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The map label for this gene is proC [H]

Identifier: 195978943

GI number: 195978943

Start: 1916292

End: 1917065

Strand: Direct

Name: proC [H]

Synonym: Sez_1850

Alternate gene names: 195978943

Gene position: 1916292-1917065 (Clockwise)

Preceding gene: 195978942

Following gene: 195978948

Centisome position: 94.67

GC content: 43.8

Gene sequence:

>774_bases
ATGAAAATTGGATTTATCGGTGTTGGCAAAATGGCAACTGCTATCATTCAAGGCCTAACACACACACCACACGAGCTAAT
CATCTCAGGCTCATCCTTAGCTCGCTCTAAAGAAATTGCTGGCCAATTGCACCTAAGCTACGCCCAATCTCACCAGGAGC
TGATCGATCAGGTTGACTTCATCATTCTAGGGATCAAGCCACAGCTCTTTGAGACTGTTCTTAACCCTCTACAGTTCAAA
CAGCCTATCATGTCAATGGCTGCTGGTATTTCCTTAGACAGACTAGCTCAATTAACAAGCTCTCATTTGCCACTCCTACG
TATCATGCCAAATATGAATGCTCAAATTCTCCAAAGCACCACTGCTTTGACTGGTAATGACTTAGTAACTGCTGATTTAT
TAGCTACTGCTAAAGAGCTAACCAACAGCTTTGGAACAACCTTTGAAATAGCTGAAAAGGATTTTGATACCTTTACTGCT
CTAGCAGGGTCAAGTCCTGCTTATCTTTACCTTTTCATCGAAGCTATGGCAAAGGCTGGGGTCAAAAATGGACTGCCTAA
AGACAAGGCCCTTAGCATTGTTAGTCAAACTGTCCTAGCTAGCGCCAAGAACCTGCTAGTCAGCACAGATAGTCCCCATG
ATTTGATTGATAAGATCTGTAGTCCCGGCGGCACAACCATTGCAGGCTTGATGGATTTCGAAAGAACAGGCCTGACACAT
TCTGTCTGCTCTGCCATTGACACAACGATCAAAAAGGCTAAGGATTTATCCTAA

Upstream 100 bases:

>100_bases
TAATCAAGAAATACTAGGAAGGATAAGGCTAAAATGCGAATCTAAGGTTCAATGAGCACTCTAGCCTATTGAGCCTTTAT
TCATTTTTAGGAACATTATT

Downstream 100 bases:

>100_bases
CCATCATCAATGCAGCTAATCGACACACCAAGCTTACTGCCTCAGACTAGCTCAAAACAGAGCCTAAATGCCTATTCTTT
CTAAAAAGGGCATATGATTC

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 257; Mature: 257

Protein sequence:

>257_residues
MKIGFIGVGKMATAIIQGLTHTPHELIISGSSLARSKEIAGQLHLSYAQSHQELIDQVDFIILGIKPQLFETVLNPLQFK
QPIMSMAAGISLDRLAQLTSSHLPLLRIMPNMNAQILQSTTALTGNDLVTADLLATAKELTNSFGTTFEIAEKDFDTFTA
LAGSSPAYLYLFIEAMAKAGVKNGLPKDKALSIVSQTVLASAKNLLVSTDSPHDLIDKICSPGGTTIAGLMDFERTGLTH
SVCSAIDTTIKKAKDLS

Sequences:

>Translated_257_residues
MKIGFIGVGKMATAIIQGLTHTPHELIISGSSLARSKEIAGQLHLSYAQSHQELIDQVDFIILGIKPQLFETVLNPLQFK
QPIMSMAAGISLDRLAQLTSSHLPLLRIMPNMNAQILQSTTALTGNDLVTADLLATAKELTNSFGTTFEIAEKDFDTFTA
LAGSSPAYLYLFIEAMAKAGVKNGLPKDKALSIVSQTVLASAKNLLVSTDSPHDLIDKICSPGGTTIAGLMDFERTGLTH
SVCSAIDTTIKKAKDLS
>Mature_257_residues
MKIGFIGVGKMATAIIQGLTHTPHELIISGSSLARSKEIAGQLHLSYAQSHQELIDQVDFIILGIKPQLFETVLNPLQFK
QPIMSMAAGISLDRLAQLTSSHLPLLRIMPNMNAQILQSTTALTGNDLVTADLLATAKELTNSFGTTFEIAEKDFDTFTA
LAGSSPAYLYLFIEAMAKAGVKNGLPKDKALSIVSQTVLASAKNLLVSTDSPHDLIDKICSPGGTTIAGLMDFERTGLTH
SVCSAIDTTIKKAKDLS

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=263, Percent_Identity=31.9391634980989, Blast_Score=128, Evalue=4e-30,
Organism=Homo sapiens, GI21361454, Length=271, Percent_Identity=29.520295202952, Blast_Score=118, Evalue=6e-27,
Organism=Homo sapiens, GI24797097, Length=268, Percent_Identity=26.865671641791, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI24797095, Length=268, Percent_Identity=26.865671641791, Blast_Score=107, Evalue=2e-23,
Organism=Escherichia coli, GI1786585, Length=264, Percent_Identity=34.8484848484849, Blast_Score=150, Evalue=7e-38,
Organism=Caenorhabditis elegans, GI17569021, Length=264, Percent_Identity=29.5454545454545, Blast_Score=120, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI17540664, Length=277, Percent_Identity=31.4079422382672, Blast_Score=116, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6320861, Length=205, Percent_Identity=29.7560975609756, Blast_Score=103, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24648116, Length=279, Percent_Identity=30.8243727598566, Blast_Score=139, Evalue=2e-33,
Organism=Drosophila melanogaster, GI21358587, Length=272, Percent_Identity=31.9852941176471, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24647700, Length=170, Percent_Identity=33.5294117647059, Blast_Score=95, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 27440; Mature: 27440

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIGFIGVGKMATAIIQGLTHTPHELIISGSSLARSKEIAGQLHLSYAQSHQELIDQVDF
CEEEEEEHHHHHHHHHHHCCCCCHHHEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHE
IILGIKPQLFETVLNPLQFKQPIMSMAAGISLDRLAQLTSSHLPLLRIMPNMNAQILQST
EEECCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEECCCCCCHHHHHHH
TALTGNDLVTADLLATAKELTNSFGTTFEIAEKDFDTFTALAGSSPAYLYLFIEAMAKAG
HCCCCCCHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
VKNGLPKDKALSIVSQTVLASAKNLLVSTDSPHDLIDKICSPGGTTIAGLMDFERTGLTH
HHCCCCHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHCCCCCEEHHHHHHHHHCCHH
SVCSAIDTTIKKAKDLS
HHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKIGFIGVGKMATAIIQGLTHTPHELIISGSSLARSKEIAGQLHLSYAQSHQELIDQVDF
CEEEEEEHHHHHHHHHHHCCCCCHHHEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHE
IILGIKPQLFETVLNPLQFKQPIMSMAAGISLDRLAQLTSSHLPLLRIMPNMNAQILQST
EEECCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEECCCCCCHHHHHHH
TALTGNDLVTADLLATAKELTNSFGTTFEIAEKDFDTFTALAGSSPAYLYLFIEAMAKAG
HCCCCCCHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
VKNGLPKDKALSIVSQTVLASAKNLLVSTDSPHDLIDKICSPGGTTIAGLMDFERTGLTH
HHCCCCHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHCCCCCEEHHHHHHHHHCCHH
SVCSAIDTTIKKAKDLS
HHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]