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The map label for this gene is htrA [H]

Identifier: 195979048

GI number: 195979048

Start: 2022054

End: 2023277

Strand: Direct

Name: htrA [H]

Synonym: Sez_1960

Alternate gene names: 195979048

Gene position: 2022054-2023277 (Clockwise)

Preceding gene: 195979046

Following gene: 195979049

Centisome position: 99.9

GC content: 39.46

Gene sequence:

>1224_bases
GTGTTAAAATCAAAAAATATATTGAAGCCCTTATGGGTTTTAGCCATTGGATTTTTAGGGGGCTTATTAGCTGCCTTAGT
TGTTAATGGATTTAGTCAGAATTCTCTAACATCTTCAAATGCAAAGGGAGCAACGACAACAAGCAACGTCAGCTTTAATA
ATACAACTGATACAACAAAGGCTGTTAAGGTGGTTCAAGATGCTGTAGTGTCTGTTATTAACTATCAAAAGGCTGCTTCG
CCTGCCATTTCAAATCCTTACATCAATCTTTTCGGAGAAGAAAATGATACCTCAGCAGTACAAAAAGAGGACGAGCTAAG
CATACACAGTGAAGGCTCGGGTGTTGTCTACAAAAAAGAAGGAAATACTGCTTATCTTGTAACCAACAATCATGTTATTG
AGGGAGCTCAACGAATTGAAATTTTAACAGCAGACGGCTCTAAGATCGTTGGAGAACTAGTTGGTGCAGACACTTATTCT
GACCTAGCTGTTGTCAAAGTTGCTGCTGATAAAATCAAAACAATAGCCAAATTTGCAGATTCAACCAAAATTAATGTTGG
AGAGGTAGCCATTGCAATTGGTAGTCCTCTTGGAACAAAATATGCCAACTCAGTGACAGAAGGGATTGTTTCAAGTCTAA
GCCGTACAGTCACTTCAAGAAATGAGGCAGGCGAGACCATCTCAACAAATGCTATCCAAACTGATGCTGCTATCAATCCA
GGTAATTCAGGTGGACCACTCATCAATATTGAAGGCCAGGTTATTGGTATCAACTCAAGTAAAATATCCTCAACACCTAC
TGGTAGCGGCGGAGCCATTGAGGGAATTGGCTTTGCTATTCCATCAAGCGATGTTGTCACCATTATTAACCAACTAGAGT
CTAACGGAGCTGTTATCAGACCAGCCTTAGGCATTACAATGGTAAACTTAAGTAATCTATCAACCAATGCATTGATTCAA
TTGAATATTCCAACAAGCGTTACCAGCGGTGTTGTCGTAGCCTCTACTCAAGATGGCATGCCTGCTCTTGGTAAATTGGA
GCAGTATGATGTCATTACTGAGGTTGACGGTAAAGAAGTCAGCTCAATTAGTGACCTACAAAGTGTCTTATATAGTCATG
AGATTAACGACACCATTAAGGTAACCTTCTACAGAGGAACTGCTAAGAAGAAAGTTGACATCAAATTAACAAAAACAACT
AAGGATCTAACTAAAAAGCAGTAA

Upstream 100 bases:

>100_bases
AGTTTTCCACAAGTTGTGGATTACTTTTCTTTTTTATGGTTTTAAGGTATAATTAAGTGAGGTTTTATATCCTATGTGAA
AACCATTCGGAGGTGATTTT

Downstream 100 bases:

>100_bases
ACATTGGGTATCCCCGTGAGATTGAGTCCGAGACGATAGTCGCGGGCTCTTGCTCTTTTATCCCATATGTATCTCTAATA
ACCGTTAAGCTACCACTATT

Product: serine protease do-like HtrA

Products: NA

Alternate protein names: HtrALl [H]

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MLKSKNILKPLWVLAIGFLGGLLAALVVNGFSQNSLTSSNAKGATTTSNVSFNNTTDTTKAVKVVQDAVVSVINYQKAAS
PAISNPYINLFGEENDTSAVQKEDELSIHSEGSGVVYKKEGNTAYLVTNNHVIEGAQRIEILTADGSKIVGELVGADTYS
DLAVVKVAADKIKTIAKFADSTKINVGEVAIAIGSPLGTKYANSVTEGIVSSLSRTVTSRNEAGETISTNAIQTDAAINP
GNSGGPLINIEGQVIGINSSKISSTPTGSGGAIEGIGFAIPSSDVVTIINQLESNGAVIRPALGITMVNLSNLSTNALIQ
LNIPTSVTSGVVVASTQDGMPALGKLEQYDVITEVDGKEVSSISDLQSVLYSHEINDTIKVTFYRGTAKKKVDIKLTKTT
KDLTKKQ

Sequences:

>Translated_407_residues
MLKSKNILKPLWVLAIGFLGGLLAALVVNGFSQNSLTSSNAKGATTTSNVSFNNTTDTTKAVKVVQDAVVSVINYQKAAS
PAISNPYINLFGEENDTSAVQKEDELSIHSEGSGVVYKKEGNTAYLVTNNHVIEGAQRIEILTADGSKIVGELVGADTYS
DLAVVKVAADKIKTIAKFADSTKINVGEVAIAIGSPLGTKYANSVTEGIVSSLSRTVTSRNEAGETISTNAIQTDAAINP
GNSGGPLINIEGQVIGINSSKISSTPTGSGGAIEGIGFAIPSSDVVTIINQLESNGAVIRPALGITMVNLSNLSTNALIQ
LNIPTSVTSGVVVASTQDGMPALGKLEQYDVITEVDGKEVSSISDLQSVLYSHEINDTIKVTFYRGTAKKKVDIKLTKTT
KDLTKKQ
>Mature_407_residues
MLKSKNILKPLWVLAIGFLGGLLAALVVNGFSQNSLTSSNAKGATTTSNVSFNNTTDTTKAVKVVQDAVVSVINYQKAAS
PAISNPYINLFGEENDTSAVQKEDELSIHSEGSGVVYKKEGNTAYLVTNNHVIEGAQRIEILTADGSKIVGELVGADTYS
DLAVVKVAADKIKTIAKFADSTKINVGEVAIAIGSPLGTKYANSVTEGIVSSLSRTVTSRNEAGETISTNAIQTDAAINP
GNSGGPLINIEGQVIGINSSKISSTPTGSGGAIEGIGFAIPSSDVVTIINQLESNGAVIRPALGITMVNLSNLSTNALIQ
LNIPTSVTSGVVVASTQDGMPALGKLEQYDVITEVDGKEVSSISDLQSVLYSHEINDTIKVTFYRGTAKKKVDIKLTKTT
KDLTKKQ

Specific function: Degrades abnormal exported proteins. Needed for the propeptide processing of a natural pro-protein and for the maturation of a native protein. Responsible for the housekeeping of exported proteins [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI24308541, Length=284, Percent_Identity=30.6338028169014, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI4506141, Length=285, Percent_Identity=29.4736842105263, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI22129776, Length=266, Percent_Identity=30.8270676691729, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI7019477, Length=266, Percent_Identity=31.9548872180451, Blast_Score=95, Evalue=1e-19,
Organism=Escherichia coli, GI1786356, Length=356, Percent_Identity=31.7415730337079, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1789629, Length=334, Percent_Identity=34.1317365269461, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1789630, Length=303, Percent_Identity=34.3234323432343, Blast_Score=118, Evalue=6e-28,
Organism=Drosophila melanogaster, GI24646839, Length=302, Percent_Identity=30.1324503311258, Blast_Score=120, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 42434; Mature: 42434

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
0.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKSKNILKPLWVLAIGFLGGLLAALVVNGFSQNSLTSSNAKGATTTSNVSFNNTTDTTK
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCEEECCCCCHHH
AVKVVQDAVVSVINYQKAASPAISNPYINLFGEENDTSAVQKEDELSIHSEGSGVVYKKE
HHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHCCCCCCEEECCCCEEEEEEC
GNTAYLVTNNHVIEGAQRIEILTADGSKIVGELVGADTYSDLAVVKVAADKIKTIAKFAD
CCEEEEEECCEEECCCEEEEEEECCCHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHC
STKINVGEVAIAIGSPLGTKYANSVTEGIVSSLSRTVTSRNEAGETISTNAIQTDAAINP
CCCEEECEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCEEECCCCCC
GNSGGPLINIEGQVIGINSSKISSTPTGSGGAIEGIGFAIPSSDVVTIINQLESNGAVIR
CCCCCCEEEECCEEEEECCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHCCCCCEEE
PALGITMVNLSNLSTNALIQLNIPTSVTSGVVVASTQDGMPALGKLEQYDVITEVDGKEV
EECCEEEEEECCCCCCEEEEEECCCCCCCCEEEEECCCCCCHHCCCHHCCEEEECCCCHH
SSISDLQSVLYSHEINDTIKVTFYRGTAKKKVDIKLTKTTKDLTKKQ
HHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEEEEEECCHHHHHCCC
>Mature Secondary Structure
MLKSKNILKPLWVLAIGFLGGLLAALVVNGFSQNSLTSSNAKGATTTSNVSFNNTTDTTK
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCEEECCCCCHHH
AVKVVQDAVVSVINYQKAASPAISNPYINLFGEENDTSAVQKEDELSIHSEGSGVVYKKE
HHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHCCCCCCEEECCCCEEEEEEC
GNTAYLVTNNHVIEGAQRIEILTADGSKIVGELVGADTYSDLAVVKVAADKIKTIAKFAD
CCEEEEEECCEEECCCEEEEEEECCCHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHC
STKINVGEVAIAIGSPLGTKYANSVTEGIVSSLSRTVTSRNEAGETISTNAIQTDAAINP
CCCEEECEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCEEECCCCCC
GNSGGPLINIEGQVIGINSSKISSTPTGSGGAIEGIGFAIPSSDVVTIINQLESNGAVIR
CCCCCCEEEECCEEEEECCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHCCCCCEEE
PALGITMVNLSNLSTNALIQLNIPTSVTSGVVVASTQDGMPALGKLEQYDVITEVDGKEV
EECCEEEEEECCCCCCEEEEEECCCCCCCCEEEEECCCCCCHHCCCHHCCEEEECCCCHH
SSISDLQSVLYSHEINDTIKVTFYRGTAKKKVDIKLTKTTKDLTKKQ
HHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEEEEEECCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10712686; 11337471 [H]