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The map label for this gene is ldh [H]

Identifier: 195978145

GI number: 195978145

Start: 1060379

End: 1061362

Strand: Direct

Name: ldh [H]

Synonym: Sez_1022

Alternate gene names: 195978145

Gene position: 1060379-1061362 (Clockwise)

Preceding gene: 195978137

Following gene: 195978155

Centisome position: 52.39

GC content: 44.11

Gene sequence:

>984_bases
ATGACTGCAACTAAACAACATAAAAAAGTCATCTTGGTTGGCGATGGTGCTGTAGGCTCTTCTTATGCCTTTGCACTAGT
AACCCAAAATATTGCCCAAGAGCTTGGTATTATTGATATTTTTAAAGAAAAAACTCAAGGAGATGCTGAGGATTTAAGTC
ACGCGCTTGCCTTTACCTCCCCTAAAAAGATCTATGCTGCTGACTATGCTGACTGTCACGACGCTGATCTAGTTGTTTTA
ACAGCTGGCGCTCCTCAAAAGCCAGGTGAGACCCGTCTTGACCTTGTTGAGAAGAATCTGCGCATTAATAAAGAGGTGGT
TACTCAAATTGTGGCCTCAGGCTTTAAGGGAATTTTCCTTGTTGCTGCTAATCCAGTTGATATTTTAACCTATTCAACCT
GGAAATTCTCAGGCTTCCCTAAGGAACGCGTCATCGGTTCTGGAACATCACTTGACTCAGCACGCTTCCGTCAAGCACTT
GCTGCTAAAATCGGTGTAGATGCACGTTCTGTCCATGCCTACATCATGGGTGAGCATGGAGATTCAGAATTTGCTGTTTG
GTCACATGCTAATGTTGCAGGGGTTGGATTGTACGACTGGCTTCAGGCTAATCGTGACGTTGATGAACAAGGCTTGGTAG
ACCTCTTTATCTCTGTACGTGACGCAGCTTACTCTATCATCAATAAAAAGGGTGCTACCTTCTATGGGATTGCAGTCGCC
CTAGCACGTATTACAAAGGCTATCCTTGATGATGAAAATGCAGTACTTCCACTTTCTGTCTTCCAAGAAGGCCAATACGA
GGGGGTTGAGGATTGCTACATCGGTCAGCCTGCTATCGTTGGTGCTTATGGTATTGTTCGTCCAGTCAACATCCCGTTGA
ATGATGCTGAGCTTCAAAAAATGCAAGCTTCAGCAAACCAATTGAAGGCTATTATCGACGAAGCCTTCTCTAAAGAAGAG
TTTGCGTCTGCTGCTAAAAACTAA

Upstream 100 bases:

>100_bases
TTCATAATTTGGTCGAATATCATGACAAAGACATTACAATGTGTTAAAATAAGGTCGTATGAGCAATTTGCTCTAACTAA
AATGAAGGAGATGTTTAGAA

Downstream 100 bases:

>100_bases
TTAAAAAATGAATAAACCTCCAGGTGTTAGATCTTGCTCTAACGTTTTGGAATCACTACAAAAAGCCTAATCCAATCGGA
TAGGCTTTTTTCATGCGTCT

Product: L-lactate dehydrogenase

Products: NA

Alternate protein names: L-LDH [H]

Number of amino acids: Translated: 327; Mature: 326

Protein sequence:

>327_residues
MTATKQHKKVILVGDGAVGSSYAFALVTQNIAQELGIIDIFKEKTQGDAEDLSHALAFTSPKKIYAADYADCHDADLVVL
TAGAPQKPGETRLDLVEKNLRINKEVVTQIVASGFKGIFLVAANPVDILTYSTWKFSGFPKERVIGSGTSLDSARFRQAL
AAKIGVDARSVHAYIMGEHGDSEFAVWSHANVAGVGLYDWLQANRDVDEQGLVDLFISVRDAAYSIINKKGATFYGIAVA
LARITKAILDDENAVLPLSVFQEGQYEGVEDCYIGQPAIVGAYGIVRPVNIPLNDAELQKMQASANQLKAIIDEAFSKEE
FASAAKN

Sequences:

>Translated_327_residues
MTATKQHKKVILVGDGAVGSSYAFALVTQNIAQELGIIDIFKEKTQGDAEDLSHALAFTSPKKIYAADYADCHDADLVVL
TAGAPQKPGETRLDLVEKNLRINKEVVTQIVASGFKGIFLVAANPVDILTYSTWKFSGFPKERVIGSGTSLDSARFRQAL
AAKIGVDARSVHAYIMGEHGDSEFAVWSHANVAGVGLYDWLQANRDVDEQGLVDLFISVRDAAYSIINKKGATFYGIAVA
LARITKAILDDENAVLPLSVFQEGQYEGVEDCYIGQPAIVGAYGIVRPVNIPLNDAELQKMQASANQLKAIIDEAFSKEE
FASAAKN
>Mature_326_residues
TATKQHKKVILVGDGAVGSSYAFALVTQNIAQELGIIDIFKEKTQGDAEDLSHALAFTSPKKIYAADYADCHDADLVVLT
AGAPQKPGETRLDLVEKNLRINKEVVTQIVASGFKGIFLVAANPVDILTYSTWKFSGFPKERVIGSGTSLDSARFRQALA
AKIGVDARSVHAYIMGEHGDSEFAVWSHANVAGVGLYDWLQANRDVDEQGLVDLFISVRDAAYSIINKKGATFYGIAVAL
ARITKAILDDENAVLPLSVFQEGQYEGVEDCYIGQPAIVGAYGIVRPVNIPLNDAELQKMQASANQLKAIIDEAFSKEEF
ASAAKN

Specific function: Catalyzes The Reversible Oxidation Of Malate To Oxaloacetate. [C]

COG id: COG0039

COG function: function code C; Malate/lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH/MDH superfamily. LDH family [H]

Homologues:

Organism=Homo sapiens, GI291575128, Length=308, Percent_Identity=38.6363636363636, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI4557032, Length=308, Percent_Identity=38.6363636363636, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI47059044, Length=314, Percent_Identity=38.8535031847134, Blast_Score=226, Evalue=2e-59,
Organism=Homo sapiens, GI221136809, Length=314, Percent_Identity=38.8535031847134, Blast_Score=226, Evalue=2e-59,
Organism=Homo sapiens, GI15082234, Length=311, Percent_Identity=37.9421221864952, Blast_Score=224, Evalue=6e-59,
Organism=Homo sapiens, GI5031857, Length=311, Percent_Identity=38.2636655948553, Blast_Score=224, Evalue=7e-59,
Organism=Homo sapiens, GI260099723, Length=311, Percent_Identity=38.2636655948553, Blast_Score=224, Evalue=8e-59,
Organism=Homo sapiens, GI9257228, Length=302, Percent_Identity=39.4039735099338, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI4504973, Length=302, Percent_Identity=39.4039735099338, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI260099727, Length=192, Percent_Identity=45.3125, Blast_Score=185, Evalue=6e-47,
Organism=Homo sapiens, GI260099725, Length=192, Percent_Identity=45.3125, Blast_Score=184, Evalue=7e-47,
Organism=Homo sapiens, GI207028494, Length=196, Percent_Identity=39.2857142857143, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI103472011, Length=308, Percent_Identity=24.3506493506494, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI103472015, Length=184, Percent_Identity=29.3478260869565, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI21735621, Length=338, Percent_Identity=25.4437869822485, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17535107, Length=289, Percent_Identity=41.522491349481, Blast_Score=227, Evalue=8e-60,
Organism=Caenorhabditis elegans, GI17554310, Length=260, Percent_Identity=27.6923076923077, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI17136226, Length=302, Percent_Identity=38.7417218543046, Blast_Score=219, Evalue=1e-57,
Organism=Drosophila melanogaster, GI45550422, Length=316, Percent_Identity=31.0126582278481, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24647881, Length=331, Percent_Identity=26.8882175226586, Blast_Score=83, Evalue=2e-16,

Paralogues:

None

Copy number: 2640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 260 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2380 Molecules/Cell In: Stationary-Phase, Rich-Media (Based on E. coli). 260 Molecules/Cell In: Stationary Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001557
- InterPro:   IPR011304
- InterPro:   IPR018177
- InterPro:   IPR022383
- InterPro:   IPR001236
- InterPro:   IPR015955
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02866 Ldh_1_C; PF00056 Ldh_1_N [H]

EC number: =1.1.1.27 [H]

Molecular weight: Translated: 35272; Mature: 35141

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00064 L_LDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATKQHKKVILVGDGAVGSSYAFALVTQNIAQELGIIDIFKEKTQGDAEDLSHALAFTS
CCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHCCC
PKKIYAADYADCHDADLVVLTAGAPQKPGETRLDLVEKNLRINKEVVTQIVASGFKGIFL
CCEEEEECCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCEEEE
VAANPVDILTYSTWKFSGFPKERVIGSGTSLDSARFRQALAAKIGVDARSVHAYIMGEHG
EECCCEEEEEEECEEECCCCHHHEECCCCCCCHHHHHHHHHHHHCCCHHEEEEEEEECCC
DSEFAVWSHANVAGVGLYDWLQANRDVDEQGLVDLFISVRDAAYSIINKKGATFYGIAVA
CCCEEEEECCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
LARITKAILDDENAVLPLSVFQEGQYEGVEDCYIGQPAIVGAYGIVRPVNIPLNDAELQK
HHHHHHHHHCCCCCEEEHHHHCCCCCCCCCHHCCCCCHHEECCCCEEECCCCCCHHHHHH
MQASANQLKAIIDEAFSKEEFASAAKN
HHHHHHHHHHHHHHHHCHHHHHHHCCC
>Mature Secondary Structure 
TATKQHKKVILVGDGAVGSSYAFALVTQNIAQELGIIDIFKEKTQGDAEDLSHALAFTS
CCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHCCC
PKKIYAADYADCHDADLVVLTAGAPQKPGETRLDLVEKNLRINKEVVTQIVASGFKGIFL
CCEEEEECCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCEEEE
VAANPVDILTYSTWKFSGFPKERVIGSGTSLDSARFRQALAAKIGVDARSVHAYIMGEHG
EECCCEEEEEEECEEECCCCHHHEECCCCCCCHHHHHHHHHHHHCCCHHEEEEEEEECCC
DSEFAVWSHANVAGVGLYDWLQANRDVDEQGLVDLFISVRDAAYSIINKKGATFYGIAVA
CCCEEEEECCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
LARITKAILDDENAVLPLSVFQEGQYEGVEDCYIGQPAIVGAYGIVRPVNIPLNDAELQK
HHHHHHHHHCCCCCEEEHHHHCCCCCCCCCHHCCCCCHHEECCCCEEECCCCCCHHHHHH
MQASANQLKAIIDEAFSKEEFASAAKN
HHHHHHHHHHHHHHHHCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA