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The map label for this gene is comEC [H]

Identifier: 195977788

GI number: 195977788

Start: 674162

End: 676405

Strand: Direct

Name: comEC [H]

Synonym: Sez_0652

Alternate gene names: 195977788

Gene position: 674162-676405 (Clockwise)

Preceding gene: 195977787

Following gene: 195977789

Centisome position: 33.31

GC content: 43.0

Gene sequence:

>2244_bases
ATGACATTTCCCTTGACTAAGTATTTTCCGATTGCTCCGATACAATTTGCCCTTTTAGTGCTTGTTTTGTATTATCAGAT
TTATAGGCCTAGCTGGTTAACAGCTGGTTTATTAGCTGGCTTGCTGGTATTATTAGGCTGTCGCTTTACCTTCAAGCAGG
TCTTAAAGACGCTTCTTTTGCTAGGTTTTTTTGGCTGTCTTTTTGCTTATCAAAAGGGTCAGCTAGAGGCTAATCAGATC
AATCAGCCTGATCGCTTATCAACGGTTGAGCTGATTCCAGATTCGATAATGGTGAATGGTGATCACCTATCCTTTATCGG
TCGGCATTCTGGGTGTCATTATCAATTGGCTTATCGCATGACATCAAAAGAAGAGGCAGATTTTTTTAAGCAGCAGAGTC
AATTACTAAAGCTAGAGGCTGACATCAGGCTAGAGGAAGCAGCAGGGCTTAGAAACTTTAAGGGCTTTAACCATCAGGCC
TATTTAGTCTATCAGGGAATCTTTAGAGTAGGAAAAATCAAAAGCTTGCAGTCATTGAAGATTATCTCTCCTAGGTCTAT
TAGTGATCGTATTAGCCAATGGCGACGTCAGGCCATCGTTTGGTGTCAGTCTAGGTTTCCACAGCCGATGAGTCATTATA
TGACAGGATTGTTATTTGGCTATCTTGATAAGTCCTTTGGGCAAATGACAGAGCTATACAGCCAGCTTGGTATTATCCAT
TTGTTTGCTTTATCTGGTATGCAGGTCGGCTTTTTTCTGACCTACCTGCGTCGTGGCTTGGTCTGGTTACATCTTCCAAT
AGACATGATTAAGCTACTGGAGATGGTATGTTCATTTTGCTATTCTGGTTTGACTGGTCATAGTATTTCTGTGGTACGTA
GCTTGCTGCAGGCCCAGCTGCGTCATATTGGTCTGACAGGACTAGATAATCTAGCAATGACTTTTTTGATAATGTTTTTG
ATTAATGGTCACTTTCTGATGTCTATTGGTGGCGTTTTGTCCTTTGCTTATGCTTTTATCCTTGCTACGGTCAGATTTGA
AGAGCTTTCTGGCAACAAGCAGAGGCTTTTGAAAGCCTTGGCCATTTCCTTTGGCATTGTGCCCTTGCTGGCCTATTATT
TCTCGGTTTTTAATCCGATCTCGGTAGTATTGACAGCCTTATTAGCCTATTTGTTTGATGGTCTTATCCTGCCAAGCCTA
GCGATATTGTTTTTCCTCTCACCTATTGCTGTTATGACTGTCGTCAATCCATTCTTTTTATGCTTAGAAAAGGGGATCGG
CATTATTGGACACTATTTTAGTGCTCCCTTGGTGTTAGGAAGTCCCACAGCCCTACAGCTTTGCCTTTGTATTGCTTGCT
TGGCTATAGCGTATGATTATCGAGGGAATCGAGGCTTACAGCTAGTTGCAGGTGGTCTGTTGTTGCTGACGCTCTTTACG
GTAAAATGGCCCCTGACCAATGAGGTAACGCTTGTAGATGTTGGGCAGGGAGACAGTATTTTTATTAGGGATAAGCAAAA
TCATACCATGCTGATTGATGTTGGAGGAGTGCCTGCTCCTCAGGAAAAGGAGCAATGGCAAAGGAAATACCAGGCCTGTA
ATGCCCATAAAACACTCATTCCTTATCTTAGAAGCCGAGGGGTGGATACGATTGATCAACTGGTGCTGACCCATACCGAT
ATTGATCATGTTGGAGATCTGGAGGCTGTTGTGAAGGCCTTTAGAGTTAAGCAAATATATGTTAGTCGGGGAAGCTTGAC
GAATATTCGCTTTGTCAAACGCTTGCAAAGACTCGCAATCAAGGTTAAGGCCATTAGTGCTGGTGATCAATTGCCCATTA
TGGGAAGCTTTTTAGAGGTGCTCTATCCTTGGGAGCTAGGAGATGGTAAAAACAATGACTCTTTAGTCCTTTATGGCAGG
CTGTTGGATAAAAGCTTTTTGTTTACGGGTGATTTGGAGGCAGAAGGAGAAGAAAGGCTGATTGCCCGTTATCCTAAGCT
TAGGGTTGATGTTTTAAAGGCAGCTCATCATGGCTCTAAGGGCTCTTCTATACCAGCATTTTTAGACCATATCCAGCCTC
AGCTAAGCTTGATTTCAGCAGGAAGGAACAATCAGTATCAGCACCCTAACCTCGAAACCTTAGCACGCTTTGAAGCGAGA
CACATTCCTTACTACAGTACAGCAAGCAGGGGTGCTATTCGCTTAACAGGTCAAGCTCACTGGCAATTAGAATCCTGTAG
ATAG

Upstream 100 bases:

>100_bases
GATATTATTGATGTACGAGAAAGCCTGGGTGGCTTTAAATCTCTAGAAGATCTGAGAAAGGTACCAGGTATTGGTGCTAA
AACACTGGAGAAGCTAAAGC

Downstream 100 bases:

>100_bases
GCTCATCGAGCCAGAGCTATATGCAAGGGCCTAGGTCTGGCAGTGAAGTAGAGAATGAAAAAGATCAGCTTTAGCAAGGT
CATATTTAGTAAGAAAATGC

Product: DNA transport late competence protein ComEC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 747; Mature: 746

Protein sequence:

>747_residues
MTFPLTKYFPIAPIQFALLVLVLYYQIYRPSWLTAGLLAGLLVLLGCRFTFKQVLKTLLLLGFFGCLFAYQKGQLEANQI
NQPDRLSTVELIPDSIMVNGDHLSFIGRHSGCHYQLAYRMTSKEEADFFKQQSQLLKLEADIRLEEAAGLRNFKGFNHQA
YLVYQGIFRVGKIKSLQSLKIISPRSISDRISQWRRQAIVWCQSRFPQPMSHYMTGLLFGYLDKSFGQMTELYSQLGIIH
LFALSGMQVGFFLTYLRRGLVWLHLPIDMIKLLEMVCSFCYSGLTGHSISVVRSLLQAQLRHIGLTGLDNLAMTFLIMFL
INGHFLMSIGGVLSFAYAFILATVRFEELSGNKQRLLKALAISFGIVPLLAYYFSVFNPISVVLTALLAYLFDGLILPSL
AILFFLSPIAVMTVVNPFFLCLEKGIGIIGHYFSAPLVLGSPTALQLCLCIACLAIAYDYRGNRGLQLVAGGLLLLTLFT
VKWPLTNEVTLVDVGQGDSIFIRDKQNHTMLIDVGGVPAPQEKEQWQRKYQACNAHKTLIPYLRSRGVDTIDQLVLTHTD
IDHVGDLEAVVKAFRVKQIYVSRGSLTNIRFVKRLQRLAIKVKAISAGDQLPIMGSFLEVLYPWELGDGKNNDSLVLYGR
LLDKSFLFTGDLEAEGEERLIARYPKLRVDVLKAAHHGSKGSSIPAFLDHIQPQLSLISAGRNNQYQHPNLETLARFEAR
HIPYYSTASRGAIRLTGQAHWQLESCR

Sequences:

>Translated_747_residues
MTFPLTKYFPIAPIQFALLVLVLYYQIYRPSWLTAGLLAGLLVLLGCRFTFKQVLKTLLLLGFFGCLFAYQKGQLEANQI
NQPDRLSTVELIPDSIMVNGDHLSFIGRHSGCHYQLAYRMTSKEEADFFKQQSQLLKLEADIRLEEAAGLRNFKGFNHQA
YLVYQGIFRVGKIKSLQSLKIISPRSISDRISQWRRQAIVWCQSRFPQPMSHYMTGLLFGYLDKSFGQMTELYSQLGIIH
LFALSGMQVGFFLTYLRRGLVWLHLPIDMIKLLEMVCSFCYSGLTGHSISVVRSLLQAQLRHIGLTGLDNLAMTFLIMFL
INGHFLMSIGGVLSFAYAFILATVRFEELSGNKQRLLKALAISFGIVPLLAYYFSVFNPISVVLTALLAYLFDGLILPSL
AILFFLSPIAVMTVVNPFFLCLEKGIGIIGHYFSAPLVLGSPTALQLCLCIACLAIAYDYRGNRGLQLVAGGLLLLTLFT
VKWPLTNEVTLVDVGQGDSIFIRDKQNHTMLIDVGGVPAPQEKEQWQRKYQACNAHKTLIPYLRSRGVDTIDQLVLTHTD
IDHVGDLEAVVKAFRVKQIYVSRGSLTNIRFVKRLQRLAIKVKAISAGDQLPIMGSFLEVLYPWELGDGKNNDSLVLYGR
LLDKSFLFTGDLEAEGEERLIARYPKLRVDVLKAAHHGSKGSSIPAFLDHIQPQLSLISAGRNNQYQHPNLETLARFEAR
HIPYYSTASRGAIRLTGQAHWQLESCR
>Mature_746_residues
TFPLTKYFPIAPIQFALLVLVLYYQIYRPSWLTAGLLAGLLVLLGCRFTFKQVLKTLLLLGFFGCLFAYQKGQLEANQIN
QPDRLSTVELIPDSIMVNGDHLSFIGRHSGCHYQLAYRMTSKEEADFFKQQSQLLKLEADIRLEEAAGLRNFKGFNHQAY
LVYQGIFRVGKIKSLQSLKIISPRSISDRISQWRRQAIVWCQSRFPQPMSHYMTGLLFGYLDKSFGQMTELYSQLGIIHL
FALSGMQVGFFLTYLRRGLVWLHLPIDMIKLLEMVCSFCYSGLTGHSISVVRSLLQAQLRHIGLTGLDNLAMTFLIMFLI
NGHFLMSIGGVLSFAYAFILATVRFEELSGNKQRLLKALAISFGIVPLLAYYFSVFNPISVVLTALLAYLFDGLILPSLA
ILFFLSPIAVMTVVNPFFLCLEKGIGIIGHYFSAPLVLGSPTALQLCLCIACLAIAYDYRGNRGLQLVAGGLLLLTLFTV
KWPLTNEVTLVDVGQGDSIFIRDKQNHTMLIDVGGVPAPQEKEQWQRKYQACNAHKTLIPYLRSRGVDTIDQLVLTHTDI
DHVGDLEAVVKAFRVKQIYVSRGSLTNIRFVKRLQRLAIKVKAISAGDQLPIMGSFLEVLYPWELGDGKNNDSLVLYGRL
LDKSFLFTGDLEAEGEERLIARYPKLRVDVLKAAHHGSKGSSIPAFLDHIQPQLSLISAGRNNQYQHPNLETLARFEARH
IPYYSTASRGAIRLTGQAHWQLESCR

Specific function: The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding [H]

COG id: COG0658

COG function: function code R; Predicted membrane metal-binding protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI [H]

Homologues:

Organism=Escherichia coli, GI87081801, Length=646, Percent_Identity=21.8266253869969, Blast_Score=91, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 84042; Mature: 83911

Theoretical pI: Translated: 9.48; Mature: 9.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFPLTKYFPIAPIQFALLVLVLYYQIYRPSWLTAGLLAGLLVLLGCRFTFKQVLKTLLL
CCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
LGFFGCLFAYQKGQLEANQINQPDRLSTVELIPDSIMVNGDHLSFIGRHSGCHYQLAYRM
HHHHHHHHHHHCCCCCHHHCCCCCCCCHHHCCCCCEEECCCCEEEEECCCCCEEEEEEEE
TSKEEADFFKQQSQLLKLEADIRLEEAAGLRNFKGFNHQAYLVYQGIFRVGKIKSLQSLK
CCCHHHHHHHHHHHHHHHHHCCEEHHHCCCCCCCCCCCCEEEEEHHHHHHHHHCCCCCEE
IISPRSISDRISQWRRQAIVWCQSRFPQPMSHYMTGLLFGYLDKSFGQMTELYSQLGIIH
CCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFALSGMQVGFFLTYLRRGLVWLHLPIDMIKLLEMVCSFCYSGLTGHSISVVRSLLQAQL
HHHHCCCHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
RHIGLTGLDNLAMTFLIMFLINGHFLMSIGGVLSFAYAFILATVRFEELSGNKQRLLKAL
HHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
AISFGIVPLLAYYFSVFNPISVVLTALLAYLFDGLILPSLAILFFLSPIAVMTVVNPFFL
HHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CLEKGIGIIGHYFSAPLVLGSPTALQLCLCIACLAIAYDYRGNRGLQLVAGGLLLLTLFT
HHHHCCHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
VKWPLTNEVTLVDVGQGDSIFIRDKQNHTMLIDVGGVPAPQEKEQWQRKYQACNAHKTLI
HCCCCCCCEEEEECCCCCEEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCHHHH
PYLRSRGVDTIDQLVLTHTDIDHVGDLEAVVKAFRVKQIYVSRGSLTNIRFVKRLQRLAI
HHHHHCCCCHHHHHHHHCCCCHHCCCHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHH
KVKAISAGDQLPIMGSFLEVLYPWELGDGKNNDSLVLYGRLLDKSFLFTGDLEAEGEERL
EEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEEHHCCCEEEECCCCCCCCHHH
IARYPKLRVDVLKAAHHGSKGSSIPAFLDHIQPQLSLISAGRNNQYQHPNLETLARFEAR
HHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHCHHHHHHHCCCCCCCCCCCHHHHHHHHHH
HIPYYSTASRGAIRLTGQAHWQLESCR
CCCCCCCCCCCEEEEECCEEEEECCCC
>Mature Secondary Structure 
TFPLTKYFPIAPIQFALLVLVLYYQIYRPSWLTAGLLAGLLVLLGCRFTFKQVLKTLLL
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
LGFFGCLFAYQKGQLEANQINQPDRLSTVELIPDSIMVNGDHLSFIGRHSGCHYQLAYRM
HHHHHHHHHHHCCCCCHHHCCCCCCCCHHHCCCCCEEECCCCEEEEECCCCCEEEEEEEE
TSKEEADFFKQQSQLLKLEADIRLEEAAGLRNFKGFNHQAYLVYQGIFRVGKIKSLQSLK
CCCHHHHHHHHHHHHHHHHHCCEEHHHCCCCCCCCCCCCEEEEEHHHHHHHHHCCCCCEE
IISPRSISDRISQWRRQAIVWCQSRFPQPMSHYMTGLLFGYLDKSFGQMTELYSQLGIIH
CCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFALSGMQVGFFLTYLRRGLVWLHLPIDMIKLLEMVCSFCYSGLTGHSISVVRSLLQAQL
HHHHCCCHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
RHIGLTGLDNLAMTFLIMFLINGHFLMSIGGVLSFAYAFILATVRFEELSGNKQRLLKAL
HHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
AISFGIVPLLAYYFSVFNPISVVLTALLAYLFDGLILPSLAILFFLSPIAVMTVVNPFFL
HHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CLEKGIGIIGHYFSAPLVLGSPTALQLCLCIACLAIAYDYRGNRGLQLVAGGLLLLTLFT
HHHHCCHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
VKWPLTNEVTLVDVGQGDSIFIRDKQNHTMLIDVGGVPAPQEKEQWQRKYQACNAHKTLI
HCCCCCCCEEEEECCCCCEEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCHHHH
PYLRSRGVDTIDQLVLTHTDIDHVGDLEAVVKAFRVKQIYVSRGSLTNIRFVKRLQRLAI
HHHHHCCCCHHHHHHHHCCCCHHCCCHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHH
KVKAISAGDQLPIMGSFLEVLYPWELGDGKNNDSLVLYGRLLDKSFLFTGDLEAEGEERL
EEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEEHHCCCEEEECCCCCCCCHHH
IARYPKLRVDVLKAAHHGSKGSSIPAFLDHIQPQLSLISAGRNNQYQHPNLETLARFEAR
HHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHCHHHHHHHCCCCCCCCCCCHHHHHHHHHH
HIPYYSTASRGAIRLTGQAHWQLESCR
CCCCCCCCCCCEEEEECCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]