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The map label for this gene is pcaI [H]

Identifier: 197103785

GI number: 197103785

Start: 312700

End: 313407

Strand: Direct

Name: pcaI [H]

Synonym: PHZ_c0319

Alternate gene names: 197103785

Gene position: 312700-313407 (Clockwise)

Preceding gene: 197103784

Following gene: 197103786

Centisome position: 7.82

GC content: 67.09

Gene sequence:

>708_bases
ATGGCTGACAAGGTTCGCAAGGACGCGGTCGAGGCGCTGGCTGGCCTGCTCTTCGACGGCATGACCATCATGGCGGGGGG
CTTCGGCCTCTGCGGCATCCCGGAAAACCTGATCGCGGCGATCCGCGCGGCGGGGACGAAGGACCTGACCGTCATCTCCA
ACAACTGCGGCGTGGACGACTTCGGCCTCGGCGTGCTGCTGGCCGGCGGCCAGATCCGCAAGATGGTCAGCTCCTACGTC
GGCGAGAACAAGCTGTTCGCCGAGCTGTACCTGTCGGGCAAGCTGGAGTTGGAGTTCAACCCGCAGGGCACCCTGGCCGA
GCGCATCCGCGCGGGCGGGGCCGGCATCCCGGCCTTCTACACGAAGACCGGGGTCGGCACGCTGGTGGCCGAGGGCAAGG
AGGTCCGCGAGTTCGACGGCGAGCTCTACGTGATGGAGCGGGGCCTCACCGCCGACCTCGCCATCGTCAAGGCCTGGAAG
GGCGACCACGAGGGCAACCTCGTGTTCCGCAAGACCGCCCGGAACTTCAATCCGATGATGGCCACCGCCGGCAAGGTGAC
GGTCGCGGAGGTCGAGCACCTGGTCGAGACCGGGACGCTGGACAAGGACCACATCCACACGCCGGGCGTCTACGTCGACC
GGATTCTTCAGGGGACGTTCGAGAAGCGCATCGAACAGCTCACCGTCCGCAAGCGCGAGGAGGCGTAA

Upstream 100 bases:

>100_bases
GCTGCGTCCCAGGCTCCGAGCGGGGCCTTTGTTCATCGATCGATGAATTTTTTGGTCGACCCCGGTTCTCAACCGGACGT
TTGCGTCGTATTGCGGCGTC

Downstream 100 bases:

>100_bases
GGCCATGGCCTGGACCCGTGACCAGATCGCCGCCCGCGCCGCCCAGGAACTGCGCGACGGCTTCTACGTGAACCTCGGCA
TCGGAATCCCGACGCTGACC

Product: 3-oxoadipate CoA-transferase, alpha subunit pcaI

Products: NA

Alternate protein names: Succinyl CoA:3-oxoacid CoA-transferase; OXCT A [H]

Number of amino acids: Translated: 235; Mature: 234

Protein sequence:

>235_residues
MADKVRKDAVEALAGLLFDGMTIMAGGFGLCGIPENLIAAIRAAGTKDLTVISNNCGVDDFGLGVLLAGGQIRKMVSSYV
GENKLFAELYLSGKLELEFNPQGTLAERIRAGGAGIPAFYTKTGVGTLVAEGKEVREFDGELYVMERGLTADLAIVKAWK
GDHEGNLVFRKTARNFNPMMATAGKVTVAEVEHLVETGTLDKDHIHTPGVYVDRILQGTFEKRIEQLTVRKREEA

Sequences:

>Translated_235_residues
MADKVRKDAVEALAGLLFDGMTIMAGGFGLCGIPENLIAAIRAAGTKDLTVISNNCGVDDFGLGVLLAGGQIRKMVSSYV
GENKLFAELYLSGKLELEFNPQGTLAERIRAGGAGIPAFYTKTGVGTLVAEGKEVREFDGELYVMERGLTADLAIVKAWK
GDHEGNLVFRKTARNFNPMMATAGKVTVAEVEHLVETGTLDKDHIHTPGVYVDRILQGTFEKRIEQLTVRKREEA
>Mature_234_residues
ADKVRKDAVEALAGLLFDGMTIMAGGFGLCGIPENLIAAIRAAGTKDLTVISNNCGVDDFGLGVLLAGGQIRKMVSSYVG
ENKLFAELYLSGKLELEFNPQGTLAERIRAGGAGIPAFYTKTGVGTLVAEGKEVREFDGELYVMERGLTADLAIVKAWKG
DHEGNLVFRKTARNFNPMMATAGKVTVAEVEHLVETGTLDKDHIHTPGVYVDRILQGTFEKRIEQLTVRKREEA

Specific function: SHORT-CHAIN FATTY ACIDS METABOLISM. [C]

COG id: COG1788

COG function: function code I; Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-oxoacid CoA-transferase subunit A family [H]

Homologues:

Organism=Homo sapiens, GI4557817, Length=247, Percent_Identity=54.6558704453441, Blast_Score=268, Evalue=2e-72,
Organism=Homo sapiens, GI11545841, Length=250, Percent_Identity=54.8, Blast_Score=258, Evalue=3e-69,
Organism=Escherichia coli, GI1788551, Length=213, Percent_Identity=44.131455399061, Blast_Score=193, Evalue=8e-51,
Organism=Caenorhabditis elegans, GI17531517, Length=247, Percent_Identity=50.6072874493927, Blast_Score=239, Evalue=1e-63,
Organism=Drosophila melanogaster, GI24655794, Length=250, Percent_Identity=50.8, Blast_Score=245, Evalue=2e-65,
Organism=Drosophila melanogaster, GI21358325, Length=250, Percent_Identity=50.8, Blast_Score=245, Evalue=2e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012792
- InterPro:   IPR004165
- InterPro:   IPR004163 [H]

Pfam domain/function: PF01144 CoA_trans [H]

EC number: =2.8.3.5 [H]

Molecular weight: Translated: 25376; Mature: 25244

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: PS01273 COA_TRANSF_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADKVRKDAVEALAGLLFDGMTIMAGGFGLCGIPENLIAAIRAAGTKDLTVISNNCGVDD
CCCHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCC
FGLGVLLAGGQIRKMVSSYVGENKLFAELYLSGKLELEFNPQGTLAERIRAGGAGIPAFY
CCCEEEECCHHHHHHHHHHHCCCCEEEEEEECCEEEEEECCCCHHHHHHHCCCCCCCHHH
TKTGVGTLVAEGKEVREFDGELYVMERGLTADLAIVKAWKGDHEGNLVFRKTARNFNPMM
HHCCCHHHHHCCHHHHHCCCEEEEEECCCCHHHHEEEECCCCCCCCEEEEECCCCCCCHH
ATAGKVTVAEVEHLVETGTLDKDHIHTPGVYVDRILQGTFEKRIEQLTVRKREEA
HCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ADKVRKDAVEALAGLLFDGMTIMAGGFGLCGIPENLIAAIRAAGTKDLTVISNNCGVDD
CCHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCC
FGLGVLLAGGQIRKMVSSYVGENKLFAELYLSGKLELEFNPQGTLAERIRAGGAGIPAFY
CCCEEEECCHHHHHHHHHHHCCCCEEEEEEECCEEEEEECCCCHHHHHHHCCCCCCCHHH
TKTGVGTLVAEGKEVREFDGELYVMERGLTADLAIVKAWKGDHEGNLVFRKTARNFNPMM
HHCCCHHHHHCCHHHHHCCCEEEEEECCCCHHHHEEEECCCCCCCCEEEEECCCCCCCHH
ATAGKVTVAEVEHLVETGTLDKDHIHTPGVYVDRILQGTFEKRIEQLTVRKREEA
HCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9385134; 11589581 [H]