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The map label for this gene is yrhP [H]

Identifier: 197103881

GI number: 197103881

Start: 422369

End: 422995

Strand: Reverse

Name: yrhP [H]

Synonym: PHZ_c0415

Alternate gene names: 197103881

Gene position: 422995-422369 (Counterclockwise)

Preceding gene: 197103882

Following gene: 197103880

Centisome position: 10.58

GC content: 74.48

Gene sequence:

>627_bases
ATGACGACGCTGGAGGCGCTGGTCGCCTTCGCCCTGGCGGCCGGCCTGCTCACCATCACGCCCGGCCTGGACGTGGCCCT
CGTCCTGCGCACCGCCGCCGCCGAGGGCGCGCGCAAGGCGTGGATGGCCGCCCTGGGCGTCTGTCTCGGCACGCTCTGCT
GGGGGGCGATCGCCGCCCTCGGGCTCGGCGCCCTGCTGGCGGCCTCGGAGCTGGCCTTCGAGATCCTGCGCTGGGCGGGC
GCGGCCTACCTCGTGTGGCTGGGCCTCAGCCTCGTCCTGCGGCCCCGGGCCCGCTTCGACCTGGCGCACGGCGCGGTCGC
CCCGCGCAGCGACGCCGGCTGGTTCTGGCGCGGCGCGCTCAACAACCTGCTGAACCCCAAGGCTGGGGTCTTCTACATCA
GCTTCCTGCCCCAGTTCGTGCCGAAGGACGCCCCCGCTGCGCCGTTCATGTTCGGCCTCGCCTGCCTGCACGTCCTGATG
GGGATCGCCTGGTTCGCCGCGCTGATCGCCGCCACCCGTCCCATCGCCGGGGCGCTGCAGAAGGCCGCCGTCGTCCGCTG
GCTGGACCGGCTGACCGGCGGCGTCTTCCTGGCCTTCGGCCTGCGCCTGGCCCTGGAACGCCGATGA

Upstream 100 bases:

>100_bases
TGGCCCCAGGGCGACGGCGGCGCCTGCCACACGGGCCAGCGCTCGTGCTTCTACCGCACCGTCGAGAACGGCAAGCTGGT
CCGCCGTCCATGACGACCCC

Downstream 100 bases:

>100_bases
GGGAGTCCATGAGGGGGCCGCCGACCAGGTTCACCTACGCCGCCGCCGAGGTCGAGCGGGCGCTGGCCGAGGCCCGCGAG
TTCCCCGCCCTCGACCAGGC

Product: threonine efflux protein

Products: homoserine lactone [Periplasm]; Proton [Cytoplasm]; homoserine [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 208; Mature: 207

Protein sequence:

>208_residues
MTTLEALVAFALAAGLLTITPGLDVALVLRTAAAEGARKAWMAALGVCLGTLCWGAIAALGLGALLAASELAFEILRWAG
AAYLVWLGLSLVLRPRARFDLAHGAVAPRSDAGWFWRGALNNLLNPKAGVFYISFLPQFVPKDAPAAPFMFGLACLHVLM
GIAWFAALIAATRPIAGALQKAAVVRWLDRLTGGVFLAFGLRLALERR

Sequences:

>Translated_208_residues
MTTLEALVAFALAAGLLTITPGLDVALVLRTAAAEGARKAWMAALGVCLGTLCWGAIAALGLGALLAASELAFEILRWAG
AAYLVWLGLSLVLRPRARFDLAHGAVAPRSDAGWFWRGALNNLLNPKAGVFYISFLPQFVPKDAPAAPFMFGLACLHVLM
GIAWFAALIAATRPIAGALQKAAVVRWLDRLTGGVFLAFGLRLALERR
>Mature_207_residues
TTLEALVAFALAAGLLTITPGLDVALVLRTAAAEGARKAWMAALGVCLGTLCWGAIAALGLGALLAASELAFEILRWAGA
AYLVWLGLSLVLRPRARFDLAHGAVAPRSDAGWFWRGALNNLLNPKAGVFYISFLPQFVPKDAPAAPFMFGLACLHVLMG
IAWFAALIAATRPIAGALQKAAVVRWLDRLTGGVFLAFGLRLALERR

Specific function: Conducts The Efflux Of Homoserine And Homoserine Lactone. [C]

COG id: COG1280

COG function: function code E; Putative threonine efflux protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the rht family [H]

Homologues:

Organism=Escherichia coli, GI48994979, Length=206, Percent_Identity=30.0970873786408, Blast_Score=80, Evalue=7e-17,
Organism=Escherichia coli, GI1788099, Length=198, Percent_Identity=27.2727272727273, Blast_Score=71, Evalue=5e-14,
Organism=Escherichia coli, GI48994978, Length=195, Percent_Identity=29.2307692307692, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1786522, Length=215, Percent_Identity=28.8372093023256, Blast_Score=68, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004778
- InterPro:   IPR001123 [H]

Pfam domain/function: PF01810 LysE [H]

EC number: NA

Molecular weight: Translated: 21979; Mature: 21848

Theoretical pI: Translated: 10.82; Mature: 10.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTLEALVAFALAAGLLTITPGLDVALVLRTAAAEGARKAWMAALGVCLGTLCWGAIAAL
CCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLGALLAASELAFEILRWAGAAYLVWLGLSLVLRPRARFDLAHGAVAPRSDAGWFWRGAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCHHHHHHH
NNLLNPKAGVFYISFLPQFVPKDAPAAPFMFGLACLHVLMGIAWFAALIAATRPIAGALQ
HHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
KAAVVRWLDRLTGGVFLAFGLRLALERR
HHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TTLEALVAFALAAGLLTITPGLDVALVLRTAAAEGARKAWMAALGVCLGTLCWGAIAAL
CHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLGALLAASELAFEILRWAGAAYLVWLGLSLVLRPRARFDLAHGAVAPRSDAGWFWRGAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCHHHHHHH
NNLLNPKAGVFYISFLPQFVPKDAPAAPFMFGLACLHVLMGIAWFAALIAATRPIAGALQ
HHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
KAAVVRWLDRLTGGVFLAFGLRLALERR
HHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; homoserine [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + homoserine lactone [Cytoplasm] = Proton [Cytoplasm] + homoserine lactone [Periplasm] Proton [Periplasm] + homoserine [Cytoplasm] = Proton [Cytoplasm] + homoserine [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9384377; 9308178 [H]