BacMap

Definition	Phenylobacterium zucineum HLK1, complete genome.
Accession	NC_011144
Length	3,996,255

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The map label for this gene is linX [H]

Identifier: 197103544

GI number: 197103544

Start: 74115

End: 74891

Strand: Direct

Name: linX [H]

Synonym: PHZ_c0078

Alternate gene names: 197103544

Gene position: 74115-74891 (Clockwise)

Preceding gene: 197103543

Following gene: 197103546

Centisome position: 1.85

GC content: 68.47

Gene sequence:

>777_bases
ATGGCCCGACGGGTCGCGGGCAAGAAGGCGTTCATCACCGGGGCGGCGCAGGGACTGGGGGCGGCGTTCGCGCGCAAGCT
GGCGTCCGAAGGCGCCAAGGTGAGCCTGGCCGACATCAACGTGGCGGGAGCGGCGGCGGTCGCCGCCGAGATCAACGCCG
CGCAGGGCGAGGGGACGGCGTTCGCCTTCCCGCTCGACGTGACCAAGGAGGAGCAGTGGATCTTCGCCCTCGAGGAGGCC
GACGCGGCCATGGGCGGGATCTCGGTGCTGGTGAACAACGCCGGCATCAGCCGCGGCGGCAATATCGAGGAGCTCAGCTT
CGAGGACTGGAAGCTGGTGATGGGCGTCAACGTCGACTCGGTCTTCCTCGGCACCAAGCACGCGCTGAAGTATCTGCGCC
AGAACCAGCCCGGCTCGATCGTCAACATCAGCTCGATCGCGGGTCTGATCGCGGCCCACAACACCCCCGTCTACAACGCC
TCGAAGGCGGCGGTCTGGCTGCTGTCGAAGGGGATCGCGCTGCACTGCGCCAAGCAGGGGCTGGACGTCCGCTCGAACTC
GATCCACCCGACCTTCATCGACACCCCGATCCTCGATCCGCTGCGCCAGCGGTTCGGCAAGGAGGAGGCCGAGGCCAAGC
TGGCCCGCCAGGTGCCGCTGGGCCGCATCGGCGAGCCGGACGACATCGCCAACGCCGTGCTCTACCTGGCCTCGGACGAG
AGCCGGTTCATGACGGCGGCAGAACTCAAGCTGGACGGCGGCATCTCGGCGATGTGA

Upstream 100 bases:

>100_bases
GTGACCCTAGCCACCCACGACGCCGACGGCGTCACCGAGCTGGACATGACCCTGGCGGGGTTCATGGACGAGATTTCGGG
GAACTAGGAGGAAACAGACG

Downstream 100 bases:

>100_bases
GGCCGCTGCTGGGCGTCAGTTCACCAGCACGGCGCCCAGCAGCACCTTGGCGCCGGCGCGGCCCAGCACCTGGTCCGTCT
GCTGCTGCAGGGCGCGGGCG

Product: short chain dehydrogenase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: 2,5-DDOL dehydrogenase [H]

Number of amino acids: Translated: 258; Mature: 257

Protein sequence:

>258_residues
MARRVAGKKAFITGAAQGLGAAFARKLASEGAKVSLADINVAGAAAVAAEINAAQGEGTAFAFPLDVTKEEQWIFALEEA
DAAMGGISVLVNNAGISRGGNIEELSFEDWKLVMGVNVDSVFLGTKHALKYLRQNQPGSIVNISSIAGLIAAHNTPVYNA
SKAAVWLLSKGIALHCAKQGLDVRSNSIHPTFIDTPILDPLRQRFGKEEAEAKLARQVPLGRIGEPDDIANAVLYLASDE
SRFMTAAELKLDGGISAM

Sequences:

>Translated_258_residues
MARRVAGKKAFITGAAQGLGAAFARKLASEGAKVSLADINVAGAAAVAAEINAAQGEGTAFAFPLDVTKEEQWIFALEEA
DAAMGGISVLVNNAGISRGGNIEELSFEDWKLVMGVNVDSVFLGTKHALKYLRQNQPGSIVNISSIAGLIAAHNTPVYNA
SKAAVWLLSKGIALHCAKQGLDVRSNSIHPTFIDTPILDPLRQRFGKEEAEAKLARQVPLGRIGEPDDIANAVLYLASDE
SRFMTAAELKLDGGISAM
>Mature_257_residues
ARRVAGKKAFITGAAQGLGAAFARKLASEGAKVSLADINVAGAAAVAAEINAAQGEGTAFAFPLDVTKEEQWIFALEEAD
AAMGGISVLVNNAGISRGGNIEELSFEDWKLVMGVNVDSVFLGTKHALKYLRQNQPGSIVNISSIAGLIAAHNTPVYNAS
KAAVWLLSKGIALHCAKQGLDVRSNSIHPTFIDTPILDPLRQRFGKEEAEAKLARQVPLGRIGEPDDIANAVLYLASDES
RFMTAAELKLDGGISAM

Specific function: Catalyzes the degradation of 2,5-dichloro-2,5- cyclohexadiene-1,4-diol (2,5-DDOL) into 2,5-dichlorohydroquinone (2,5-DCHQ). LinX appears not to be involved in gamma-HCH degradation pathway [H]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI15277342, Length=262, Percent_Identity=32.4427480916031, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI40254992, Length=248, Percent_Identity=32.6612903225806, Blast_Score=120, Evalue=9e-28,
Organism=Homo sapiens, GI31542939, Length=245, Percent_Identity=33.8775510204082, Blast_Score=107, Evalue=8e-24,
Organism=Homo sapiens, GI66933014, Length=255, Percent_Identity=34.9019607843137, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI32483357, Length=261, Percent_Identity=31.4176245210728, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI59889578, Length=234, Percent_Identity=33.7606837606838, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI109715829, Length=246, Percent_Identity=29.2682926829268, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI4758504, Length=267, Percent_Identity=32.5842696629214, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI224922801, Length=166, Percent_Identity=37.9518072289157, Blast_Score=88, Evalue=8e-18,
Organism=Homo sapiens, GI5031737, Length=251, Percent_Identity=30.2788844621514, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI83715985, Length=267, Percent_Identity=31.8352059925094, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI7705925, Length=255, Percent_Identity=27.4509803921569, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI19923817, Length=256, Percent_Identity=27.34375, Blast_Score=81, Evalue=7e-16,
Organism=Homo sapiens, GI40254986, Length=178, Percent_Identity=32.5842696629214, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI10190704, Length=247, Percent_Identity=27.5303643724696, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI33667109, Length=216, Percent_Identity=30.0925925925926, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI25282469, Length=255, Percent_Identity=26.2745098039216, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI4504505, Length=193, Percent_Identity=28.4974093264249, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI142976729, Length=236, Percent_Identity=26.6949152542373, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI126723750, Length=261, Percent_Identity=24.904214559387, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI40807363, Length=213, Percent_Identity=28.169014084507, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI210032110, Length=194, Percent_Identity=26.2886597938144, Blast_Score=66, Evalue=4e-11,
Organism=Homo sapiens, GI126723191, Length=193, Percent_Identity=29.5336787564767, Blast_Score=65, Evalue=7e-11,
Organism=Escherichia coli, GI1787335, Length=249, Percent_Identity=34.5381526104418, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1790717, Length=251, Percent_Identity=32.6693227091633, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI87082100, Length=255, Percent_Identity=31.7647058823529, Blast_Score=120, Evalue=8e-29,
Organism=Escherichia coli, GI1789208, Length=250, Percent_Identity=32, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI1789057, Length=252, Percent_Identity=28.5714285714286, Blast_Score=104, Evalue=6e-24,
Organism=Escherichia coli, GI1786812, Length=258, Percent_Identity=32.1705426356589, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI2367175, Length=251, Percent_Identity=31.8725099601594, Blast_Score=100, Evalue=8e-23,
Organism=Escherichia coli, GI1787905, Length=251, Percent_Identity=33.4661354581673, Blast_Score=98, Evalue=5e-22,
Organism=Escherichia coli, GI1788459, Length=247, Percent_Identity=30.3643724696356, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI87082160, Length=252, Percent_Identity=28.5714285714286, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1789378, Length=253, Percent_Identity=29.2490118577075, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI2367365, Length=255, Percent_Identity=27.4509803921569, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI1787820, Length=233, Percent_Identity=27.4678111587983, Blast_Score=61, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI25147288, Length=258, Percent_Identity=35.6589147286822, Blast_Score=135, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17555706, Length=252, Percent_Identity=34.5238095238095, Blast_Score=127, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI115534694, Length=250, Percent_Identity=31.6, Blast_Score=106, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71994604, Length=255, Percent_Identity=33.3333333333333, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17561402, Length=262, Percent_Identity=31.2977099236641, Blast_Score=100, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17560676, Length=252, Percent_Identity=29.3650793650794, Blast_Score=95, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71994600, Length=253, Percent_Identity=32.0158102766798, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17559104, Length=268, Percent_Identity=32.4626865671642, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17508651, Length=254, Percent_Identity=31.1023622047244, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17538182, Length=266, Percent_Identity=28.9473684210526, Blast_Score=90, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI17538480, Length=274, Percent_Identity=30.2919708029197, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17563726, Length=269, Percent_Identity=30.8550185873606, Blast_Score=87, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17560332, Length=269, Percent_Identity=31.9702602230483, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17531453, Length=273, Percent_Identity=30.4029304029304, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17564282, Length=194, Percent_Identity=30.9278350515464, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17538486, Length=281, Percent_Identity=27.7580071174377, Blast_Score=84, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17562906, Length=266, Percent_Identity=29.6992481203008, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17551412, Length=276, Percent_Identity=28.9855072463768, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17562990, Length=275, Percent_Identity=28.7272727272727, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17562908, Length=269, Percent_Identity=29.7397769516729, Blast_Score=80, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI193203117, Length=202, Percent_Identity=28.7128712871287, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI72000259, Length=262, Percent_Identity=28.6259541984733, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI193203115, Length=205, Percent_Identity=28.2926829268293, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17560220, Length=273, Percent_Identity=29.3040293040293, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17560150, Length=272, Percent_Identity=28.6764705882353, Blast_Score=77, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17568967, Length=200, Percent_Identity=31.5, Blast_Score=77, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17562910, Length=266, Percent_Identity=29.3233082706767, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17562904, Length=271, Percent_Identity=28.7822878228782, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17536651, Length=258, Percent_Identity=28.6821705426357, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17565030, Length=270, Percent_Identity=28.1481481481481, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17536025, Length=258, Percent_Identity=29.4573643410853, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17508895, Length=196, Percent_Identity=31.1224489795918, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17558628, Length=144, Percent_Identity=32.6388888888889, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71982365, Length=146, Percent_Identity=30.8219178082192, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI193204405, Length=268, Percent_Identity=26.865671641791, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17567345, Length=197, Percent_Identity=26.3959390862944, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17561272, Length=245, Percent_Identity=28.1632653061224, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=240, Percent_Identity=29.1666666666667, Blast_Score=69, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6323882, Length=252, Percent_Identity=28.5714285714286, Blast_Score=67, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6324126, Length=251, Percent_Identity=27.4900398406374, Blast_Score=63, Evalue=5e-11,
Organism=Drosophila melanogaster, GI23397609, Length=255, Percent_Identity=37.2549019607843, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24639444, Length=254, Percent_Identity=32.6771653543307, Blast_Score=118, Evalue=3e-27,
Organism=Drosophila melanogaster, GI28571526, Length=256, Percent_Identity=37.890625, Blast_Score=116, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24644339, Length=258, Percent_Identity=35.2713178294574, Blast_Score=114, Evalue=5e-26,
Organism=Drosophila melanogaster, GI21357041, Length=256, Percent_Identity=36.328125, Blast_Score=113, Evalue=1e-25,
Organism=Drosophila melanogaster, GI21355319, Length=259, Percent_Identity=31.6602316602317, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24644337, Length=259, Percent_Identity=36.6795366795367, Blast_Score=94, Evalue=7e-20,
Organism=Drosophila melanogaster, GI17737361, Length=264, Percent_Identity=30.6818181818182, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24643142, Length=267, Percent_Identity=31.4606741573034, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24649181, Length=195, Percent_Identity=29.7435897435897, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24640492, Length=203, Percent_Identity=31.5270935960591, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI281364892, Length=200, Percent_Identity=32.5, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI18859837, Length=198, Percent_Identity=32.3232323232323, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI28571387, Length=242, Percent_Identity=28.5123966942149, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21357673, Length=194, Percent_Identity=28.8659793814433, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24648693, Length=247, Percent_Identity=30.3643724696356, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21355889, Length=247, Percent_Identity=30.3643724696356, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21356301, Length=241, Percent_Identity=26.9709543568465, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24641388, Length=207, Percent_Identity=31.4009661835749, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24641232, Length=247, Percent_Identity=28.3400809716599, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI21355631, Length=163, Percent_Identity=25.1533742331288, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24663911, Length=246, Percent_Identity=26.0162601626016, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI116007236, Length=241, Percent_Identity=26.1410788381743, Blast_Score=67, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 27113; Mature: 26982

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARRVAGKKAFITGAAQGLGAAFARKLASEGAKVSLADINVAGAAAVAAEINAAQGEGTA
CCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHCCCCCCCCCE
FAFPLDVTKEEQWIFALEEADAAMGGISVLVNNAGISRGGNIEELSFEDWKLVMGVNVDS
EEEECCCCCCCCEEEEEEHHCHHHCCEEEEEECCCCCCCCCCCCCCCCCEEEEEECCCCE
VFLGTKHALKYLRQNQPGSIVNISSIAGLIAAHNTPVYNASKAAVWLLSKGIALHCAKQG
EECCHHHHHHHHHCCCCCCEEEHHHHHHHHHCCCCCCCCCCHHEEEEHHCCCEEEEHHCC
LDVRSNSIHPTFIDTPILDPLRQRFGKEEAEAKLARQVPLGRIGEPDDIANAVLYLASDE
CCCCCCCCCCEECCCCCHHHHHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHEEEEEECCC
SRFMTAAELKLDGGISAM
CCEEEEEEEEECCCCCCC
>Mature Secondary Structure 
ARRVAGKKAFITGAAQGLGAAFARKLASEGAKVSLADINVAGAAAVAAEINAAQGEGTA
CCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHCCCCCCCCCE
FAFPLDVTKEEQWIFALEEADAAMGGISVLVNNAGISRGGNIEELSFEDWKLVMGVNVDS
EEEECCCCCCCCEEEEEEHHCHHHCCEEEEEECCCCCCCCCCCCCCCCCEEEEEECCCCE
VFLGTKHALKYLRQNQPGSIVNISSIAGLIAAHNTPVYNASKAAVWLLSKGIALHCAKQG
EECCHHHHHHHHHCCCCCCEEEHHHHHHHHHCCCCCCCCCCHHEEEEHHCCCEEEEHHCC
LDVRSNSIHPTFIDTPILDPLRQRFGKEEAEAKLARQVPLGRIGEPDDIANAVLYLASDE
CCCCCCCCCCEECCCCCHHHHHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHEEEEEECCC
SRFMTAAELKLDGGISAM
CCEEEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7515041; 12450824 [H]