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The map label for this gene is ald [H]

Identifier: 197103737

GI number: 197103737

Start: 267215

End: 268327

Strand: Direct

Name: ald [H]

Synonym: PHZ_c0271

Alternate gene names: 197103737

Gene position: 267215-268327 (Clockwise)

Preceding gene: 197103736

Following gene: 197103738

Centisome position: 6.69

GC content: 73.41

Gene sequence:

>1113_bases
ATGCGCGTCGGCGTGCCCCGCGAGATCAAGCCGGACGAATATCGGGTCGGGCTGACGCCCACCGCGGTCCGCGAGTACGT
CACCCACGGGCACGAGGTGCTGGTGGAGGCCGGCGCCGGCGCGGGCGCGGGCTACGCCGACGACCTCTACGTTCGCGCCG
GGGCGACGATCCTGCCGGACGCCGAGGCGGTGTTCCGCGAGGCCGGAATGATCGTGAAGGTGAAGGAGCCGCAGCCCCGC
GAGTGGGCGCGGCTCACCGAGGCGCACATCCTCTTCACCTACCTGCACCTGGCGCCCGACCCGGCCCAGGCCGACGGCCT
GCTGGCCTCGGGCTGCGCGGCCATCGCCTACGAGACGGTGACCGACGACGCCGGCGGCCTGCCGCTGCTGGCCCCGATGT
CCGAGGTGGCCGGGCGCATCGCGGTCTTCTCGGCGGGGGAGACGCTGCTGAAGCACAACGGCGGCATGGGCCTGCTGATC
TCGGGCGTGCCGGGCGTGCCGCCGGCGCGGGTCTGCGTCCTGGGCGGCGGGGTCGTGGGCGCGAACGCCGCCCGCATGGC
CGCGGGCCTCGGCGCCGAGGTGGTGATCCTGGAGCGGTCGATCCCGCGCATGCGCTACCTGGACGACATCTTCGCCGGGC
GGGCGATCACCCGCTATTCGACCATCGACGCGGTGGAGGAGGAGATCCTCAGGGCCGACGTGGTGATCGGCGCCGTGCTG
ACCGCCGGGGCCGCCGCGCCCAAGCTGGTCCGGCGCGAGCACCTGTCGCGGATGAAGCCGGGCTCGGTGCTGGTGGACGT
CTCCATCGACCAGGGCGGCTGCTTCGAGACCAGCCGGCCGACCACCCACGCCGACCCCACCTACACGGTGGACGGGGTCG
TCCACTACTGCGTGGCCAACATGCCGGGGGCCGCGCCCCGGACCTCGTCGGAGGCCCTGGTCCACGCGACCCTGCCCTTC
GGCCTGCTGCTCGCCGACCAGGGCCTGGACGCCCTGAAGAAGAACCGCCACCTGGCCAAGGGGCTGAACGTCCTGAAGGG
CCAGATCACCCACCCCGCCGTCGCCGACGCCCTCGGCAAGCCGTTCAAGGACCCCTACGGCGCCTGGAGCTGA

Upstream 100 bases:

>100_bases
CGGTCCCGGGACTGGCGCTCGCCGAACCCCGGTTGACAGCGCACGTCCATCCTCCCAAACCAGCCGCCTGCCGCAACAGC
CTTGCCCGAAGGAGGCCTTC

Downstream 100 bases:

>100_bases
CGGCGCCCCAGGGAAGGGGACCGGCGGGGCTTTCCTCCCGCGCAATAACCCCGCAACAATCGCCCCCACGCTTGCGGGCG
AGGACATAAGGGAGGACGCG

Product: alanine dehydrogenase

Products: NA

Alternate protein names: 40 kDa antigen; TB43 [H]

Number of amino acids: Translated: 370; Mature: 370

Protein sequence:

>370_residues
MRVGVPREIKPDEYRVGLTPTAVREYVTHGHEVLVEAGAGAGAGYADDLYVRAGATILPDAEAVFREAGMIVKVKEPQPR
EWARLTEAHILFTYLHLAPDPAQADGLLASGCAAIAYETVTDDAGGLPLLAPMSEVAGRIAVFSAGETLLKHNGGMGLLI
SGVPGVPPARVCVLGGGVVGANAARMAAGLGAEVVILERSIPRMRYLDDIFAGRAITRYSTIDAVEEEILRADVVIGAVL
TAGAAAPKLVRREHLSRMKPGSVLVDVSIDQGGCFETSRPTTHADPTYTVDGVVHYCVANMPGAAPRTSSEALVHATLPF
GLLLADQGLDALKKNRHLAKGLNVLKGQITHPAVADALGKPFKDPYGAWS

Sequences:

>Translated_370_residues
MRVGVPREIKPDEYRVGLTPTAVREYVTHGHEVLVEAGAGAGAGYADDLYVRAGATILPDAEAVFREAGMIVKVKEPQPR
EWARLTEAHILFTYLHLAPDPAQADGLLASGCAAIAYETVTDDAGGLPLLAPMSEVAGRIAVFSAGETLLKHNGGMGLLI
SGVPGVPPARVCVLGGGVVGANAARMAAGLGAEVVILERSIPRMRYLDDIFAGRAITRYSTIDAVEEEILRADVVIGAVL
TAGAAAPKLVRREHLSRMKPGSVLVDVSIDQGGCFETSRPTTHADPTYTVDGVVHYCVANMPGAAPRTSSEALVHATLPF
GLLLADQGLDALKKNRHLAKGLNVLKGQITHPAVADALGKPFKDPYGAWS
>Mature_370_residues
MRVGVPREIKPDEYRVGLTPTAVREYVTHGHEVLVEAGAGAGAGYADDLYVRAGATILPDAEAVFREAGMIVKVKEPQPR
EWARLTEAHILFTYLHLAPDPAQADGLLASGCAAIAYETVTDDAGGLPLLAPMSEVAGRIAVFSAGETLLKHNGGMGLLI
SGVPGVPPARVCVLGGGVVGANAARMAAGLGAEVVILERSIPRMRYLDDIFAGRAITRYSTIDAVEEEILRADVVIGAVL
TAGAAAPKLVRREHLSRMKPGSVLVDVSIDQGGCFETSRPTTHADPTYTVDGVVHYCVANMPGAAPRTSSEALVHATLPF
GLLLADQGLDALKKNRHLAKGLNVLKGQITHPAVADALGKPFKDPYGAWS

Specific function: May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer [H]

COG id: COG0686

COG function: function code E; Alanine dehydrogenase

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=330, Percent_Identity=27.8787878787879, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI122939153, Length=330, Percent_Identity=27.8787878787879, Blast_Score=113, Evalue=3e-25,
Organism=Escherichia coli, GI1787887, Length=378, Percent_Identity=29.6296296296296, Blast_Score=118, Evalue=8e-28,
Organism=Caenorhabditis elegans, GI17550456, Length=377, Percent_Identity=29.4429708222812, Blast_Score=132, Evalue=4e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886
- InterPro:   IPR008141 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.4.1.1 [H]

Molecular weight: Translated: 38812; Mature: 38812

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVGVPREIKPDEYRVGLTPTAVREYVTHGHEVLVEAGAGAGAGYADDLYVRAGATILPD
CCCCCCCCCCCCCEEECCCHHHHHHHHHCCCEEEEECCCCCCCCCCCCEEEECCCEECCC
AEAVFREAGMIVKVKEPQPREWARLTEAHILFTYLHLAPDPAQADGLLASGCAAIAYETV
HHHHHHHCCCEEEECCCCCHHHHHHHHHHHEEHHHHCCCCCCHHCCHHHCCHHHEEEEEE
TDDAGGLPLLAPMSEVAGRIAVFSAGETLLKHNGGMGLLISGVPGVPPARVCVLGGGVVG
CCCCCCCCCCCCHHHHCCEEEEEECCCHHHHCCCCCEEEEECCCCCCCCEEEEEECCEEC
ANAARMAAGLGAEVVILERSIPRMRYLDDIFAGRAITRYSTIDAVEEEILRADVVIGAVL
CCHHHHHHCCCCEEEEEECCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
TAGAAAPKLVRREHLSRMKPGSVLVDVSIDQGGCFETSRPTTHADPTYTVDGVVHYCVAN
HCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEHHHHHHHHHHC
MPGAAPRTSSEALVHATLPFGLLLADQGLDALKKNRHLAKGLNVLKGQITHPAVADALGK
CCCCCCCCCCCEEEEEECCCEEEEHHCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCC
PFKDPYGAWS
CCCCCCCCCC
>Mature Secondary Structure
MRVGVPREIKPDEYRVGLTPTAVREYVTHGHEVLVEAGAGAGAGYADDLYVRAGATILPD
CCCCCCCCCCCCCEEECCCHHHHHHHHHCCCEEEEECCCCCCCCCCCCEEEECCCEECCC
AEAVFREAGMIVKVKEPQPREWARLTEAHILFTYLHLAPDPAQADGLLASGCAAIAYETV
HHHHHHHCCCEEEECCCCCHHHHHHHHHHHEEHHHHCCCCCCHHCCHHHCCHHHEEEEEE
TDDAGGLPLLAPMSEVAGRIAVFSAGETLLKHNGGMGLLISGVPGVPPARVCVLGGGVVG
CCCCCCCCCCCCHHHHCCEEEEEECCCHHHHCCCCCEEEEECCCCCCCCEEEEEECCEEC
ANAARMAAGLGAEVVILERSIPRMRYLDDIFAGRAITRYSTIDAVEEEILRADVVIGAVL
CCHHHHHHCCCCEEEEEECCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
TAGAAAPKLVRREHLSRMKPGSVLVDVSIDQGGCFETSRPTTHADPTYTVDGVVHYCVAN
HCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEHHHHHHHHHHC
MPGAAPRTSSEALVHATLPFGLLLADQGLDALKKNRHLAKGLNVLKGQITHPAVADALGK
CCCCCCCCCCCEEEEEECCCEEEEHHCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCC
PFKDPYGAWS
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1587598; 9634230; 12218036; 7822223 [H]