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The map label for this gene is hisI [H]

Identifier: 197103882

GI number: 197103882

Start: 423003

End: 423395

Strand: Reverse

Name: hisI [H]

Synonym: PHZ_c0416

Alternate gene names: 197103882

Gene position: 423395-423003 (Counterclockwise)

Preceding gene: 197103883

Following gene: 197103881

Centisome position: 10.59

GC content: 71.5

Gene sequence:

>393_bases
ATGACCGCCTTCCCCACCGCCCCCAGCGCCGACGCCCTCGAGAACGGCAAGGTCCTCGCCCCGCGCTTCGACGACAACGG
CCTGATCGCCGCCGTCGCCACCCACGCCGAGACGGGCGAGGTGCTGATGCTGGCCTGGATGAACGCCGAGGCCCTGCAGC
GGACCCTGGAGACGGGCGAGGCGCACTACTGGAGCCGTTCGCGCCAGGAGCTGTGGCACAAGGGCGCCACCTCGGGCCAG
GTCCAGGTGCTGGAGGAGCTGCGCATCGACTGCGACCAGGACGCGGTCTGGCTGAAGGTCTGGCCCCAGGGCGACGGCGG
CGCCTGCCACACGGGCCAGCGCTCGTGCTTCTACCGCACCGTCGAGAACGGCAAGCTGGTCCGCCGTCCATGA

Upstream 100 bases:

>100_bases
AGAGGATTGAGGAGAGGGCCCGCGCGCAGCGCGGGAGCCGCCGCGCCTTCGCCCGACCCGGCCCGGTGACGCCGCCGCCG
GTTCGCGGCATAACCGCGCC

Downstream 100 bases:

>100_bases
CGACCCCATGACGACGCTGGAGGCGCTGGTCGCCTTCGCCCTGGCGGCCGGCCTGCTCACCATCACGCCCGGCCTGGACG
TGGCCCTCGTCCTGCGCACC

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH [H]

Number of amino acids: Translated: 130; Mature: 129

Protein sequence:

>130_residues
MTAFPTAPSADALENGKVLAPRFDDNGLIAAVATHAETGEVLMLAWMNAEALQRTLETGEAHYWSRSRQELWHKGATSGQ
VQVLEELRIDCDQDAVWLKVWPQGDGGACHTGQRSCFYRTVENGKLVRRP

Sequences:

>Translated_130_residues
MTAFPTAPSADALENGKVLAPRFDDNGLIAAVATHAETGEVLMLAWMNAEALQRTLETGEAHYWSRSRQELWHKGATSGQ
VQVLEELRIDCDQDAVWLKVWPQGDGGACHTGQRSCFYRTVENGKLVRRP
>Mature_129_residues
TAFPTAPSADALENGKVLAPRFDDNGLIAAVATHAETGEVLMLAWMNAEALQRTLETGEAHYWSRSRQELWHKGATSGQV
QVLEELRIDCDQDAVWLKVWPQGDGGACHTGQRSCFYRTVENGKLVRRP

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=92, Percent_Identity=44.5652173913043, Blast_Score=87, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH [H]

EC number: =3.5.4.19 [H]

Molecular weight: Translated: 14409; Mature: 14278

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAFPTAPSADALENGKVLAPRFDDNGLIAAVATHAETGEVLMLAWMNAEALQRTLETGE
CCCCCCCCCCCCCCCCCEEEEEECCCCEEEEEEECCCCCCEEEEEECCHHHHHHHHHCCC
AHYWSRSRQELWHKGATSGQVQVLEELRIDCDQDAVWLKVWPQGDGGACHTGQRSCFYRT
CHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCCCCCEEEEE
VENGKLVRRP
CCCCEEEECC
>Mature Secondary Structure 
TAFPTAPSADALENGKVLAPRFDDNGLIAAVATHAETGEVLMLAWMNAEALQRTLETGE
CCCCCCCCCCCCCCCCEEEEEECCCCEEEEEEECCCCCCEEEEEECCHHHHHHHHHCCC
AHYWSRSRQELWHKGATSGQVQVLEELRIDCDQDAVWLKVWPQGDGGACHTGQRSCFYRT
CHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCCCCCEEEEE
VENGKLVRRP
CCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA