Click here to switch to the map view.

The map label for this gene is pyrD [H]

Identifier: 197103908

GI number: 197103908

Start: 446880

End: 447929

Strand: Direct

Name: pyrD [H]

Synonym: PHZ_c0442

Alternate gene names: 197103908

Gene position: 446880-447929 (Clockwise)

Preceding gene: 197103907

Following gene: 197103909

Centisome position: 11.18

GC content: 74.67

Gene sequence:

>1050_bases
ATGAGCGCGCTGCACGGCCTGGCCACGCGGGCGCTGCGGGGGCTGGACCCGGAGGACGCCCACACCCTCGCCATCCGCGC
GCTCCAGGCGGGGCTGGGGCCGGTCGGGGGGGCGGACGATCCGATCCTGGCGACGACGCTGGCCGGCATGGCGCTGCCGA
ACCCGGTGGGCCTGGCGCCCGGCTTCGACAAGAACGCCCAGGTGTTCGGGCCCATGCTGCGGGCGGGCTTCGGCTTCGTG
GAGTGCGGCACGGTCACGCCGAAGCCGCAGGCGGGCAATCCGCGGCCGCGCCTATTCCGCCTGAGCGAGGACCGGGCGGT
GATCAACCGCATGGGGTTCAACAACGAGGGCCTGGAGGCCTTCGCCGCCCGCCTGGCGCGGCGGGGCGCGGGCCAGGGCG
TGGTGGGCGCCAACATCGGCGCCAACAAGGATTCCGAGGACCGCGCCGCCGACTACGTGGCCTGCCTGAAGCGGCTGTGG
GGCCTGGCCTCGTACTTCACGGTGAACATCTCCTCGCCGAACACGCCCGGGCTGCGCGCCCTGCAGACGAAGGCCGCGCT
GGAGGACCTGCTGGGCCGCCTGGCCGAGGCGCGCGATTCCCTGCCGCCGGCGGGGCGGGTCCCGATGTTCCTGAAGGTCG
CGCCCGACCTGGAGGACGCCGAGGTGGAGGCGATCACCGAGGTGGTGGCCGCCCACGGCCTGTCCGGGATCATCGTCTCG
AACACCACCATCGGCCGCCCGGCCCTGCGCTCGCGCTTCCGGGACGAGGCGGGCGGACTGTCCGGCGCGCCGCTGAAGGG
GCTGGCCGCCGAGCGGCTGGAACGGTTCGCCGAGGCGGCGCAGGGGCGGCTGACGCTGATCGGGGCCGGGGGGATCGCCT
CGGGCGCGGACGCCTATGCGCGGATCCGCGCCGGCGCCTCGGCCGTGCAGCTCTATTCGGCGCTGGTGTTCGAGGGGCCC
GGGCTGGCGACCCGGATCAAGCGCGAGCTCGCCCAGCGTCTGCGCGCGGACGGTTTTGCTTCGCTCGGCGACGCGGTGGG
CGCAAAATAG

Upstream 100 bases:

>100_bases
TCTTTCCGCACCTCTACGGGCCGCTCGACGTGGCGCACGTGCGGGCGGTGACGGACGCGCCGCCGGACGCGGACGGCGTT
CCGCAGACGGGGCTTTCGGC

Downstream 100 bases:

>100_bases
CAGAGCTGTCAGGGCCTTGCGTTGCCCTGGCCCTCCGCTCGCATTAACTCGGAAGGATGATGGCGGACGCCCCAGCGCCC
AACGAGCCGCCCGCGCGGGA

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 349; Mature: 348

Protein sequence:

>349_residues
MSALHGLATRALRGLDPEDAHTLAIRALQAGLGPVGGADDPILATTLAGMALPNPVGLAPGFDKNAQVFGPMLRAGFGFV
ECGTVTPKPQAGNPRPRLFRLSEDRAVINRMGFNNEGLEAFAARLARRGAGQGVVGANIGANKDSEDRAADYVACLKRLW
GLASYFTVNISSPNTPGLRALQTKAALEDLLGRLAEARDSLPPAGRVPMFLKVAPDLEDAEVEAITEVVAAHGLSGIIVS
NTTIGRPALRSRFRDEAGGLSGAPLKGLAAERLERFAEAAQGRLTLIGAGGIASGADAYARIRAGASAVQLYSALVFEGP
GLATRIKRELAQRLRADGFASLGDAVGAK

Sequences:

>Translated_349_residues
MSALHGLATRALRGLDPEDAHTLAIRALQAGLGPVGGADDPILATTLAGMALPNPVGLAPGFDKNAQVFGPMLRAGFGFV
ECGTVTPKPQAGNPRPRLFRLSEDRAVINRMGFNNEGLEAFAARLARRGAGQGVVGANIGANKDSEDRAADYVACLKRLW
GLASYFTVNISSPNTPGLRALQTKAALEDLLGRLAEARDSLPPAGRVPMFLKVAPDLEDAEVEAITEVVAAHGLSGIIVS
NTTIGRPALRSRFRDEAGGLSGAPLKGLAAERLERFAEAAQGRLTLIGAGGIASGADAYARIRAGASAVQLYSALVFEGP
GLATRIKRELAQRLRADGFASLGDAVGAK
>Mature_348_residues
SALHGLATRALRGLDPEDAHTLAIRALQAGLGPVGGADDPILATTLAGMALPNPVGLAPGFDKNAQVFGPMLRAGFGFVE
CGTVTPKPQAGNPRPRLFRLSEDRAVINRMGFNNEGLEAFAARLARRGAGQGVVGANIGANKDSEDRAADYVACLKRLWG
LASYFTVNISSPNTPGLRALQTKAALEDLLGRLAEARDSLPPAGRVPMFLKVAPDLEDAEVEAITEVVAAHGLSGIIVSN
TTIGRPALRSRFRDEAGGLSGAPLKGLAAERLERFAEAAQGRLTLIGAGGIASGADAYARIRAGASAVQLYSALVFEGPG
LATRIKRELAQRLRADGFASLGDAVGAK

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=357, Percent_Identity=47.0588235294118, Blast_Score=300, Evalue=1e-81,
Organism=Escherichia coli, GI1787177, Length=326, Percent_Identity=40.4907975460123, Blast_Score=237, Evalue=8e-64,
Organism=Caenorhabditis elegans, GI17509475, Length=346, Percent_Identity=44.7976878612717, Blast_Score=280, Evalue=9e-76,
Organism=Saccharomyces cerevisiae, GI6322633, Length=268, Percent_Identity=26.4925373134328, Blast_Score=73, Evalue=6e-14,
Organism=Drosophila melanogaster, GI281361352, Length=345, Percent_Identity=43.4782608695652, Blast_Score=282, Evalue=2e-76,
Organism=Drosophila melanogaster, GI17137316, Length=345, Percent_Identity=43.4782608695652, Blast_Score=282, Evalue=2e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 36161; Mature: 36030

Theoretical pI: Translated: 9.79; Mature: 9.79

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSALHGLATRALRGLDPEDAHTLAIRALQAGLGPVGGADDPILATTLAGMALPNPVGLAP
CCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCCC
GFDKNAQVFGPMLRAGFGFVECGTVTPKPQAGNPRPRLFRLSEDRAVINRMGFNNEGLEA
CCCCCHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCEEEECCHHHHHHHCCCCCCCHHH
FAARLARRGAGQGVVGANIGANKDSEDRAADYVACLKRLWGLASYFTVNISSPNTPGLRA
HHHHHHHCCCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHCCHHEEEEEECCCCCCCHHH
LQTKAALEDLLGRLAEARDSLPPAGRVPMFLKVAPDLEDAEVEAITEVVAAHGLSGIIVS
HHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCEEEE
NTTIGRPALRSRFRDEAGGLSGAPLKGLAAERLERFAEAAQGRLTLIGAGGIASGADAYA
CCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHH
RIRAGASAVQLYSALVFEGPGLATRIKRELAQRLRADGFASLGDAVGAK
HHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHCCC
>Mature Secondary Structure 
SALHGLATRALRGLDPEDAHTLAIRALQAGLGPVGGADDPILATTLAGMALPNPVGLAP
CHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCCC
GFDKNAQVFGPMLRAGFGFVECGTVTPKPQAGNPRPRLFRLSEDRAVINRMGFNNEGLEA
CCCCCHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCEEEECCHHHHHHHCCCCCCCHHH
FAARLARRGAGQGVVGANIGANKDSEDRAADYVACLKRLWGLASYFTVNISSPNTPGLRA
HHHHHHHCCCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHCCHHEEEEEECCCCCCCHHH
LQTKAALEDLLGRLAEARDSLPPAGRVPMFLKVAPDLEDAEVEAITEVVAAHGLSGIIVS
HHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCEEEE
NTTIGRPALRSRFRDEAGGLSGAPLKGLAAERLERFAEAAQGRLTLIGAGGIASGADAYA
CCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHH
RIRAGASAVQLYSALVFEGPGLATRIKRELAQRLRADGFASLGDAVGAK
HHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA