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The map label for this gene is hasA [H]

Identifier: 195977346

GI number: 195977346

Start: 218366

End: 219619

Strand: Direct

Name: hasA [H]

Synonym: Sez_0199

Alternate gene names: 195977346

Gene position: 218366-219619 (Clockwise)

Preceding gene: 195977344

Following gene: 195977347

Centisome position: 10.79

GC content: 39.95

Gene sequence:

>1254_bases
ATGAGAACATTAAAAAACCTCATAACTGTTGTGGCCTTTAGTATTTTTTGGGTACTGTTGATTTACGTCAATGTTTATCT
CTTTGGTGCTAAAGGAAGCTTGTCAATTTATGGCTTTTTGCTGATAGCTTACCTATTAGTCAAAATGTCCTTATCCTTTT
TTTACAAGCCATTTAAGGGAAGGGCTGGGCAATATAAGGTTGCAGCCATTATTCCCTCTTATAACGAAGATGCTGAGTCA
TTGCTAGAGACCTTAAAAAGTGTTCAGCAGCAAACCTATCCCCTAGCAGAAATTTATGTTGTTGACGATGGAAGTGCTGA
TGAGACAGGTATTAAGCGCATTGAAGACTATGTGCGTGACACTGGTGACCTATCAAGCAATGTCATTGTTCATCGGTCAG
AGAAAAATCAAGGAAAGCGTCATGCACAGGCCTGGGCCTTTGAAAGATCAGACGCTGATGTCTTTTTGACCGTTGACTCA
GATACTTATATCTACCCTGATGCTTTAGAGGAGTTGTTAAAAACCTTTAATGACCCAACTGTTTTTGCTGCGACGGGTCA
CCTTAATGTCAGAAATAGACAAACCAATCTCTTAACACGCTTGACAGATATTCGCTATGATAATGCTTTTGGCGTTGAAC
GAGCTGCCCAATCCGTTACAGGTAATATCCTTGTTTGCTCAGGTCCGCTTAGCGTTTACAGACGCGAGGTGGTTGTTCCT
AACATAGATAGATACATCAACCAGACCTTCCTGGGTATTCCTGTAAGTATTGGTGATGACAGGTGCTTGACCAACTATGC
AACTGATTTAGGAAAGACTGTTTATCAATCCACTGCTAAATGTATTACAGATGTTCCTGACAAGATGTCTACTTACTTGA
AGCAGCAAAACCGCTGGAACAAGTCCTTCTTTAGAGAGTCCATTATTTCTGTTAAGAAAATCATGAACAATCCTTTTGTA
GCCCTATGGACCATACTTGAGGTGTCTATGTTTATGATGCTTGTTTATTCTGTGGTGGATTTCTTTGTAGGCAATGTCAG
AGAATTTGATTGGCTCAGGGTTTTAGCCTTTCTGGTGATTATCTTCATTGTTGCCCTGTGTCGGAACATTCATTACATGC
TTAAGCACCCGCTGTCCTTCTTGTTATCTCCGTTTTATGGGGTGCTGCATTTGTTTGTCCTACAGCCCTTGAAATTATAT
TCTCTTTTTACTATTAGAAATGCTGACTGGGGAACACGTAAAAAATTATTATAA

Upstream 100 bases:

>100_bases
GTAAATTAATGACCTTGTTTGCTTGCTGTGACAGATAGTATATTATGGTTAGCGTTTAAAGGCAAAATACAAAGCGCAAG
AAAGGAACAAACCAATCACA

Downstream 100 bases:

>100_bases
ACCAACTAGACCTAGGTTCTGACAAGGGAGCTAAGCTAGGGATAAACAAAGAGTTTTGATCCGACTCGAGCAGCTCATAA
ACGAAAGCTATCCCACTTGT

Product: hyaluronan synthase HasA

Products: NA

Alternate protein names: Hyaluronate synthase; Hyaluronic acid synthase; HA synthase [H]

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MRTLKNLITVVAFSIFWVLLIYVNVYLFGAKGSLSIYGFLLIAYLLVKMSLSFFYKPFKGRAGQYKVAAIIPSYNEDAES
LLETLKSVQQQTYPLAEIYVVDDGSADETGIKRIEDYVRDTGDLSSNVIVHRSEKNQGKRHAQAWAFERSDADVFLTVDS
DTYIYPDALEELLKTFNDPTVFAATGHLNVRNRQTNLLTRLTDIRYDNAFGVERAAQSVTGNILVCSGPLSVYRREVVVP
NIDRYINQTFLGIPVSIGDDRCLTNYATDLGKTVYQSTAKCITDVPDKMSTYLKQQNRWNKSFFRESIISVKKIMNNPFV
ALWTILEVSMFMMLVYSVVDFFVGNVREFDWLRVLAFLVIIFIVALCRNIHYMLKHPLSFLLSPFYGVLHLFVLQPLKLY
SLFTIRNADWGTRKKLL

Sequences:

>Translated_417_residues
MRTLKNLITVVAFSIFWVLLIYVNVYLFGAKGSLSIYGFLLIAYLLVKMSLSFFYKPFKGRAGQYKVAAIIPSYNEDAES
LLETLKSVQQQTYPLAEIYVVDDGSADETGIKRIEDYVRDTGDLSSNVIVHRSEKNQGKRHAQAWAFERSDADVFLTVDS
DTYIYPDALEELLKTFNDPTVFAATGHLNVRNRQTNLLTRLTDIRYDNAFGVERAAQSVTGNILVCSGPLSVYRREVVVP
NIDRYINQTFLGIPVSIGDDRCLTNYATDLGKTVYQSTAKCITDVPDKMSTYLKQQNRWNKSFFRESIISVKKIMNNPFV
ALWTILEVSMFMMLVYSVVDFFVGNVREFDWLRVLAFLVIIFIVALCRNIHYMLKHPLSFLLSPFYGVLHLFVLQPLKLY
SLFTIRNADWGTRKKLL
>Mature_417_residues
MRTLKNLITVVAFSIFWVLLIYVNVYLFGAKGSLSIYGFLLIAYLLVKMSLSFFYKPFKGRAGQYKVAAIIPSYNEDAES
LLETLKSVQQQTYPLAEIYVVDDGSADETGIKRIEDYVRDTGDLSSNVIVHRSEKNQGKRHAQAWAFERSDADVFLTVDS
DTYIYPDALEELLKTFNDPTVFAATGHLNVRNRQTNLLTRLTDIRYDNAFGVERAAQSVTGNILVCSGPLSVYRREVVVP
NIDRYINQTFLGIPVSIGDDRCLTNYATDLGKTVYQSTAKCITDVPDKMSTYLKQQNRWNKSFFRESIISVKKIMNNPFV
ALWTILEVSMFMMLVYSVVDFFVGNVREFDWLRVLAFLVIIFIVALCRNIHYMLKHPLSFLLSPFYGVLHLFVLQPLKLY
SLFTIRNADWGTRKKLL

Specific function: Glycosaminoglycan synthesis. The hyaluronic acid capsule is involved in the pathogenicity of group A Streptococci; it may be the major virulence determinant [H]

COG id: COG1215

COG function: function code M; Glycosyltransferases, probably involved in cell wall biogenesis

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nodC/HAS family [H]

Homologues:

Organism=Homo sapiens, GI20302153, Length=441, Percent_Identity=28.3446712018141, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI4885391, Length=432, Percent_Identity=26.8518518518519, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI167466171, Length=444, Percent_Identity=27.7027027027027, Blast_Score=132, Evalue=7e-31,
Organism=Escherichia coli, GI1787259, Length=237, Percent_Identity=24.4725738396624, Blast_Score=73, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001173 [H]

Pfam domain/function: PF00535 Glycos_transf_2 [H]

EC number: =2.4.1.212 [H]

Molecular weight: Translated: 47778; Mature: 47778

Theoretical pI: Translated: 9.04; Mature: 9.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTLKNLITVVAFSIFWVLLIYVNVYLFGAKGSLSIYGFLLIAYLLVKMSLSFFYKPFKG
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
RAGQYKVAAIIPSYNEDAESLLETLKSVQQQTYPLAEIYVVDDGSADETGIKRIEDYVRD
CCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHC
TGDLSSNVIVHRSEKNQGKRHAQAWAFERSDADVFLTVDSDTYIYPDALEELLKTFNDPT
CCCCCCCEEEEECCCCCCHHHHHHHHEECCCCEEEEEECCCCEECHHHHHHHHHHCCCCE
VFAATGHLNVRNRQTNLLTRLTDIRYDNAFGVERAAQSVTGNILVCSGPLSVYRREVVVP
EEEEECCEEECCHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCEEEECCCHHHHHHHCCCC
NIDRYINQTFLGIPVSIGDDRCLTNYATDLGKTVYQSTAKCITDVPDKMSTYLKQQNRWN
CHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCC
KSFFRESIISVKKIMNNPFVALWTILEVSMFMMLVYSVVDFFVGNVREFDWLRVLAFLVI
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
IFIVALCRNIHYMLKHPLSFLLSPFYGVLHLFVLQPLKLYSLFTIRNADWGTRKKLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCC
>Mature Secondary Structure
MRTLKNLITVVAFSIFWVLLIYVNVYLFGAKGSLSIYGFLLIAYLLVKMSLSFFYKPFKG
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
RAGQYKVAAIIPSYNEDAESLLETLKSVQQQTYPLAEIYVVDDGSADETGIKRIEDYVRD
CCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHC
TGDLSSNVIVHRSEKNQGKRHAQAWAFERSDADVFLTVDSDTYIYPDALEELLKTFNDPT
CCCCCCCEEEEECCCCCCHHHHHHHHEECCCCEEEEEECCCCEECHHHHHHHHHHCCCCE
VFAATGHLNVRNRQTNLLTRLTDIRYDNAFGVERAAQSVTGNILVCSGPLSVYRREVVVP
EEEEECCEEECCHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCEEEECCCHHHHHHHCCCC
NIDRYINQTFLGIPVSIGDDRCLTNYATDLGKTVYQSTAKCITDVPDKMSTYLKQQNRWN
CHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCC
KSFFRESIISVKKIMNNPFVALWTILEVSMFMMLVYSVVDFFVGNVREFDWLRVLAFLVI
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
IFIVALCRNIHYMLKHPLSFLLSPFYGVLHLFVLQPLKLYSLFTIRNADWGTRKKLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]