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The map label for this gene is pyrC [H]

Identifier: 197104038

GI number: 197104038

Start: 607295

End: 608629

Strand: Reverse

Name: pyrC [H]

Synonym: PHZ_c0572

Alternate gene names: 197104038

Gene position: 608629-607295 (Counterclockwise)

Preceding gene: 197104039

Following gene: 197104036

Centisome position: 15.23

GC content: 71.91

Gene sequence:

>1335_bases
ATGCCTGAGACCTTCGACCTGATCGTGCGCGGCGGCGAGGTGGTGAACCACGCCGGACGCGGCCGCGCCGACATCGGCGT
CCGCGGCGGCAAGATCGCCGCCATCGGCGACCTCGCCCAGGCTTCGGCGGGCGAGACCTTCGACGCCTCCGGCCTGACGG
TGATGCCGGGGGTCATCGACACCCAGGTCCACTTCCGCGAGCCCGGCCTGGAGTGGAAGGAGGACCTCGAGACCGGCTCG
CGCGCCGCGGTGCTCGGCGGCGTCACCGCCGTGTTCGAGATGCCGAACACCGAGCCGACCACCACCGACCCCGACACCCT
GGCCGACAAGCTCGCCCGCGCCCGCGACCGCATGCACTGCGATCACGCCTTCTACGTCGGCGGCACGCACGAGAACGCGC
GCTTCCTGGGCGAGCTGGAACGCCTGCCCGGCTGCTGCGGGATCAAGGTGTTCATGGGGGCCTCCACGGGCACGCTGCTG
GTGCAGGACGACGAGGGCGTGGAGCAGGTGCTGCGCCACATCTCCCGCCGCGCGGCCTTCCACTCCGAGGACGAGTACCG
GCTGGCCGAGCGCCGGCCGCTCGCCCGCACGGGCGACTGGACCAGCCACTACGAGGTGCGCGACGCCCAGTCGGCGATCC
AGTCCACGGAGCGCCTGGTGCGCCTGGCCCGCAAGTGCGGCAAGCGCATCCACGTCCTGCACGTGACGACGCGCGAGGAG
ATCGCCTTCCTCGCCGGCCACAAGGACGTCGCCTCGGTCGAGGTGACCCCCCAGCACCTGACCCTCGCCGGGCCCGAGGC
CTATGAACGTCTGAAGGGCTTCGCCCAGATGAACCCGCCGATCCGTGGGGCCGAGCACCGCGAGGGGCTGTGGGTCGGGG
TGGCGAACGGCGTCGCCGACGTCATCGGCTCGGACCACGCCCCGCACACCCGCGAGGAGAAGGCCCGGCCCTACCCCGCC
TCGCCTTCCGGGATGCCTGGCGTGCAGACCCTGCTGCCGGTGATGCTGACCCACGTCGCCGAGGGCCGGCTGACGCTGGA
GCGCCTCGTCGACCTGACCAGCCACGGCGCGAACCGCATCTTCAACCTGGCCGACAAGGGCCGGCTGGCGGTGGGCTACG
ACGCCGACCTGACCGTGGTGGACCTCAAGGCCCGACGCACGCTCCGGCACGAGGACATGGCCAGCCGCGTCGGCTGGACG
CCCTTCGACGGCTTCGAGGCGAAGGGTTGGCCGATGGCGACGATCGTTCGCGGAACGGTCGTCATGCGCGACGACGAGAT
CGTCGCCCCGCATCTCGGCCAGCCGGTGCGGTTCGGCGAGACTCTCACGAGCTAG

Upstream 100 bases:

>100_bases
GACCCGGAACTCTCGCAGGCCATCTGCCACATGATGGACCTGCCGGTGGAGAAGGTGGTAGGCGCGGCGGAGGAACTCCT
GGCCGCCACCGAGGCCCCAC

Downstream 100 bases:

>100_bases
CCTCTACAACGCCTCGATCACCGCCTTCGCGAACGCCGCCTCGTCGAAGCGCTTGCCGGCGGGATCGAAGCCGCGGCGGA
CGATGACCAGCTTCCGCGAG

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MPETFDLIVRGGEVVNHAGRGRADIGVRGGKIAAIGDLAQASAGETFDASGLTVMPGVIDTQVHFREPGLEWKEDLETGS
RAAVLGGVTAVFEMPNTEPTTTDPDTLADKLARARDRMHCDHAFYVGGTHENARFLGELERLPGCCGIKVFMGASTGTLL
VQDDEGVEQVLRHISRRAAFHSEDEYRLAERRPLARTGDWTSHYEVRDAQSAIQSTERLVRLARKCGKRIHVLHVTTREE
IAFLAGHKDVASVEVTPQHLTLAGPEAYERLKGFAQMNPPIRGAEHREGLWVGVANGVADVIGSDHAPHTREEKARPYPA
SPSGMPGVQTLLPVMLTHVAEGRLTLERLVDLTSHGANRIFNLADKGRLAVGYDADLTVVDLKARRTLRHEDMASRVGWT
PFDGFEAKGWPMATIVRGTVVMRDDEIVAPHLGQPVRFGETLTS

Sequences:

>Translated_444_residues
MPETFDLIVRGGEVVNHAGRGRADIGVRGGKIAAIGDLAQASAGETFDASGLTVMPGVIDTQVHFREPGLEWKEDLETGS
RAAVLGGVTAVFEMPNTEPTTTDPDTLADKLARARDRMHCDHAFYVGGTHENARFLGELERLPGCCGIKVFMGASTGTLL
VQDDEGVEQVLRHISRRAAFHSEDEYRLAERRPLARTGDWTSHYEVRDAQSAIQSTERLVRLARKCGKRIHVLHVTTREE
IAFLAGHKDVASVEVTPQHLTLAGPEAYERLKGFAQMNPPIRGAEHREGLWVGVANGVADVIGSDHAPHTREEKARPYPA
SPSGMPGVQTLLPVMLTHVAEGRLTLERLVDLTSHGANRIFNLADKGRLAVGYDADLTVVDLKARRTLRHEDMASRVGWT
PFDGFEAKGWPMATIVRGTVVMRDDEIVAPHLGQPVRFGETLTS
>Mature_443_residues
PETFDLIVRGGEVVNHAGRGRADIGVRGGKIAAIGDLAQASAGETFDASGLTVMPGVIDTQVHFREPGLEWKEDLETGSR
AAVLGGVTAVFEMPNTEPTTTDPDTLADKLARARDRMHCDHAFYVGGTHENARFLGELERLPGCCGIKVFMGASTGTLLV
QDDEGVEQVLRHISRRAAFHSEDEYRLAERRPLARTGDWTSHYEVRDAQSAIQSTERLVRLARKCGKRIHVLHVTTREEI
AFLAGHKDVASVEVTPQHLTLAGPEAYERLKGFAQMNPPIRGAEHREGLWVGVANGVADVIGSDHAPHTREEKARPYPAS
PSGMPGVQTLLPVMLTHVAEGRLTLERLVDLTSHGANRIFNLADKGRLAVGYDADLTVVDLKARRTLRHEDMASRVGWTP
FDGFEAKGWPMATIVRGTVVMRDDEIVAPHLGQPVRFGETLTS

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=400, Percent_Identity=33.25, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI19923821, Length=442, Percent_Identity=27.6018099547511, Blast_Score=129, Evalue=6e-30,
Organism=Homo sapiens, GI4503379, Length=444, Percent_Identity=25.9009009009009, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI4503375, Length=443, Percent_Identity=28.6681715575621, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI190194363, Length=468, Percent_Identity=27.7777777777778, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI4503051, Length=445, Percent_Identity=25.6179775280899, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI62422571, Length=445, Percent_Identity=25.6179775280899, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI4503377, Length=441, Percent_Identity=25.3968253968254, Blast_Score=110, Evalue=2e-24,
Organism=Escherichia coli, GI1786722, Length=435, Percent_Identity=32.4137931034483, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI87082175, Length=442, Percent_Identity=26.6968325791855, Blast_Score=150, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI193204318, Length=394, Percent_Identity=30.7106598984772, Blast_Score=174, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI71989490, Length=447, Percent_Identity=27.7404921700224, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17539558, Length=448, Percent_Identity=26.7857142857143, Blast_Score=114, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6322218, Length=392, Percent_Identity=27.0408163265306, Blast_Score=127, Evalue=5e-30,
Organism=Drosophila melanogaster, GI24642586, Length=388, Percent_Identity=34.7938144329897, Blast_Score=202, Evalue=3e-52,
Organism=Drosophila melanogaster, GI221377917, Length=452, Percent_Identity=27.212389380531, Blast_Score=115, Evalue=8e-26,
Organism=Drosophila melanogaster, GI17137462, Length=442, Percent_Identity=26.6968325791855, Blast_Score=112, Evalue=7e-25,
Organism=Drosophila melanogaster, GI18859883, Length=434, Percent_Identity=27.6497695852535, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24644287, Length=248, Percent_Identity=27.8225806451613, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24644289, Length=191, Percent_Identity=29.8429319371728, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 48495; Mature: 48364

Theoretical pI: Translated: 6.47; Mature: 6.47

Prosite motif: PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPETFDLIVRGGEVVNHAGRGRADIGVRGGKIAAIGDLAQASAGETFDASGLTVMPGVID
CCCCEEEEEECCHHHHCCCCCCCCCCCCCCEEEEECCHHHHCCCCCCCCCCCEECCCCEE
TQVHFREPGLEWKEDLETGSRAAVLGGVTAVFEMPNTEPTTTDPDTLADKLARARDRMHC
CEEEECCCCCCHHHHHCCCCCEEHHHCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCC
DHAFYVGGTHENARFLGELERLPGCCGIKVFMGASTGTLLVQDDEGVEQVLRHISRRAAF
CCEEEECCCCCCHHHHHHHHHCCCCCCEEEEECCCCCEEEEECCCCHHHHHHHHHHHHHC
HSEDEYRLAERRPLARTGDWTSHYEVRDAQSAIQSTERLVRLARKCGKRIHVLHVTTREE
CCCCHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEECHHH
IAFLAGHKDVASVEVTPQHLTLAGPEAYERLKGFAQMNPPIRGAEHREGLWVGVANGVAD
HHEEECCCCCEEEEECCCEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEHHHHHH
VIGSDHAPHTREEKARPYPASPSGMPGVQTLLPVMLTHVAEGRLTLERLVDLTSHGANRI
HHCCCCCCCCCHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHE
FNLADKGRLAVGYDADLTVVDLKARRTLRHEDMASRVGWTPFDGFEAKGWPMATIVRGTV
EECCCCCCEEEECCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECEE
VMRDDEIVAPHLGQPVRFGETLTS
EEECCCEECCCCCCCCCCCHHHCC
>Mature Secondary Structure 
PETFDLIVRGGEVVNHAGRGRADIGVRGGKIAAIGDLAQASAGETFDASGLTVMPGVID
CCCEEEEEECCHHHHCCCCCCCCCCCCCCEEEEECCHHHHCCCCCCCCCCCEECCCCEE
TQVHFREPGLEWKEDLETGSRAAVLGGVTAVFEMPNTEPTTTDPDTLADKLARARDRMHC
CEEEECCCCCCHHHHHCCCCCEEHHHCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCC
DHAFYVGGTHENARFLGELERLPGCCGIKVFMGASTGTLLVQDDEGVEQVLRHISRRAAF
CCEEEECCCCCCHHHHHHHHHCCCCCCEEEEECCCCCEEEEECCCCHHHHHHHHHHHHHC
HSEDEYRLAERRPLARTGDWTSHYEVRDAQSAIQSTERLVRLARKCGKRIHVLHVTTREE
CCCCHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEECHHH
IAFLAGHKDVASVEVTPQHLTLAGPEAYERLKGFAQMNPPIRGAEHREGLWVGVANGVAD
HHEEECCCCCEEEEECCCEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEHHHHHH
VIGSDHAPHTREEKARPYPASPSGMPGVQTLLPVMLTHVAEGRLTLERLVDLTSHGANRI
HHCCCCCCCCCHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHE
FNLADKGRLAVGYDADLTVVDLKARRTLRHEDMASRVGWTPFDGFEAKGWPMATIVRGTV
EECCCCCCEEEECCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECEE
VMRDDEIVAPHLGQPVRFGETLTS
EEECCCEECCCCCCCCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]