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The map label for this gene is mexA [H]

Identifier: 197103867

GI number: 197103867

Start: 404304

End: 405449

Strand: Direct

Name: mexA [H]

Synonym: PHZ_c0401

Alternate gene names: 197103867

Gene position: 404304-405449 (Clockwise)

Preceding gene: 197103866

Following gene: 197103868

Centisome position: 10.12

GC content: 76.53

Gene sequence:

>1146_bases
ATGAGACAGGCCCCGATGAGAGACGGCATGCGACTGAAGCTCACCCTCGTTCCGGTCCTCGCGGCCCTGGCGCTGGCGGC
CTGCCACAAGCCCCCGCCCCCGCCGCCGTCCGACGACCAGCAGGCCCGCTCGGTCCGCGTCGTGCGCCTCGAGCCCCGAG
CGATCGCCGGGTCGCTGTCGGCCTCGGGCGACCTCGTGCCCCGGGAGGAGGCGGCCGTCGCGCCCGAGGTGACCGGCTTC
CGCGTGCTGCGGGTGATGGCCGATGTCGGCGACTACGTCCGCGCGGGCCAGACGCTGGTCCAGCTCGACCCTGCCCTGCT
GCAGGCCCAGGTGGCCCAGGCCGAGGCCCAGGCGGCCCAGGCCGAGGACCAGGCCCGGCGGGTGGAAGGCCTCGACGGCG
AAGGGGTGCTCTCGCAGGAGCAGATCGCCCAGCGGCGGTTCCAGGCCCAGGCGGCCCGGGCGAACCTGCGCGACCTGCAG
ACCCGCATGCGCAAGCTCTCGGTTGCGGCGCCCGTCTCGGGCCTGGTGCTGGAGCGGACGGTGCGGCCGGGCGACCTGGC
CGCCGGCGCCGGCACGCCATGGTTCCGCATCGCCCGCGACGGCCAGATCGAGCTGTCGGCCGACATGTCCCAGGACGACC
TCGCCCGCATCCGGCCCGGCCAGACGGCCACCGTCACCCTGCCGAACGGGCCCGCCGTGCAGGGCCGCGTGCGCCTGGTC
AGCCCGCAGATCGACCCGCAGACCAAGCTGGGCGAGGTGCGCATCCTGCTGCCGGTGCGCAGCGACATCCGCGCGGGCGG
CTTCGCCCGGGCCGAGTTCGACGACGCCGTGGGCGCGGTTCCCGCCCTGCCCGAGACGGCGATCCGCTACGACGCCGACG
GCGCCAGCGTGATGGTGGTGGGCGCCGACAACCGCGTGCGCCGCGTCCCGGTCCAGACGGGCCAGCGCGGCTCGGGCCTG
GTTGAGATCGTCCGCGGCCCGCCGGCCGGCTCGCGCGTCGTGCAGAACGCCGCCGCCTTCCTGCTCGACGGCGACCGCGT
GCGGCCCGTCGAAGGCGCCGCCGCCCAGCCGGACGGCAAGGCGGCCGGCAAGGCGGCTGCCCCGGCCCAGACCTCGGCCG
CCAACACCCAGGCGACCCGCCGATGA

Upstream 100 bases:

>100_bases
GGTCCAGGCCTACAAGGCCGTGGGCGGCGGCTGGCCTGCCCAAAGCTACGCCCAAACCGGCCCGCAGGCCGGATGAGACT
GGCTGGATGAGACTGGCCGG

Downstream 100 bases:

>100_bases
GCCAGCCGCACGCGCGCACCGACTTCCCGATCTCGGCCTGGGCGATCCGCAACCCGGTCCCCGTGGCCGTGCTGTTCATC
GGCCTGGTGGTCGCCGGCCT

Product: HlyD family secretion protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MRQAPMRDGMRLKLTLVPVLAALALAACHKPPPPPPSDDQQARSVRVVRLEPRAIAGSLSASGDLVPREEAAVAPEVTGF
RVLRVMADVGDYVRAGQTLVQLDPALLQAQVAQAEAQAAQAEDQARRVEGLDGEGVLSQEQIAQRRFQAQAARANLRDLQ
TRMRKLSVAAPVSGLVLERTVRPGDLAAGAGTPWFRIARDGQIELSADMSQDDLARIRPGQTATVTLPNGPAVQGRVRLV
SPQIDPQTKLGEVRILLPVRSDIRAGGFARAEFDDAVGAVPALPETAIRYDADGASVMVVGADNRVRRVPVQTGQRGSGL
VEIVRGPPAGSRVVQNAAAFLLDGDRVRPVEGAAAQPDGKAAGKAAAPAQTSAANTQATRR

Sequences:

>Translated_381_residues
MRQAPMRDGMRLKLTLVPVLAALALAACHKPPPPPPSDDQQARSVRVVRLEPRAIAGSLSASGDLVPREEAAVAPEVTGF
RVLRVMADVGDYVRAGQTLVQLDPALLQAQVAQAEAQAAQAEDQARRVEGLDGEGVLSQEQIAQRRFQAQAARANLRDLQ
TRMRKLSVAAPVSGLVLERTVRPGDLAAGAGTPWFRIARDGQIELSADMSQDDLARIRPGQTATVTLPNGPAVQGRVRLV
SPQIDPQTKLGEVRILLPVRSDIRAGGFARAEFDDAVGAVPALPETAIRYDADGASVMVVGADNRVRRVPVQTGQRGSGL
VEIVRGPPAGSRVVQNAAAFLLDGDRVRPVEGAAAQPDGKAAGKAAAPAQTSAANTQATRR
>Mature_381_residues
MRQAPMRDGMRLKLTLVPVLAALALAACHKPPPPPPSDDQQARSVRVVRLEPRAIAGSLSASGDLVPREEAAVAPEVTGF
RVLRVMADVGDYVRAGQTLVQLDPALLQAQVAQAEAQAAQAEDQARRVEGLDGEGVLSQEQIAQRRFQAQAARANLRDLQ
TRMRKLSVAAPVSGLVLERTVRPGDLAAGAGTPWFRIARDGQIELSADMSQDDLARIRPGQTATVTLPNGPAVQGRVRLV
SPQIDPQTKLGEVRILLPVRSDIRAGGFARAEFDDAVGAVPALPETAIRYDADGASVMVVGADNRVRRVPVQTGQRGSGL
VEIVRGPPAGSRVVQNAAAFLLDGDRVRPVEGAAAQPDGKAAGKAAAPAQTSAANTQATRR

Specific function: The ability to export antibiotics and solvents is dramatically decreased in the presence of the proton conductor carbonyl cyanide m-chlorophenylhydrazone (CCCP), showing that an energized inner membrane is required for efflux. It is thought that the mexB

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Lipid-anchor. Note=The membrane anchor is not necessary for antibiotic efflux as the protein is functional when targeted to the periplasm by a foreign signal peptide [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 40134; Mature: 40134

Theoretical pI: Translated: 10.72; Mature: 10.72

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQAPMRDGMRLKLTLVPVLAALALAACHKPPPPPPSDDQQARSVRVVRLEPRAIAGSLS
CCCCCCCCCCEEEEEHHHHHHHHHHHHHCCCCCCCCCCCHHHHCEEEEEECCHHHCCCCC
ASGDLVPREEAAVAPEVTGFRVLRVMADVGDYVRAGQTLVQLDPALLQAQVAQAEAQAAQ
CCCCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECHHHHHHHHHHHHHHHHH
AEDQARRVEGLDGEGVLSQEQIAQRRFQAQAARANLRDLQTRMRKLSVAAPVSGLVLERT
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCC
VRPGDLAAGAGTPWFRIARDGQIELSADMSQDDLARIRPGQTATVTLPNGPAVQGRVRLV
CCCCCCCCCCCCCCEEEECCCEEEEECCCCHHHHHHCCCCCEEEEECCCCCCCCCEEEEE
SPQIDPQTKLGEVRILLPVRSDIRAGGFARAEFDDAVGAVPALPETAIRYDADGASVMVV
CCCCCCCCCCCCEEEEEEECCCCCCCCEECCCHHHHHCCCCCCCCHHEEECCCCCEEEEE
GADNRVRRVPVQTGQRGSGLVEIVRGPPAGSRVVQNAAAFLLDGDRVRPVEGAAAQPDGK
CCCCCEEECCCCCCCCCCCEEEEEECCCCHHHHHHHHHHEEECCCCCCCCCCCCCCCCCC
AAGKAAAPAQTSAANTQATRR
CCCCCCCCCCCCCCCCHHCCC
>Mature Secondary Structure
MRQAPMRDGMRLKLTLVPVLAALALAACHKPPPPPPSDDQQARSVRVVRLEPRAIAGSLS
CCCCCCCCCCEEEEEHHHHHHHHHHHHHCCCCCCCCCCCHHHHCEEEEEECCHHHCCCCC
ASGDLVPREEAAVAPEVTGFRVLRVMADVGDYVRAGQTLVQLDPALLQAQVAQAEAQAAQ
CCCCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECHHHHHHHHHHHHHHHHH
AEDQARRVEGLDGEGVLSQEQIAQRRFQAQAARANLRDLQTRMRKLSVAAPVSGLVLERT
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCC
VRPGDLAAGAGTPWFRIARDGQIELSADMSQDDLARIRPGQTATVTLPNGPAVQGRVRLV
CCCCCCCCCCCCCCEEEECCCEEEEECCCCHHHHHHCCCCCEEEEECCCCCCCCCEEEEE
SPQIDPQTKLGEVRILLPVRSDIRAGGFARAEFDDAVGAVPALPETAIRYDADGASVMVV
CCCCCCCCCCCCEEEEEEECCCCCCCCEECCCHHHHHCCCCCCCCHHEEECCCCCEEEEE
GADNRVRRVPVQTGQRGSGLVEIVRGPPAGSRVVQNAAAFLLDGDRVRPVEGAAAQPDGK
CCCCCEEECCCCCCCCCCCEEEEEECCCCHHHHHHHHHHEEECCCCCCCCCCCCCCCCCC
AAGKAAAPAQTSAANTQATRR
CCCCCCCCCCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7968531; 10984043; 9989496; 8226684; 8540696; 9603892; 10671490 [H]