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The map label for this gene is divL [H]

Identifier: 197103684

GI number: 197103684

Start: 220380

End: 222695

Strand: Reverse

Name: divL [H]

Synonym: PHZ_c0218

Alternate gene names: 197103684

Gene position: 222695-220380 (Counterclockwise)

Preceding gene: 197103692

Following gene: 197103682

Centisome position: 5.57

GC content: 74.4

Gene sequence:

>2316_bases
ATGAGCGCGGACCAACTGATCCTGGCGGCGGCGGCCGGCGCGGTGTGCCTGGCGCTTTCGGCGGTGCTGTGGGCCCTGGC
CCAGCGCCGGGCCGACCAGGCCCGGCTCGAGGCGCTGGCGGCCCAGATCCGGTCCATGCAGATCCGCGCCGAGGCGGCCC
AGGCCTCGGCCGAGGCCTTCGATTCCGCCCTGCTCGCGGTCGAGGACGGCCAGGCCCTGCTGGCCTCGGGCGAGGAGAGC
CTTGCCGTCTGCGCCGAGGCCCTGGGCCTTGCCGCCGGCGAGCCCCAGGCGGTGCTCAACGCCTTGATGCGCGCCGATCC
CGATCACGCCCGGCGCCTGCGCGCCCTGTTCGAGCGGGGCGAGGCCTGCGCCTTCGAGGTCCAGGGCGAGGCCGGCGTGG
TCACGGTCGAGGGCCGGGCCGCCGGCGCCCTGGCCTGGCTGCGGCTGTCGGGGATGCTGGGCGAGGACGCCGGCCTGCCC
ACCGCCCCGCGCTTCGCCGCCTTCCTGCACACCCGGTCCTGCCCCGCCTGGATCGCGGCCGCCGACGGCTCGCCCGTCTG
GGTCAACGCCGCCTGGCTGCGCGCCGTGGGCGCCGAGACGCTGGACGAGGCCGCCCGCCGGGGCGCGGCCTTCGACCGGG
GCGCCGATTCCGTGGCCAGCGAGGCCGCCAACCTCGGCCAGCGGCGCGAGGCGGTCCGCTGGCTCGCCTTCGACGGCCGC
CGCCGCGCCTTCCACATCGTGGCCCAGCCGCTGGAGGGCGGCGGCGTCGCCGTCTGGACCGACGACGTCACCGAGGTCGA
GGAGCTGCGCGAGCAGCTCAAGCGCAACATCGAGGCCCACGACCAGACGCTGAACCGCATCGACGACGCCGTCGCCATCT
TCGGCGAGGGCAAGCGGCTGATCTTCCACAACACCGCCTTCGCCGAGCTGTGGGGCATCGAGCCCGCCTGGCTCGAGGAG
CGGCCCACCCACGGCGAGGTGCTGGACCGCCTGCGCCAGCGCCGCCGCCTGCCCGAGACCGCCGACTACGCCAAGTGGAA
GGCCGCCGAGCTCGACCGCTACGAGAAGCTGGGCGCCGAGCCCGACGACCTGTGGAGCCTGCCCGACGGGCGCACCCTGC
GCGTGGTGCGCCAGCCGCACCCCATGGGCGGCATGCTGGTCCTCTTCGCCGACATCACCGGCGAGCTGAAGCTGAAGGCC
CAGTACAACGCCCTGATCCAGGTCCAGCAGGCCACCCTCGACAAGCTGTCCGACGCGGTCGCCGTGTTCGGCTCGGACGG
GCGCCTGCGCCTGCACAACGAGAGCTTCGAGCGCTTCTGGGGCATCGGCCACGACCAGCTCGAGGCCGCCGACTTCGAGG
CCGTGGTCCAGCTCTGCGTGCCCAAGCTGCACGACCTCGGCTTCTGGCGCGAGCTGAAGGGCCGGGTCGGCGATCCCGAC
CCCGGCGCCCGCACGCCGATGACCGGCGAGGCGCGCACCTCCGACGACCGCATCGTCGAGTACCGCTCGCGGCCCCTGCC
CGACGGGGCCACCCTGATCGCCTTCACCGACGTGACCGACGCGCGCCGGCTGGAGAGCGCCCTGGCCGACCGCGAGGCCG
CCCTCTCCGAGGCCGAGCGGCTGAAGCGCGACTTCGTCGGAAACGTGTCGTACGAGCTGCGCACCCCGCTCACCACCATC
ATCGGCTACTCCGAGCTGCTGGAGCATTCCGGCGACGCGCTGCCCGAGCGCGCCCGCGCCCACGCCGCGTCGGTCAAGTC
GGCCGCCACCCAGCTCGCCCGCTCGATCGACGACGTGCTCGACATGGCCCAGATCGACGCCGACGAGATGGCCCTCGACC
TCGCCGACGTGAACGTGGCCGAGCTGATGATCGGCGTCGCCGGCCGCTGGCTGAAGCCGGCCGAGGCGGCCCGCGTCTCG
CTGGTCATCGAGCGGCCCGACGACATCGGCCTGATCCGCGGCGACGCCAAGCGGCTGGCCCAGATCCTCGACCACCTGGT
CGAGAACGCCCTCACCCAGACCCCCGCCGGCGGCACGATCACCCTGGCCGCCCGCAAGGCGCTGGGCGAGATCCAGCTCC
AGGTCTCCGACACCGGCCGCGGCATCCCCTTCCACGTCCAGGCGCACATCTTCGACCGGTTCATCGGCCGCGAGCGCGGC
GGCCCGGGCCTGGGCCTGGCCCTCGTCAAGGCGCTCACCGAGCTCCACGGCGGCTGGGTCGCCCTCGAAAGCGAGCCCGG
CGCCGGCGCCCGCTTCACCTGCCACCTCCCCGAAGGCGCCGAAGCCGTCACCGCCCAACGCGAACTGGCGCTCTAG

Upstream 100 bases:

>100_bases
GCGACACCTCCCCGCGCCCCCACATTTCGGGCAGGCCCGCTCGCCACAGCCGGCCCTCCATGCCGTAAGCTCGGGCCGGG
TGATTCGGGCCGGGGAGGCC

Downstream 100 bases:

>100_bases
GGCGCCTGCGCCCCGCCGCCGCCCGCCGCGCCCACGCGCCGCCGCCAGCCCCCCGCCCCGCCCCTCCCGCCGTCATCCCA
CGGTCAGCCAAAGGCTGATC

Product: tyrosine kinase DivL

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 771; Mature: 770

Protein sequence:

>771_residues
MSADQLILAAAAGAVCLALSAVLWALAQRRADQARLEALAAQIRSMQIRAEAAQASAEAFDSALLAVEDGQALLASGEES
LAVCAEALGLAAGEPQAVLNALMRADPDHARRLRALFERGEACAFEVQGEAGVVTVEGRAAGALAWLRLSGMLGEDAGLP
TAPRFAAFLHTRSCPAWIAAADGSPVWVNAAWLRAVGAETLDEAARRGAAFDRGADSVASEAANLGQRREAVRWLAFDGR
RRAFHIVAQPLEGGGVAVWTDDVTEVEELREQLKRNIEAHDQTLNRIDDAVAIFGEGKRLIFHNTAFAELWGIEPAWLEE
RPTHGEVLDRLRQRRRLPETADYAKWKAAELDRYEKLGAEPDDLWSLPDGRTLRVVRQPHPMGGMLVLFADITGELKLKA
QYNALIQVQQATLDKLSDAVAVFGSDGRLRLHNESFERFWGIGHDQLEAADFEAVVQLCVPKLHDLGFWRELKGRVGDPD
PGARTPMTGEARTSDDRIVEYRSRPLPDGATLIAFTDVTDARRLESALADREAALSEAERLKRDFVGNVSYELRTPLTTI
IGYSELLEHSGDALPERARAHAASVKSAATQLARSIDDVLDMAQIDADEMALDLADVNVAELMIGVAGRWLKPAEAARVS
LVIERPDDIGLIRGDAKRLAQILDHLVENALTQTPAGGTITLAARKALGEIQLQVSDTGRGIPFHVQAHIFDRFIGRERG
GPGLGLALVKALTELHGGWVALESEPGAGARFTCHLPEGAEAVTAQRELAL

Sequences:

>Translated_771_residues
MSADQLILAAAAGAVCLALSAVLWALAQRRADQARLEALAAQIRSMQIRAEAAQASAEAFDSALLAVEDGQALLASGEES
LAVCAEALGLAAGEPQAVLNALMRADPDHARRLRALFERGEACAFEVQGEAGVVTVEGRAAGALAWLRLSGMLGEDAGLP
TAPRFAAFLHTRSCPAWIAAADGSPVWVNAAWLRAVGAETLDEAARRGAAFDRGADSVASEAANLGQRREAVRWLAFDGR
RRAFHIVAQPLEGGGVAVWTDDVTEVEELREQLKRNIEAHDQTLNRIDDAVAIFGEGKRLIFHNTAFAELWGIEPAWLEE
RPTHGEVLDRLRQRRRLPETADYAKWKAAELDRYEKLGAEPDDLWSLPDGRTLRVVRQPHPMGGMLVLFADITGELKLKA
QYNALIQVQQATLDKLSDAVAVFGSDGRLRLHNESFERFWGIGHDQLEAADFEAVVQLCVPKLHDLGFWRELKGRVGDPD
PGARTPMTGEARTSDDRIVEYRSRPLPDGATLIAFTDVTDARRLESALADREAALSEAERLKRDFVGNVSYELRTPLTTI
IGYSELLEHSGDALPERARAHAASVKSAATQLARSIDDVLDMAQIDADEMALDLADVNVAELMIGVAGRWLKPAEAARVS
LVIERPDDIGLIRGDAKRLAQILDHLVENALTQTPAGGTITLAARKALGEIQLQVSDTGRGIPFHVQAHIFDRFIGRERG
GPGLGLALVKALTELHGGWVALESEPGAGARFTCHLPEGAEAVTAQRELAL
>Mature_770_residues
SADQLILAAAAGAVCLALSAVLWALAQRRADQARLEALAAQIRSMQIRAEAAQASAEAFDSALLAVEDGQALLASGEESL
AVCAEALGLAAGEPQAVLNALMRADPDHARRLRALFERGEACAFEVQGEAGVVTVEGRAAGALAWLRLSGMLGEDAGLPT
APRFAAFLHTRSCPAWIAAADGSPVWVNAAWLRAVGAETLDEAARRGAAFDRGADSVASEAANLGQRREAVRWLAFDGRR
RAFHIVAQPLEGGGVAVWTDDVTEVEELREQLKRNIEAHDQTLNRIDDAVAIFGEGKRLIFHNTAFAELWGIEPAWLEER
PTHGEVLDRLRQRRRLPETADYAKWKAAELDRYEKLGAEPDDLWSLPDGRTLRVVRQPHPMGGMLVLFADITGELKLKAQ
YNALIQVQQATLDKLSDAVAVFGSDGRLRLHNESFERFWGIGHDQLEAADFEAVVQLCVPKLHDLGFWRELKGRVGDPDP
GARTPMTGEARTSDDRIVEYRSRPLPDGATLIAFTDVTDARRLESALADREAALSEAERLKRDFVGNVSYELRTPLTTII
GYSELLEHSGDALPERARAHAASVKSAATQLARSIDDVLDMAQIDADEMALDLADVNVAELMIGVAGRWLKPAEAARVSL
VIERPDDIGLIRGDAKRLAQILDHLVENALTQTPAGGTITLAARKALGEIQLQVSDTGRGIPFHVQAHIFDRFIGRERGG
PGLGLALVKALTELHGGWVALESEPGAGARFTCHLPEGAEAVTAQRELAL

Specific function: Required for cell division and growth. It catalyzes the phosphorylation of CtrA and activates transcription in vitro of the cell cycle-regulated fliF promoter [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI145693157, Length=293, Percent_Identity=27.6450511945392, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1789149, Length=248, Percent_Identity=31.0483870967742, Blast_Score=113, Evalue=5e-26,
Organism=Escherichia coli, GI1788713, Length=374, Percent_Identity=26.7379679144385, Blast_Score=104, Evalue=2e-23,
Organism=Escherichia coli, GI1788393, Length=257, Percent_Identity=28.0155642023346, Blast_Score=100, Evalue=6e-22,
Organism=Escherichia coli, GI1786912, Length=229, Percent_Identity=30.5676855895196, Blast_Score=97, Evalue=5e-21,
Organism=Escherichia coli, GI1786600, Length=270, Percent_Identity=29.6296296296296, Blast_Score=96, Evalue=8e-21,
Organism=Escherichia coli, GI48994928, Length=260, Percent_Identity=28.8461538461538, Blast_Score=90, Evalue=5e-19,
Organism=Escherichia coli, GI1790436, Length=212, Percent_Identity=28.7735849056604, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1788549, Length=250, Percent_Identity=27.6, Blast_Score=81, Evalue=3e-16,
Organism=Escherichia coli, GI1790300, Length=283, Percent_Identity=28.6219081272085, Blast_Score=80, Evalue=6e-16,
Organism=Escherichia coli, GI1790861, Length=267, Percent_Identity=28.0898876404494, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1786783, Length=223, Percent_Identity=29.5964125560538, Blast_Score=76, Evalue=8e-15,
Organism=Escherichia coli, GI87081816, Length=234, Percent_Identity=29.9145299145299, Blast_Score=76, Evalue=9e-15,
Organism=Escherichia coli, GI1790346, Length=233, Percent_Identity=28.755364806867, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI87082128, Length=231, Percent_Identity=27.7056277056277, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 83416; Mature: 83285

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSADQLILAAAAGAVCLALSAVLWALAQRRADQARLEALAAQIRSMQIRAEAAQASAEAF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DSALLAVEDGQALLASGEESLAVCAEALGLAAGEPQAVLNALMRADPDHARRLRALFERG
HHEEEEEECCCEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCC
EACAFEVQGEAGVVTVEGRAAGALAWLRLSGMLGEDAGLPTAPRFAAFLHTRSCPAWIAA
CEEEEEECCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCEEEE
ADGSPVWVNAAWLRAVGAETLDEAARRGAAFDRGADSVASEAANLGQRREAVRWLAFDGR
CCCCCEEEEHHHHHHHCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
RRAFHIVAQPLEGGGVAVWTDDVTEVEELREQLKRNIEAHDQTLNRIDDAVAIFGEGKRL
CEEEEEEECCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCEE
IFHNTAFAELWGIEPAWLEERPTHGEVLDRLRQRRRLPETADYAKWKAAELDRYEKLGAE
EEECCHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCC
PDDLWSLPDGRTLRVVRQPHPMGGMLVLFADITGELKLKAQYNALIQVQQATLDKLSDAV
CHHHCCCCCCCEEEEEECCCCCCCEEEEEEECCCCEEEEEEHHHHHHHHHHHHHHHHHHH
AVFGSDGRLRLHNESFERFWGIGHDQLEAADFEAVVQLCVPKLHDLGFWRELKGRVGDPD
EEECCCCEEEECCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCCC
PGARTPMTGEARTSDDRIVEYRSRPLPDGATLIAFTDVTDARRLESALADREAALSEAER
CCCCCCCCCCCCCCCCHHHHHCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHH
LKRDFVGNVSYELRTPLTTIIGYSELLEHSGDALPERARAHAASVKSAATQLARSIDDVL
HHHHHHCCCCEEHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
DMAQIDADEMALDLADVNVAELMIGVAGRWLKPAEAARVSLVIERPDDIGLIRGDAKRLA
HHHHCCHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCEEEECCHHHHH
QILDHLVENALTQTPAGGTITLAARKALGEIQLQVSDTGRGIPFHVQAHIFDRFIGRERG
HHHHHHHHHHHHCCCCCCEEEHHHHHCCCEEEEEECCCCCCCCEEEHHHHHHHHHCCCCC
GPGLGLALVKALTELHGGWVALESEPGAGARFTCHLPEGAEAVTAQRELAL
CCCHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEECCCCCHHHHHHHHHCC
>Mature Secondary Structure 
SADQLILAAAAGAVCLALSAVLWALAQRRADQARLEALAAQIRSMQIRAEAAQASAEAF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DSALLAVEDGQALLASGEESLAVCAEALGLAAGEPQAVLNALMRADPDHARRLRALFERG
HHEEEEEECCCEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCC
EACAFEVQGEAGVVTVEGRAAGALAWLRLSGMLGEDAGLPTAPRFAAFLHTRSCPAWIAA
CEEEEEECCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCEEEE
ADGSPVWVNAAWLRAVGAETLDEAARRGAAFDRGADSVASEAANLGQRREAVRWLAFDGR
CCCCCEEEEHHHHHHHCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
RRAFHIVAQPLEGGGVAVWTDDVTEVEELREQLKRNIEAHDQTLNRIDDAVAIFGEGKRL
CEEEEEEECCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCEE
IFHNTAFAELWGIEPAWLEERPTHGEVLDRLRQRRRLPETADYAKWKAAELDRYEKLGAE
EEECCHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCC
PDDLWSLPDGRTLRVVRQPHPMGGMLVLFADITGELKLKAQYNALIQVQQATLDKLSDAV
CHHHCCCCCCCEEEEEECCCCCCCEEEEEEECCCCEEEEEEHHHHHHHHHHHHHHHHHHH
AVFGSDGRLRLHNESFERFWGIGHDQLEAADFEAVVQLCVPKLHDLGFWRELKGRVGDPD
EEECCCCEEEECCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCCC
PGARTPMTGEARTSDDRIVEYRSRPLPDGATLIAFTDVTDARRLESALADREAALSEAER
CCCCCCCCCCCCCCCCHHHHHCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHH
LKRDFVGNVSYELRTPLTTIIGYSELLEHSGDALPERARAHAASVKSAATQLARSIDDVL
HHHHHHCCCCEEHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
DMAQIDADEMALDLADVNVAELMIGVAGRWLKPAEAARVSLVIERPDDIGLIRGDAKRLA
HHHHCCHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCEEEECCHHHHH
QILDHLVENALTQTPAGGTITLAARKALGEIQLQVSDTGRGIPFHVQAHIFDRFIGRERG
HHHHHHHHHHHHCCCCCCEEEHHHHHCCCEEEEEECCCCCCCCEEEHHHHHHHHHCCCCC
GPGLGLALVKALTELHGGWVALESEPGAGARFTCHLPEGAEAVTAQRELAL
CCCHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEECCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10557274; 11259647 [H]