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The map label for this gene is fkpA [H]

Identifier: 197104554

GI number: 197104554

Start: 1230732

End: 1231253

Strand: Reverse

Name: fkpA [H]

Synonym: PHZ_c1088

Alternate gene names: 197104554

Gene position: 1231253-1230732 (Counterclockwise)

Preceding gene: 197104556

Following gene: 197104551

Centisome position: 30.81

GC content: 73.75

Gene sequence:

>522_bases
ATGATCCGCCACGCCGCCTGCGCCGCCCTTGGCGGCCTGCTCGTCGCCGCCTGCGCCAGCGCGCCAGCTCCATCCGCGCC
GACGTCCGCCCCGGCCGCCGACCTCTCGCCCCAGGCGCGCTGGGAAGCCGGCCAGGCGGCGTACCTCGCCTGGAACACCC
GCCGCCACGGCTGGAAGACCACCGACAGCGGCCTGCAGTACAAGGTGTTGAAGCGGGCCCCGGCCTCGGCGCCGCGGCCC
GAGCCCGGCGCCACCGTGACCATCCACTACACGGGGACGTTCATCGACGGGCGCAAGTTCGACTCCTCGCGCGACCGCGG
CGAGCCGGCGACCTTCCCGCTCGGCCGGCTGATCAAGGGCTGGCAGGAAGGCGTGCCGATGATGCGCGTCGGCGAGCGCT
GGCTGTTCGCCATCCCCGCCGACCTGGCCTACGGGAACCGCAACCGCGACCCGATCCCGAACGGCAGCGCGCTCCTCTTC
GACATCGAGCTCATCGCCGTCGAGGGGAACGCCGTCCGCTGA

Upstream 100 bases:

>100_bases
CCCCCCAGACGAAGGCGCCATTGAGCCCAGGTCGGGCCTTGCGCGCAACCGCTCCAAGCAGGACGGTGTTCGCCGAAATC
CTGGGGAGTCGGGGAAGAAA

Downstream 100 bases:

>100_bases
CCTCCTCCTCCCCCGCCGGGGGAGGGGGACCATGCGCAGCATGGTGGAGGGGCTGGCCCGAAATGCTCGGCTCGGGACCG
GCCTTCTACAGGTCGTCCGG

Product: FKBP-type peptidyl-prolyl isomerase-like protein

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 173; Mature: 173

Protein sequence:

>173_residues
MIRHAACAALGGLLVAACASAPAPSAPTSAPAADLSPQARWEAGQAAYLAWNTRRHGWKTTDSGLQYKVLKRAPASAPRP
EPGATVTIHYTGTFIDGRKFDSSRDRGEPATFPLGRLIKGWQEGVPMMRVGERWLFAIPADLAYGNRNRDPIPNGSALLF
DIELIAVEGNAVR

Sequences:

>Translated_173_residues
MIRHAACAALGGLLVAACASAPAPSAPTSAPAADLSPQARWEAGQAAYLAWNTRRHGWKTTDSGLQYKVLKRAPASAPRP
EPGATVTIHYTGTFIDGRKFDSSRDRGEPATFPLGRLIKGWQEGVPMMRVGERWLFAIPADLAYGNRNRDPIPNGSALLF
DIELIAVEGNAVR
>Mature_173_residues
MIRHAACAALGGLLVAACASAPAPSAPTSAPAADLSPQARWEAGQAAYLAWNTRRHGWKTTDSGLQYKVLKRAPASAPRP
EPGATVTIHYTGTFIDGRKFDSSRDRGEPATFPLGRLIKGWQEGVPMMRVGERWLFAIPADLAYGNRNRDPIPNGSALLF
DIELIAVEGNAVR

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. FkpA probably acts in the folding of extracytoplasmic proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI17149836, Length=92, Percent_Identity=47.8260869565217, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI4503725, Length=92, Percent_Identity=47.8260869565217, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI206725530, Length=107, Percent_Identity=40.1869158878505, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI17149844, Length=107, Percent_Identity=40.1869158878505, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI17149842, Length=107, Percent_Identity=40.1869158878505, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI4758380, Length=92, Percent_Identity=42.3913043478261, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI224809329, Length=105, Percent_Identity=40, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI224809327, Length=105, Percent_Identity=40, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI4758384, Length=105, Percent_Identity=40, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI224809331, Length=108, Percent_Identity=38.8888888888889, Blast_Score=77, Evalue=8e-15,
Organism=Homo sapiens, GI4503729, Length=112, Percent_Identity=38.3928571428571, Blast_Score=75, Evalue=4e-14,
Organism=Escherichia coli, GI87082390, Length=140, Percent_Identity=41.4285714285714, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1789745, Length=141, Percent_Identity=38.2978723404255, Blast_Score=92, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17540882, Length=107, Percent_Identity=46.7289719626168, Blast_Score=96, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI17561782, Length=101, Percent_Identity=45.5445544554455, Blast_Score=91, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI71993519, Length=95, Percent_Identity=47.3684210526316, Blast_Score=90, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6320727, Length=115, Percent_Identity=43.4782608695652, Blast_Score=86, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6324194, Length=105, Percent_Identity=45.7142857142857, Blast_Score=84, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6323482, Length=99, Percent_Identity=36.3636363636364, Blast_Score=61, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6323566, Length=99, Percent_Identity=38.3838383838384, Blast_Score=61, Evalue=9e-11,
Organism=Drosophila melanogaster, GI24655568, Length=92, Percent_Identity=50, Blast_Score=90, Evalue=8e-19,
Organism=Drosophila melanogaster, GI281363946, Length=111, Percent_Identity=44.1441441441441, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17352457, Length=111, Percent_Identity=44.1441441441441, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24583150, Length=111, Percent_Identity=37.8378378378378, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21356629, Length=112, Percent_Identity=34.8214285714286, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 18548; Mature: 18548

Theoretical pI: Translated: 9.89; Mature: 9.89

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRHAACAALGGLLVAACASAPAPSAPTSAPAADLSPQARWEAGQAAYLAWNTRRHGWKT
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCC
TDSGLQYKVLKRAPASAPRPEPGATVTIHYTGTFIDGRKFDSSRDRGEPATFPLGRLIKG
CCCCCEEEEECCCCCCCCCCCCCCEEEEEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHH
WQEGVPMMRVGERWLFAIPADLAYGNRNRDPIPNGSALLFDIELIAVEGNAVR
HHHCCCCEEECCEEEEEECCHHCCCCCCCCCCCCCCEEEEEEEEEEECCCCCC
>Mature Secondary Structure
MIRHAACAALGGLLVAACASAPAPSAPTSAPAADLSPQARWEAGQAAYLAWNTRRHGWKT
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCC
TDSGLQYKVLKRAPASAPRPEPGATVTIHYTGTFIDGRKFDSSRDRGEPATFPLGRLIKG
CCCCCEEEEECCCCCCCCCCCCCCEEEEEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHH
WQEGVPMMRVGERWLFAIPADLAYGNRNRDPIPNGSALLFDIELIAVEGNAVR
HHHCCCCEEECCEEEEEECCHHCCCCCCCCCCCCCCEEEEEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9171380 [H]