Click here to switch to the map view.

The map label for this gene is hutU

Identifier: 197103934

GI number: 197103934

Start: 484327

End: 485994

Strand: Direct

Name: hutU

Synonym: PHZ_c0468

Alternate gene names: 197103934

Gene position: 484327-485994 (Clockwise)

Preceding gene: 197103933

Following gene: 197103936

Centisome position: 12.12

GC content: 71.28

Gene sequence:

>1668_bases
ATGACCCGACACGACCCGAACCGCGTCATCCGCCCGCCGGTGGGACCCGAGCTGACCTGCCGGAGCTGGCTGACCGAGGC
GCCGCTCCGCATGCTGATGAACAACCTGCATCCGGATGTGGCCGAGAACCCCGCCGAGCTGGTGGTCTACGGCGGCGTCG
GCCGGGCGGCGCGCGACTGGGAGAGCTACGACCGCATCGTGGAGACCCTGCGCCGGCTGGGCGACGACGAGACGCTGCTG
GTCCAGTCCGGCAAGCCGGTGGGCGTCTTCCGCACCCACGCCGACGCCCCGCGCGTGCTGATCGCCAACTCCAACCTCGT
GCCGAAGTGGGCGACCTGGGAGCACTTCAACGAACTCGATCGCAAGGGCCTGGCCATGTACGGCCAGATGACGGCCGGAT
CGTGGATCTACATCGGCACCCAGGGGATCGTTCAGGGCACCTACGAGACCTTCGTCGAGATGGGCCGCCAGCACTACGGC
GGCGACCTCTCGGGCCGCTGGCTGCTGACCGCAGGCCTGGGCGGCATGGGCGGCGCCCAGCCCCTGGCGGCGGTGATGGC
GGGCGCCTCGTGCCTGGCGATCGAGTGCCAGCCCAGCCGGATCGAGATGCGCCTGCGCACCGGCTACCTCGACCATGCGG
CGCAGACGCTGGACGAGGCGCTGGAGATCATCGAGCGGTCCTGCCGGGAGAAGCGGCCGGTCTCGGTCGGCCTGGTCGGC
AACGCCTGCGAGGTGCTGCCGCAGATCCTGGAGCGCGGCGTCCTGCCCGATCTGCTGACCGACCAGACCTCGGCCCACGA
CCCGGTGAACGGCTACCTGCCGAAGGGCTGGAGCCTGGAGCGCTGGGCCGCCATGCGCGAGCAGGCGCCGGACCAGGTGG
AGGAGGCGGCCCGCGCCTCGATGGCCGAGCACGTCCAGGCGATGCTGGCGTTCCGCAAGGCGGGCGTGCCGACCGTCGAC
TACGGCAACAACATCCGTCAGGTGGCGAAGGACGCGGGGGTCACCGACGCGTTCGATTTCCCGGGCTTCGTGCCGGCCTA
CATCCGCCCGCTGTTCTGCCGCGGGATCGGGCCGTTCCGCTGGGCCGCGCTCTCGGGCGACCCGGACGACATCTTCAGGA
CCGACGCGAAGGTTAAGGAGCTGATCCCCGACAACCCGCACCTGCACAACTGGCTCGACATGGCCGGCGAGCGGATCAGG
TTCCAGGGCCTGCCGGCGCGGATCTGCTGGGTCGGGCTGGGCGACCGGCACCGGCTGGGCCTGGCGTTCAACGAGATGGT
GGCGAAGGGCGAGCTGAAGGCGCCGGTGGTGATCGGCCGCGACCACCTCGATTCGGGCTCGGTGGCCTCGCCCAACCGCG
AGACCGAGGCCATGCGCGACGGCTCGGACGCGGTGTCGGACTGGCCGCTGCTGAACGCCCTGCTGAACACCGCCTCGGGG
GCGACCTGGGTCAGCCTGCACCATGGCGGCGGGGTCGGCATGGGCTACTCCCAGCACGCTGGCATGGTGATCGTCTGCGA
CGGGACCGAAGCGGCGGCCCGGCGGATCGAGCGCGTGCTGTGGAACGACCCGGCCAGCGGCGTCATGCGCCACGCCGACG
CCGGCTACGACATCGCGCTGTCGGTGGCTCGCGAGAAGGGGCTGGACCTGCCGGGCATCCTGGGCTGA

Upstream 100 bases:

>100_bases
CCCCGCAGACCTGGCCCACCCCCTACGATCCCGACCGCGCCGAATACATGCGCGGCGCGCTCTCCCACGTCCTCAAGGCC
TGCCTGGACTTCACACGCCC

Downstream 100 bases:

>100_bases
CCGCGCTCAGGCGGTCTGCACCAGGTTCATCTTCAGGAACCGGCCCACGACCTCGACCATGAGGCTGGGCTGCAGTGTCG
TGGCGACAGAGAGCTCAGCG

Product: urocanate hydratase

Products: NA

Alternate protein names: Urocanase; Imidazolonepropionate hydrolase

Number of amino acids: Translated: 555; Mature: 554

Protein sequence:

>555_residues
MTRHDPNRVIRPPVGPELTCRSWLTEAPLRMLMNNLHPDVAENPAELVVYGGVGRAARDWESYDRIVETLRRLGDDETLL
VQSGKPVGVFRTHADAPRVLIANSNLVPKWATWEHFNELDRKGLAMYGQMTAGSWIYIGTQGIVQGTYETFVEMGRQHYG
GDLSGRWLLTAGLGGMGGAQPLAAVMAGASCLAIECQPSRIEMRLRTGYLDHAAQTLDEALEIIERSCREKRPVSVGLVG
NACEVLPQILERGVLPDLLTDQTSAHDPVNGYLPKGWSLERWAAMREQAPDQVEEAARASMAEHVQAMLAFRKAGVPTVD
YGNNIRQVAKDAGVTDAFDFPGFVPAYIRPLFCRGIGPFRWAALSGDPDDIFRTDAKVKELIPDNPHLHNWLDMAGERIR
FQGLPARICWVGLGDRHRLGLAFNEMVAKGELKAPVVIGRDHLDSGSVASPNRETEAMRDGSDAVSDWPLLNALLNTASG
ATWVSLHHGGGVGMGYSQHAGMVIVCDGTEAAARRIERVLWNDPASGVMRHADAGYDIALSVAREKGLDLPGILG

Sequences:

>Translated_555_residues
MTRHDPNRVIRPPVGPELTCRSWLTEAPLRMLMNNLHPDVAENPAELVVYGGVGRAARDWESYDRIVETLRRLGDDETLL
VQSGKPVGVFRTHADAPRVLIANSNLVPKWATWEHFNELDRKGLAMYGQMTAGSWIYIGTQGIVQGTYETFVEMGRQHYG
GDLSGRWLLTAGLGGMGGAQPLAAVMAGASCLAIECQPSRIEMRLRTGYLDHAAQTLDEALEIIERSCREKRPVSVGLVG
NACEVLPQILERGVLPDLLTDQTSAHDPVNGYLPKGWSLERWAAMREQAPDQVEEAARASMAEHVQAMLAFRKAGVPTVD
YGNNIRQVAKDAGVTDAFDFPGFVPAYIRPLFCRGIGPFRWAALSGDPDDIFRTDAKVKELIPDNPHLHNWLDMAGERIR
FQGLPARICWVGLGDRHRLGLAFNEMVAKGELKAPVVIGRDHLDSGSVASPNRETEAMRDGSDAVSDWPLLNALLNTASG
ATWVSLHHGGGVGMGYSQHAGMVIVCDGTEAAARRIERVLWNDPASGVMRHADAGYDIALSVAREKGLDLPGILG
>Mature_554_residues
TRHDPNRVIRPPVGPELTCRSWLTEAPLRMLMNNLHPDVAENPAELVVYGGVGRAARDWESYDRIVETLRRLGDDETLLV
QSGKPVGVFRTHADAPRVLIANSNLVPKWATWEHFNELDRKGLAMYGQMTAGSWIYIGTQGIVQGTYETFVEMGRQHYGG
DLSGRWLLTAGLGGMGGAQPLAAVMAGASCLAIECQPSRIEMRLRTGYLDHAAQTLDEALEIIERSCREKRPVSVGLVGN
ACEVLPQILERGVLPDLLTDQTSAHDPVNGYLPKGWSLERWAAMREQAPDQVEEAARASMAEHVQAMLAFRKAGVPTVDY
GNNIRQVAKDAGVTDAFDFPGFVPAYIRPLFCRGIGPFRWAALSGDPDDIFRTDAKVKELIPDNPHLHNWLDMAGERIRF
QGLPARICWVGLGDRHRLGLAFNEMVAKGELKAPVVIGRDHLDSGSVASPNRETEAMRDGSDAVSDWPLLNALLNTASGA
TWVSLHHGGGVGMGYSQHAGMVIVCDGTEAAARRIERVLWNDPASGVMRHADAGYDIALSVAREKGLDLPGILG

Specific function: Unknown

COG id: COG2987

COG function: function code E; Urocanate hydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the urocanase family

Homologues:

Organism=Homo sapiens, GI21389467, Length=578, Percent_Identity=33.3910034602076, Blast_Score=302, Evalue=6e-82,
Organism=Homo sapiens, GI260306182, Length=638, Percent_Identity=30.8777429467085, Blast_Score=274, Evalue=2e-73,
Organism=Caenorhabditis elegans, GI71997891, Length=557, Percent_Identity=34.1113105924596, Blast_Score=310, Evalue=1e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HUTU_PHEZH (B4REE0)

Other databases:

- EMBL:   CP000747
- RefSeq:   YP_002129311.1
- ProteinModelPortal:   B4REE0
- GeneID:   6789959
- GenomeReviews:   CP000747_GR
- KEGG:   pzu:PHZ_c0468
- HOGENOM:   HBG305285
- OMA:   IRQMAFE
- ProtClustDB:   PRK05414
- GO:   GO:0005737
- HAMAP:   MF_00577
- InterPro:   IPR000193
- PIRSF:   PIRSF001423
- TIGRFAMs:   TIGR01228

Pfam domain/function: PF01175 Urocanase; SSF111326 Urocanase

EC number: =4.2.1.49

Molecular weight: Translated: 60623; Mature: 60492

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS01233 UROCANASE

Important sites: ACT_SITE 409-409

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRHDPNRVIRPPVGPELTCRSWLTEAPLRMLMNNLHPDVAENPAELVVYGGVGRAARDW
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCHHHHH
ESYDRIVETLRRLGDDETLLVQSGKPVGVFRTHADAPRVLIANSNLVPKWATWEHFNELD
HHHHHHHHHHHHCCCCCEEEEECCCCCEEEEECCCCCEEEEECCCCCCCCCCHHHHHHHH
RKGLAMYGQMTAGSWIYIGTQGIVQGTYETFVEMGRQHYGGDLSGRWLLTAGLGGMGGAQ
HCCCEEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCHH
PLAAVMAGASCLAIECQPSRIEMRLRTGYLDHAAQTLDEALEIIERSCREKRPVSVGLVG
HHHHHHCCCCEEEEEECCCCEEEEHHHCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECC
NACEVLPQILERGVLPDLLTDQTSAHDPVNGYLPKGWSLERWAAMREQAPDQVEEAARAS
HHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHH
MAEHVQAMLAFRKAGVPTVDYGNNIRQVAKDAGVTDAFDFPGFVPAYIRPLFCRGIGPFR
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCE
WAALSGDPDDIFRTDAKVKELIPDNPHLHNWLDMAGERIRFQGLPARICWVGLGDRHRLG
EEECCCCHHHHHHCCHHHHHHCCCCCCHHHHHHHCCCEEEECCCCEEEEEEECCCCCEEC
LAFNEMVAKGELKAPVVIGRDHLDSGSVASPNRETEAMRDGSDAVSDWPLLNALLNTASG
HHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHCCC
ATWVSLHHGGGVGMGYSQHAGMVIVCDGTEAAARRIERVLWNDPASGVMRHADAGYDIAL
CEEEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCHHHHHHHCCCCCCEEE
SVAREKGLDLPGILG
EEHHHCCCCCCCCCC
>Mature Secondary Structure 
TRHDPNRVIRPPVGPELTCRSWLTEAPLRMLMNNLHPDVAENPAELVVYGGVGRAARDW
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCHHHHH
ESYDRIVETLRRLGDDETLLVQSGKPVGVFRTHADAPRVLIANSNLVPKWATWEHFNELD
HHHHHHHHHHHHCCCCCEEEEECCCCCEEEEECCCCCEEEEECCCCCCCCCCHHHHHHHH
RKGLAMYGQMTAGSWIYIGTQGIVQGTYETFVEMGRQHYGGDLSGRWLLTAGLGGMGGAQ
HCCCEEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCHH
PLAAVMAGASCLAIECQPSRIEMRLRTGYLDHAAQTLDEALEIIERSCREKRPVSVGLVG
HHHHHHCCCCEEEEEECCCCEEEEHHHCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECC
NACEVLPQILERGVLPDLLTDQTSAHDPVNGYLPKGWSLERWAAMREQAPDQVEEAARAS
HHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHH
MAEHVQAMLAFRKAGVPTVDYGNNIRQVAKDAGVTDAFDFPGFVPAYIRPLFCRGIGPFR
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCE
WAALSGDPDDIFRTDAKVKELIPDNPHLHNWLDMAGERIRFQGLPARICWVGLGDRHRLG
EEECCCCHHHHHHCCHHHHHHCCCCCCHHHHHHHCCCEEEECCCCEEEEEEECCCCCEEC
LAFNEMVAKGELKAPVVIGRDHLDSGSVASPNRETEAMRDGSDAVSDWPLLNALLNTASG
HHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHCCC
ATWVSLHHGGGVGMGYSQHAGMVIVCDGTEAAARRIERVLWNDPASGVMRHADAGYDIAL
CEEEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCHHHHHHHCCCCCCEEE
SVAREKGLDLPGILG
EEHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA