Click here to switch to the map view.

The map label for this gene is moeB [H]

Identifier: 197103743

GI number: 197103743

Start: 272920

End: 273465

Strand: Reverse

Name: moeB [H]

Synonym: PHZ_c0277

Alternate gene names: 197103743

Gene position: 273465-272920 (Counterclockwise)

Preceding gene: 197103744

Following gene: 197103742

Centisome position: 6.84

GC content: 70.33

Gene sequence:

>546_bases
ATGAACGCCTTCACCCCCGGCGGCCGCATCGACGAGACCCGGCCCTTCAAGCCCGTGCGCATCGCCGTGCTGACCATCTC
GGACACCCGCGACGAGGAGAGCGACACCTCGGGCCGCCTGCTCGCCGAGCGGGTGACCGGCGCGGGCCACGAGCTGGCCG
GCAAGGGCATCGTCCGCGACGACGTCGAGGAGATCCGCCGCCAGATCCGCCAGTGGGTGGACGAGGGCGTGGAGGCCATC
GTCACCACCGGCGGCACCGGCATCACCGGCCGGGACGTGACGCCCGAGGCGATCCGGCCGCTGTTCGACAAGGAGATCGA
CGGCTTCTCGGTGATCTTCCACCTGGTCAGCTACCAGTCGGTGGGGCTCTCGACCCTGCAGAGCCGCGCGCTGGCCGGCA
TCGTGAAGGGCTGCTTCGTCTTCTGCCTGCCGGGGTCGAACGGGGCGGTGAAGGACGGCTGGGACAAGGTGATCGCCGCC
CAGCTCGACAGCCGCCACGGCCCCTGCAACATGGTCGAGCTCATGCCGAGGCTGATGGAGGCGTGA

Upstream 100 bases:

>100_bases
CGTTCTGGAAGAAGGAGCACGGCCCCGGCGGCGCCCGCTGGATCGAGCCCACCGCCCAGGACCACGCCGACCGCGCCCGC
TGGGAAAAGGAGACCCCGCC

Downstream 100 bases:

>100_bases
GCAGGCTCACCCATCTCGACGAGACCGGCCGGGCCCGGATGGTCGACGTCTCGGACAAGCCGGTCACCGCCCGCGAGGCT
GTGGCGGAAGGTTTCGTGCG

Product: molybdopterin biosynthesis protein B

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 181; Mature: 181

Protein sequence:

>181_residues
MNAFTPGGRIDETRPFKPVRIAVLTISDTRDEESDTSGRLLAERVTGAGHELAGKGIVRDDVEEIRRQIRQWVDEGVEAI
VTTGGTGITGRDVTPEAIRPLFDKEIDGFSVIFHLVSYQSVGLSTLQSRALAGIVKGCFVFCLPGSNGAVKDGWDKVIAA
QLDSRHGPCNMVELMPRLMEA

Sequences:

>Translated_181_residues
MNAFTPGGRIDETRPFKPVRIAVLTISDTRDEESDTSGRLLAERVTGAGHELAGKGIVRDDVEEIRRQIRQWVDEGVEAI
VTTGGTGITGRDVTPEAIRPLFDKEIDGFSVIFHLVSYQSVGLSTLQSRALAGIVKGCFVFCLPGSNGAVKDGWDKVIAA
QLDSRHGPCNMVELMPRLMEA
>Mature_181_residues
MNAFTPGGRIDETRPFKPVRIAVLTISDTRDEESDTSGRLLAERVTGAGHELAGKGIVRDDVEEIRRQIRQWVDEGVEAI
VTTGGTGITGRDVTPEAIRPLFDKEIDGFSVIFHLVSYQSVGLSTLQSRALAGIVKGCFVFCLPGSNGAVKDGWDKVIAA
QLDSRHGPCNMVELMPRLMEA

Specific function: Maybe involved in the biosynthesis of molybdopterin. Can bind GTP and has low GTPase activity. Can bind MPT, but has no MPT adenylyl transferase activity [H]

COG id: COG0521

COG function: function code H; Molybdopterin biosynthesis enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moaB/mog family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=148, Percent_Identity=33.7837837837838, Blast_Score=74, Evalue=5e-14,
Organism=Homo sapiens, GI10880983, Length=148, Percent_Identity=33.7837837837838, Blast_Score=74, Evalue=5e-14,
Organism=Escherichia coli, GI1787000, Length=157, Percent_Identity=45.2229299363057, Blast_Score=157, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI17564954, Length=146, Percent_Identity=34.9315068493151, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI17136978, Length=153, Percent_Identity=39.2156862745098, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24638841, Length=153, Percent_Identity=39.2156862745098, Blast_Score=91, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR012245
- InterPro:   IPR013484
- InterPro:   IPR008284
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth [H]

EC number: NA

Molecular weight: Translated: 19653; Mature: 19653

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS01078 MOCF_BIOSYNTHESIS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAFTPGGRIDETRPFKPVRIAVLTISDTRDEESDTSGRLLAERVTGAGHELAGKGIVRD
CCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCHHHHHHHHHCCCCHHHCCCCCCHH
DVEEIRRQIRQWVDEGVEAIVTTGGTGITGRDVTPEAIRPLFDKEIDGFSVIFHLVSYQS
HHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHH
VGLSTLQSRALAGIVKGCFVFCLPGSNGAVKDGWDKVIAAQLDSRHGPCNMVELMPRLME
HHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHC
A
C
>Mature Secondary Structure
MNAFTPGGRIDETRPFKPVRIAVLTISDTRDEESDTSGRLLAERVTGAGHELAGKGIVRD
CCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCHHHHHHHHHCCCCHHHCCCCCCHH
DVEEIRRQIRQWVDEGVEAIVTTGGTGITGRDVTPEAIRPLFDKEIDGFSVIFHLVSYQS
HHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHH
VGLSTLQSRALAGIVKGCFVFCLPGSNGAVKDGWDKVIAAQLDSRHGPCNMVELMPRLME
HHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHC
A
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Involved in molybdopterin precursor biosynthesis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]