Click here to switch to the map view.

The map label for this gene is adhA [H]

Identifier: 195977198

GI number: 195977198

Start: 57813

End: 58829

Strand: Direct

Name: adhA [H]

Synonym: Sez_0046

Alternate gene names: 195977198

Gene position: 57813-58829 (Clockwise)

Preceding gene: 195977197

Following gene: 195977199

Centisome position: 2.86

GC content: 44.44

Gene sequence:

>1017_bases
ATGAAGGCTGTAGTTGTTAACCAAACCAGCAGTGGTGTAGAGGTTGTAGAGCATGATGTACCATCAATCGGTCATGGAGA
AGCTCTTGTTAAAGTAGAATATTGTGGCGTATGTCATACTGACTTGCATGTTGCGCATGGTGATTTTGGTCAGGTTCCAG
GGCGTATCCTCGGTCATGAAGGTATCGGTATTGTTGAAAAGCTAGGTGAAGGCGTTACCTCCTTAAAGGTTGGTGATCGT
GTATCAATTGCTTGGTTCTTTGAAGGCTGCGGTCACTGTGAATATTGTACAACAGGTCGCGAAACCCTATGCCGTTCAGT
CAAAAATGCTGGCTATTCAGTTGATGGTGGGATGAGTGAGTATGCAGTTGTTACAGCTGACTATGCTGTGAAAGTGCCAG
ATGGTCTTGACCCAGCTCAAGCATCATCAATTACCTGTGCAGGCGTTACAACCTATAAGGCTATCAAAGAAGCAGGTGCC
GCTCCAGGACAATGGATTGTTATCTTTGGTGCCGGTGGACTTGGTAACCTAGCTGTTCAGTATGCTAAAAAGGTTTTCAA
TGCCCATGTTGTAGCAGTGGACATTAACAACGATAAGCTAGAGCTGGCCAAGGAGGTTGGAGCAGATATCGTTGTCAATG
GTAAAGAAATCGAAGATGTTGCAGGCTATATCCAAGAAAAAACAGGTGGTGCTCATGGTGTCGTAGTAACTGCTGTTTCT
AAAGTAGCCTTTAACCAAGCTATTGATAGTGTGCGTGCAGGAGGAACTGTTGTTGCTGTAGGACTTCCATCAGAATACAT
GGAATTATCTATTGTAAAAACTGTTCTAGACGGAATCAAGGTAGTCGGATCGCTTGTAGGAACTCGTAAAGACTTGGAAG
AAGCCTTTGCCTTTGGTGCAGAAGGCTTGGTTGTGCCAGTTGTAGAAAAGGTTCCAGTTGAGACTGCTCCAGAAGTCTTT
GACGAAATGGAACGTGGCCTCATTCAAGGAAGAAAGGTATTGGATTTCACGATTTAA

Upstream 100 bases:

>100_bases
AAGAAATTGGTTGACAAACCTTGTGAAAAAGTATACAATAAAAATTGTAAACGGTTGCAAAAAAATAGATAAACCGAGAC
TTAGAAATTGGAGGCATCCT

Downstream 100 bases:

>100_bases
GGCTGATTTTGGAAAAAATTAGCAGCAAGACAAGCTAGCTGATTGTCTCAGATGATTAATAAAGTCCTTAGAATTGATTT
TCTAAGGACTTTTTTGGTGA

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: Alcohol dehydrogenase I; ADH I [H]

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MKAVVVNQTSSGVEVVEHDVPSIGHGEALVKVEYCGVCHTDLHVAHGDFGQVPGRILGHEGIGIVEKLGEGVTSLKVGDR
VSIAWFFEGCGHCEYCTTGRETLCRSVKNAGYSVDGGMSEYAVVTADYAVKVPDGLDPAQASSITCAGVTTYKAIKEAGA
APGQWIVIFGAGGLGNLAVQYAKKVFNAHVVAVDINNDKLELAKEVGADIVVNGKEIEDVAGYIQEKTGGAHGVVVTAVS
KVAFNQAIDSVRAGGTVVAVGLPSEYMELSIVKTVLDGIKVVGSLVGTRKDLEEAFAFGAEGLVVPVVEKVPVETAPEVF
DEMERGLIQGRKVLDFTI

Sequences:

>Translated_338_residues
MKAVVVNQTSSGVEVVEHDVPSIGHGEALVKVEYCGVCHTDLHVAHGDFGQVPGRILGHEGIGIVEKLGEGVTSLKVGDR
VSIAWFFEGCGHCEYCTTGRETLCRSVKNAGYSVDGGMSEYAVVTADYAVKVPDGLDPAQASSITCAGVTTYKAIKEAGA
APGQWIVIFGAGGLGNLAVQYAKKVFNAHVVAVDINNDKLELAKEVGADIVVNGKEIEDVAGYIQEKTGGAHGVVVTAVS
KVAFNQAIDSVRAGGTVVAVGLPSEYMELSIVKTVLDGIKVVGSLVGTRKDLEEAFAFGAEGLVVPVVEKVPVETAPEVF
DEMERGLIQGRKVLDFTI
>Mature_338_residues
MKAVVVNQTSSGVEVVEHDVPSIGHGEALVKVEYCGVCHTDLHVAHGDFGQVPGRILGHEGIGIVEKLGEGVTSLKVGDR
VSIAWFFEGCGHCEYCTTGRETLCRSVKNAGYSVDGGMSEYAVVTADYAVKVPDGLDPAQASSITCAGVTTYKAIKEAGA
APGQWIVIFGAGGLGNLAVQYAKKVFNAHVVAVDINNDKLELAKEVGADIVVNGKEIEDVAGYIQEKTGGAHGVVVTAVS
KVAFNQAIDSVRAGGTVVAVGLPSEYMELSIVKTVLDGIKVVGSLVGTRKDLEEAFAFGAEGLVVPVVEKVPVETAPEVF
DEMERGLIQGRKVLDFTI

Specific function: Preferred Specificity Is Towards 1-Propanol. [C]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=371, Percent_Identity=29.3800539083558, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI34577061, Length=371, Percent_Identity=29.9191374663073, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI156627571, Length=334, Percent_Identity=27.8443113772455, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI71743840, Length=295, Percent_Identity=29.8305084745763, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI262073058, Length=295, Percent_Identity=29.8305084745763, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI4501929, Length=361, Percent_Identity=29.0858725761773, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI71565154, Length=250, Percent_Identity=34, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI71565152, Length=347, Percent_Identity=27.0893371757925, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI4501939, Length=250, Percent_Identity=30, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI156523966, Length=250, Percent_Identity=30, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI28557745, Length=275, Percent_Identity=26.5454545454545, Blast_Score=69, Evalue=8e-12,
Organism=Escherichia coli, GI87081918, Length=336, Percent_Identity=66.0714285714286, Blast_Score=405, Evalue=1e-114,
Organism=Escherichia coli, GI1790045, Length=337, Percent_Identity=29.3768545994065, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1787863, Length=346, Percent_Identity=28.9017341040462, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1786518, Length=324, Percent_Identity=28.0864197530864, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1788073, Length=265, Percent_Identity=32.0754716981132, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI226510992, Length=339, Percent_Identity=28.6135693215339, Blast_Score=118, Evalue=7e-28,
Organism=Escherichia coli, GI87082401, Length=343, Percent_Identity=25.9475218658892, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1788075, Length=344, Percent_Identity=28.1976744186047, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1790718, Length=310, Percent_Identity=28.7096774193548, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1786552, Length=246, Percent_Identity=33.739837398374, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1788407, Length=297, Percent_Identity=29.2929292929293, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI87082125, Length=343, Percent_Identity=25.3644314868805, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1786825, Length=371, Percent_Identity=26.9541778975741, Blast_Score=87, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17562582, Length=342, Percent_Identity=38.8888888888889, Blast_Score=204, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI17562584, Length=341, Percent_Identity=37.8299120234604, Blast_Score=202, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI71988145, Length=341, Percent_Identity=37.2434017595308, Blast_Score=201, Evalue=5e-52,
Organism=Caenorhabditis elegans, GI17562876, Length=264, Percent_Identity=32.9545454545455, Blast_Score=123, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17562878, Length=271, Percent_Identity=31.7343173431734, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI25146526, Length=271, Percent_Identity=28.7822878228782, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71997431, Length=279, Percent_Identity=26.8817204301075, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17565904, Length=264, Percent_Identity=27.6515151515151, Blast_Score=82, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6324486, Length=340, Percent_Identity=40.5882352941176, Blast_Score=237, Evalue=2e-63,
Organism=Saccharomyces cerevisiae, GI6319621, Length=341, Percent_Identity=40.4692082111437, Blast_Score=236, Evalue=3e-63,
Organism=Saccharomyces cerevisiae, GI6323961, Length=341, Percent_Identity=39.8826979472141, Blast_Score=233, Evalue=3e-62,
Organism=Saccharomyces cerevisiae, GI6323729, Length=340, Percent_Identity=39.7058823529412, Blast_Score=232, Evalue=7e-62,
Organism=Saccharomyces cerevisiae, GI6319949, Length=335, Percent_Identity=29.5522388059701, Blast_Score=132, Evalue=9e-32,
Organism=Saccharomyces cerevisiae, GI6323980, Length=319, Percent_Identity=28.5266457680251, Blast_Score=112, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6320033, Length=230, Percent_Identity=36.5217391304348, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6322619, Length=333, Percent_Identity=27.6276276276276, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6319955, Length=325, Percent_Identity=27.3846153846154, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6323099, Length=263, Percent_Identity=31.5589353612167, Blast_Score=93, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6319258, Length=289, Percent_Identity=24.5674740484429, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319257, Length=314, Percent_Identity=24.203821656051, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17737897, Length=197, Percent_Identity=34.010152284264, Blast_Score=107, Evalue=8e-24,
Organism=Drosophila melanogaster, GI17137530, Length=222, Percent_Identity=31.981981981982, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI17737895, Length=345, Percent_Identity=29.2753623188406, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI45550770, Length=280, Percent_Identity=23.5714285714286, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI221457811, Length=280, Percent_Identity=23.5714285714286, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI45551930, Length=280, Percent_Identity=23.5714285714286, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 35343; Mature: 35343

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVVVNQTSSGVEVVEHDVPSIGHGEALVKVEYCGVCHTDLHVAHGDFGQVPGRILGHE
CCEEEEECCCCCCHHHHCCCCCCCCCCEEEEEEECCEECCCEEEECCCCCCCCCEEECCC
GIGIVEKLGEGVTSLKVGDRVSIAWFFEGCGHCEYCTTGRETLCRSVKNAGYSVDGGMSE
CCHHHHHHCCCCEEEECCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCC
YAVVTADYAVKVPDGLDPAQASSITCAGVTTYKAIKEAGAAPGQWIVIFGAGGLGNLAVQ
EEEEEECEEEECCCCCCCCCCCCEEEECHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHH
YAKKVFNAHVVAVDINNDKLELAKEVGADIVVNGKEIEDVAGYIQEKTGGAHGVVVTAVS
HHHHHHCCEEEEEEECCCHHHHHHHCCCEEEECCCHHHHHHHHHHHCCCCCCEEHHHHHH
KVAFNQAIDSVRAGGTVVAVGLPSEYMELSIVKTVLDGIKVVGSLVGTRKDLEEAFAFGA
HHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCC
EGLVVPVVEKVPVETAPEVFDEMERGLIQGRKVLDFTI
CCEEEEHHHHCCCCCCHHHHHHHHHHHHCCCEEEEECC
>Mature Secondary Structure
MKAVVVNQTSSGVEVVEHDVPSIGHGEALVKVEYCGVCHTDLHVAHGDFGQVPGRILGHE
CCEEEEECCCCCCHHHHCCCCCCCCCCEEEEEEECCEECCCEEEECCCCCCCCCEEECCC
GIGIVEKLGEGVTSLKVGDRVSIAWFFEGCGHCEYCTTGRETLCRSVKNAGYSVDGGMSE
CCHHHHHHCCCCEEEECCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCC
YAVVTADYAVKVPDGLDPAQASSITCAGVTTYKAIKEAGAAPGQWIVIFGAGGLGNLAVQ
EEEEEECEEEECCCCCCCCCCCCEEEECHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHH
YAKKVFNAHVVAVDINNDKLELAKEVGADIVVNGKEIEDVAGYIQEKTGGAHGVVVTAVS
HHHHHHCCEEEEEEECCCHHHHHHHCCCEEEECCCHHHHHHHHHHHCCCCCCEEHHHHHH
KVAFNQAIDSVRAGGTVVAVGLPSEYMELSIVKTVLDGIKVVGSLVGTRKDLEEAFAFGA
HHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCC
EGLVVPVVEKVPVETAPEVFDEMERGLIQGRKVLDFTI
CCEEEEHHHHCCCCCCHHHHHHHHHHHHCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2185223; 8320209; 2935393 [H]