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The map label for this gene is cya [H]

Identifier: 197103830

GI number: 197103830

Start: 368614

End: 369612

Strand: Reverse

Name: cya [H]

Synonym: PHZ_c0364

Alternate gene names: 197103830

Gene position: 369612-368614 (Counterclockwise)

Preceding gene: 197103832

Following gene: 197103829

Centisome position: 9.25

GC content: 72.07

Gene sequence:

>999_bases
ATGGCCATCATCACGGGTACGGCCGGGGACGACCGGCTGGAAGGCACGCCCGAGGCGGACACCCTGACGGGCCTGGGCGG
CAACGACGTGCTGCTCGGCGGCGTCGGCGACGATCGCCTCGACGGCGGCGCGGGCGAGGACTGGCTCGCGCCCGGCGACG
GCCTCAACACCCTGGTGGGCGGCGAGGGCTTCGACACCGTCGACTATTCCGACCTGTCCACCAGCATCGGCGCCGACCTC
TACGCCGGCGCCTGGCGCAACGCCGGCGTCTATGTGGACAGCTTCGACAGCATCGAGAACCTCGTCGGCACCGGGTTCAA
CGACACCCTGCTGGGCGACTGGCGCGACAACATCCTCATCGGCAACGCCGGGGACGACGCCCTTGACGGCCGCGAGGGCG
CCGACCGGCTGATGGGCGGCGACGGGGCCGACACCCTCACGGGCGGCGACGGCCAGGACTATGTCCGCGGCGAGGCCGGG
AGCGACAGCCTCTACGGCGGGGCCGGATTCGACGACCTGCACGGCAACCTGGGCGAGGACACCGTCGACGGCGGGCCCGG
CACGGACTGGGTCGTGGGCGGCCAGGGGCACGACTACCTGCTGGGCGGCTCGGACGACTCCTACGACGTGGTCTACGGCA
ATCTCGGCAACGACAGCTGCCACGGCGGCGGCGGGAACGACTGGGTCCGCGGCGGTCAGGGCGACGATGCGCTCTACGGC
GGCGCCGGCGACGACTGGATCTGGGGCGACCGCGGGAACGACACCATCGAAGGCGGCGCGGGCGCGGATACGTTCTTCGT
GTTCGGCGAGGCCGGCATCGACCACATCCGCGACTTCGACTTCGCGGAGGGCGACCGTGTCCGGGTGGAGGCCGGCTACA
CCTACAGCGCCGCCCAGGTGGGCGGGGACGTGGTGGTCAGCATCAGCGGCGGGGCGACCCTGACCCTGCAGGGAGTGCAG
CTTTCCGCCCTTGGGGACGGCTGGATCACGGTCGGCTGA

Upstream 100 bases:

>100_bases
CCCTTCGCTTGAGGCGAGCGGAACCGCTGCGGCCGGTTCCGCTTTCTCCCGGCCATGACGGCTGCGCCTTCGCGCAGCGC
TCGGAGCTGGGAGCGGTTTG

Downstream 100 bases:

>100_bases
TCGGTTCAGCCTTGGGTCGGAGGCGGTGACGGCGATATGTAGTCGCCATGCCGCTCTCCGCCTTCACCAACACCTTCGCC
GGCAACCCGCTCGACCGGGC

Product: hypothetical protein

Products: NA

Alternate protein names: AC-HLY; ACT; Cyclolysin; ATP pyrophosphate-lyase; Adenylyl cyclase [H]

Number of amino acids: Translated: 332; Mature: 331

Protein sequence:

>332_residues
MAIITGTAGDDRLEGTPEADTLTGLGGNDVLLGGVGDDRLDGGAGEDWLAPGDGLNTLVGGEGFDTVDYSDLSTSIGADL
YAGAWRNAGVYVDSFDSIENLVGTGFNDTLLGDWRDNILIGNAGDDALDGREGADRLMGGDGADTLTGGDGQDYVRGEAG
SDSLYGGAGFDDLHGNLGEDTVDGGPGTDWVVGGQGHDYLLGGSDDSYDVVYGNLGNDSCHGGGGNDWVRGGQGDDALYG
GAGDDWIWGDRGNDTIEGGAGADTFFVFGEAGIDHIRDFDFAEGDRVRVEAGYTYSAAQVGGDVVVSISGGATLTLQGVQ
LSALGDGWITVG

Sequences:

>Translated_332_residues
MAIITGTAGDDRLEGTPEADTLTGLGGNDVLLGGVGDDRLDGGAGEDWLAPGDGLNTLVGGEGFDTVDYSDLSTSIGADL
YAGAWRNAGVYVDSFDSIENLVGTGFNDTLLGDWRDNILIGNAGDDALDGREGADRLMGGDGADTLTGGDGQDYVRGEAG
SDSLYGGAGFDDLHGNLGEDTVDGGPGTDWVVGGQGHDYLLGGSDDSYDVVYGNLGNDSCHGGGGNDWVRGGQGDDALYG
GAGDDWIWGDRGNDTIEGGAGADTFFVFGEAGIDHIRDFDFAEGDRVRVEAGYTYSAAQVGGDVVVSISGGATLTLQGVQ
LSALGDGWITVG
>Mature_331_residues
AIITGTAGDDRLEGTPEADTLTGLGGNDVLLGGVGDDRLDGGAGEDWLAPGDGLNTLVGGEGFDTVDYSDLSTSIGADLY
AGAWRNAGVYVDSFDSIENLVGTGFNDTLLGDWRDNILIGNAGDDALDGREGADRLMGGDGADTLTGGDGQDYVRGEAGS
DSLYGGAGFDDLHGNLGEDTVDGGPGTDWVVGGQGHDYLLGGSDDSYDVVYGNLGNDSCHGGGGNDWVRGGQGDDALYGG
AGDDWIWGDRGNDTIEGGAGADTFFVFGEAGIDHIRDFDFAEGDRVRVEAGYTYSAAQVGGDVVVSISGGATLTLQGVQL
SALGDGWITVG

Specific function: This adenylate cyclase belongs to a special class of bacterial toxin. It causes whooping cough by acting on mammalian cells by elevating cAMP-concentration and thus disrupts normal cell function [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 17 hemolysin-type calcium-binding repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005165
- InterPro:   IPR018511
- InterPro:   IPR001343
- InterPro:   IPR018504
- InterPro:   IPR003995
- InterPro:   IPR011049 [H]

Pfam domain/function: PF03497 Anthrax_toxA; PF00353 HemolysinCabind; PF02382 RTX [H]

EC number: =4.6.1.1 [H]

Molecular weight: Translated: 33666; Mature: 33535

Theoretical pI: Translated: 3.49; Mature: 3.49

Prosite motif: PS00330 HEMOLYSIN_CALCIUM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIITGTAGDDRLEGTPEADTLTGLGGNDVLLGGVGDDRLDGGAGEDWLAPGDGLNTLVG
CEEEECCCCCCCCCCCCCCCEEECCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCEEEC
GEGFDTVDYSDLSTSIGADLYAGAWRNAGVYVDSFDSIENLVGTGFNDTLLGDWRDNILI
CCCCCCCCCCHHHHHHCCHHHHCCCCCCCEEEECHHHHHHHHCCCCCCCEECCCCCCEEE
GNAGDDALDGREGADRLMGGDGADTLTGGDGQDYVRGEAGSDSLYGGAGFDDLHGNLGED
ECCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCHHHCCCCCCC
TVDGGPGTDWVVGGQGHDYLLGGSDDSYDVVYGNLGNDSCHGGGGNDWVRGGQGDDALYG
CCCCCCCCCEEECCCCCEEEECCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEC
GAGDDWIWGDRGNDTIEGGAGADTFFVFGEAGIDHIRDFDFAEGDRVRVEAGYTYSAAQV
CCCCCCEECCCCCCCCCCCCCCCEEEEEECCCCHHHHCCCCCCCCEEEEEECCEEEHHHC
GGDVVVSISGGATLTLQGVQLSALGDGWITVG
CCEEEEEECCCCEEEEECEEEEEECCCEEECC
>Mature Secondary Structure 
AIITGTAGDDRLEGTPEADTLTGLGGNDVLLGGVGDDRLDGGAGEDWLAPGDGLNTLVG
EEEECCCCCCCCCCCCCCCEEECCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCEEEC
GEGFDTVDYSDLSTSIGADLYAGAWRNAGVYVDSFDSIENLVGTGFNDTLLGDWRDNILI
CCCCCCCCCCHHHHHHCCHHHHCCCCCCCEEEECHHHHHHHHCCCCCCCEECCCCCCEEE
GNAGDDALDGREGADRLMGGDGADTLTGGDGQDYVRGEAGSDSLYGGAGFDDLHGNLGED
ECCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCHHHCCCCCCC
TVDGGPGTDWVVGGQGHDYLLGGSDDSYDVVYGNLGNDSCHGGGGNDWVRGGQGDDALYG
CCCCCCCCCEEECCCCCEEEECCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEC
GAGDDWIWGDRGNDTIEGGAGADTFFVFGEAGIDHIRDFDFAEGDRVRVEAGYTYSAAQV
CCCCCCEECCCCCCCCCCCCCCCEEEEEECCCCHHHHCCCCCCCCEEEEEECCEEEHHHC
GGDVVVSISGGATLTLQGVQLSALGDGWITVG
CCEEEEEECCCCEEEEECEEEEEECCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7557410; 12910271 [H]