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The map label for this gene is ciaH [H]

Identifier: 195978047

GI number: 195978047

Start: 962506

End: 963816

Strand: Direct

Name: ciaH [H]

Synonym: Sez_0920

Alternate gene names: 195978047

Gene position: 962506-963816 (Clockwise)

Preceding gene: 195978046

Following gene: 195978048

Centisome position: 47.55

GC content: 38.52

Gene sequence:

>1311_bases
ATGAATAAACTAAAAAAAGGATTATTGTCCGATAATTATACGCATTTTTTTCATTTCTTTGCTATTTTTACAGGCATTTT
TGTTGTCATGACCATCATTATTTTGCAAATCATGAGGTTTAGTGTCTATTCCACAGTAGACAGCAGTCTCATTTCGGTCG
GTCAAAATGCCAGCAACTATGCTAATAGGACCATGGCGAGAATATCTTCCTTTTATTTTGATGCAGAAAATAACCTTATT
CAGGCTCTTCCTGAACTGGAAGCGTCAAAATCACTTGGCTCCTCCACCACTAATATGGATATTATTTTATTTAGTGCTAA
TGGGACGATATTGAACTCCTTTGACGCTTTCTCTAATTACCAAAGCTTTCGTTTAGACAAAAGTCAGCTCAATAACATTG
TCACCACACAGCTGATGAATTTTTATGGGCAAAAGGAGAAATACCATACCCTAACCGTTAAGGTTCACATCAAAAACTAT
CCAGCAGTGGCTTATATGATGGCAGTGGTTAATGTCCAGCAGCTGGATACTGCTAATGAGCGCTATGAACAGATTATTAT
CATGGTTATGATTGTCTTTTGGTTAATTTCGATTTTGGCCAGTATTTATTTGGCTAAGTGGAGCAGAAAGCCAATTATGG
AGAGCTATGCCAAGCAAAAAATGTTTGTAGAAAATGCCAGTCATGAGCTTAGGACTCCTTTAGCGGTGCTGCAAAATCGT
TTGGAATCGCTGTTTAGAAAGCCTAACGAAACCATTTTAGATAATAGCGAGCATATTGCGTCAAGCCTAGATGAGGTTCG
TAATATGAGAATATTAACAACTAATCTGTTAAATTTAGCTAGACGCGATGATGGGATCAAGCCGCAGCTAGTTGATGTTG
ATGCAGCCTTTTTTGACACTGTTTTTGAAAATTATCAATTAGTTGCAGAAGAATCAGGCAAGCAGTTTATCTCAGCTAAT
CAGATCAATAGGCCCTTAAAGACGGATAAGGCTTTGCTCAAGCAGCTGATGACCATTTTGTTTGATAATGCGATCAAATA
CACTGATCATAACGGTGTGGTTGAGGTCAAGGTTAGAACGACCGATAAGCATTTATTGATTTCTGTTATTGATAATGGCC
CAGGGATCAAGGACGATGATAAGAAAAAGATTTTTGATCGCTTTTACCGAGTGGATAAAGCAAGGACACGCCAAAAAGGA
GGCTTTGGACTCGGATTGGCCTTAGCGCAGCAGATCGTTACCTCATTAAAAGGAACGATTACCGTCAGTGATAATAAGCC
TACCGGCGCCATCTTTGAAGTAAAATTATAG

Upstream 100 bases:

>100_bases
GTAGAGGTCTATGTCTCTAAAATTCGTAAGAAGCTTAAGGGGACAGACTTTGTTAATCATCTTCAAACCTTGAGAAGTGT
AGGATATATCTTAAAAGCTA

Downstream 100 bases:

>100_bases
CACTGAGTTCTTGCTAGCTCATAATCAGTATGAAAATAACAGTCACTAGATCAAGAAGTCTAGTGACTTTTTTTATTGTC
TTCTTTTTGCTGTTAACCAA

Product: TCS sensor kinase protein ciaH

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MNKLKKGLLSDNYTHFFHFFAIFTGIFVVMTIIILQIMRFSVYSTVDSSLISVGQNASNYANRTMARISSFYFDAENNLI
QALPELEASKSLGSSTTNMDIILFSANGTILNSFDAFSNYQSFRLDKSQLNNIVTTQLMNFYGQKEKYHTLTVKVHIKNY
PAVAYMMAVVNVQQLDTANERYEQIIIMVMIVFWLISILASIYLAKWSRKPIMESYAKQKMFVENASHELRTPLAVLQNR
LESLFRKPNETILDNSEHIASSLDEVRNMRILTTNLLNLARRDDGIKPQLVDVDAAFFDTVFENYQLVAEESGKQFISAN
QINRPLKTDKALLKQLMTILFDNAIKYTDHNGVVEVKVRTTDKHLLISVIDNGPGIKDDDKKKIFDRFYRVDKARTRQKG
GFGLGLALAQQIVTSLKGTITVSDNKPTGAIFEVKL

Sequences:

>Translated_436_residues
MNKLKKGLLSDNYTHFFHFFAIFTGIFVVMTIIILQIMRFSVYSTVDSSLISVGQNASNYANRTMARISSFYFDAENNLI
QALPELEASKSLGSSTTNMDIILFSANGTILNSFDAFSNYQSFRLDKSQLNNIVTTQLMNFYGQKEKYHTLTVKVHIKNY
PAVAYMMAVVNVQQLDTANERYEQIIIMVMIVFWLISILASIYLAKWSRKPIMESYAKQKMFVENASHELRTPLAVLQNR
LESLFRKPNETILDNSEHIASSLDEVRNMRILTTNLLNLARRDDGIKPQLVDVDAAFFDTVFENYQLVAEESGKQFISAN
QINRPLKTDKALLKQLMTILFDNAIKYTDHNGVVEVKVRTTDKHLLISVIDNGPGIKDDDKKKIFDRFYRVDKARTRQKG
GFGLGLALAQQIVTSLKGTITVSDNKPTGAIFEVKL
>Mature_436_residues
MNKLKKGLLSDNYTHFFHFFAIFTGIFVVMTIIILQIMRFSVYSTVDSSLISVGQNASNYANRTMARISSFYFDAENNLI
QALPELEASKSLGSSTTNMDIILFSANGTILNSFDAFSNYQSFRLDKSQLNNIVTTQLMNFYGQKEKYHTLTVKVHIKNY
PAVAYMMAVVNVQQLDTANERYEQIIIMVMIVFWLISILASIYLAKWSRKPIMESYAKQKMFVENASHELRTPLAVLQNR
LESLFRKPNETILDNSEHIASSLDEVRNMRILTTNLLNLARRDDGIKPQLVDVDAAFFDTVFENYQLVAEESGKQFISAN
QINRPLKTDKALLKQLMTILFDNAIKYTDHNGVVEVKVRTTDKHLLISVIDNGPGIKDDDKKKIFDRFYRVDKARTRQKG
GFGLGLALAQQIVTSLKGTITVSDNKPTGAIFEVKL

Specific function: Member of the two-component regulatory system CiaH/CiaR. Involved in early steps of competence regulation and in penicillin susceptibility. Probably phosphorylates CiaR [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=225, Percent_Identity=32.4444444444444, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1786783, Length=221, Percent_Identity=28.9592760180996, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1786600, Length=219, Percent_Identity=30.1369863013699, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1790861, Length=220, Percent_Identity=28.6363636363636, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1790346, Length=216, Percent_Identity=29.6296296296296, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1787894, Length=221, Percent_Identity=29.4117647058824, Blast_Score=85, Evalue=9e-18,
Organism=Escherichia coli, GI1788549, Length=230, Percent_Identity=27.3913043478261, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI1786912, Length=220, Percent_Identity=30.9090909090909, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI1787374, Length=223, Percent_Identity=30.0448430493274, Blast_Score=76, Evalue=6e-15,
Organism=Escherichia coli, GI1788279, Length=215, Percent_Identity=27.906976744186, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI145693157, Length=226, Percent_Identity=26.9911504424779, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1789149, Length=242, Percent_Identity=27.2727272727273, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI48994928, Length=226, Percent_Identity=30.5309734513274, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1788713, Length=238, Percent_Identity=24.3697478991597, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI87082128, Length=226, Percent_Identity=23.8938053097345, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI87081816, Length=229, Percent_Identity=24.4541484716157, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790436, Length=276, Percent_Identity=25, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1789808, Length=220, Percent_Identity=24.0909090909091, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49575; Mature: 49575

Theoretical pI: Translated: 9.66; Mature: 9.66

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKLKKGLLSDNYTHFFHFFAIFTGIFVVMTIIILQIMRFSVYSTVDSSLISVGQNASNY
CCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
ANRTMARISSFYFDAENNLIQALPELEASKSLGSSTTNMDIILFSANGTILNSFDAFSNY
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEECHHHHCCH
QSFRLDKSQLNNIVTTQLMNFYGQKEKYHTLTVKVHIKNYPAVAYMMAVVNVQQLDTANE
HHHCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHH
RYEQIIIMVMIVFWLISILASIYLAKWSRKPIMESYAKQKMFVENASHELRTPLAVLQNR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHCHHHHHHHH
LESLFRKPNETILDNSEHIASSLDEVRNMRILTTNLLNLARRDDGIKPQLVDVDAAFFDT
HHHHHHCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCEEEECHHHHHHH
VFENYQLVAEESGKQFISANQINRPLKTDKALLKQLMTILFDNAIKYTDHNGVVEVKVRT
HHHHHHEEEHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCEEEECCCCEEEEEEEE
TDKHLLISVIDNGPGIKDDDKKKIFDRFYRVDKARTRQKGGFGLGLALAQQIVTSLKGTI
CCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEE
TVSDNKPTGAIFEVKL
EECCCCCCCCEEEEEC
>Mature Secondary Structure
MNKLKKGLLSDNYTHFFHFFAIFTGIFVVMTIIILQIMRFSVYSTVDSSLISVGQNASNY
CCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
ANRTMARISSFYFDAENNLIQALPELEASKSLGSSTTNMDIILFSANGTILNSFDAFSNY
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEECHHHHCCH
QSFRLDKSQLNNIVTTQLMNFYGQKEKYHTLTVKVHIKNYPAVAYMMAVVNVQQLDTANE
HHHCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHH
RYEQIIIMVMIVFWLISILASIYLAKWSRKPIMESYAKQKMFVENASHELRTPLAVLQNR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHCHHHHHHHH
LESLFRKPNETILDNSEHIASSLDEVRNMRILTTNLLNLARRDDGIKPQLVDVDAAFFDT
HHHHHHCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCEEEECHHHHHHH
VFENYQLVAEESGKQFISANQINRPLKTDKALLKQLMTILFDNAIKYTDHNGVVEVKVRT
HHHHHHEEEHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCEEEECCCCEEEEEEEE
TDKHLLISVIDNGPGIKDDDKKKIFDRFYRVDKARTRQKGGFGLGLALAQQIVTSLKGTI
CCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEE
TVSDNKPTGAIFEVKL
EECCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11463916 [H]