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The map label for this gene is prs [H]

Identifier: 195978168

GI number: 195978168

Start: 1081699

End: 1082673

Strand: Direct

Name: prs [H]

Synonym: Sez_1047

Alternate gene names: 195978168

Gene position: 1081699-1082673 (Clockwise)

Preceding gene: 195978167

Following gene: 195978169

Centisome position: 53.44

GC content: 41.03

Gene sequence:

>975_bases
ATGACTGAACGATATGCTGACAAGCAAATCAAGCTGTTTTCACTCACTTCAAATCTCGCAATCGCTGAAAAAATTTCTAA
GGCTGCTGGTATTCCGCTTGGAAAGGTCTCATCTCGTCAATTTTCTGATGGTGAGATCATGATTAACATTGAAGAAACAG
TTCGTGGTGATGATATTTATATCATTCAATCAACAAGCTTTCCTGTCAACGATAACCTATGGGAACTGCTCATCATGATT
GATGCTTGTAAGCGCGCAAGTGCTAATACAGTCAATATTGTTTTGCCATATTTTGGTTATTCGCGTCAGGATCGTGTTGC
AAAATCTCGCGAGCCTATTACAGCAAAGCTGGTCGCAAACATGCTGACCAAAGCAGGGATTGATCGCGTTGTAACCCTTG
ATTTGCATGCGGTTCAGGTCCAAGGCTTTTTTGACATTCCAGTTGATAATTTATTTACAGTGCCTTTGTTTGCTAAGCAC
TACTACCCGCTTGGTTTATCAGGATCTGATACGGTTATTGTCAGCCCTAAAAATTCTGGTATCAAGCGTGCTAGAAGCTT
AGCAGAATATCTTAACTCTCCAATTGCCATTATCGATTATGCACAAGACGACGCTGAGCGCGAAGAAGGCTATGTGATTG
GTGATGTTGCTGGCAAAAAGGCTATCTTGATTGATGATATTCTAAACACAGGAAAAACCTTTGCAGAGGCGGCTAAAATC
CTAGAACGTGCAGGAGCAACTGACATTTATGCAGTGGCTAGTCATGGGCTTTTTGCAGGAGGTGCAGCTGATATTTTAGA
GACTGCTCCAATTAAAGAGATCATTGTCACAGACTCTGTCAAGACTAAAAATCGTGTCCCTAAAACAGTAACTTATCTTA
GTGCCAGTGATTTAATTGCAGAGGCTATCATTCGCATTCACGAAAGAAAACCACTAAGCCCACTGTTTTCTTACAAACCT
GAAAGCAATAACTAA

Upstream 100 bases:

>100_bases
TTTCTGTTTTTTTGTTAAAATAATACTGTCTATTTGTAATCTTGAATAACTGTTAACCTGTTATTCTATCGTTAATGTAA
TGTAAGGAGCTAATTTTATC

Downstream 100 bases:

>100_bases
TCATGATTTATTTTGATAATGCTGCTACAACACCGCTCAGTCAAGCCGCTATCAAGGCGATGACTGAGGCTATGGCTGAT
GATTTTGGGAACCCATCTAG

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK 2; Phosphoribosyl pyrophosphate synthase 2; P-Rib-PP synthase 2; PRPP synthase 2 [H]

Number of amino acids: Translated: 324; Mature: 323

Protein sequence:

>324_residues
MTERYADKQIKLFSLTSNLAIAEKISKAAGIPLGKVSSRQFSDGEIMINIEETVRGDDIYIIQSTSFPVNDNLWELLIMI
DACKRASANTVNIVLPYFGYSRQDRVAKSREPITAKLVANMLTKAGIDRVVTLDLHAVQVQGFFDIPVDNLFTVPLFAKH
YYPLGLSGSDTVIVSPKNSGIKRARSLAEYLNSPIAIIDYAQDDAEREEGYVIGDVAGKKAILIDDILNTGKTFAEAAKI
LERAGATDIYAVASHGLFAGGAADILETAPIKEIIVTDSVKTKNRVPKTVTYLSASDLIAEAIIRIHERKPLSPLFSYKP
ESNN

Sequences:

>Translated_324_residues
MTERYADKQIKLFSLTSNLAIAEKISKAAGIPLGKVSSRQFSDGEIMINIEETVRGDDIYIIQSTSFPVNDNLWELLIMI
DACKRASANTVNIVLPYFGYSRQDRVAKSREPITAKLVANMLTKAGIDRVVTLDLHAVQVQGFFDIPVDNLFTVPLFAKH
YYPLGLSGSDTVIVSPKNSGIKRARSLAEYLNSPIAIIDYAQDDAEREEGYVIGDVAGKKAILIDDILNTGKTFAEAAKI
LERAGATDIYAVASHGLFAGGAADILETAPIKEIIVTDSVKTKNRVPKTVTYLSASDLIAEAIIRIHERKPLSPLFSYKP
ESNN
>Mature_323_residues
TERYADKQIKLFSLTSNLAIAEKISKAAGIPLGKVSSRQFSDGEIMINIEETVRGDDIYIIQSTSFPVNDNLWELLIMID
ACKRASANTVNIVLPYFGYSRQDRVAKSREPITAKLVANMLTKAGIDRVVTLDLHAVQVQGFFDIPVDNLFTVPLFAKHY
YPLGLSGSDTVIVSPKNSGIKRARSLAEYLNSPIAIIDYAQDDAEREEGYVIGDVAGKKAILIDDILNTGKTFAEAAKIL
ERAGATDIYAVASHGLFAGGAADILETAPIKEIIVTDSVKTKNRVPKTVTYLSASDLIAEAIIRIHERKPLSPLFSYKPE
SNN

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=315, Percent_Identity=43.8095238095238, Blast_Score=258, Evalue=4e-69,
Organism=Homo sapiens, GI28557709, Length=315, Percent_Identity=43.8095238095238, Blast_Score=256, Evalue=1e-68,
Organism=Homo sapiens, GI4506129, Length=314, Percent_Identity=42.9936305732484, Blast_Score=254, Evalue=6e-68,
Organism=Homo sapiens, GI84875539, Length=317, Percent_Identity=42.5867507886435, Blast_Score=251, Evalue=6e-67,
Organism=Homo sapiens, GI4506133, Length=343, Percent_Identity=36.1516034985423, Blast_Score=185, Evalue=4e-47,
Organism=Homo sapiens, GI194018537, Length=343, Percent_Identity=35.5685131195335, Blast_Score=175, Evalue=6e-44,
Organism=Homo sapiens, GI310128524, Length=140, Percent_Identity=37.8571428571429, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI310115209, Length=140, Percent_Identity=37.8571428571429, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI310118259, Length=140, Percent_Identity=37.8571428571429, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI310119946, Length=140, Percent_Identity=37.8571428571429, Blast_Score=99, Evalue=8e-21,
Organism=Escherichia coli, GI1787458, Length=314, Percent_Identity=43.312101910828, Blast_Score=263, Evalue=1e-71,
Organism=Caenorhabditis elegans, GI25149168, Length=315, Percent_Identity=43.4920634920635, Blast_Score=245, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI17554702, Length=315, Percent_Identity=43.4920634920635, Blast_Score=245, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI71989924, Length=314, Percent_Identity=43.6305732484076, Blast_Score=244, Evalue=5e-65,
Organism=Caenorhabditis elegans, GI17554704, Length=312, Percent_Identity=43.2692307692308, Blast_Score=242, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI17570245, Length=348, Percent_Identity=34.4827586206897, Blast_Score=191, Evalue=3e-49,
Organism=Saccharomyces cerevisiae, GI6319403, Length=321, Percent_Identity=40.4984423676012, Blast_Score=230, Evalue=2e-61,
Organism=Saccharomyces cerevisiae, GI6320946, Length=314, Percent_Identity=41.7197452229299, Blast_Score=230, Evalue=2e-61,
Organism=Saccharomyces cerevisiae, GI6321776, Length=315, Percent_Identity=39.3650793650794, Blast_Score=214, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6322667, Length=191, Percent_Identity=38.7434554973822, Blast_Score=144, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6324511, Length=107, Percent_Identity=43.9252336448598, Blast_Score=80, Evalue=5e-16,
Organism=Drosophila melanogaster, GI21355239, Length=316, Percent_Identity=45.253164556962, Blast_Score=255, Evalue=2e-68,
Organism=Drosophila melanogaster, GI45551540, Length=339, Percent_Identity=42.1828908554572, Blast_Score=243, Evalue=2e-64,
Organism=Drosophila melanogaster, GI281362873, Length=343, Percent_Identity=34.1107871720117, Blast_Score=184, Evalue=5e-47,
Organism=Drosophila melanogaster, GI24651454, Length=343, Percent_Identity=34.1107871720117, Blast_Score=184, Evalue=5e-47,
Organism=Drosophila melanogaster, GI24651458, Length=343, Percent_Identity=34.1107871720117, Blast_Score=184, Evalue=6e-47,
Organism=Drosophila melanogaster, GI24651456, Length=343, Percent_Identity=34.1107871720117, Blast_Score=184, Evalue=6e-47,
Organism=Drosophila melanogaster, GI24651462, Length=190, Percent_Identity=38.9473684210526, Blast_Score=131, Evalue=5e-31,
Organism=Drosophila melanogaster, GI24651464, Length=190, Percent_Identity=38.9473684210526, Blast_Score=131, Evalue=5e-31,
Organism=Drosophila melanogaster, GI45552010, Length=190, Percent_Identity=38.9473684210526, Blast_Score=131, Evalue=6e-31,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 35452; Mature: 35321

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTERYADKQIKLFSLTSNLAIAEKISKAAGIPLGKVSSRQFSDGEIMINIEETVRGDDIY
CCCCCCCCEEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEHHHCCCCEEE
IIQSTSFPVNDNLWELLIMIDACKRASANTVNIVLPYFGYSRQDRVAKSREPITAKLVAN
EEECCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHCCCCHHHHHHHH
MLTKAGIDRVVTLDLHAVQVQGFFDIPVDNLFTVPLFAKHYYPLGLSGSDTVIVSPKNSG
HHHHCCCCEEEEEEEEEEEEEEEEECCCCCEEECCHHHHCCCCCCCCCCCEEEECCCCCH
IKRARSLAEYLNSPIAIIDYAQDDAEREEGYVIGDVAGKKAILIDDILNTGKTFAEAAKI
HHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEEEECCCCCEEEEHHHHHCCHHHHHHHHH
LERAGATDIYAVASHGLFAGGAADILETAPIKEIIVTDSVKTKNRVPKTVTYLSASDLIA
HHHCCCCEEEEECCCCEECCCHHHHHHCCCCHHEEEECCCHHCCCCCCEEEEECHHHHHH
EAIIRIHERKPLSPLFSYKPESNN
HHHHHHHCCCCCCHHHCCCCCCCC
>Mature Secondary Structure 
TERYADKQIKLFSLTSNLAIAEKISKAAGIPLGKVSSRQFSDGEIMINIEETVRGDDIY
CCCCCCCEEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEHHHCCCCEEE
IIQSTSFPVNDNLWELLIMIDACKRASANTVNIVLPYFGYSRQDRVAKSREPITAKLVAN
EEECCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHCCCCHHHHHHHH
MLTKAGIDRVVTLDLHAVQVQGFFDIPVDNLFTVPLFAKHYYPLGLSGSDTVIVSPKNSG
HHHHCCCCEEEEEEEEEEEEEEEEECCCCCEEECCHHHHCCCCCCCCCCCEEEECCCCCH
IKRARSLAEYLNSPIAIIDYAQDDAEREEGYVIGDVAGKKAILIDDILNTGKTFAEAAKI
HHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEEEECCCCCEEEEHHHHHCCHHHHHHHHH
LERAGATDIYAVASHGLFAGGAADILETAPIKEIIVTDSVKTKNRVPKTVTYLSASDLIA
HHHCCCCEEEEECCCCEECCCHHHHHHCCCCHHEEEECCCHHCCCCCCEEEEECHHHHHH
EAIIRIHERKPLSPLFSYKPESNN
HHHHHHHCCCCCCHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]