLVRMPAGVGALIGKQGPY
CCCCCEEEEECCCCCHHHHHHCCCCCCCEEEEEECCCCCCEEEEECCCCCHHHHCCCCCC
NWGFWTEPEPHLDGRRLWWPRGKGWGGSSSINGMIYIRGHARDYDQWRQMGLTGWGYADV
CCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCEEEEEEECCCCHHHHHHCCCCCCCHHHH
LPYFKRSETFEGGADSWHGDEGPLHVSKAASPNPIYRAAVEAGAQAGHPVTSDFNGYQQE
HHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHC
GWGPYQMTIKDGQRWSAARGYLHPVLNRPNLTCLTGARTTRVLLENGRAVGVEIVEGKNP
CCCCEEEEEECCCCCHHHHCHHHHHCCCCCEEEEECCCEEEEEEECCCEEEEEEEECCCC
ARAVYADAEVIVAAGAVQSPHILQLSGIGDGEDLGKHGIKAVHELKGVGANLQDHLDACL
CEEEEECCEEEEEECCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
SWECPQPITIYSMRKGVKQLFVGLNYMLFNKGIGRENFLESGAFLRSRPDLDRPDLQIHT
CCCCCCCEEHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHCCCHHCCCCCCCCCCCHHHH
VLAIMQDHGKVSVNKDGFTFHVCQLRPESRGKVGLKSADPMADPAIFANYLAAEEDRRAM
HHHHHHCCCEEEECCCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
REGVKMMRDVAAQAALDPYRGAEYSPGKDVRTDAEIDAWIRRAAETIYHPVGTCRMGVAG
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEECCCC
DAMAVVDGECRVQGLSGLRVVDASVMPTLVGGNTNAPTIMIAEKISDAIRGKAFLPAEDA
CEEEEECCCEEEECCCCEEEEECCCCCEEECCCCCCCEEEEHHHHHHHHCCCEECCCCCC
PVYGDEKAAA
CCCCCCCCCC
>Mature Secondary Structure
MERYDYIIIGAGSAGCVLANRLSEDPQTKVLLLEAGGKDASLLVRMPAGVGALIGKQGPY
CCCCCEEEEECCCCCHHHHHHCCCCCCCEEEEEECCCCCCEEEEECCCCCHHHHCCCCCC
NWGFWTEPEPHLDGRRLWWPRGKGWGGSSSINGMIYIRGHARDYDQWRQMGLTGWGYADV
CCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCEEEEEEECCCCHHHHHHCCCCCCCHHHH
LPYFKRSETFEGGADSWHGDEGPLHVSKAASPNPIYRAAVEAGAQAGHPVTSDFNGYQQE
HHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHC
GWGPYQMTIKDGQRWSAARGYLHPVLNRPNLTCLTGARTTRVLLENGRAVGVEIVEGKNP
CCCCEEEEEECCCCCHHHHCHHHHHCCCCCEEEEECCCEEEEEEECCCEEEEEEEECCCC
ARAVYADAEVIVAAGAVQSPHILQLSGIGDGEDLGKHGIKAVHELKGVGANLQDHLDACL
CEEEEECCEEEEEECCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
SWECPQPITIYSMRKGVKQLFVGLNYMLFNKGIGRENFLESGAFLRSRPDLDRPDLQIHT
CCCCCCCEEHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHCCCHHCCCCCCCCCCCHHHH
VLAIMQDHGKVSVNKDGFTFHVCQLRPESRGKVGLKSADPMADPAIFANYLAAEEDRRAM
HHHHHHCCCEEEECCCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
REGVKMMRDVAAQAALDPYRGAEYSPGKDVRTDAEIDAWIRRAAETIYHPVGTCRMGVAG
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEECCCC
DAMAVVDGECRVQGLSGLRVVDASVMPTLVGGNTNAPTIMIAEKISDAIRGKAFLPAEDA
CEEEEECCCEEEECCCCEEEEECCCCCEEECCCCCCCEEEEHHHHHHHHCCCEECCCCCC
PVYGDEKAAA
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA