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The map label for this gene is fadA [H]

Identifier: 197104226

GI number: 197104226

Start: 839168

End: 840340

Strand: Reverse

Name: fadA [H]

Synonym: PHZ_c0760

Alternate gene names: 197104226

Gene position: 840340-839168 (Counterclockwise)

Preceding gene: 197104230

Following gene: 197104224

Centisome position: 21.03

GC content: 69.48

Gene sequence:

>1173_bases
ATGCGCGAAGCGGTCATCGTCTCCTACGCCCGGACGGGCCTGGCCAAGTCCGCCCGCGGCGGATTCAACATGACCCCGAC
GGTCTCGATGGCCGCGCACGCGGTGAAGCATGCCGTCGAGCGCTCGGGCGTGGCCCCCGCCGAGATCGAGGACGTCTTCC
TGGGCAACGTGGCGCACGGCGGCGGCAACCTCGGCCGTCAGGCGGGCCTGCTGGGCGGCCTGCCGATCACCACCTCGGGC
GTGACCGTCAACCGCTTCTGCTCGTCGGGCCTGCAGACCATCGCCATGGGCGCCGACTACATCCGCAACGGCGGCGCCGA
CGTCGTCGTGGCCGGCGGGGTGGAGTCGATCTCCATGCCGAACCCGGGCCCCGGCAGCGCCGAGAACTTCGACCCCGAGC
TGACCCGGCTGTACCCGGCCATCTTCATGCCGATGATCGACACCGCCGACATCGTCGCCGAGCGCTACAACGTCAGCCGC
GAGGCCCAGGACGAGTACTCGCTCGAGAGCCAACGCCGGATGGCCGCCGCCCAGCAGGCCGAGAAGTTCAAGGACGAGAT
CGTCCCGATGAAGACCAAGATGAAGGTGGTCAACAAGGAGACGAAGGAGGAGTCCGTCGTCGACTACGTGGTCGACCGCG
ACGAGTGCAACCGCCCCGACACCACGCTGGAAGGCCTGGCCAAGCTCCAGCCGGTCCGCGGCGAGGGCAAGTTCATCACC
GCCGGCAACGCCTCGCAGCTCTCGGACGGCGCGGCCGCCGTGGTGGTGATGGAGGCCAAGGAGGCCGAGCGCCGCGGGCT
GAAGCCGCTCGGCGTGTTCAAGGGTTGGGCGGTCGCGGGCTGCGAGCCCGACGAGATGGGCATCGGCCCGGTGTTCGCGA
TCCCGCGCCTGCTCGAGCGCCACGGCCTGAAGGTCGACGACATCGACCTGTGGGAGCTGAACGAGGCCTTCGCCAGCCAG
TGCCTCTACTGCCGCGACAAGCTCGGCATCGATCCTGAGAAGTACAACGTCAACGGCGGCTCGATCGCCATCGGCCACCC
CTTCGGCATGACCGGCGCGCGCCTGGCGGGCCACGTCCTGCAGGAAGGCAAGCGCCGCGGCGCCAAGAACGTCGTCGTCT
CCATGTGCATCGGCGGCGGCATGGGCGGCGCGGGCCTCTTCGAGGTCTTCTAG

Upstream 100 bases:

>100_bases
GGGCCGTCCCTAGCCATTTCCATCCCGGGATGCAAAGGTTGCCCCGAGTTCCAACGCTTGTTTAAAAGCGCCAACCGATT
GTCCCGGAGGATCATTTAAA

Downstream 100 bases:

>100_bases
GCGCTCCCAGCCTTTCGGGCGGATCGGCCCTCCCCTCTGCGGGAGGGCCTTTTCTTTATGGCCACGAACAAACACGAACC
AACACGAACAGGGGGTCCCC

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MREAVIVSYARTGLAKSARGGFNMTPTVSMAAHAVKHAVERSGVAPAEIEDVFLGNVAHGGGNLGRQAGLLGGLPITTSG
VTVNRFCSSGLQTIAMGADYIRNGGADVVVAGGVESISMPNPGPGSAENFDPELTRLYPAIFMPMIDTADIVAERYNVSR
EAQDEYSLESQRRMAAAQQAEKFKDEIVPMKTKMKVVNKETKEESVVDYVVDRDECNRPDTTLEGLAKLQPVRGEGKFIT
AGNASQLSDGAAAVVVMEAKEAERRGLKPLGVFKGWAVAGCEPDEMGIGPVFAIPRLLERHGLKVDDIDLWELNEAFASQ
CLYCRDKLGIDPEKYNVNGGSIAIGHPFGMTGARLAGHVLQEGKRRGAKNVVVSMCIGGGMGGAGLFEVF

Sequences:

>Translated_390_residues
MREAVIVSYARTGLAKSARGGFNMTPTVSMAAHAVKHAVERSGVAPAEIEDVFLGNVAHGGGNLGRQAGLLGGLPITTSG
VTVNRFCSSGLQTIAMGADYIRNGGADVVVAGGVESISMPNPGPGSAENFDPELTRLYPAIFMPMIDTADIVAERYNVSR
EAQDEYSLESQRRMAAAQQAEKFKDEIVPMKTKMKVVNKETKEESVVDYVVDRDECNRPDTTLEGLAKLQPVRGEGKFIT
AGNASQLSDGAAAVVVMEAKEAERRGLKPLGVFKGWAVAGCEPDEMGIGPVFAIPRLLERHGLKVDDIDLWELNEAFASQ
CLYCRDKLGIDPEKYNVNGGSIAIGHPFGMTGARLAGHVLQEGKRRGAKNVVVSMCIGGGMGGAGLFEVF
>Mature_390_residues
MREAVIVSYARTGLAKSARGGFNMTPTVSMAAHAVKHAVERSGVAPAEIEDVFLGNVAHGGGNLGRQAGLLGGLPITTSG
VTVNRFCSSGLQTIAMGADYIRNGGADVVVAGGVESISMPNPGPGSAENFDPELTRLYPAIFMPMIDTADIVAERYNVSR
EAQDEYSLESQRRMAAAQQAEKFKDEIVPMKTKMKVVNKETKEESVVDYVVDRDECNRPDTTLEGLAKLQPVRGEGKFIT
AGNASQLSDGAAAVVVMEAKEAERRGLKPLGVFKGWAVAGCEPDEMGIGPVFAIPRLLERHGLKVDDIDLWELNEAFASQ
CLYCRDKLGIDPEKYNVNGGSIAIGHPFGMTGARLAGHVLQEGKRRGAKNVVVSMCIGGGMGGAGLFEVF

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=392, Percent_Identity=44.1326530612245, Blast_Score=291, Evalue=6e-79,
Organism=Homo sapiens, GI167614485, Length=404, Percent_Identity=38.8613861386139, Blast_Score=242, Evalue=4e-64,
Organism=Homo sapiens, GI4557237, Length=406, Percent_Identity=36.6995073891626, Blast_Score=228, Evalue=7e-60,
Organism=Homo sapiens, GI148539872, Length=404, Percent_Identity=35.3960396039604, Blast_Score=221, Evalue=7e-58,
Organism=Homo sapiens, GI4504327, Length=443, Percent_Identity=31.1512415349887, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI194353979, Length=242, Percent_Identity=34.297520661157, Blast_Score=111, Evalue=1e-24,
Organism=Escherichia coli, GI87082165, Length=401, Percent_Identity=38.4039900249377, Blast_Score=237, Evalue=1e-63,
Organism=Escherichia coli, GI1787663, Length=414, Percent_Identity=40.0966183574879, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI1788554, Length=402, Percent_Identity=39.3034825870647, Blast_Score=233, Evalue=1e-62,
Organism=Escherichia coli, GI48994986, Length=400, Percent_Identity=37.5, Blast_Score=224, Evalue=6e-60,
Organism=Escherichia coli, GI1788683, Length=411, Percent_Identity=31.6301703163017, Blast_Score=158, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI133906874, Length=370, Percent_Identity=39.7297297297297, Blast_Score=231, Evalue=4e-61,
Organism=Caenorhabditis elegans, GI25147385, Length=398, Percent_Identity=34.1708542713568, Blast_Score=201, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI17535921, Length=410, Percent_Identity=35.1219512195122, Blast_Score=192, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI17551802, Length=439, Percent_Identity=29.6127562642369, Blast_Score=158, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI17535917, Length=391, Percent_Identity=29.4117647058824, Blast_Score=144, Evalue=6e-35,
Organism=Saccharomyces cerevisiae, GI6322031, Length=397, Percent_Identity=37.27959697733, Blast_Score=220, Evalue=3e-58,
Organism=Saccharomyces cerevisiae, GI6325229, Length=396, Percent_Identity=32.8282828282828, Blast_Score=181, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24655093, Length=396, Percent_Identity=40.6565656565657, Blast_Score=260, Evalue=1e-69,
Organism=Drosophila melanogaster, GI17648125, Length=361, Percent_Identity=40.4432132963989, Blast_Score=238, Evalue=6e-63,
Organism=Drosophila melanogaster, GI24640423, Length=403, Percent_Identity=37.2208436724566, Blast_Score=227, Evalue=9e-60,
Organism=Drosophila melanogaster, GI17137578, Length=436, Percent_Identity=31.8807339449541, Blast_Score=174, Evalue=1e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 41461; Mature: 41461

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS00060 ADH_IRON_2 ; PS00098 THIOLASE_1 ; PS00737 THIOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREAVIVSYARTGLAKSARGGFNMTPTVSMAAHAVKHAVERSGVAPAEIEDVFLGNVAHG
CCCEEEEHHHHHCHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCC
GGNLGRQAGLLGGLPITTSGVTVNRFCSSGLQTIAMGADYIRNGGADVVVAGGVESISMP
CCCCHHHCCCCCCCCEEECCCCHHHHHHHHHHHHHHCHHHHHCCCCCEEEECCCCCCCCC
NPGPGSAENFDPELTRLYPAIFMPMIDTADIVAERYNVSREAQDEYSLESQRRMAAAQQA
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
EKFKDEIVPMKTKMKVVNKETKEESVVDYVVDRDECNRPDTTLEGLAKLQPVRGEGKFIT
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCHHHHHHHHCCCCCCCCCEEE
AGNASQLSDGAAAVVVMEAKEAERRGLKPLGVFKGWAVAGCEPDEMGIGPVFAIPRLLER
CCCHHHCCCCCEEEEEEECHHHHHCCCCCCCCCCCCEEECCCCHHCCCCHHHHHHHHHHH
HGLKVDDIDLWELNEAFASQCLYCRDKLGIDPEKYNVNGGSIAIGHPFGMTGARLAGHVL
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCEEEECCCCCCCHHHHHHHHH
QEGKRRGAKNVVVSMCIGGGMGGAGLFEVF
HHHHHCCHHHHEEEEECCCCCCCCCHHHCC
>Mature Secondary Structure
MREAVIVSYARTGLAKSARGGFNMTPTVSMAAHAVKHAVERSGVAPAEIEDVFLGNVAHG
CCCEEEEHHHHHCHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCC
GGNLGRQAGLLGGLPITTSGVTVNRFCSSGLQTIAMGADYIRNGGADVVVAGGVESISMP
CCCCHHHCCCCCCCCEEECCCCHHHHHHHHHHHHHHCHHHHHCCCCCEEEECCCCCCCCC
NPGPGSAENFDPELTRLYPAIFMPMIDTADIVAERYNVSREAQDEYSLESQRRMAAAQQA
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
EKFKDEIVPMKTKMKVVNKETKEESVVDYVVDRDECNRPDTTLEGLAKLQPVRGEGKFIT
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCHHHHHHHHCCCCCCCCCEEE
AGNASQLSDGAAAVVVMEAKEAERRGLKPLGVFKGWAVAGCEPDEMGIGPVFAIPRLLER
CCCHHHCCCCCEEEEEEECHHHHHCCCCCCCCCCCCEEECCCCHHCCCCHHHHHHHHHHH
HGLKVDDIDLWELNEAFASQCLYCRDKLGIDPEKYNVNGGSIAIGHPFGMTGARLAGHVL
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCEEEECCCCCCCHHHHHHHHH
QEGKRRGAKNVVVSMCIGGGMGGAGLFEVF
HHHHHCCHHHHEEEEECCCCCCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]