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The map label for this gene is ffh [H]

Identifier: 195978137

GI number: 195978137

Start: 1050157

End: 1051728

Strand: Direct

Name: ffh [H]

Synonym: Sez_1014

Alternate gene names: 195978137

Gene position: 1050157-1051728 (Clockwise)

Preceding gene: 195978136

Following gene: 195978145

Centisome position: 51.88

GC content: 42.24

Gene sequence:

>1572_bases
ATGGCATTTGAAAGCCTAACCCAACGTTTACAGGACGTTTTTAAGCACATTCGTGGTAAAAAAACCTTATCTGAAGCCGA
TGTTCAGGAAGTGACCAAGGAGATTCGTCTAGCCTTATTAGAGGCAGATGTTGCACTTCCAGTTGTTAAGACCTTTATCA
AGCGTATACGTGAGCGAGCTGTTGGCCACGAAATTATTGATACCCTTGATCCAACGCAACAAATACTTAAAATTGTTAAT
GAGGAATTAACTGGTATCTTAGGATCAGAAACCGCGGAGCTTGATAAATCACCTAAAATCCCTACTGTCATCATGATGGT
GGGCTTGCAGGGAGCTGGTAAAACGACCTTTGCAGGAAAATTAGCCAATAAGCTCATCAAGGAAGAAAATGCTCGTCCAT
TGATGATTGCAGCAGACATCTATCGTCCGGCTGCTATTGACCAGTTGAAAACCTTGGGACAGCAAATAAATGTTCCTGTT
TTTGATATGGGGACAAATCATTCAGCAGTTGATATTGTTGCCAATGGTTTGGCACAGGCAAAAGAGAACCGTCATGACTA
TGTTTTGATTGATACGGCAGGACGGTTACAAATTGATGAGAAACTAATGGGCGAGCTTCGTGAGGTTAAAGCACTAGCTA
AACCAAACGAAATCCTTCTTGTTGTTGACAGCATGATCGGACAAGAAGCTGCCAACGTTGCCTATGAATTTAACAATCAG
CTCGATATCACTGGAGTAGTGTTAACAAAGATTGACGGTGATACTCGTGGTGGTGCGGCCCTTTCTATACGTGAAATAAC
TGGTAAGCCAATCAAATTTACCGGAACTGGTGAAAAAATCACTGATATTGAAACCTTCCATCCAGACCGTATGTCAAGTC
GTATCTTGGGAATGGGAGACCTTCTTACCTTGATCGAAAAGGCAAGTCAGGAATATGATGAGAAAAAATCATTAGAGCTT
GCCGCAAAAATGCGTGAGAATACCTTTGATTTTAATGACTTTATCGAGCAATTAGACCAAGTGCAAAACATGGGGCCAAT
GGAAGATCTGTTAAAAATGATTCCAGGTATGGCAACTAATCCTGCTCTAGCCAATATTAAGGTTGACGACAAGCAAATTG
CTCGCAAGCGTGCTATCGTTTCTTCTATGACACCTGAGGAGCGTGAGCAGCCAGAGCTTTTAACACCAAGTCGCCGCCGT
CGCATTGCAGCTGGATCAGGTAATAGTTTCGTTGAAGTCAACAAATTTATTAAAGATTTTAACCAAGCCAAAGCCATGAT
GCAGGGTGTCATGTCAGGTGATATGACTAAAATGATGAAACAAATGGGAATCAACCCTAATAACCTCCCTAAAAACATGC
CAAATATGCCAGGAGGCATGCCTGATATGTCTGCCCTTGAAGGAATGATGGGGCAAGGTGGTTTACCTGACATGTCTGCA
TTGGGTGGTGATATGGATATGAGCCAGCTCTTTGGAGGTGGTCTAAAGGGTAAGATTGGTCAATTTGCCATGAAGCAGGC
CATGAAGCGTCAAGCTAATAAGATTAAAAAGGCCAAGAAAAAACGAAAATAG

Upstream 100 bases:

>100_bases
TTGATGATATTCTTGCAAAATATCCCAGTGACCACTATTTACGTGACAAAATTTCCATTTTAACTAGTATTGACAACAGA
GATTAAGAGGAGTTATAGCT

Downstream 100 bases:

>100_bases
ACTAAAAGAATGGTTGCCTTGTATTCTGCCTCTAATCGTTAGATGCTATTCTAATTTGGAGTGCAGGTCAGTAGCGACCA
TCTTTTTTATAAATACAATC

Product: signal recognition particle protein Ffh

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 523; Mature: 522

Protein sequence:

>523_residues
MAFESLTQRLQDVFKHIRGKKTLSEADVQEVTKEIRLALLEADVALPVVKTFIKRIRERAVGHEIIDTLDPTQQILKIVN
EELTGILGSETAELDKSPKIPTVIMMVGLQGAGKTTFAGKLANKLIKEENARPLMIAADIYRPAAIDQLKTLGQQINVPV
FDMGTNHSAVDIVANGLAQAKENRHDYVLIDTAGRLQIDEKLMGELREVKALAKPNEILLVVDSMIGQEAANVAYEFNNQ
LDITGVVLTKIDGDTRGGAALSIREITGKPIKFTGTGEKITDIETFHPDRMSSRILGMGDLLTLIEKASQEYDEKKSLEL
AAKMRENTFDFNDFIEQLDQVQNMGPMEDLLKMIPGMATNPALANIKVDDKQIARKRAIVSSMTPEEREQPELLTPSRRR
RIAAGSGNSFVEVNKFIKDFNQAKAMMQGVMSGDMTKMMKQMGINPNNLPKNMPNMPGGMPDMSALEGMMGQGGLPDMSA
LGGDMDMSQLFGGGLKGKIGQFAMKQAMKRQANKIKKAKKKRK

Sequences:

>Translated_523_residues
MAFESLTQRLQDVFKHIRGKKTLSEADVQEVTKEIRLALLEADVALPVVKTFIKRIRERAVGHEIIDTLDPTQQILKIVN
EELTGILGSETAELDKSPKIPTVIMMVGLQGAGKTTFAGKLANKLIKEENARPLMIAADIYRPAAIDQLKTLGQQINVPV
FDMGTNHSAVDIVANGLAQAKENRHDYVLIDTAGRLQIDEKLMGELREVKALAKPNEILLVVDSMIGQEAANVAYEFNNQ
LDITGVVLTKIDGDTRGGAALSIREITGKPIKFTGTGEKITDIETFHPDRMSSRILGMGDLLTLIEKASQEYDEKKSLEL
AAKMRENTFDFNDFIEQLDQVQNMGPMEDLLKMIPGMATNPALANIKVDDKQIARKRAIVSSMTPEEREQPELLTPSRRR
RIAAGSGNSFVEVNKFIKDFNQAKAMMQGVMSGDMTKMMKQMGINPNNLPKNMPNMPGGMPDMSALEGMMGQGGLPDMSA
LGGDMDMSQLFGGGLKGKIGQFAMKQAMKRQANKIKKAKKKRK
>Mature_522_residues
AFESLTQRLQDVFKHIRGKKTLSEADVQEVTKEIRLALLEADVALPVVKTFIKRIRERAVGHEIIDTLDPTQQILKIVNE
ELTGILGSETAELDKSPKIPTVIMMVGLQGAGKTTFAGKLANKLIKEENARPLMIAADIYRPAAIDQLKTLGQQINVPVF
DMGTNHSAVDIVANGLAQAKENRHDYVLIDTAGRLQIDEKLMGELREVKALAKPNEILLVVDSMIGQEAANVAYEFNNQL
DITGVVLTKIDGDTRGGAALSIREITGKPIKFTGTGEKITDIETFHPDRMSSRILGMGDLLTLIEKASQEYDEKKSLELA
AKMRENTFDFNDFIEQLDQVQNMGPMEDLLKMIPGMATNPALANIKVDDKQIARKRAIVSSMTPEEREQPELLTPSRRRR
IAAGSGNSFVEVNKFIKDFNQAKAMMQGVMSGDMTKMMKQMGINPNNLPKNMPNMPGGMPDMSALEGMMGQGGLPDMSAL
GGDMDMSQLFGGGLKGKIGQFAMKQAMKRQANKIKKAKKKRK

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=489, Percent_Identity=29.8568507157464, Blast_Score=204, Evalue=2e-52,
Organism=Homo sapiens, GI226371618, Length=426, Percent_Identity=30.9859154929577, Blast_Score=185, Evalue=7e-47,
Organism=Homo sapiens, GI23308697, Length=308, Percent_Identity=28.8961038961039, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI295424842, Length=308, Percent_Identity=28.8961038961039, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI89061728, Length=146, Percent_Identity=36.3013698630137, Blast_Score=101, Evalue=2e-21,
Organism=Escherichia coli, GI1788963, Length=420, Percent_Identity=50, Blast_Score=419, Evalue=1e-118,
Organism=Escherichia coli, GI1789874, Length=266, Percent_Identity=33.4586466165414, Blast_Score=147, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17539958, Length=488, Percent_Identity=28.0737704918033, Blast_Score=207, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI193206261, Length=299, Percent_Identity=29.4314381270903, Blast_Score=108, Evalue=6e-24,
Organism=Saccharomyces cerevisiae, GI6325345, Length=460, Percent_Identity=31.5217391304348, Blast_Score=207, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6320498, Length=315, Percent_Identity=26.3492063492064, Blast_Score=100, Evalue=8e-22,
Organism=Drosophila melanogaster, GI17647949, Length=493, Percent_Identity=30.4259634888438, Blast_Score=199, Evalue=4e-51,
Organism=Drosophila melanogaster, GI24641198, Length=310, Percent_Identity=30.6451612903226, Blast_Score=124, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 57611; Mature: 57480

Theoretical pI: Translated: 9.34; Mature: 9.34

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
6.3 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
6.1 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFESLTQRLQDVFKHIRGKKTLSEADVQEVTKEIRLALLEADVALPVVKTFIKRIRERA
CCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGHEIIDTLDPTQQILKIVNEELTGILGSETAELDKSPKIPTVIMMVGLQGAGKTTFAGK
HHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCEEEEEEECCCCCCCHHHHH
LANKLIKEENARPLMIAADIYRPAAIDQLKTLGQQINVPVFDMGTNHSAVDIVANGLAQA
HHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHH
KENRHDYVLIDTAGRLQIDEKLMGELREVKALAKPNEILLVVDSMIGQEAANVAYEFNNQ
HCCCCCEEEEECCCCCEECHHHHHHHHHHHHHCCCCCEEEEHHHHHCHHHHHHHHHCCCC
LDITGVVLTKIDGDTRGGAALSIREITGKPIKFTGTGEKITDIETFHPDRMSSRILGMGD
EEEEEEEEEEECCCCCCCCEEEEEECCCCCEEEECCCCEECCCHHCCCHHHHHHHCCHHH
LLTLIEKASQEYDEKKSLELAAKMRENTFDFNDFIEQLDQVQNMGPMEDLLKMIPGMATN
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCC
PALANIKVDDKQIARKRAIVSSMTPEEREQPELLTPSRRRRIAAGSGNSFVEVNKFIKDF
CCEEEEEECHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCEEECCCCCCHHHHHHHHHHH
NQAKAMMQGVMSGDMTKMMKQMGINPNNLPKNMPNMPGGMPDMSALEGMMGQGGLPDMSA
HHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCHHH
LGGDMDMSQLFGGGLKGKIGQFAMKQAMKRQANKIKKAKKKRK
CCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AFESLTQRLQDVFKHIRGKKTLSEADVQEVTKEIRLALLEADVALPVVKTFIKRIRERA
CHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGHEIIDTLDPTQQILKIVNEELTGILGSETAELDKSPKIPTVIMMVGLQGAGKTTFAGK
HHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCEEEEEEECCCCCCCHHHHH
LANKLIKEENARPLMIAADIYRPAAIDQLKTLGQQINVPVFDMGTNHSAVDIVANGLAQA
HHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHH
KENRHDYVLIDTAGRLQIDEKLMGELREVKALAKPNEILLVVDSMIGQEAANVAYEFNNQ
HCCCCCEEEEECCCCCEECHHHHHHHHHHHHHCCCCCEEEEHHHHHCHHHHHHHHHCCCC
LDITGVVLTKIDGDTRGGAALSIREITGKPIKFTGTGEKITDIETFHPDRMSSRILGMGD
EEEEEEEEEEECCCCCCCCEEEEEECCCCCEEEECCCCEECCCHHCCCHHHHHHHCCHHH
LLTLIEKASQEYDEKKSLELAAKMRENTFDFNDFIEQLDQVQNMGPMEDLLKMIPGMATN
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCC
PALANIKVDDKQIARKRAIVSSMTPEEREQPELLTPSRRRRIAAGSGNSFVEVNKFIKDF
CCEEEEEECHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCEEECCCCCCHHHHHHHHHHH
NQAKAMMQGVMSGDMTKMMKQMGINPNNLPKNMPNMPGGMPDMSALEGMMGQGGLPDMSA
HHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCHHH
LGGDMDMSQLFGGGLKGKIGQFAMKQAMKRQANKIKKAKKKRK
CCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12397186; 8763945 [H]