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The map label for this gene is hhoB [H]

Identifier: 197103992

GI number: 197103992

Start: 552553

End: 553827

Strand: Reverse

Name: hhoB [H]

Synonym: PHZ_c0526

Alternate gene names: 197103992

Gene position: 553827-552553 (Counterclockwise)

Preceding gene: 197103993

Following gene: 197103989

Centisome position: 13.86

GC content: 67.22

Gene sequence:

>1275_bases
GTGATCGTCAGATACGCACAGGGGGGCGACGATGAAGGGGTGGATCGTGATCGTTGGCGCGCTGGCGCTGGCGGTCGGAA
CAGCGCAGGCGCAGCCGCTTGGCTCGCCGGCGCCGGCGCCGACGTCGGCGAAGGCCTCGTCGTCCGCAGGCGTTTCGGCT
TCGGTGACCCTGACGCGCGTGGGCAGCCCCCTCCGCGACGAGCAGAAGGTCGGCACCTATTGGTGGGGAACCGTCTGCAT
CCAGCCGACGCCGCTGCTGTGGAAGGATCTCGCCGAGATGATGACAGGTCTGGACGCCGTCTTCGCGGAAGAGTTCGCCG
CCGCGGCCTGAAGGCCGGCTCCGACCCGTCCAACCTCTTCGCCGAAGCTGCTCCGACATCTGGGGACCTGCAGGTCGGCG
CCCTCGTCAAGAGCGCGGACGCCTCCTACTGCGAGAACGTGATCAAGACCTCCGGCAAGGTTACGCTCGGCGTCGAGTGG
CAAATCTACTCAGGCCTGCGGCGCGAGGTGGTCGCCAGAATCGAGACGACCGGCACCTACGAGGCGAAGAAGCTCGACGA
CCGCAGCAAGCGCAGCCTCGCCCAGGAGGCGTTCGCCGCCAACGTCCGCAGTCTCCTGGCGGACGAGCGATTCCGACAGG
TGATGGCCGACGATCCCGCTCAGGCCATCGGCTCCCCCGCGACCCGCTTCGAGGCGATCCAGATCGTTGGCCCCAAGGCG
GCGTCTGTGCCTCTATCTGCGGCGGTGCAGTCGGTTGCGGCCGTGTTTGCAGGCGGCGGCCACGGCAGCGGCTTCGTGGT
CTCGAGCGACGGCTATCTGCTCACCAACCAGCATGTCGTCGGCGACGCCAAGTACGTGAAGGTCCGCTGGGCGGATGGCT
TCGAGGCATTGGGCGAGGTTGTCAGATCGGACCGCCGACGCGACGTCGCGCTCATCAAGACGAGCGCCAAAGCGACACCC
CTGGCGCTCCGCTCTTCGCCGGCGGCGCTGGGCGAGACCGTGTTCGCGATCGGAACGCCCCTCGACGCGAAATTCCAGAA
CACGGTGACGAAGGGCGTCGTGTCGGCGAGCAGGACCTACGACGGCCTCGCGTTTCTCCAGAGCGATGTGGGGATCAATC
CCGGCAACAGTGGAGGTCCGCTGCTTGACGAGAAGGGTTCGGTGCTCGGGATCTCCGTCTCGACCTACCAGGTCAACGAC
GCGCCGACGGGCCTGAACCTCTTCATCCCGATCGCTGAGGCGCTGGACACCTTGGCGCTCAGGCCGGCGAACTGA

Upstream 100 bases:

>100_bases
CCGGCGGGCGGCGGTTCCACTTCCGCGACCCCGCCGGCAACGAGCTGGCGGTCTGGAGCGAGGGGTAGCGTCAAACAACC
TTAAGCTGACTAAGGTTGAG

Downstream 100 bases:

>100_bases
GCCTCACCAGAGGCTCTTGACCGCGCGGGCGGGCCAGTCGGCGTCATAGGCTTGGCCGCCGACCTCACCGCCGGTGAGGG
CGGCGAGGATCTGGCCGGGG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MIVRYAQGGDDEGVDRDRWRAGAGGRNSAGAAAWLAGAGADVGEGLVVRRRFGFGDPDARGQPPPRRAEGRHLLVGNRLH
PADAAAVEGSRRDDDRSGRRLRGRVRRRGLKAGSDPSNLFAEAAPTSGDLQVGALVKSADASYCENVIKTSGKVTLGVEW
QIYSGLRREVVARIETTGTYEAKKLDDRSKRSLAQEAFAANVRSLLADERFRQVMADDPAQAIGSPATRFEAIQIVGPKA
ASVPLSAAVQSVAAVFAGGGHGSGFVVSSDGYLLTNQHVVGDAKYVKVRWADGFEALGEVVRSDRRRDVALIKTSAKATP
LALRSSPAALGETVFAIGTPLDAKFQNTVTKGVVSASRTYDGLAFLQSDVGINPGNSGGPLLDEKGSVLGISVSTYQVND
APTGLNLFIPIAEALDTLALRPAN

Sequences:

>Translated_424_residues
MIVRYAQGGDDEGVDRDRWRAGAGGRNSAGAAAWLAGAGADVGEGLVVRRRFGFGDPDARGQPPPRRAEGRHLLVGNRLH
PADAAAVEGSRRDDDRSGRRLRGRVRRRGLKAGSDPSNLFAEAAPTSGDLQVGALVKSADASYCENVIKTSGKVTLGVEW
QIYSGLRREVVARIETTGTYEAKKLDDRSKRSLAQEAFAANVRSLLADERFRQVMADDPAQAIGSPATRFEAIQIVGPKA
ASVPLSAAVQSVAAVFAGGGHGSGFVVSSDGYLLTNQHVVGDAKYVKVRWADGFEALGEVVRSDRRRDVALIKTSAKATP
LALRSSPAALGETVFAIGTPLDAKFQNTVTKGVVSASRTYDGLAFLQSDVGINPGNSGGPLLDEKGSVLGISVSTYQVND
APTGLNLFIPIAEALDTLALRPAN
>Mature_424_residues
MIVRYAQGGDDEGVDRDRWRAGAGGRNSAGAAAWLAGAGADVGEGLVVRRRFGFGDPDARGQPPPRRAEGRHLLVGNRLH
PADAAAVEGSRRDDDRSGRRLRGRVRRRGLKAGSDPSNLFAEAAPTSGDLQVGALVKSADASYCENVIKTSGKVTLGVEW
QIYSGLRREVVARIETTGTYEAKKLDDRSKRSLAQEAFAANVRSLLADERFRQVMADDPAQAIGSPATRFEAIQIVGPKA
ASVPLSAAVQSVAAVFAGGGHGSGFVVSSDGYLLTNQHVVGDAKYVKVRWADGFEALGEVVRSDRRRDVALIKTSAKATP
LALRSSPAALGETVFAIGTPLDAKFQNTVTKGVVSASRTYDGLAFLQSDVGINPGNSGGPLLDEKGSVLGISVSTYQVND
APTGLNLFIPIAEALDTLALRPAN

Specific function: A putative protease, its function overlaps that of the related putative proteases HtrA and HhoA [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=161, Percent_Identity=40.3726708074534, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI24308541, Length=160, Percent_Identity=36.875, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI22129776, Length=166, Percent_Identity=35.5421686746988, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI7019477, Length=162, Percent_Identity=36.4197530864198, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI1789630, Length=168, Percent_Identity=37.5, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1789629, Length=160, Percent_Identity=35, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1786356, Length=160, Percent_Identity=34.375, Blast_Score=82, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24646839, Length=164, Percent_Identity=34.1463414634146, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 44600; Mature: 44600

Theoretical pI: Translated: 9.93; Mature: 9.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
0.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVRYAQGGDDEGVDRDRWRAGAGGRNSAGAAAWLAGAGADVGEGLVVRRRFGFGDPDAR
CEEEECCCCCCCCCCHHHHCCCCCCCCCCCHHHHEECCCCCCCCCEEEEEECCCCCCCCC
GQPPPRRAEGRHLLVGNRLHPADAAAVEGSRRDDDRSGRRLRGRVRRRGLKAGSDPSNLF
CCCCCCCCCCCEEEECCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHH
AEAAPTSGDLQVGALVKSADASYCENVIKTSGKVTLGVEWQIYSGLRREVVARIETTGTY
HHCCCCCCCEEEEHHHHHCCHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHHHCCCCC
EAKKLDDRSKRSLAQEAFAANVRSLLADERFRQVMADDPAQAIGSPATRFEAIQIVGPKA
CHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHEEEEEEECCCC
ASVPLSAAVQSVAAVFAGGGHGSGFVVSSDGYLLTNQHVVGDAKYVKVRWADGFEALGEV
CCCCHHHHHHHHHHHHCCCCCCCCEEEECCCEEEECCEEECCCEEEEEEECCCHHHHHHH
VRSDRRRDVALIKTSAKATPLALRSSPAALGETVFAIGTPLDAKFQNTVTKGVVSASRTY
HHHCCCCCEEEEEECCCCCCEEECCCCHHHCCEEEEECCCCCCHHHHHHHHHHHHHCCCC
DGLAFLQSDVGINPGNSGGPLLDEKGSVLGISVSTYQVNDAPTGLNLFIPIAEALDTLAL
CHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEEEEEECCCCCCCEEEEEHHHHHHHHCC
RPAN
CCCC
>Mature Secondary Structure
MIVRYAQGGDDEGVDRDRWRAGAGGRNSAGAAAWLAGAGADVGEGLVVRRRFGFGDPDAR
CEEEECCCCCCCCCCHHHHCCCCCCCCCCCHHHHEECCCCCCCCCEEEEEECCCCCCCCC
GQPPPRRAEGRHLLVGNRLHPADAAAVEGSRRDDDRSGRRLRGRVRRRGLKAGSDPSNLF
CCCCCCCCCCCEEEECCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHH
AEAAPTSGDLQVGALVKSADASYCENVIKTSGKVTLGVEWQIYSGLRREVVARIETTGTY
HHCCCCCCCEEEEHHHHHCCHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHHHCCCCC
EAKKLDDRSKRSLAQEAFAANVRSLLADERFRQVMADDPAQAIGSPATRFEAIQIVGPKA
CHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHEEEEEEECCCC
ASVPLSAAVQSVAAVFAGGGHGSGFVVSSDGYLLTNQHVVGDAKYVKVRWADGFEALGEV
CCCCHHHHHHHHHHHHCCCCCCCCEEEECCCEEEECCEEECCCEEEEEEECCCHHHHHHH
VRSDRRRDVALIKTSAKATPLALRSSPAALGETVFAIGTPLDAKFQNTVTKGVVSASRTY
HHHCCCCCEEEEEECCCCCCEEECCCCHHHCCEEEEECCCCCCHHHHHHHHHHHHHCCCC
DGLAFLQSDVGINPGNSGGPLLDEKGSVLGISVSTYQVNDAPTGLNLFIPIAEALDTLAL
CHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEEEEEECCCCCCCEEEEEHHHHHHHHCC
RPAN
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]