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The map label for this gene is msrAB [H]

Identifier: 195977698

GI number: 195977698

Start: 585547

End: 586659

Strand: Direct

Name: msrAB [H]

Synonym: Sez_0560

Alternate gene names: 195977698

Gene position: 585547-586659 (Clockwise)

Preceding gene: 195977697

Following gene: 195977699

Centisome position: 28.93

GC content: 41.87

Gene sequence:

>1113_bases
ATGGAACACAAATGGAAATTATTGCTACTCGTTTTTGGAGCCTTAGTATTTTTAGGAGGTGTTTTGATGGTCTTTCAAAG
AGGCTACGCTACTAGCTACCATAATAATCAGGTCAAGCTGCCTGCCAAAGGGACGTCTCAGCTCAAGAAGACTGCTAATG
CCAAGCTGCCTGAGAAGAAAAAGGAGATTTACCTTGCAGGAGGCTGTTTCTGGGGTGTGGAGGAGTATTTTTCAAATGTT
GATGGTGTTCTAGATGCTGTTTCTGGCTATGCTAATGGTAGAGGCGACACAACCTCTTATCAATTATTGCACCAGACAGG
ACACGCTGAGACAGTTCAGGTTGTGTATGATGCTAATCGGATTAGCTTAAAGGAGCTTCTCTTACACTACTTTAGAATCA
TTGACCCAACAAGCCTCAATAAGCAGGGCAATGATCGTGGCAGTCAGTACCGTACAGGCGTTTATTATACGGATCCATCT
GATTTGACTGTTATTGATATGGTCTTTCAGGAAAAAGCTTCGGATTACAAAAAGAAAATTGTTGTGGAAAAAGCTCCCCT
AAAGAGCTTTACCAAGGCTGAGGAATATCATCAGGATTACCTCAAGAAAAATCCTAATGGCTACTGCCATATTAATGTCA
ACGAGGCTTCTTACCCAGTGATTGATAAGACAAAATACCCTAAGCCAAGTAAGGAAGAGATTAAAAAGAAGCTATCAAAG
GATGAGTATCGTGTGACCCAAAACAATGAGACTGAAAAAGCCTTTTCAAATAGGTATTGGGATTCCTTTGAAGCAGGGAT
CTATGTAGATGTGGTCACTGGTGAGCCGCTGTTTTCTTCCAAGGATAAATTTGAATCAGGCTGTGGCTGGCCAAGCTTTA
GCAGGCCTATTAGCCCAGATGTGCTACGCTATAAGACAGATAAGAGCTTCAATATGAACCGTACAGAGGTGAGAAGCCGC
TCAGGCAATTCCCATTTAGGTCATGTCTTTACCGATGGTCCTAAGGATCAGGGTGGTCTGCGTTATTGTATTAACAGTTT
ATCCATTCGATTTATTCCAAAGGCTGAAATGGAAGCTAAAGGCTATGGTTACCTTTTAACAGCAGTTGATTAG

Upstream 100 bases:

>100_bases
GCAGTGATGGCATTTTAGCTAAGAAGCATATTGGTTATGCAAAGAAATCAGAGATTGAAAAAACCTTAAAGGAGATTAAA
TAAGCAAAGGAGGCTGTCTC

Downstream 100 bases:

>100_bases
AAGATTATCCTAAGATTTGTTATAATAAGATGAGGAAGCACAGATGATTGATTATAGTTATTAAGACCTGAAGAGTGCTT
CAGTTGATATAAGCGAAATG

Product: peptide methionine sulfoxide reductase MsrA/MsrB

Products: NA

Alternate protein names: Peptide methionine sulfoxide reductase msrA; Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase; Peptide methionine sulfoxide reductase msrB; Peptide-methionine (R)-S-oxide reductase [H]

Number of amino acids: Translated: 370; Mature: 370

Protein sequence:

>370_residues
MEHKWKLLLLVFGALVFLGGVLMVFQRGYATSYHNNQVKLPAKGTSQLKKTANAKLPEKKKEIYLAGGCFWGVEEYFSNV
DGVLDAVSGYANGRGDTTSYQLLHQTGHAETVQVVYDANRISLKELLLHYFRIIDPTSLNKQGNDRGSQYRTGVYYTDPS
DLTVIDMVFQEKASDYKKKIVVEKAPLKSFTKAEEYHQDYLKKNPNGYCHINVNEASYPVIDKTKYPKPSKEEIKKKLSK
DEYRVTQNNETEKAFSNRYWDSFEAGIYVDVVTGEPLFSSKDKFESGCGWPSFSRPISPDVLRYKTDKSFNMNRTEVRSR
SGNSHLGHVFTDGPKDQGGLRYCINSLSIRFIPKAEMEAKGYGYLLTAVD

Sequences:

>Translated_370_residues
MEHKWKLLLLVFGALVFLGGVLMVFQRGYATSYHNNQVKLPAKGTSQLKKTANAKLPEKKKEIYLAGGCFWGVEEYFSNV
DGVLDAVSGYANGRGDTTSYQLLHQTGHAETVQVVYDANRISLKELLLHYFRIIDPTSLNKQGNDRGSQYRTGVYYTDPS
DLTVIDMVFQEKASDYKKKIVVEKAPLKSFTKAEEYHQDYLKKNPNGYCHINVNEASYPVIDKTKYPKPSKEEIKKKLSK
DEYRVTQNNETEKAFSNRYWDSFEAGIYVDVVTGEPLFSSKDKFESGCGWPSFSRPISPDVLRYKTDKSFNMNRTEVRSR
SGNSHLGHVFTDGPKDQGGLRYCINSLSIRFIPKAEMEAKGYGYLLTAVD
>Mature_370_residues
MEHKWKLLLLVFGALVFLGGVLMVFQRGYATSYHNNQVKLPAKGTSQLKKTANAKLPEKKKEIYLAGGCFWGVEEYFSNV
DGVLDAVSGYANGRGDTTSYQLLHQTGHAETVQVVYDANRISLKELLLHYFRIIDPTSLNKQGNDRGSQYRTGVYYTDPS
DLTVIDMVFQEKASDYKKKIVVEKAPLKSFTKAEEYHQDYLKKNPNGYCHINVNEASYPVIDKTKYPKPSKEEIKKKLSK
DEYRVTQNNETEKAFSNRYWDSFEAGIYVDVVTGEPLFSSKDKFESGCGWPSFSRPISPDVLRYKTDKSFNMNRTEVRSR
SGNSHLGHVFTDGPKDQGGLRYCINSLSIRFIPKAEMEAKGYGYLLTAVD

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the msrB Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI301336164, Length=124, Percent_Identity=44.3548387096774, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI301336162, Length=124, Percent_Identity=44.3548387096774, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI73089054, Length=124, Percent_Identity=44.3548387096774, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI37620216, Length=124, Percent_Identity=44.3548387096774, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI6912516, Length=175, Percent_Identity=36, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI208609995, Length=175, Percent_Identity=36, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI117606353, Length=133, Percent_Identity=42.1052631578947, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI208609993, Length=133, Percent_Identity=36.8421052631579, Blast_Score=86, Evalue=6e-17,
Organism=Escherichia coli, GI1788077, Length=124, Percent_Identity=48.3870967741936, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1790665, Length=180, Percent_Identity=33.8888888888889, Blast_Score=99, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI115532676, Length=133, Percent_Identity=45.1127819548872, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17553450, Length=133, Percent_Identity=45.1127819548872, Blast_Score=112, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6320881, Length=162, Percent_Identity=41.358024691358, Blast_Score=117, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6319816, Length=122, Percent_Identity=33.6065573770492, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI45553335, Length=124, Percent_Identity=44.3548387096774, Blast_Score=108, Evalue=8e-24,
Organism=Drosophila melanogaster, GI21356369, Length=124, Percent_Identity=44.3548387096774, Blast_Score=108, Evalue=8e-24,
Organism=Drosophila melanogaster, GI24645799, Length=124, Percent_Identity=44.3548387096774, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI221378664, Length=127, Percent_Identity=42.5196850393701, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI221378662, Length=134, Percent_Identity=40.2985074626866, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24645804, Length=135, Percent_Identity=40.7407407407407, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24645801, Length=135, Percent_Identity=40.7407407407407, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002579
- InterPro:   IPR011057
- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR; PF01641 SelR [H]

EC number: =1.8.4.11; =1.8.4.12 [H]

Molecular weight: Translated: 42035; Mature: 42035

Theoretical pI: Translated: 9.23; Mature: 9.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEHKWKLLLLVFGALVFLGGVLMVFQRGYATSYHNNQVKLPAKGTSQLKKTANAKLPEKK
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCHHHHHHHHCCCCCCCC
KEIYLAGGCFWGVEEYFSNVDGVLDAVSGYANGRGDTTSYQLLHQTGHAETVQVVYDANR
CEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCEEEEEECCCC
ISLKELLLHYFRIIDPTSLNKQGNDRGSQYRTGVYYTDPSDLTVIDMVFQEKASDYKKKI
CCHHHHHHHHHHHCCCCCCCCCCCCCCCCEECCEEEECCCCCEEHHHHHHHHHHHHHHHE
VVEKAPLKSFTKAEEYHQDYLKKNPNGYCHINVNEASYPVIDKTKYPKPSKEEIKKKLSK
EEECCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHCC
DEYRVTQNNETEKAFSNRYWDSFEAGIYVDVVTGEPLFSSKDKFESGCGWPSFSRPISPD
CCEEECCCCCHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCHHHHCCCCCCCCCCCCCCC
VLRYKTDKSFNMNRTEVRSRSGNSHLGHVFTDGPKDQGGLRYCINSLSIRFIPKAEMEAK
CEEEECCCCCCCCHHHHHHCCCCCCCCEEECCCCCCCCHHHHHHHCCEEEEECCCCCCCC
GYGYLLTAVD
CCEEEEEECC
>Mature Secondary Structure
MEHKWKLLLLVFGALVFLGGVLMVFQRGYATSYHNNQVKLPAKGTSQLKKTANAKLPEKK
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCHHHHHHHHCCCCCCCC
KEIYLAGGCFWGVEEYFSNVDGVLDAVSGYANGRGDTTSYQLLHQTGHAETVQVVYDANR
CEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCEEEEEECCCC
ISLKELLLHYFRIIDPTSLNKQGNDRGSQYRTGVYYTDPSDLTVIDMVFQEKASDYKKKI
CCHHHHHHHHHHHCCCCCCCCCCCCCCCCEECCEEEECCCCCEEHHHHHHHHHHHHHHHE
VVEKAPLKSFTKAEEYHQDYLKKNPNGYCHINVNEASYPVIDKTKYPKPSKEEIKKKLSK
EEECCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHCC
DEYRVTQNNETEKAFSNRYWDSFEAGIYVDVVTGEPLFSSKDKFESGCGWPSFSRPISPD
CCEEECCCCCHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCHHHHCCCCCCCCCCCCCCC
VLRYKTDKSFNMNRTEVRSRSGNSHLGHVFTDGPKDQGGLRYCINSLSIRFIPKAEMEAK
CEEEECCCCCCCCHHHHHHCCCCCCCCEEECCCCCCCCHHHHHHHCCEEEEECCCCCCCC
GYGYLLTAVD
CCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]