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The map label for this gene is comEA [H]

Identifier: 195977787

GI number: 195977787

Start: 673504

End: 674181

Strand: Direct

Name: comEA [H]

Synonym: Sez_0651

Alternate gene names: 195977787

Gene position: 673504-674181 (Clockwise)

Preceding gene: 195977786

Following gene: 195977788

Centisome position: 33.27

GC content: 43.36

Gene sequence:

>678_bases
ATGTTAGAAGAATTGTTCCTAAAGGGTAAAGAGATGATAAAGGCCCCTTATTTTCTGTCACGCTGTGTTACTGTTGTGCT
GTCTGTAGGACTTTTGCTGGTGCTGTGGCTTGCCTTGGCTGGAGGGGAAAAAGCAAGAAAGGAGTCAGTTTCATTTCCTG
ACCATTCTCAGATTCAGCAGTCAGAAAAGCCAGCTCAGCCAGAAGCTAGTGAGCAAGAAGTAGCAGCTGAGGATATCGTA
GTGGATATTAAGGGAGCTGTTCATAAGGAGGGCGTCTATAAGCTGGCTAAGGGAAGTCGTATCACAGATCTGATTGAGCT
GGCAGGTGGCTTGACAGAGCAAGCTGATAAAAATGCTATTAATCTAGCTGAAAAGTTATCTGATGAAAAGGTCATTTATG
TTGCTAAGCTGGGTGAGAATATATCAGTCATTAAAGAGCCTTCATCTGAGACTCAATCAGCGTCTGCTGATCATCAGAAG
CCTGAAAAGGTTCATTTGAACAGGGCTAGTCTTGCTGATTTGCAACGCATTTCAGGCATTGGTGCAAAGAGAGCACAGGA
TATTATTGATGTACGAGAAAGCCTGGGTGGCTTTAAATCTCTAGAAGATCTGAGAAAGGTACCAGGTATTGGTGCTAAAA
CACTGGAGAAGCTAAAGCATGACATTTCCCTTGACTAA

Upstream 100 bases:

>100_bases
TGAGCTTAAAGAGGTAGTCCATTTTGGACTGCTTTTTTAATATGCTAGAAAATAGAACAATTTTAAAGGCTTTTATCGAA
TAATATATTGAGGTGAAAAA

Downstream 100 bases:

>100_bases
GTATTTTCCGATTGCTCCGATACAATTTGCCCTTTTAGTGCTTGTTTTGTATTATCAGATTTATAGGCCTAGCTGGTTAA
CAGCTGGTTTATTAGCTGGC

Product: DNA receptor late competence protein ComEA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MLEELFLKGKEMIKAPYFLSRCVTVVLSVGLLLVLWLALAGGEKARKESVSFPDHSQIQQSEKPAQPEASEQEVAAEDIV
VDIKGAVHKEGVYKLAKGSRITDLIELAGGLTEQADKNAINLAEKLSDEKVIYVAKLGENISVIKEPSSETQSASADHQK
PEKVHLNRASLADLQRISGIGAKRAQDIIDVRESLGGFKSLEDLRKVPGIGAKTLEKLKHDISLD

Sequences:

>Translated_225_residues
MLEELFLKGKEMIKAPYFLSRCVTVVLSVGLLLVLWLALAGGEKARKESVSFPDHSQIQQSEKPAQPEASEQEVAAEDIV
VDIKGAVHKEGVYKLAKGSRITDLIELAGGLTEQADKNAINLAEKLSDEKVIYVAKLGENISVIKEPSSETQSASADHQK
PEKVHLNRASLADLQRISGIGAKRAQDIIDVRESLGGFKSLEDLRKVPGIGAKTLEKLKHDISLD
>Mature_225_residues
MLEELFLKGKEMIKAPYFLSRCVTVVLSVGLLLVLWLALAGGEKARKESVSFPDHSQIQQSEKPAQPEASEQEVAAEDIV
VDIKGAVHKEGVYKLAKGSRITDLIELAGGLTEQADKNAINLAEKLSDEKVIYVAKLGENISVIKEPSSETQSASADHQK
PEKVHLNRASLADLQRISGIGAKRAQDIIDVRESLGGFKSLEDLRKVPGIGAKTLEKLKHDISLD

Specific function: Needed for both DNA binding and transport. It is absolutely required for the uptake of transforming DNA but not for binding. Its role in binding may be indirect [H]

COG id: COG1555

COG function: function code L; DNA uptake protein and related DNA-binding proteins

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 HhH domains [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004787
- InterPro:   IPR004509
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR019554 [H]

Pfam domain/function: PF00633 HHH; PF10531 SLBB [H]

EC number: NA

Molecular weight: Translated: 24473; Mature: 24473

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEELFLKGKEMIKAPYFLSRCVTVVLSVGLLLVLWLALAGGEKARKESVSFPDHSQIQQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCHHHHHH
SEKPAQPEASEQEVAAEDIVVDIKGAVHKEGVYKLAKGSRITDLIELAGGLTEQADKNAI
HCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHH
NLAEKLSDEKVIYVAKLGENISVIKEPSSETQSASADHQKPEKVHLNRASLADLQRISGI
HHHHHCCCCCEEEEEECCCCCEEEECCCCHHHHCCCCCCCCHHHHCCHHHHHHHHHHHCC
GAKRAQDIIDVRESLGGFKSLEDLRKVPGIGAKTLEKLKHDISLD
CHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MLEELFLKGKEMIKAPYFLSRCVTVVLSVGLLLVLWLALAGGEKARKESVSFPDHSQIQQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCHHHHHH
SEKPAQPEASEQEVAAEDIVVDIKGAVHKEGVYKLAKGSRITDLIELAGGLTEQADKNAI
HCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHH
NLAEKLSDEKVIYVAKLGENISVIKEPSSETQSASADHQKPEKVHLNRASLADLQRISGI
HHHHHCCCCCEEEEEECCCCCEEEECCCCHHHHCCCCCCCCHHHHCCHHHHHHHHHHHCC
GAKRAQDIIDVRESLGGFKSLEDLRKVPGIGAKTLEKLKHDISLD
CHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377; 7768800 [H]