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The map label for this gene is hasB [H]

Identifier: 195977347

GI number: 195977347

Start: 219878

End: 221083

Strand: Direct

Name: hasB [H]

Synonym: Sez_0200

Alternate gene names: 195977347

Gene position: 219878-221083 (Clockwise)

Preceding gene: 195977346

Following gene: 195977348

Centisome position: 10.86

GC content: 41.79

Gene sequence:

>1206_bases
GTGAAAATTTCTGTAGCAGGCTCAGGATATGTCGGCCTATCCTTGAGTATTTTACTGGCACAACATAATGACGTCACTGT
TGTTGACATTATTGATGAAAAGGTGAGATTGATCAATCAAGGCATATCGCCAATCAAGGATGCTGATATTGAGGAGTATT
TAAAAAATGCGCCGCTAAATCTCACAGCGACGCTTGATGGCGCAAGCGCTTATAGCAATGCAGACCTTATTATCATTGCT
ACTCCGACAAATTATGACAGCGAACGCAACTACTTTGACACAAGGCATGTTGAAGAGGTCATCGAGCAGGTCCTAGACCT
AAATGCGTCAGCAACCATTATTATCAAATCAACCATACCACTAGGCTTTATCAAGCATGTTAGGGAAAAATACCAGACAG
ATCGTATTATTTTTAGCCCAGAATTTTTAAGAGAATCAAAAGCCTTATACGATAACCTTTACCCAAGTCGGATCATTGTT
TCTTATGAAAAGGACGACTCACCAAGGGTTATTCAGGCTGCTAAAGCCTTTGCTGGTCTTTTAAAGGAAGGAGCCAAAAG
CAAGGATACTCCGGTCTTATTTATGGGCTCACAGGAGGCTGAGGCGGTCAAGCTATTTGCGAATACCTTTTTGGCTATGC
GGGTGTCTTACTTTAATGAATTAGACACCTATTCCGAAAGCAAGGGTCTAGATGCTCAGCGCGTGATTGAAGGAGTCTGT
CATGATCAGCGCATTGGTAACCATTACAATAACCCTTCCTTTGGATATGGCGGCTATTGCCTGCCAAAGGACAGCAAGCA
GCTGTTGGCAAATTATAGAGGCATTCCCCAGTCCTTGATGTCAGCGATTGTTGAATCCAACAAGATACGAAAATCTTATT
TGGCTGAACAAATATTAGACAGAGCCTCTAGTCAAAAGCAGGCTGGTGTACCATTAACGATTGGCTTTTACCGCTTGATT
ATGAAAAGCAACTCTGATAATTTCCGAGAAAGCGCCATTAAAGATATTATTGATATCATCAACGACTATGGGGTTAATAT
TGTCATTTACGAACCCATGCTTGGCGAGGATATTGGCTACAGGGTTGTCAAGGACTTAGAGCAGTTCAAAAACGAGTCTA
CAATCATTGTGTCAAATCGCTTTGAGGACGACCTAGGAGATGTCATTGATAAGGTTTATACGAGAGATGTCTTTGGAAGA
GACTAG

Upstream 100 bases:

>100_bases
TCAGCTTTGGTGTGAGGGCTAGGTCATTATGATCCTTCAGGTGTGGCACCTGAGCTCCGGCAGTAGCTAACTGTACTAAG
GTATCAAAGGAAAAAATGAA

Downstream 100 bases:

>100_bases
TCAGAAAACGAATGGCACTCATAAGGAACCACAAATCAAGGAGGAACTCATGACAAAGGTCAGAAAAGCCATTATCCCAG
CCGCCGGCCTAGGCACTCGC

Product: UDP-glucose 6-dehydrogenase HasB

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH [H]

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MKISVAGSGYVGLSLSILLAQHNDVTVVDIIDEKVRLINQGISPIKDADIEEYLKNAPLNLTATLDGASAYSNADLIIIA
TPTNYDSERNYFDTRHVEEVIEQVLDLNASATIIIKSTIPLGFIKHVREKYQTDRIIFSPEFLRESKALYDNLYPSRIIV
SYEKDDSPRVIQAAKAFAGLLKEGAKSKDTPVLFMGSQEAEAVKLFANTFLAMRVSYFNELDTYSESKGLDAQRVIEGVC
HDQRIGNHYNNPSFGYGGYCLPKDSKQLLANYRGIPQSLMSAIVESNKIRKSYLAEQILDRASSQKQAGVPLTIGFYRLI
MKSNSDNFRESAIKDIIDIINDYGVNIVIYEPMLGEDIGYRVVKDLEQFKNESTIIVSNRFEDDLGDVIDKVYTRDVFGR
D

Sequences:

>Translated_401_residues
MKISVAGSGYVGLSLSILLAQHNDVTVVDIIDEKVRLINQGISPIKDADIEEYLKNAPLNLTATLDGASAYSNADLIIIA
TPTNYDSERNYFDTRHVEEVIEQVLDLNASATIIIKSTIPLGFIKHVREKYQTDRIIFSPEFLRESKALYDNLYPSRIIV
SYEKDDSPRVIQAAKAFAGLLKEGAKSKDTPVLFMGSQEAEAVKLFANTFLAMRVSYFNELDTYSESKGLDAQRVIEGVC
HDQRIGNHYNNPSFGYGGYCLPKDSKQLLANYRGIPQSLMSAIVESNKIRKSYLAEQILDRASSQKQAGVPLTIGFYRLI
MKSNSDNFRESAIKDIIDIINDYGVNIVIYEPMLGEDIGYRVVKDLEQFKNESTIIVSNRFEDDLGDVIDKVYTRDVFGR
D
>Mature_401_residues
MKISVAGSGYVGLSLSILLAQHNDVTVVDIIDEKVRLINQGISPIKDADIEEYLKNAPLNLTATLDGASAYSNADLIIIA
TPTNYDSERNYFDTRHVEEVIEQVLDLNASATIIIKSTIPLGFIKHVREKYQTDRIIFSPEFLRESKALYDNLYPSRIIV
SYEKDDSPRVIQAAKAFAGLLKEGAKSKDTPVLFMGSQEAEAVKLFANTFLAMRVSYFNELDTYSESKGLDAQRVIEGVC
HDQRIGNHYNNPSFGYGGYCLPKDSKQLLANYRGIPQSLMSAIVESNKIRKSYLAEQILDRASSQKQAGVPLTIGFYRLI
MKSNSDNFRESAIKDIIDIINDYGVNIVIYEPMLGEDIGYRVVKDLEQFKNESTIIVSNRFEDDLGDVIDKVYTRDVFGR
D

Specific function: Catalyzes the formation of UDP-glucuronic acid which is required for capsular hyaluronic acid synthesis [H]

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=387, Percent_Identity=25.8397932816537, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI296040438, Length=288, Percent_Identity=25, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI296040443, Length=374, Percent_Identity=23.2620320855615, Blast_Score=90, Evalue=5e-18,
Organism=Escherichia coli, GI1788340, Length=403, Percent_Identity=53.5980148883375, Blast_Score=451, Evalue=1e-128,
Organism=Caenorhabditis elegans, GI17560350, Length=377, Percent_Identity=26.525198938992, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI17136908, Length=375, Percent_Identity=27.2, Blast_Score=115, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 44994; Mature: 44994

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKISVAGSGYVGLSLSILLAQHNDVTVVDIIDEKVRLINQGISPIKDADIEEYLKNAPLN
CEEEECCCCCCCEEEEEEEECCCCEEEEEHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCE
LTATLDGASAYSNADLIIIATPTNYDSERNYFDTRHVEEVIEQVLDLNASATIIIKSTIP
EEEEECCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCC
LGFIKHVREKYQTDRIIFSPEFLRESKALYDNLYPSRIIVSYEKDDSPRVIQAAKAFAGL
HHHHHHHHHHHCCCEEEECHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHH
LKEGAKSKDTPVLFMGSQEAEAVKLFANTFLAMRVSYFNELDTYSESKGLDAQRVIEGVC
HHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
HDQRIGNHYNNPSFGYGGYCLPKDSKQLLANYRGIPQSLMSAIVESNKIRKSYLAEQILD
HHHHHCCCCCCCCCCCCCEECCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RASSQKQAGVPLTIGFYRLIMKSNSDNFRESAIKDIIDIINDYGVNIVIYEPMLGEDIGY
HHCCHHHCCCCEEHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHH
RVVKDLEQFKNESTIIVSNRFEDDLGDVIDKVYTRDVFGRD
HHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKISVAGSGYVGLSLSILLAQHNDVTVVDIIDEKVRLINQGISPIKDADIEEYLKNAPLN
CEEEECCCCCCCEEEEEEEECCCCEEEEEHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCE
LTATLDGASAYSNADLIIIATPTNYDSERNYFDTRHVEEVIEQVLDLNASATIIIKSTIP
EEEEECCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCC
LGFIKHVREKYQTDRIIFSPEFLRESKALYDNLYPSRIIVSYEKDDSPRVIQAAKAFAGL
HHHHHHHHHHHCCCEEEECHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHH
LKEGAKSKDTPVLFMGSQEAEAVKLFANTFLAMRVSYFNELDTYSESKGLDAQRVIEGVC
HHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
HDQRIGNHYNNPSFGYGGYCLPKDSKQLLANYRGIPQSLMSAIVESNKIRKSYLAEQILD
HHHHHCCCCCCCCCCCCCEECCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RASSQKQAGVPLTIGFYRLIMKSNSDNFRESAIKDIIDIINDYGVNIVIYEPMLGEDIGY
HHCCHHHCCCCEEHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHH
RVVKDLEQFKNESTIIVSNRFEDDLGDVIDKVYTRDVFGRD
HHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]