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The map label for this gene is metC [H]

Identifier: 197103538

GI number: 197103538

Start: 67426

End: 68625

Strand: Direct

Name: metC [H]

Synonym: PHZ_c0072

Alternate gene names: 197103538

Gene position: 67426-68625 (Clockwise)

Preceding gene: 197103537

Following gene: 197103540

Centisome position: 1.69

GC content: 70.0

Gene sequence:

>1200_bases
GTGACCAGCGACAGCCCCAAGACCTCTCCCACGACCCTTGGCGGGAAGAACCGGCTGGAGTTCGCCACCCGGACCATCCA
CGGCGGCCAGAGCCACGATCCCAGCACCGGCGCGGTGATGCCGCCGATCTACGCGACCTCGACCTACGCCCAGTCCTCGC
CCGGCGTGCACCAGGGCTTCGAGTACTCGCGCAGCCACAACCCGACCCGCTTCGCCTTGGAGCGGGCGCTGGCGGACCTG
GAGAGCGGGACGAACGGCTACGCCTTCGCCTCGGGCCTGGCGGCCATCTCAACCCTGCTGGAGGTGCTGGACGCGGGCGA
CCACGTCATCGCCTCCGAGGACCTCTACGGCGGCTCGTTCCGACTGTTCGACAAGGTGAAGCGCCGCTCGGCGGGCCTCG
AGTTCAGCTTCGTGGACCTGGCCGACGTCGCGGCCATCGAGGCGGCGATCACGCCGAAGACCCGGATGATCTGGGTGGAG
ACGCCCACCAATCCGCTGCTGCGGCTCGCGGACCTGGAGGCCATCGCCGACCTGTGCAAGCGCCGCGGCCTGATCGCGGC
GGCCGACAACACCTTCGCCAGCCCCTACGTCCAGCGGCCGCTGGAGCTGGGCTTCGACGTGGTGATGCACTCGACCACCA
AGTACCTGGGCGGCCACTCCGACGTGGTCGGCGGGGCGCTGGTGGTCGGCGACAACGCCGCCCTGCGCGACCAGCTCACC
TTCCTGCAGAACGCCGTGGGCGCGGTGGCCTCGCCGTTCGACAGCTTCCTGACGCTGCGCGGGGTGAAGACCCTGGCGCT
GCGCATGGAGCGCCATTGCGAGAACGGGATGAAGATCGCCCGCTGGCTGGAGGCGCGCGGCCACATCCGCCAGGTGATCT
ATCCGGGCCTGGAGAGCCATCCGCAGCACGCGCTGGCGAAGAAGCAGATGCACGGCTTCGGCGGCATGATCACCGCCATC
CTCGACCGCGACCTCGACGGCACGCGGCGGATGCTGGAGCGGACCCGCCTCTTCACCCTGGCAGAGAGCCTGGGCGGGGT
GGAGAGCCTGATCGAGCACCCGGCGATCATGACCCACGCCTCGATCCCGCCCGAGACCCGCGCGCGCATCGGCATCTCGG
ACGGCCTGATCCGCCTGTCCGTGGGCGTGGAGTCCGCCGACGACCTGATCGCAGACTTGGAGCAGGCGCTGGCTCCGTAA

Upstream 100 bases:

>100_bases
CGATCTTCGAGCAGGACCAGGTGGCCATCGTCATGGACGGCCGGGACTTCCTGGGCCTCATCACCCGCATCGACCTGATC
AACTACATGAGGCGCTCGGC

Downstream 100 bases:

>100_bases
CGGCGCTCCCCCTTCAGGGGGAGCCCCACTACAGGAACAGCTCCGCCGCCGCGTCGACGATGGCGTCCACGTCGAGGCGG
TAGTGGCGGTAGAGGTCGGG

Product: cystathionine gamma-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 399; Mature: 398

Protein sequence:

>399_residues
MTSDSPKTSPTTLGGKNRLEFATRTIHGGQSHDPSTGAVMPPIYATSTYAQSSPGVHQGFEYSRSHNPTRFALERALADL
ESGTNGYAFASGLAAISTLLEVLDAGDHVIASEDLYGGSFRLFDKVKRRSAGLEFSFVDLADVAAIEAAITPKTRMIWVE
TPTNPLLRLADLEAIADLCKRRGLIAAADNTFASPYVQRPLELGFDVVMHSTTKYLGGHSDVVGGALVVGDNAALRDQLT
FLQNAVGAVASPFDSFLTLRGVKTLALRMERHCENGMKIARWLEARGHIRQVIYPGLESHPQHALAKKQMHGFGGMITAI
LDRDLDGTRRMLERTRLFTLAESLGGVESLIEHPAIMTHASIPPETRARIGISDGLIRLSVGVESADDLIADLEQALAP

Sequences:

>Translated_399_residues
MTSDSPKTSPTTLGGKNRLEFATRTIHGGQSHDPSTGAVMPPIYATSTYAQSSPGVHQGFEYSRSHNPTRFALERALADL
ESGTNGYAFASGLAAISTLLEVLDAGDHVIASEDLYGGSFRLFDKVKRRSAGLEFSFVDLADVAAIEAAITPKTRMIWVE
TPTNPLLRLADLEAIADLCKRRGLIAAADNTFASPYVQRPLELGFDVVMHSTTKYLGGHSDVVGGALVVGDNAALRDQLT
FLQNAVGAVASPFDSFLTLRGVKTLALRMERHCENGMKIARWLEARGHIRQVIYPGLESHPQHALAKKQMHGFGGMITAI
LDRDLDGTRRMLERTRLFTLAESLGGVESLIEHPAIMTHASIPPETRARIGISDGLIRLSVGVESADDLIADLEQALAP
>Mature_398_residues
TSDSPKTSPTTLGGKNRLEFATRTIHGGQSHDPSTGAVMPPIYATSTYAQSSPGVHQGFEYSRSHNPTRFALERALADLE
SGTNGYAFASGLAAISTLLEVLDAGDHVIASEDLYGGSFRLFDKVKRRSAGLEFSFVDLADVAAIEAAITPKTRMIWVET
PTNPLLRLADLEAIADLCKRRGLIAAADNTFASPYVQRPLELGFDVVMHSTTKYLGGHSDVVGGALVVGDNAALRDQLTF
LQNAVGAVASPFDSFLTLRGVKTLALRMERHCENGMKIARWLEARGHIRQVIYPGLESHPQHALAKKQMHGFGGMITAIL
DRDLDGTRRMLERTRLFTLAESLGGVESLIEHPAIMTHASIPPETRARIGISDGLIRLSVGVESADDLIADLEQALAP

Specific function: Methionine biosynthesis; second step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=379, Percent_Identity=52.2427440633245, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI299473759, Length=379, Percent_Identity=47.7572559366755, Blast_Score=321, Evalue=9e-88,
Organism=Homo sapiens, GI25453487, Length=378, Percent_Identity=47.0899470899471, Blast_Score=304, Evalue=1e-82,
Organism=Escherichia coli, GI1790375, Length=377, Percent_Identity=43.5013262599469, Blast_Score=307, Evalue=6e-85,
Organism=Escherichia coli, GI1789383, Length=392, Percent_Identity=30.1020408163265, Blast_Score=160, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17538055, Length=380, Percent_Identity=50.7894736842105, Blast_Score=371, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI17560056, Length=380, Percent_Identity=48.1578947368421, Blast_Score=361, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI71980708, Length=370, Percent_Identity=38.6486486486486, Blast_Score=239, Evalue=3e-63,
Organism=Saccharomyces cerevisiae, GI6319307, Length=388, Percent_Identity=46.1340206185567, Blast_Score=330, Evalue=2e-91,
Organism=Saccharomyces cerevisiae, GI6323333, Length=434, Percent_Identity=31.3364055299539, Blast_Score=188, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6321254, Length=402, Percent_Identity=31.8407960199005, Blast_Score=186, Evalue=6e-48,
Organism=Saccharomyces cerevisiae, GI6321904, Length=398, Percent_Identity=30.9045226130653, Blast_Score=141, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6321170, Length=327, Percent_Identity=29.9694189602446, Blast_Score=137, Evalue=3e-33,
Organism=Drosophila melanogaster, GI19922554, Length=380, Percent_Identity=49.7368421052632, Blast_Score=389, Evalue=1e-108,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 43039; Mature: 42908

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSDSPKTSPTTLGGKNRLEFATRTIHGGQSHDPSTGAVMPPIYATSTYAQSSPGVHQGF
CCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCC
EYSRSHNPTRFALERALADLESGTNGYAFASGLAAISTLLEVLDAGDHVIASEDLYGGSF
CHHCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCHH
RLFDKVKRRSAGLEFSFVDLADVAAIEAAITPKTRMIWVETPTNPLLRLADLEAIADLCK
HHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHH
RRGLIAAADNTFASPYVQRPLELGFDVVMHSTTKYLGGHSDVVGGALVVGDNAALRDQLT
HCCCEEECCCCCCCHHHHCHHHHCHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHH
FLQNAVGAVASPFDSFLTLRGVKTLALRMERHCENGMKIARWLEARGHIRQVIYPGLESH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PQHALAKKQMHGFGGMITAILDRDLDGTRRMLERTRLFTLAESLGGVESLIEHPAIMTHA
HHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCEEEC
SIPPETRARIGISDGLIRLSVGVESADDLIADLEQALAP
CCCCCHHHEECCCCCEEEEEECCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
TSDSPKTSPTTLGGKNRLEFATRTIHGGQSHDPSTGAVMPPIYATSTYAQSSPGVHQGF
CCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCC
EYSRSHNPTRFALERALADLESGTNGYAFASGLAAISTLLEVLDAGDHVIASEDLYGGSF
CHHCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCHH
RLFDKVKRRSAGLEFSFVDLADVAAIEAAITPKTRMIWVETPTNPLLRLADLEAIADLCK
HHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHH
RRGLIAAADNTFASPYVQRPLELGFDVVMHSTTKYLGGHSDVVGGALVVGDNAALRDQLT
HCCCEEECCCCCCCHHHHCHHHHCHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHH
FLQNAVGAVASPFDSFLTLRGVKTLALRMERHCENGMKIARWLEARGHIRQVIYPGLESH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PQHALAKKQMHGFGGMITAILDRDLDGTRRMLERTRLFTLAESLGGVESLIEHPAIMTHA
HHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCEEEC
SIPPETRARIGISDGLIRLSVGVESADDLIADLEQALAP
CCCCCHHHEECCCCCEEEEEECCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12704232 [H]