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The map label for this gene is trxC [H]

Identifier: 197103535

GI number: 197103535

Start: 65202

End: 65645

Strand: Direct

Name: trxC [H]

Synonym: PHZ_c0069

Alternate gene names: 197103535

Gene position: 65202-65645 (Clockwise)

Preceding gene: 197103534

Following gene: 197103536

Centisome position: 1.63

GC content: 72.97

Gene sequence:

>444_bases
ATGCGACAGCTCGTCTGCCACGCGTGCAACGCGGTGAACCGGATGCCGCTCGGCAAGGACCCGCTGGAGGCCAAGTGCGG
CCGCTGCGGGGACCGACTGTTCGCGGGCCGGCCGATCGAGGTGACCGGCGCCGAACTGGCCGTCCACCGGGGATCGACCA
AGGGCGCGGCCCTGTTGCTCGACGTCTGGGCGCCCTGGTGCGGCCCCTGCCGGATGATGGCGCCGCACTTCGAAAAGGCG
GCCGCCCGGCTGGAACCGCAGGTGCGGCTGCTGAAGCTAAATTCCGAGCAGGACCCGCAGGCCGCCGCCGACCTGCAGGT
GTCGGGCATCCCGACGCTGATCCTGTTCCGGGACGGCGGGGTCGTCGCCCGCCAGGCCGGCGCCCTGAGCGCCGACCAGA
TCGTCGCCTGGACCCAGCAGGCGCTCGCCAAGGCGCCCGCCTGA

Upstream 100 bases:

>100_bases
AGTACTTCATCGGCAAGGTGAAGCGCGGCGAGGCCGAGCCCTTCTACGAGAAGCTGGCGCTCGACCTCATGGGCGCCCGC
AAGCTCAAGGCCTGACGCCC

Downstream 100 bases:

>100_bases
GACTGAGAGACAAGGAGCCTTCCGAATGACCCTCGACCGCGCCGTCTTCGTCTTCGCCGGCTGCATGATCCTGCTCAGCG
TGGCCCTGGCCTACTACGTC

Product: thioredoxin

Products: NA

Alternate protein names: Trx-2; Protein-disulfide reductase [H]

Number of amino acids: Translated: 147; Mature: 147

Protein sequence:

>147_residues
MRQLVCHACNAVNRMPLGKDPLEAKCGRCGDRLFAGRPIEVTGAELAVHRGSTKGAALLLDVWAPWCGPCRMMAPHFEKA
AARLEPQVRLLKLNSEQDPQAAADLQVSGIPTLILFRDGGVVARQAGALSADQIVAWTQQALAKAPA

Sequences:

>Translated_147_residues
MRQLVCHACNAVNRMPLGKDPLEAKCGRCGDRLFAGRPIEVTGAELAVHRGSTKGAALLLDVWAPWCGPCRMMAPHFEKA
AARLEPQVRLLKLNSEQDPQAAADLQVSGIPTLILFRDGGVVARQAGALSADQIVAWTQQALAKAPA
>Mature_147_residues
MRQLVCHACNAVNRMPLGKDPLEAKCGRCGDRLFAGRPIEVTGAELAVHRGSTKGAALLLDVWAPWCGPCRMMAPHFEKA
AARLEPQVRLLKLNSEQDPQAAADLQVSGIPTLILFRDGGVVARQAGALSADQIVAWTQQALAKAPA

Specific function: Efficient electron donor for the essential enzyme ribonucleotide reductase. Is also able to reduce the interchain disulfide bridges of insulin [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361657, Length=89, Percent_Identity=40.4494382022472, Blast_Score=68, Evalue=3e-12,
Organism=Escherichia coli, GI1788936, Length=140, Percent_Identity=37.1428571428571, Blast_Score=107, Evalue=3e-25,
Organism=Escherichia coli, GI87082331, Length=87, Percent_Identity=42.5287356321839, Blast_Score=81, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6319925, Length=71, Percent_Identity=38.0281690140845, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17647799, Length=86, Percent_Identity=37.2093023255814, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: =1.8.1.8 [H]

Molecular weight: Translated: 15689; Mature: 15689

Theoretical pI: Translated: 8.63; Mature: 8.63

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
4.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQLVCHACNAVNRMPLGKDPLEAKCGRCGDRLFAGRPIEVTGAELAVHRGSTKGAALLL
CCHHHHHHHHHHHCCCCCCCCHHHHHCCCCCHHHCCCCEEECCCEEEEECCCCCCCEEEE
DVWAPWCGPCRMMAPHFEKAAARLEPQVRLLKLNSEQDPQAAADLQVSGIPTLILFRDGG
EECCCCCCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCHHCEEECCCCEEEEEECCC
VVARQAGALSADQIVAWTQQALAKAPA
EEEECCCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRQLVCHACNAVNRMPLGKDPLEAKCGRCGDRLFAGRPIEVTGAELAVHRGSTKGAALLL
CCHHHHHHHHHHHCCCCCCCCHHHHHCCCCCHHHCCCCEEECCCEEEEECCCCCCCEEEE
DVWAPWCGPCRMMAPHFEKAAARLEPQVRLLKLNSEQDPQAAADLQVSGIPTLILFRDGG
EECCCCCCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCHHCEEECCCCEEEEEECCC
VVARQAGALSADQIVAWTQQALAKAPA
EEEECCCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]