Click here to switch to the map view.

The map label for this gene is clpL [H]

Identifier: 195978193

GI number: 195978193

Start: 1104821

End: 1106914

Strand: Direct

Name: clpL [H]

Synonym: Sez_1072

Alternate gene names: 195978193

Gene position: 1104821-1106914 (Clockwise)

Preceding gene: 195978192

Following gene: 195978200

Centisome position: 54.58

GC content: 44.46

Gene sequence:

>2094_bases
ATGACAACTTATTATGGAAAAGACCCCTTTGGAAATATGGACGATATTTTCAATCAATTAATGGGAAACATTGGTGGCTA
TCGCAGTGAAAATCGGCGCTATCTTGTCAATGGACGTGAGATGACACCAGAGGAATTTCAGGAATACCGGAAAACCGGTA
AGCTAGCTGCAACTGAAGGACAAGACAAACAGGCTGGTAGCCTTAAAAAAGACGGCATTCTAACCAAGCTCGGAACAAAT
CTGACTGAAGAAGCTCGTCAAGGAAGGCTAGATCCTGTCATCGGACGAAACGATGAGATTCAAGCAACCGCAGAAATTCT
AGCTAGGCGAACCAAGAATAACCCTGTGCTTGTCGGTGACGCTGGCGTTGGTAAAACTGCTGTTGTCGAAGGTTTAGCCC
AGGCTATCGTCAATGGTGATGTGCCAGCTGCTATCAAAAATAAAGAGATTATCTCAATTGATATTTCTGGCCTTGAGGCT
GGCACACAGTATCGTGGCTCCTTTGAAGAAAACATTCAAAACATGGTTAAAGAGGTTAAAGAGGCTGGTAATATTATCCT
CTTCTTTGACGAAATTCATCAAATCCTTGGTGCAGGGTCAGCTGGTTCAGACTCAGGCTCTAAAGGCTTGGCTGATATTC
TAAAGCCAGCCCTCTCACGCGGTGAGTTGACCTTGATTGGTGCCACAACTCAAGATGAGTATCGCAATACTATTTTAAAA
AATGCTGCCCTTGCTCGTCGTTTCAACGAGGTTAAGGTTAATGCTCCTTCAGCAGAGGATACCTTCCACATATTGATGGG
CATTCGCAACCTCTACGAGCAGCACCACAATGTGATCCTGCCAGATTCTGTCTTGAAAGCAGCTATTGATTATGCTATCC
AATATATTCCACAACGAAGCCTGCCTGATAAAGCCATTGACCTTGTTGATATGACGGCTGCCCACCTAGCAGCTCAGCAC
CCTGTCACTGATCTAAAGTCACTTGAAGCAGAAATCGCTAAGCAAAAGGAGCTACAGGAAAAGGCTGTTGCAGAAGAAGA
CTTTGAAAAGGCCTTAACTGCTAAGACACGCATTGAGGAGCTTCAAAAGCAAATCAATCATCACAGTGAAGGGCAAAAGG
TCACTGCCACCGTCAATGATATTGCAGAATCTGTTGAACGACTAACTGGTGTCCCAGTCTCAAATATGGGGGCTAATGAT
TTAGAAAGGCTCAAAGAAATCAGTAATCGTCTTAAAGGCCATGTTATCGGACAAGATGGTGCAGTTGAGGCTGTTGCTCG
TGCGATTCGACGCAACCGCGCAGGCTTTGATGACGGTAATCGCCCAATTGGCTCCTTCCTCTTTGTTGGCCCAACTGGTG
TTGGTAAGACCGAGCTGGCTAAGCAGTTAGCCCTTGATATGTTCGGCTCAAAGGACGCTATCATTCGCTTAGATATGTCT
GAATATAGTGACCGCACAGCTGTTTCCAAATTAATCGGAACAACAGCTGGCTATGTTGGCTATGATGATAATCAAAATAC
CCTTACAGAACGTGTCCGTCGCAGTCCTTACTCTATCATCTTGCTTGATGAAATCGAAAAAGCAGACCCACAGGTCATTA
CACTGCTTCTTCAAGTGCTTGATGATGGGCGATTGACAGATGGACAAGGCAACACGATCAATTTCAAAAATACGGTTATC
ATCGCAACCTCTAATGCTGGTTTTGGCCATCAAGCAGGAGATAGTGCTGATCAAGAGCCTGCTATCATGGAGCGTATTGC
ACCTTACTTTAGACCAGAATTCTTGAATCGCTTCAACGGTGTCATCGAATTCAACCATTTAGCGAAAAAGGATCTACAAG
AAATCGTTGCTTTAATGCTAGCAGAGGTGAACCAAACCCTTGCTAAAAAAGGGATTAGCCTTGAGGTGACTGACGATGTT
AAAGAGCGTTTGATTGATCTGGGCTATGATCATGCAATGGGAGTTCGTCCACTTAGACGTGTCATCGAACAAGAAATTCG
TGACCGCATTACGGATTACTACCTGGATCACCCGACTGCTAAACACCTATTAGCAAGCCTTGATCAAGATACTATTACGA
TAAGTGAGAAGTAA

Upstream 100 bases:

>100_bases
ACCTCTCTAAGATCTCCGTATGAGCCAACATCTATCACCTTCTACCTATACCAGTAGCTCATAATGACTGGTAAATATAA
TACAAGTGAGGTAATTGTAT

Downstream 100 bases:

>100_bases
GCTTCACACAAAAAAGAATCACAAGCTAAAAAAAGCCTGAAATGCTAGTAAAAGTCATTTCAGGCTTTTTGGTTTTTGAA
GCTCAAGCCCCAGCCCACAC

Product: ATP-dependent protease ATP-binding subunit ClpL

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 697; Mature: 696

Protein sequence:

>697_residues
MTTYYGKDPFGNMDDIFNQLMGNIGGYRSENRRYLVNGREMTPEEFQEYRKTGKLAATEGQDKQAGSLKKDGILTKLGTN
LTEEARQGRLDPVIGRNDEIQATAEILARRTKNNPVLVGDAGVGKTAVVEGLAQAIVNGDVPAAIKNKEIISIDISGLEA
GTQYRGSFEENIQNMVKEVKEAGNIILFFDEIHQILGAGSAGSDSGSKGLADILKPALSRGELTLIGATTQDEYRNTILK
NAALARRFNEVKVNAPSAEDTFHILMGIRNLYEQHHNVILPDSVLKAAIDYAIQYIPQRSLPDKAIDLVDMTAAHLAAQH
PVTDLKSLEAEIAKQKELQEKAVAEEDFEKALTAKTRIEELQKQINHHSEGQKVTATVNDIAESVERLTGVPVSNMGAND
LERLKEISNRLKGHVIGQDGAVEAVARAIRRNRAGFDDGNRPIGSFLFVGPTGVGKTELAKQLALDMFGSKDAIIRLDMS
EYSDRTAVSKLIGTTAGYVGYDDNQNTLTERVRRSPYSIILLDEIEKADPQVITLLLQVLDDGRLTDGQGNTINFKNTVI
IATSNAGFGHQAGDSADQEPAIMERIAPYFRPEFLNRFNGVIEFNHLAKKDLQEIVALMLAEVNQTLAKKGISLEVTDDV
KERLIDLGYDHAMGVRPLRRVIEQEIRDRITDYYLDHPTAKHLLASLDQDTITISEK

Sequences:

>Translated_697_residues
MTTYYGKDPFGNMDDIFNQLMGNIGGYRSENRRYLVNGREMTPEEFQEYRKTGKLAATEGQDKQAGSLKKDGILTKLGTN
LTEEARQGRLDPVIGRNDEIQATAEILARRTKNNPVLVGDAGVGKTAVVEGLAQAIVNGDVPAAIKNKEIISIDISGLEA
GTQYRGSFEENIQNMVKEVKEAGNIILFFDEIHQILGAGSAGSDSGSKGLADILKPALSRGELTLIGATTQDEYRNTILK
NAALARRFNEVKVNAPSAEDTFHILMGIRNLYEQHHNVILPDSVLKAAIDYAIQYIPQRSLPDKAIDLVDMTAAHLAAQH
PVTDLKSLEAEIAKQKELQEKAVAEEDFEKALTAKTRIEELQKQINHHSEGQKVTATVNDIAESVERLTGVPVSNMGAND
LERLKEISNRLKGHVIGQDGAVEAVARAIRRNRAGFDDGNRPIGSFLFVGPTGVGKTELAKQLALDMFGSKDAIIRLDMS
EYSDRTAVSKLIGTTAGYVGYDDNQNTLTERVRRSPYSIILLDEIEKADPQVITLLLQVLDDGRLTDGQGNTINFKNTVI
IATSNAGFGHQAGDSADQEPAIMERIAPYFRPEFLNRFNGVIEFNHLAKKDLQEIVALMLAEVNQTLAKKGISLEVTDDV
KERLIDLGYDHAMGVRPLRRVIEQEIRDRITDYYLDHPTAKHLLASLDQDTITISEK
>Mature_696_residues
TTYYGKDPFGNMDDIFNQLMGNIGGYRSENRRYLVNGREMTPEEFQEYRKTGKLAATEGQDKQAGSLKKDGILTKLGTNL
TEEARQGRLDPVIGRNDEIQATAEILARRTKNNPVLVGDAGVGKTAVVEGLAQAIVNGDVPAAIKNKEIISIDISGLEAG
TQYRGSFEENIQNMVKEVKEAGNIILFFDEIHQILGAGSAGSDSGSKGLADILKPALSRGELTLIGATTQDEYRNTILKN
AALARRFNEVKVNAPSAEDTFHILMGIRNLYEQHHNVILPDSVLKAAIDYAIQYIPQRSLPDKAIDLVDMTAAHLAAQHP
VTDLKSLEAEIAKQKELQEKAVAEEDFEKALTAKTRIEELQKQINHHSEGQKVTATVNDIAESVERLTGVPVSNMGANDL
ERLKEISNRLKGHVIGQDGAVEAVARAIRRNRAGFDDGNRPIGSFLFVGPTGVGKTELAKQLALDMFGSKDAIIRLDMSE
YSDRTAVSKLIGTTAGYVGYDDNQNTLTERVRRSPYSIILLDEIEKADPQVITLLLQVLDDGRLTDGQGNTINFKNTVII
ATSNAGFGHQAGDSADQEPAIMERIAPYFRPEFLNRFNGVIEFNHLAKKDLQEIVALMLAEVNQTLAKKGISLEVTDDVK
ERLIDLGYDHAMGVRPLRRVIEQEIRDRITDYYLDHPTAKHLLASLDQDTITISEK

Specific function: ATP-Dependent Specificity Component Of The Clpp Protease. It Directs The Protease To Specific Substrates. The Primary Function Of The Clpa-Clpp Complex Appears To Be The Degradation Of Unfolded Or Abnormal Proteins. [C]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family. ClpC subfamily [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=303, Percent_Identity=34.3234323432343, Blast_Score=163, Evalue=5e-40,
Organism=Escherichia coli, GI1787109, Length=619, Percent_Identity=39.5799676898223, Blast_Score=441, Evalue=1e-124,
Organism=Escherichia coli, GI1788943, Length=362, Percent_Identity=44.475138121547, Blast_Score=288, Evalue=1e-78,
Organism=Saccharomyces cerevisiae, GI6323002, Length=683, Percent_Identity=38.7994143484627, Blast_Score=460, Evalue=1e-130,
Organism=Saccharomyces cerevisiae, GI6320464, Length=683, Percent_Identity=38.9458272327965, Blast_Score=445, Evalue=1e-125,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR019489 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 76755; Mature: 76624

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTYYGKDPFGNMDDIFNQLMGNIGGYRSENRRYLVNGREMTPEEFQEYRKTGKLAATEG
CCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCEEECCC
QDKQAGSLKKDGILTKLGTNLTEEARQGRLDPVIGRNDEIQATAEILARRTKNNPVLVGD
CCCCCCCCCCCCCHHHHCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEC
AGVGKTAVVEGLAQAIVNGDVPAAIKNKEIISIDISGLEAGTQYRGSFEENIQNMVKEVK
CCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCHHCCCHHHHHHHHHHHHH
EAGNIILFFDEIHQILGAGSAGSDSGSKGLADILKPALSRGELTLIGATTQDEYRNTILK
HHCCEEEEHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCHHHHHHHHHH
NAALARRFNEVKVNAPSAEDTFHILMGIRNLYEQHHNVILPDSVLKAAIDYAIQYIPQRS
HHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHCCEECCHHHHHHHHHHHHHHCCCCC
LPDKAIDLVDMTAAHLAAQHPVTDLKSLEAEIAKQKELQEKAVAEEDFEKALTAKTRIEE
CCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LQKQINHHSEGQKVTATVNDIAESVERLTGVPVSNMGANDLERLKEISNRLKGHVIGQDG
HHHHHHCCCCCCEEEEHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCEECCCCH
AVEAVARAIRRNRAGFDDGNRPIGSFLFVGPTGVGKTELAKQLALDMFGSKDAIIRLDMS
HHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEEHH
EYSDRTAVSKLIGTTAGYVGYDDNQNTLTERVRRSPYSIILLDEIEKADPQVITLLLQVL
HCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHH
DDGRLTDGQGNTINFKNTVIIATSNAGFGHQAGDSADQEPAIMERIAPYFRPEFLNRFNG
CCCCEECCCCCEEEECCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHCC
VIEFNHLAKKDLQEIVALMLAEVNQTLAKKGISLEVTDDVKERLIDLGYDHAMGVRPLRR
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHCCCCHHCCHHHHHH
VIEQEIRDRITDYYLDHPTAKHLLASLDQDTITISEK
HHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEECCC
>Mature Secondary Structure 
TTYYGKDPFGNMDDIFNQLMGNIGGYRSENRRYLVNGREMTPEEFQEYRKTGKLAATEG
CCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCEEECCC
QDKQAGSLKKDGILTKLGTNLTEEARQGRLDPVIGRNDEIQATAEILARRTKNNPVLVGD
CCCCCCCCCCCCCHHHHCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEC
AGVGKTAVVEGLAQAIVNGDVPAAIKNKEIISIDISGLEAGTQYRGSFEENIQNMVKEVK
CCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCHHCCCHHHHHHHHHHHHH
EAGNIILFFDEIHQILGAGSAGSDSGSKGLADILKPALSRGELTLIGATTQDEYRNTILK
HHCCEEEEHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCHHHHHHHHHH
NAALARRFNEVKVNAPSAEDTFHILMGIRNLYEQHHNVILPDSVLKAAIDYAIQYIPQRS
HHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHCCEECCHHHHHHHHHHHHHHCCCCC
LPDKAIDLVDMTAAHLAAQHPVTDLKSLEAEIAKQKELQEKAVAEEDFEKALTAKTRIEE
CCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LQKQINHHSEGQKVTATVNDIAESVERLTGVPVSNMGANDLERLKEISNRLKGHVIGQDG
HHHHHHCCCCCCEEEEHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCEECCCCH
AVEAVARAIRRNRAGFDDGNRPIGSFLFVGPTGVGKTELAKQLALDMFGSKDAIIRLDMS
HHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEEHH
EYSDRTAVSKLIGTTAGYVGYDDNQNTLTERVRRSPYSIILLDEIEKADPQVITLLLQVL
HCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHH
DDGRLTDGQGNTINFKNTVIIATSNAGFGHQAGDSADQEPAIMERIAPYFRPEFLNRFNG
CCCCEECCCCCEEEECCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHCC
VIEFNHLAKKDLQEIVALMLAEVNQTLAKKGISLEVTDDVKERLIDLGYDHAMGVRPLRR
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHCCCCHHCCHHHHHH
VIEQEIRDRITDYYLDHPTAKHLLASLDQDTITISEK
HHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA