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The map label for this gene is nrdA [H]

Identifier: 197103807

GI number: 197103807

Start: 343299

End: 345158

Strand: Direct

Name: nrdA [H]

Synonym: PHZ_c0341

Alternate gene names: 197103807

Gene position: 343299-345158 (Clockwise)

Preceding gene: 197103806

Following gene: 197103808

Centisome position: 8.59

GC content: 66.34

Gene sequence:

>1860_bases
ATGAGCGAAGCGGCGAAGGTTGGGATTGCCGACAGTGCGGAACGGGTCCAGGCGCAGCCGGCCAAGCCGCAACTCCAGCT
CGTGCGCAAGGTCCAGGTGGACCGCAGCCGCGACGCGAACCTGACCGATTTCGGCAAGACGACCCTCGAGGACCGCTATC
TGCTGCCCGGCGAGTCCTATCAGGACATGTTCGCCCGCGTGGCCACGGCCTTCGCAGACGACGCCGACCACGCCCAGCGC
ATCTACGACTACATCTCGAACCTGTGGTTCATGCCGGCGACGCCGGTGCTGTCGAACGGCGGCGCGAGCCGCGGCCTGCC
GATCTCGTGCTTCCTGAACGCGGTTCCCGACAACCTGGACGGCATCGTCAGCGTCTGGAACGAGAACGTCGCCCTGGCCT
CCAACGGCGGCGGCATCGGCACCTACTGGGGCGGTGTCCGCTCGATCGGCGAGAAGGTGAAGGGCGCCGGCCAGACCAGC
GGGATCATCCCCTTCATCCGGGTCATGGACTCGCTGACCCTCGCCATCAGCCAGGGTTCGCTGCGCCGCGGCTCGGCGGC
CGTCTACCTCGACATCCACCACCCGGAGATCGAGGAGTTCCTCGAGATCCGGAAGCCCTCGGGCGACTTCAACCGCAAGA
GCCTGAACCTCCACCACGGCCTGTCGATCACCGACGAGTTCATGGAGGCGGTCCGCGACGGCGCCATGTTCGGCCTGCGC
TCGCCCAAGACCGGCGAGGTGATCCGCGAGGTGGACGCCCGCTCGCTCTGGCAGAAGATCCTCGAGATCCGCCTGCAGAC
GGGCGAGCCCTACCTGATCTTCTCCGACACCGTGAACCGGGCCATGCCGCAGCACCAGCGCGAGCTCGGCCTGCAGGTCC
GCCAGTCGAACCTGTGCTCGGAGATCATGCTGCACACCGGTCAGGACCACCTGGGCCAGGAGCGGACGGCGGTCTGCTGC
CTCTCGTCGGTCAACGCCGAGAAGTTCCTGGAGTGGCGCGACCACCCGACGTTCATCGAGGACGTCATGCGCTTCCTCGA
CAACGTGCTGGAGGACTTCATCCACCGCGCGCCGCCCGAGATGAAGAACGCCGTCTACGCGGCCAAGCGCGAGCGCTCGG
TGGGCCTTGGCCTGATGGGCTTCCACTCGTTCCTGCAGCAGCAGAACGTGCCGTTCGAGAGCGCCCTGGCCAAGAGCTGG
AACATGCGGCTCTTCAAGACCCTGCGCCGCCAGTGCGACGCGGCCTCCCGCACCCTCGCCGCCGAGCGCGGCCCGTGCCC
GGACGCGGCCGAGCGCGGAGTCATGGAGCGATTCAGCCACAAGCTGGCCATCGCCCCCACCGCCTCGATCTCGATCATCT
GCGGCGGCACCAGCGCCGGCATCGAGCCGATCCCTGCCAACATCTACAGCCACAAGACCCTGTCGGGCACCTTCGCGGTG
AAGAACCCCTACCTGGAGCGCCTGCTCGACGAGAAGGGTCAGAACACCGCGGCGGTGTGGGATTCGATCCTCGCCAACGA
AGGTTCCGTCCAGCACCTCGAGTTCCTGAGCCAGGACGAGAAGGACGTCTTCAAGACGGCGTTCGAAATCGACCAGCGCT
GGATCGTAGAGCTTGCAGCAGACCGCACGCCGGATATTTGCCAGTCCCAGTCCGTGAACCTGTTCCTTCCGGGCGATATT
GATAAGTGGGACCTGCATATGCTTCACTGGACTGCGTGGGAGCGGGGGTGCAAGTCGCTTTACTATCTGCGTTCGAAGTC
CGTGCAGCGGGCGGCGCACGCGGGGGGCGAGGCCGCGCAGGCGGTGGAGATGCAGGTCGAAGGCAAGACCGACTACGAGG
AATGCCTCGCCTGCCAGTGA

Upstream 100 bases:

>100_bases
CCCATATGTGGGTTGTTCGGGCTGGGGGCCCACAACATGTAGGGGCTCGGGACGGCGACCAGGGAGGTCGAGGTTCCGCA
GAGGCATAGGTTCGAGGGAA

Downstream 100 bases:

>100_bases
GTTAACCATCTGATCTTTTGGGGCTTGCCCGCCGCCCCGATCGTGGAACTATGGACCCAGGACCCGCGCTCCAGACGCGG
GCTGGGAGATGCGCATGATG

Product: ribonucleotide-diphosphate reductase subunit alpha

Products: NA

Alternate protein names: Ribonucleotide reductase [H]

Number of amino acids: Translated: 619; Mature: 618

Protein sequence:

>619_residues
MSEAAKVGIADSAERVQAQPAKPQLQLVRKVQVDRSRDANLTDFGKTTLEDRYLLPGESYQDMFARVATAFADDADHAQR
IYDYISNLWFMPATPVLSNGGASRGLPISCFLNAVPDNLDGIVSVWNENVALASNGGGIGTYWGGVRSIGEKVKGAGQTS
GIIPFIRVMDSLTLAISQGSLRRGSAAVYLDIHHPEIEEFLEIRKPSGDFNRKSLNLHHGLSITDEFMEAVRDGAMFGLR
SPKTGEVIREVDARSLWQKILEIRLQTGEPYLIFSDTVNRAMPQHQRELGLQVRQSNLCSEIMLHTGQDHLGQERTAVCC
LSSVNAEKFLEWRDHPTFIEDVMRFLDNVLEDFIHRAPPEMKNAVYAAKRERSVGLGLMGFHSFLQQQNVPFESALAKSW
NMRLFKTLRRQCDAASRTLAAERGPCPDAAERGVMERFSHKLAIAPTASISIICGGTSAGIEPIPANIYSHKTLSGTFAV
KNPYLERLLDEKGQNTAAVWDSILANEGSVQHLEFLSQDEKDVFKTAFEIDQRWIVELAADRTPDICQSQSVNLFLPGDI
DKWDLHMLHWTAWERGCKSLYYLRSKSVQRAAHAGGEAAQAVEMQVEGKTDYEECLACQ

Sequences:

>Translated_619_residues
MSEAAKVGIADSAERVQAQPAKPQLQLVRKVQVDRSRDANLTDFGKTTLEDRYLLPGESYQDMFARVATAFADDADHAQR
IYDYISNLWFMPATPVLSNGGASRGLPISCFLNAVPDNLDGIVSVWNENVALASNGGGIGTYWGGVRSIGEKVKGAGQTS
GIIPFIRVMDSLTLAISQGSLRRGSAAVYLDIHHPEIEEFLEIRKPSGDFNRKSLNLHHGLSITDEFMEAVRDGAMFGLR
SPKTGEVIREVDARSLWQKILEIRLQTGEPYLIFSDTVNRAMPQHQRELGLQVRQSNLCSEIMLHTGQDHLGQERTAVCC
LSSVNAEKFLEWRDHPTFIEDVMRFLDNVLEDFIHRAPPEMKNAVYAAKRERSVGLGLMGFHSFLQQQNVPFESALAKSW
NMRLFKTLRRQCDAASRTLAAERGPCPDAAERGVMERFSHKLAIAPTASISIICGGTSAGIEPIPANIYSHKTLSGTFAV
KNPYLERLLDEKGQNTAAVWDSILANEGSVQHLEFLSQDEKDVFKTAFEIDQRWIVELAADRTPDICQSQSVNLFLPGDI
DKWDLHMLHWTAWERGCKSLYYLRSKSVQRAAHAGGEAAQAVEMQVEGKTDYEECLACQ
>Mature_618_residues
SEAAKVGIADSAERVQAQPAKPQLQLVRKVQVDRSRDANLTDFGKTTLEDRYLLPGESYQDMFARVATAFADDADHAQRI
YDYISNLWFMPATPVLSNGGASRGLPISCFLNAVPDNLDGIVSVWNENVALASNGGGIGTYWGGVRSIGEKVKGAGQTSG
IIPFIRVMDSLTLAISQGSLRRGSAAVYLDIHHPEIEEFLEIRKPSGDFNRKSLNLHHGLSITDEFMEAVRDGAMFGLRS
PKTGEVIREVDARSLWQKILEIRLQTGEPYLIFSDTVNRAMPQHQRELGLQVRQSNLCSEIMLHTGQDHLGQERTAVCCL
SSVNAEKFLEWRDHPTFIEDVMRFLDNVLEDFIHRAPPEMKNAVYAAKRERSVGLGLMGFHSFLQQQNVPFESALAKSWN
MRLFKTLRRQCDAASRTLAAERGPCPDAAERGVMERFSHKLAIAPTASISIICGGTSAGIEPIPANIYSHKTLSGTFAVK
NPYLERLLDEKGQNTAAVWDSILANEGSVQHLEFLSQDEKDVFKTAFEIDQRWIVELAADRTPDICQSQSVNLFLPGDID
KWDLHMLHWTAWERGCKSLYYLRSKSVQRAAHAGGEAAQAVEMQVEGKTDYEECLACQ

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 3 ATP-cone domains [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=618, Percent_Identity=30.5825242718447, Blast_Score=262, Evalue=8e-70,
Organism=Escherichia coli, GI1789030, Length=658, Percent_Identity=25.531914893617, Blast_Score=172, Evalue=6e-44,
Organism=Escherichia coli, GI2367133, Length=440, Percent_Identity=24.7727272727273, Blast_Score=105, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI17555242, Length=654, Percent_Identity=29.8165137614679, Blast_Score=252, Evalue=5e-67,
Organism=Saccharomyces cerevisiae, GI6320914, Length=628, Percent_Identity=30.7324840764331, Blast_Score=257, Evalue=5e-69,
Organism=Saccharomyces cerevisiae, GI6322123, Length=628, Percent_Identity=29.4585987261146, Blast_Score=246, Evalue=1e-65,
Organism=Drosophila melanogaster, GI17352481, Length=641, Percent_Identity=29.1731669266771, Blast_Score=238, Evalue=1e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013346
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 68918; Mature: 68787

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEAAKVGIADSAERVQAQPAKPQLQLVRKVQVDRSRDANLTDFGKTTLEDRYLLPGESY
CCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEECCCCCH
QDMFARVATAFADDADHAQRIYDYISNLWFMPATPVLSNGGASRGLPISCFLNAVPDNLD
HHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHCCCCCCCCCCCEEEEECCCCCHH
GIVSVWNENVALASNGGGIGTYWGGVRSIGEKVKGAGQTSGIIPFIRVMDSLTLAISQGS
HHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHEECCCC
LRRGSAAVYLDIHHPEIEEFLEIRKPSGDFNRKSLNLHHGLSITDEFMEAVRDGAMFGLR
CCCCCEEEEEEECCCCHHHHHHHCCCCCCCCCCEECHHCCCCHHHHHHHHHHCCCCCCCC
SPKTGEVIREVDARSLWQKILEIRLQTGEPYLIFSDTVNRAMPQHQRELGLQVRQSNLCS
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHCHHHHHHHHHHHHHHHHHH
EIMLHTGQDHLGQERTAVCCLSSVNAEKFLEWRDHPTFIEDVMRFLDNVLEDFIHRAPPE
HHHHHCCCHHCCCHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHH
MKNAVYAAKRERSVGLGLMGFHSFLQQQNVPFESALAKSWNMRLFKTLRRQCDAASRTLA
HHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
AERGPCPDAAERGVMERFSHKLAIAPTASISIICGGTSAGIEPIPANIYSHKTLSGTFAV
HCCCCCCCHHHHHHHHHHCCCEEEECCCEEEEEECCCCCCCCCCCCCHHCCCCCCCEEEE
KNPYLERLLDEKGQNTAAVWDSILANEGSVQHLEFLSQDEKDVFKTAFEIDQRWIVELAA
CCHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHC
DRTPDICQSQSVNLFLPGDIDKWDLHMLHWTAWERGCKSLYYLRSKSVQRAAHAGGEAAQ
CCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
AVEMQVEGKTDYEECLACQ
EEEEEECCCCCHHHHHCCC
>Mature Secondary Structure 
SEAAKVGIADSAERVQAQPAKPQLQLVRKVQVDRSRDANLTDFGKTTLEDRYLLPGESY
CCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEECCCCCH
QDMFARVATAFADDADHAQRIYDYISNLWFMPATPVLSNGGASRGLPISCFLNAVPDNLD
HHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHCCCCCCCCCCCEEEEECCCCCHH
GIVSVWNENVALASNGGGIGTYWGGVRSIGEKVKGAGQTSGIIPFIRVMDSLTLAISQGS
HHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHEECCCC
LRRGSAAVYLDIHHPEIEEFLEIRKPSGDFNRKSLNLHHGLSITDEFMEAVRDGAMFGLR
CCCCCEEEEEEECCCCHHHHHHHCCCCCCCCCCEECHHCCCCHHHHHHHHHHCCCCCCCC
SPKTGEVIREVDARSLWQKILEIRLQTGEPYLIFSDTVNRAMPQHQRELGLQVRQSNLCS
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHCHHHHHHHHHHHHHHHHHH
EIMLHTGQDHLGQERTAVCCLSSVNAEKFLEWRDHPTFIEDVMRFLDNVLEDFIHRAPPE
HHHHHCCCHHCCCHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHH
MKNAVYAAKRERSVGLGLMGFHSFLQQQNVPFESALAKSWNMRLFKTLRRQCDAASRTLA
HHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
AERGPCPDAAERGVMERFSHKLAIAPTASISIICGGTSAGIEPIPANIYSHKTLSGTFAV
HCCCCCCCHHHHHHHHHHCCCEEEECCCEEEEEECCCCCCCCCCCCCHHCCCCCCCEEEE
KNPYLERLLDEKGQNTAAVWDSILANEGSVQHLEFLSQDEKDVFKTAFEIDQRWIVELAA
CCHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHC
DRTPDICQSQSVNLFLPGDIDKWDLHMLHWTAWERGCKSLYYLRSKSVQRAAHAGGEAAQ
CCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
AVEMQVEGKTDYEECLACQ
EEEEEECCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]