Click here to switch to the map view.

The map label for this gene is cocE [H]

Identifier: 197104478

GI number: 197104478

Start: 1126322

End: 1128268

Strand: Reverse

Name: cocE [H]

Synonym: PHZ_c1012

Alternate gene names: 197104478

Gene position: 1128268-1126322 (Counterclockwise)

Preceding gene: 197104479

Following gene: 197104476

Centisome position: 28.23

GC content: 69.23

Gene sequence:

>1947_bases
ATGACCTTCAAGACCCTGCTGCGCGCGGCCGCCGCCTGCGCCGCCATCGCCCTGCCCGCCCAGGCCCAGACCCCGACCCA
GACCCCAACTGGGGCGCCGACGCCCCCGATGACGCCGGACATTCCGGCGACGTTCGCCGCGCCCACCCAGCACTACGACT
ACGAGAAGCGCACGGTGATGATCCCGATGCGCGACGGGGTGAAGCTGCACACGATCCTTCTGGTCCCCAAGGGCGTGAAG
GACGCGCCCATCCTGCTGACGCGGACGCCCTACAACGCCAAGACGCCCAGCGGGCGGTTCAACTCGCCCTACGCCGCCGC
GGCCGGGGCCCAGATGGACGAGCCGTTCCTGGCCGACGGCTACATCCGCGCCTACCAGGACGTGCGCGGCAAGTACGGCT
CCGAGGGCGATTACGTCCTGACCCGCCCGCTGCGCGGCCCGCTCAACGACACGCCCGTCGACCACGCCACCGACGCCTAC
GACACCATCGAGTGGCTGGTGAAGAACACGCCGGAGACCAATGGCCGGGTCGGCGTGATCGGCTCCTCCTATCCGGGCTT
CACCAGCGCCATGGCGCTCATCGACCCGCACCCGGCGCTGAAGGCGGCCGTGCCGCAGAGCCCGATGATCGACGGCTGGA
TGGGCGACGACTGGTTCCAGAACGGCGCCTTCCGCCAGACCATGCTCGCCTGGTTCATGCGCCAGATGACCGAGAAGGGC
GCCGGTCCCGACCTGCCTCGCGACGCGCTGGACGACTACGAGAACTACCTGCGGGCCGGCAACGCCTGGGACTTCGGCCG
ACGCGCGGGCCTCGACCAGATCCCGGCCTTCCGCAAGATCGTGGAGCATCCAGCTTACGACGCCTTCTGGCAGAACCAGG
CGCTGGACAAGATCCTGGCCAGGCATCCGTTGAAGGTCCCGACGCTGTGGGTCGGCTCGCTGTTCGACCAGGAGGACATC
TACGGCGCCGTTCACGCCTACCGCGCCACCGAGGCGAAGGACGCCGGCAACGACATGAACTTCCTGGCGCTCGGCGCCTG
GCGGCACTCGGGGGTGAACTACGAGCAGCGCCAGCTGGGGGCGGCGATCAAGCTGCCCGGCGACACCGCCACCGAGTTCC
GCCGCAAGGTGCTCAAGCCGTTCCTCGACCAGCACCTGAAGACGAACGGCCCCAAGGCCGACATCGCCCCCGTGACGATC
TTCGAGACGGGCTCGATGGAGTGGCGCCGCTACGATCGCTGGCCGCTGGCGTGCGAACGCGGCTGCGCGACGCAGATGCG
GCCCCTCTACCTGCAGCCCGGCCTGAAGCTCGGGTTCGAGCCGCCGAAGGGCGCGGCCTATGACGAGTACGTCTCCGACC
CCGCCAAGCCCGTGCCGTTCGTGCCCCAGCCGGTGCGGGCGGACGATCCCGACCAGTGGCGCTACTGGCTGGTGTCGGAC
CAGCGCCACGCGGCCAGCCGCCCCGACGTGCTGACCTACGTCTCCGAGCCCCTGACGACGCCGCTGCAGATCTCGGGCGA
GCCGATCGTCAACCTGTTCGCCTCGACCAGCGGGACGGATTCGGACTGGGTCGTGAAGCTGATCGACGTGCATCCGGACG
TCGTGCCTTCCGACCTGGCGCTCAGCGGCTACCAGATGCCCATCGCCATGGAGATCTTCCGCGGCCGCTATCGGAACAGC
TTCGAGACGCCCTCGCCAGTCCCGGCGGGCAAGGTCCAGACCTACCGTTTCGAGCTTCCGACGGCGAACCACGTCTTCCA
GCCGGGCCACCGGATCATGGTGCAGGTGCAGTCCAGCTGGTTCCCGCTCTACGACCGCAACCCGCAGACCTACGTGGAGA
ACATCTTCTTCGCCCCGCCGGCGGCCTACCGGAAGGCGACCCAGCGCGTGTTCCACACCCGCGGGGCCGCCTCGTCCATC
GAGCTGCCGGTCGTCCCGGCGAACTAG

Upstream 100 bases:

>100_bases
CTCGGGTCGGCGGACGGCGCCATCCTCTTCCAGAGCGCCCTCGCCAGCGCCTGACGGCCGCGCTAGCGTCCCCGGCGTCG
AGTTGCCCGGGGACCTCTGC

Downstream 100 bases:

>100_bases
CCGCCGGGGAACGGCGCCCCGCCGTCAGACGATCCAGCCGGGGGGCAGGTCGGCCAGGCGGACGCCCGCCAGCGACATCT
CGCCCCCGCCGGTCATGCGG

Product: acylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 648; Mature: 647

Protein sequence:

>648_residues
MTFKTLLRAAAACAAIALPAQAQTPTQTPTGAPTPPMTPDIPATFAAPTQHYDYEKRTVMIPMRDGVKLHTILLVPKGVK
DAPILLTRTPYNAKTPSGRFNSPYAAAAGAQMDEPFLADGYIRAYQDVRGKYGSEGDYVLTRPLRGPLNDTPVDHATDAY
DTIEWLVKNTPETNGRVGVIGSSYPGFTSAMALIDPHPALKAAVPQSPMIDGWMGDDWFQNGAFRQTMLAWFMRQMTEKG
AGPDLPRDALDDYENYLRAGNAWDFGRRAGLDQIPAFRKIVEHPAYDAFWQNQALDKILARHPLKVPTLWVGSLFDQEDI
YGAVHAYRATEAKDAGNDMNFLALGAWRHSGVNYEQRQLGAAIKLPGDTATEFRRKVLKPFLDQHLKTNGPKADIAPVTI
FETGSMEWRRYDRWPLACERGCATQMRPLYLQPGLKLGFEPPKGAAYDEYVSDPAKPVPFVPQPVRADDPDQWRYWLVSD
QRHAASRPDVLTYVSEPLTTPLQISGEPIVNLFASTSGTDSDWVVKLIDVHPDVVPSDLALSGYQMPIAMEIFRGRYRNS
FETPSPVPAGKVQTYRFELPTANHVFQPGHRIMVQVQSSWFPLYDRNPQTYVENIFFAPPAAYRKATQRVFHTRGAASSI
ELPVVPAN

Sequences:

>Translated_648_residues
MTFKTLLRAAAACAAIALPAQAQTPTQTPTGAPTPPMTPDIPATFAAPTQHYDYEKRTVMIPMRDGVKLHTILLVPKGVK
DAPILLTRTPYNAKTPSGRFNSPYAAAAGAQMDEPFLADGYIRAYQDVRGKYGSEGDYVLTRPLRGPLNDTPVDHATDAY
DTIEWLVKNTPETNGRVGVIGSSYPGFTSAMALIDPHPALKAAVPQSPMIDGWMGDDWFQNGAFRQTMLAWFMRQMTEKG
AGPDLPRDALDDYENYLRAGNAWDFGRRAGLDQIPAFRKIVEHPAYDAFWQNQALDKILARHPLKVPTLWVGSLFDQEDI
YGAVHAYRATEAKDAGNDMNFLALGAWRHSGVNYEQRQLGAAIKLPGDTATEFRRKVLKPFLDQHLKTNGPKADIAPVTI
FETGSMEWRRYDRWPLACERGCATQMRPLYLQPGLKLGFEPPKGAAYDEYVSDPAKPVPFVPQPVRADDPDQWRYWLVSD
QRHAASRPDVLTYVSEPLTTPLQISGEPIVNLFASTSGTDSDWVVKLIDVHPDVVPSDLALSGYQMPIAMEIFRGRYRNS
FETPSPVPAGKVQTYRFELPTANHVFQPGHRIMVQVQSSWFPLYDRNPQTYVENIFFAPPAAYRKATQRVFHTRGAASSI
ELPVVPAN
>Mature_647_residues
TFKTLLRAAAACAAIALPAQAQTPTQTPTGAPTPPMTPDIPATFAAPTQHYDYEKRTVMIPMRDGVKLHTILLVPKGVKD
APILLTRTPYNAKTPSGRFNSPYAAAAGAQMDEPFLADGYIRAYQDVRGKYGSEGDYVLTRPLRGPLNDTPVDHATDAYD
TIEWLVKNTPETNGRVGVIGSSYPGFTSAMALIDPHPALKAAVPQSPMIDGWMGDDWFQNGAFRQTMLAWFMRQMTEKGA
GPDLPRDALDDYENYLRAGNAWDFGRRAGLDQIPAFRKIVEHPAYDAFWQNQALDKILARHPLKVPTLWVGSLFDQEDIY
GAVHAYRATEAKDAGNDMNFLALGAWRHSGVNYEQRQLGAAIKLPGDTATEFRRKVLKPFLDQHLKTNGPKADIAPVTIF
ETGSMEWRRYDRWPLACERGCATQMRPLYLQPGLKLGFEPPKGAAYDEYVSDPAKPVPFVPQPVRADDPDQWRYWLVSDQ
RHAASRPDVLTYVSEPLTTPLQISGEPIVNLFASTSGTDSDWVVKLIDVHPDVVPSDLALSGYQMPIAMEIFRGRYRNSF
ETPSPVPAGKVQTYRFELPTANHVFQPGHRIMVQVQSSWFPLYDRNPQTYVENIFFAPPAAYRKATQRVFHTRGAASSIE
LPVVPAN

Specific function: Hydrolyzes cocaine to benzoate and ecgonine methyl ester, endowing the bacteria with the ability to utilize cocaine as a sole source of carbon and energy for growth, as this bacterium lives in the rhizosphere of coca plants [H]

COG id: COG2936

COG function: function code R; Predicted acyl esterases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alpha/beta hydrolase family. Carboxylesterase subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005674
- InterPro:   IPR008979
- InterPro:   IPR013736
- InterPro:   IPR000383 [H]

Pfam domain/function: PF02129 Peptidase_S15; PF08530 PepX_C [H]

EC number: NA

Molecular weight: Translated: 72163; Mature: 72032

Theoretical pI: Translated: 7.05; Mature: 7.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFKTLLRAAAACAAIALPAQAQTPTQTPTGAPTPPMTPDIPATFAAPTQHYDYEKRTVM
CCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEE
IPMRDGVKLHTILLVPKGVKDAPILLTRTPYNAKTPSGRFNSPYAAAAGAQMDEPFLADG
EECCCCCEEEEEEEECCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCH
YIRAYQDVRGKYGSEGDYVLTRPLRGPLNDTPVDHATDAYDTIEWLVKNTPETNGRVGVI
HHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEE
GSSYPGFTSAMALIDPHPALKAAVPQSPMIDGWMGDDWFQNGAFRQTMLAWFMRQMTEKG
CCCCCCHHHHHEHCCCCHHHHHCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHCC
AGPDLPRDALDDYENYLRAGNAWDFGRRAGLDQIPAFRKIVEHPAYDAFWQNQALDKILA
CCCCCCHHHHHHHHHHHHCCCCCCCHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
RHPLKVPTLWVGSLFDQEDIYGAVHAYRATEAKDAGNDMNFLALGAWRHSGVNYEQRQLG
HCCCCCCEEHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCHHHHHCC
AAIKLPGDTATEFRRKVLKPFLDQHLKTNGPKADIAPVTIFETGSMEWRRYDRWPLACER
CEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCHHHCCCCCCHHHC
GCATQMRPLYLQPGLKLGFEPPKGAAYDEYVSDPAKPVPFVPQPVRADDPDQWRYWLVSD
CCCCCCCCEEECCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEEC
QRHAASRPDVLTYVSEPLTTPLQISGEPIVNLFASTSGTDSDWVVKLIDVHPDVVPSDLA
CCCCCCCCCEEHHHHCCCCCCEEECCCHHEEEEECCCCCCCCEEEEEEECCCCCCCCCCC
LSGYQMPIAMEIFRGRYRNSFETPSPVPAGKVQTYRFELPTANHVFQPGHRIMVQVQSSW
CCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCEEEEEEECCC
FPLYDRNPQTYVENIFFAPPAAYRKATQRVFHTRGAASSIELPVVPAN
CCCCCCCHHHHHHHEECCCCHHHHHHHHHHHHHCCCCCCCEEEEECCC
>Mature Secondary Structure 
TFKTLLRAAAACAAIALPAQAQTPTQTPTGAPTPPMTPDIPATFAAPTQHYDYEKRTVM
CHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEE
IPMRDGVKLHTILLVPKGVKDAPILLTRTPYNAKTPSGRFNSPYAAAAGAQMDEPFLADG
EECCCCCEEEEEEEECCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCH
YIRAYQDVRGKYGSEGDYVLTRPLRGPLNDTPVDHATDAYDTIEWLVKNTPETNGRVGVI
HHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEE
GSSYPGFTSAMALIDPHPALKAAVPQSPMIDGWMGDDWFQNGAFRQTMLAWFMRQMTEKG
CCCCCCHHHHHEHCCCCHHHHHCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHCC
AGPDLPRDALDDYENYLRAGNAWDFGRRAGLDQIPAFRKIVEHPAYDAFWQNQALDKILA
CCCCCCHHHHHHHHHHHHCCCCCCCHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
RHPLKVPTLWVGSLFDQEDIYGAVHAYRATEAKDAGNDMNFLALGAWRHSGVNYEQRQLG
HCCCCCCEEHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCHHHHHCC
AAIKLPGDTATEFRRKVLKPFLDQHLKTNGPKADIAPVTIFETGSMEWRRYDRWPLACER
CEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCHHHCCCCCCHHHC
GCATQMRPLYLQPGLKLGFEPPKGAAYDEYVSDPAKPVPFVPQPVRADDPDQWRYWLVSD
CCCCCCCCEEECCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEEC
QRHAASRPDVLTYVSEPLTTPLQISGEPIVNLFASTSGTDSDWVVKLIDVHPDVVPSDLA
CCCCCCCCCEEHHHHCCCCCCEEECCCHHEEEEECCCCCCCCEEEEEEECCCCCCCCCCC
LSGYQMPIAMEIFRGRYRNSFETPSPVPAGKVQTYRFELPTANHVFQPGHRIMVQVQSSW
CCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCEEEEEEECCC
FPLYDRNPQTYVENIFFAPPAAYRKATQRVFHTRGAASSIELPVVPAN
CCCCCCCHHHHHHHEECCCCHHHHHHHHHHHHHCCCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10698749; 11742345; 12369817 [H]