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The map label for this gene is ciaR [H]

Identifier: 195978046

GI number: 195978046

Start: 961839

End: 962513

Strand: Direct

Name: ciaR [H]

Synonym: Sez_0919

Alternate gene names: 195978046

Gene position: 961839-962513 (Clockwise)

Preceding gene: 195978045

Following gene: 195978047

Centisome position: 47.52

GC content: 37.04

Gene sequence:

>675_bases
ATGATAAAACTATTATTAGTAGAAGACGATTTAAGCTTGTCAAATTCTATCTTTGATTTTTTAGATGACTTTGCTGATGT
GACGCAGGTTTTTGATGGTGACGAAGGACTCTATGAGGCAGAAAGCGGTATTTATGATTTGATTCTGTTAGATTTGATGC
TGCCTGAAAAGGATGGCTTTCAAGTGTTAAAAGCCTTACGTGAAAAAGACATCAAAATTCCCGTCTTGATCATGACTGCC
AAAGAAAGCATCGATGACAAAGGGCATGGCTTTGAGCTTGGTGCTGATGACTATTTAACCAAGCCCTTTTACCTAGAAGA
ATTAAAAATGCGGATTCAGGCCTTGCTTAAGCGCGTAGGAAAGTTTAATGATAAGAGCCTTAAATTTGGCAACTTGACTG
TAGATACTACCCGTAAAGAGGTACAGGTCAATGGGCAGGCCATAGAGCTATTAGGCAAGGAGCTTGATTTACTAATCTAT
ATCCTTCAAAATCAAAATGTTATTTTGCCAAAATCACAAATTTTTGATCGTATCTGGGGCTTTGATAGTGATACCACTAT
CTCTGTTGTAGAGGTCTATGTCTCTAAAATTCGTAAGAAGCTTAAGGGGACAGACTTTGTTAATCATCTTCAAACCTTGA
GAAGTGTAGGATATATCTTAAAAGCTAATGAATAA

Upstream 100 bases:

>100_bases
CTTTTTGTGTTATCGTTAGATTAGAGAATTCATTTAGTAAGGTAATCCCTAAAGACTACTTGAGCGAGGCTGTTAGTCTT
TAGAGAATTGAGGTATCATA

Downstream 100 bases:

>100_bases
ACTAAAAAAAGGATTATTGTCCGATAATTATACGCATTTTTTTCATTTCTTTGCTATTTTTACAGGCATTTTTGTTGTCA
TGACCATCATTATTTTGCAA

Product: TCS transcriptional regulatory protein ciaR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MIKLLLVEDDLSLSNSIFDFLDDFADVTQVFDGDEGLYEAESGIYDLILLDLMLPEKDGFQVLKALREKDIKIPVLIMTA
KESIDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRVGKFNDKSLKFGNLTVDTTRKEVQVNGQAIELLGKELDLLIY
ILQNQNVILPKSQIFDRIWGFDSDTTISVVEVYVSKIRKKLKGTDFVNHLQTLRSVGYILKANE

Sequences:

>Translated_224_residues
MIKLLLVEDDLSLSNSIFDFLDDFADVTQVFDGDEGLYEAESGIYDLILLDLMLPEKDGFQVLKALREKDIKIPVLIMTA
KESIDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRVGKFNDKSLKFGNLTVDTTRKEVQVNGQAIELLGKELDLLIY
ILQNQNVILPKSQIFDRIWGFDSDTTISVVEVYVSKIRKKLKGTDFVNHLQTLRSVGYILKANE
>Mature_224_residues
MIKLLLVEDDLSLSNSIFDFLDDFADVTQVFDGDEGLYEAESGIYDLILLDLMLPEKDGFQVLKALREKDIKIPVLIMTA
KESIDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRVGKFNDKSLKFGNLTVDTTRKEVQVNGQAIELLGKELDLLIY
ILQNQNVILPKSQIFDRIWGFDSDTTISVVEVYVSKIRKKLKGTDFVNHLQTLRSVGYILKANE

Specific function: Member of the two-component regulatory system CiaH/CiaR. Involved in early steps of competence regulation and in penicillin susceptibility [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789402, Length=223, Percent_Identity=35.4260089686099, Blast_Score=140, Evalue=6e-35,
Organism=Escherichia coli, GI1790552, Length=224, Percent_Identity=35.2678571428571, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI1786784, Length=223, Percent_Identity=36.322869955157, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI87082012, Length=218, Percent_Identity=34.4036697247706, Blast_Score=127, Evalue=8e-31,
Organism=Escherichia coli, GI1787375, Length=221, Percent_Identity=28.0542986425339, Blast_Score=114, Evalue=6e-27,
Organism=Escherichia coli, GI1786599, Length=221, Percent_Identity=29.8642533936652, Blast_Score=113, Evalue=8e-27,
Organism=Escherichia coli, GI1786911, Length=224, Percent_Identity=30.3571428571429, Blast_Score=108, Evalue=2e-25,
Organism=Escherichia coli, GI1790860, Length=221, Percent_Identity=28.5067873303167, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI2367329, Length=230, Percent_Identity=33.9130434782609, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1787229, Length=230, Percent_Identity=26.5217391304348, Blast_Score=87, Evalue=6e-19,
Organism=Escherichia coli, GI1788394, Length=225, Percent_Identity=27.1111111111111, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1789809, Length=228, Percent_Identity=26.3157894736842, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1790863, Length=226, Percent_Identity=27.8761061946903, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI145693140, Length=243, Percent_Identity=27.5720164609054, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1790437, Length=126, Percent_Identity=29.3650793650794, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1788550, Length=72, Percent_Identity=37.5, Blast_Score=62, Evalue=2e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25542; Mature: 25542

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKLLLVEDDLSLSNSIFDFLDDFADVTQVFDGDEGLYEAESGIYDLILLDLMLPEKDGF
CEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCHHHHHHHHHHCCCCCCH
QVLKALREKDIKIPVLIMTAKESIDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRVG
HHHHHHHHCCCCCEEEEEECCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHC
KFNDKSLKFGNLTVDTTRKEVQVNGQAIELLGKELDLLIYILQNQNVILPKSQIFDRIWG
CCCCCCEEECCEEEECCHHEEEECCHHHHHHHHHHHEEEEEECCCCEECCHHHHHHHHHC
FDSDTTISVVEVYVSKIRKKLKGTDFVNHLQTLRSVGYILKANE
CCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEECCC
>Mature Secondary Structure
MIKLLLVEDDLSLSNSIFDFLDDFADVTQVFDGDEGLYEAESGIYDLILLDLMLPEKDGF
CEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCHHHHHHHHHHCCCCCCH
QVLKALREKDIKIPVLIMTAKESIDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRVG
HHHHHHHHCCCCCEEEEEECCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHC
KFNDKSLKFGNLTVDTTRKEVQVNGQAIELLGKELDLLIYILQNQNVILPKSQIFDRIWG
CCCCCCEEECCEEEECCHHEEEECCHHHHHHHHHHHEEEEEECCCCEECCHHHHHHHHHC
FDSDTTISVVEVYVSKIRKKLKGTDFVNHLQTLRSVGYILKANE
CCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11463916 [H]