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The map label for this gene is cbs [H]

Identifier: 197103537

GI number: 197103537

Start: 66047

End: 67429

Strand: Direct

Name: cbs [H]

Synonym: PHZ_c0071

Alternate gene names: 197103537

Gene position: 66047-67429 (Clockwise)

Preceding gene: 197103536

Following gene: 197103538

Centisome position: 1.65

GC content: 69.27

Gene sequence:

>1383_bases
GTGACCGCCCAACCCCTGCCGCCGCCGGCGGACTCCGCGCTCGAGCTGATCGGGCGCACCCCCATGGTCGAGCTGCATGG
CTTCGACACCGGCCCCTGCCGCCTGTTCGTCAAGCTCGAGAACGCCAATCCCGGCGGCTCCATCAAGGACCGCATCGCCC
GCTCGATGATCGAGGCGGCCGAGAAGGACGGCCGGCTGAAGCCCGGCGGCACCATCGTCGAGGCCACCGCCGGCAACACG
GGCCTGGGCCTGGCCCAGGTGGGCCTGCTGAAGGGCTACAAGCTGCTGCTGGTCGTGCCCGACAAGATGGCCCGCGAGAA
GATCCAGCACCTGCGGGCCATGGGCGTCGATGTGCGCATCACCCGCTCCGACGTCGGCAAGGGCCATCCCGAGTACTACC
AGGACATGGCCGCCGCCATCGCGGCGAAGCTGAACAACGCCGTCTACATCAACCAGTTCGAGAACCCGGCGAACCCGCTG
GCCCACGAGACCACCACGGGTCCGGAGATCTTCGAGCAGATGGAGGGCGACGTGGACGCCGTCGTCGTGGGCGTCGGCTC
GGGCGGCACGCTCACCGGCCTCGGCCGCTACTTCGCGAAGGTCTCGCCCAAGACCAGGATGGTGCTGGCCGATCCGGTGG
GCTCGATCCTCGCCCCCCTCGTCAACGAAGGGAAGCACGTCGAGGCCGGCTCGTGGATCGTCGAGGGCATCGGCGAGGAC
TTCGTGCCCGACATCTGCGACCTCGACCTCGTCGAGAAGGCCTATGCGATCACCGACCAGGAAAGCGTGGCCACCGCCCG
CGAGCTGCTGATGAAGGCGGGCATCCTGGCCGGCTCCTCGTCGGGCACCCTGCTGGCCGCGGCGCTGAAGTACTGCCGCG
AGCAGACCGAGCCGAAGCGGGTCGTGACCCTCGTGTGCGACACCGGCTCCCGCTACCTGTCCAAGATGTACAACGACAGC
TGGGTGGCCGAGCAGGGCCTGGCCGACCGCCAGCTGCACGGCGACCTGCGCGACCTGATCGCCCGCTCGGAGGGCGAGGC
GGTCACGGTCGGGCCCGAGGACACCCTGCTCACCGCCTACAACCGCATGCGCCAGGCCGACGTCAGCCAGCTGCCGGTGA
TGGACGACGGCCGCCTGATCGGCCTGATCGACGAGAGCGACCTGCTGGAGGCCGTCGAGCGGCGCCAGGCCGAGGGCCGC
TTCAAGCAGCCGGTGAGCGCGGCCATGACCGCCAAGCTCAACACGCTCCAGGCGAACCAACCGCTGGACGCCCTGCTGCC
GATCTTCGAGCAGGACCAGGTGGCCATCGTCATGGACGGCCGGGACTTCCTGGGCCTCATCACCCGCATCGACCTGATCA
ACTACATGAGGCGCTCGGCGTGA

Upstream 100 bases:

>100_bases
CGCCGCGCTTGGGCTTAATGTCTACCACCGCTAGCTGAACTCGAAGCAATCCGGTTCCGTTTCGTAGAGCCGTGCGCTTC
CGCCACTCCAGAGGCTAGTC

Downstream 100 bases:

>100_bases
CCAGCGACAGCCCCAAGACCTCTCCCACGACCCTTGGCGGGAAGAACCGGCTGGAGTTCGCCACCCGGACCATCCACGGC
GGCCAGAGCCACGATCCCAG

Product: cystathionine beta-synthase

Products: NA

Alternate protein names: Beta-thionase; Serine sulfhydrase [H]

Number of amino acids: Translated: 460; Mature: 459

Protein sequence:

>460_residues
MTAQPLPPPADSALELIGRTPMVELHGFDTGPCRLFVKLENANPGGSIKDRIARSMIEAAEKDGRLKPGGTIVEATAGNT
GLGLAQVGLLKGYKLLLVVPDKMAREKIQHLRAMGVDVRITRSDVGKGHPEYYQDMAAAIAAKLNNAVYINQFENPANPL
AHETTTGPEIFEQMEGDVDAVVVGVGSGGTLTGLGRYFAKVSPKTRMVLADPVGSILAPLVNEGKHVEAGSWIVEGIGED
FVPDICDLDLVEKAYAITDQESVATARELLMKAGILAGSSSGTLLAAALKYCREQTEPKRVVTLVCDTGSRYLSKMYNDS
WVAEQGLADRQLHGDLRDLIARSEGEAVTVGPEDTLLTAYNRMRQADVSQLPVMDDGRLIGLIDESDLLEAVERRQAEGR
FKQPVSAAMTAKLNTLQANQPLDALLPIFEQDQVAIVMDGRDFLGLITRIDLINYMRRSA

Sequences:

>Translated_460_residues
MTAQPLPPPADSALELIGRTPMVELHGFDTGPCRLFVKLENANPGGSIKDRIARSMIEAAEKDGRLKPGGTIVEATAGNT
GLGLAQVGLLKGYKLLLVVPDKMAREKIQHLRAMGVDVRITRSDVGKGHPEYYQDMAAAIAAKLNNAVYINQFENPANPL
AHETTTGPEIFEQMEGDVDAVVVGVGSGGTLTGLGRYFAKVSPKTRMVLADPVGSILAPLVNEGKHVEAGSWIVEGIGED
FVPDICDLDLVEKAYAITDQESVATARELLMKAGILAGSSSGTLLAAALKYCREQTEPKRVVTLVCDTGSRYLSKMYNDS
WVAEQGLADRQLHGDLRDLIARSEGEAVTVGPEDTLLTAYNRMRQADVSQLPVMDDGRLIGLIDESDLLEAVERRQAEGR
FKQPVSAAMTAKLNTLQANQPLDALLPIFEQDQVAIVMDGRDFLGLITRIDLINYMRRSA
>Mature_459_residues
TAQPLPPPADSALELIGRTPMVELHGFDTGPCRLFVKLENANPGGSIKDRIARSMIEAAEKDGRLKPGGTIVEATAGNTG
LGLAQVGLLKGYKLLLVVPDKMAREKIQHLRAMGVDVRITRSDVGKGHPEYYQDMAAAIAAKLNNAVYINQFENPANPLA
HETTTGPEIFEQMEGDVDAVVVGVGSGGTLTGLGRYFAKVSPKTRMVLADPVGSILAPLVNEGKHVEAGSWIVEGIGEDF
VPDICDLDLVEKAYAITDQESVATARELLMKAGILAGSSSGTLLAAALKYCREQTEPKRVVTLVCDTGSRYLSKMYNDSW
VAEQGLADRQLHGDLRDLIARSEGEAVTVGPEDTLLTAYNRMRQADVSQLPVMDDGRLIGLIDESDLLEAVERRQAEGRF
KQPVSAAMTAKLNTLQANQPLDALLPIFEQDQVAIVMDGRDFLGLITRIDLINYMRRSA

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=472, Percent_Identity=33.8983050847458, Blast_Score=255, Evalue=6e-68,
Organism=Homo sapiens, GI295821200, Length=472, Percent_Identity=33.8983050847458, Blast_Score=255, Evalue=6e-68,
Organism=Homo sapiens, GI4557415, Length=472, Percent_Identity=33.8983050847458, Blast_Score=255, Evalue=6e-68,
Organism=Escherichia coli, GI1788754, Length=301, Percent_Identity=41.8604651162791, Blast_Score=196, Evalue=3e-51,
Organism=Escherichia coli, GI2367138, Length=302, Percent_Identity=37.4172185430464, Blast_Score=186, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17562970, Length=307, Percent_Identity=40.3908794788274, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI32566674, Length=300, Percent_Identity=41, Blast_Score=199, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI17535051, Length=305, Percent_Identity=40, Blast_Score=197, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI25147552, Length=332, Percent_Identity=37.9518072289157, Blast_Score=192, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI17534315, Length=332, Percent_Identity=39.4578313253012, Blast_Score=188, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI115535073, Length=333, Percent_Identity=39.6396396396396, Blast_Score=187, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17561720, Length=311, Percent_Identity=37.2990353697749, Blast_Score=166, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI32566672, Length=223, Percent_Identity=36.7713004484305, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI71996324, Length=358, Percent_Identity=28.4916201117318, Blast_Score=105, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17539800, Length=345, Percent_Identity=27.8260869565217, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17539640, Length=357, Percent_Identity=27.7310924369748, Blast_Score=75, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6321594, Length=502, Percent_Identity=33.0677290836653, Blast_Score=251, Evalue=1e-67,
Organism=Saccharomyces cerevisiae, GI6321449, Length=338, Percent_Identity=32.2485207100592, Blast_Score=147, Evalue=4e-36,
Organism=Drosophila melanogaster, GI24643623, Length=462, Percent_Identity=33.1168831168831, Blast_Score=226, Evalue=2e-59,
Organism=Drosophila melanogaster, GI20129101, Length=462, Percent_Identity=33.1168831168831, Blast_Score=226, Evalue=2e-59,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005857
- InterPro:   IPR000644
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00571 CBS; PF00291 PALP [H]

EC number: =4.2.1.22 [H]

Molecular weight: Translated: 49678; Mature: 49546

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAQPLPPPADSALELIGRTPMVELHGFDTGPCRLFVKLENANPGGSIKDRIARSMIEAA
CCCCCCCCCHHHHHHHHCCCCEEEEECCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHH
EKDGRLKPGGTIVEATAGNTGLGLAQVGLLKGYKLLLVVPDKMAREKIQHLRAMGVDVRI
HHCCCCCCCCEEEEECCCCCCCHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHCCCEEEE
TRSDVGKGHPEYYQDMAAAIAAKLNNAVYINQFENPANPLAHETTTGPEIFEQMEGDVDA
ECCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCHHHHHHHCCCEEE
VVVGVGSGGTLTGLGRYFAKVSPKTRMVLADPVGSILAPLVNEGKHVEAGSWIVEGIGED
EEEEECCCCCHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHCCCCEECCCCHHHHHCCCC
FVPDICDLDLVEKAYAITDQESVATARELLMKAGILAGSSSGTLLAAALKYCREQTEPKR
CCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCEECCCCCHHHHHHHHHHHHCCCCCE
VVTLVCDTGSRYLSKMYNDSWVAEQGLADRQLHGDLRDLIARSEGEAVTVGPEDTLLTAY
EEEEEECCCHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHH
NRMRQADVSQLPVMDDGRLIGLIDESDLLEAVERRQAEGRFKQPVSAAMTAKLNTLQANQ
HHHHHCCHHHCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCC
PLDALLPIFEQDQVAIVMDGRDFLGLITRIDLINYMRRSA
CHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TAQPLPPPADSALELIGRTPMVELHGFDTGPCRLFVKLENANPGGSIKDRIARSMIEAA
CCCCCCCCHHHHHHHHCCCCEEEEECCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHH
EKDGRLKPGGTIVEATAGNTGLGLAQVGLLKGYKLLLVVPDKMAREKIQHLRAMGVDVRI
HHCCCCCCCCEEEEECCCCCCCHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHCCCEEEE
TRSDVGKGHPEYYQDMAAAIAAKLNNAVYINQFENPANPLAHETTTGPEIFEQMEGDVDA
ECCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCHHHHHHHCCCEEE
VVVGVGSGGTLTGLGRYFAKVSPKTRMVLADPVGSILAPLVNEGKHVEAGSWIVEGIGED
EEEEECCCCCHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHCCCCEECCCCHHHHHCCCC
FVPDICDLDLVEKAYAITDQESVATARELLMKAGILAGSSSGTLLAAALKYCREQTEPKR
CCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCEECCCCCHHHHHHHHHHHHCCCCCE
VVTLVCDTGSRYLSKMYNDSWVAEQGLADRQLHGDLRDLIARSEGEAVTVGPEDTLLTAY
EEEEEECCCHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHH
NRMRQADVSQLPVMDDGRLIGLIDESDLLEAVERRQAEGRFKQPVSAAMTAKLNTLQANQ
HHHHHCCHHHCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCC
PLDALLPIFEQDQVAIVMDGRDFLGLITRIDLINYMRRSA
CHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]