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The map label for this gene is adh [H]

Identifier: 195977197

GI number: 195977197

Start: 56556

End: 57608

Strand: Direct

Name: adh [H]

Synonym: Sez_0045

Alternate gene names: 195977197

Gene position: 56556-57608 (Clockwise)

Preceding gene: 195977196

Following gene: 195977198

Centisome position: 2.79

GC content: 40.74

Gene sequence:

>1053_bases
ATGAAAGCAGCTACATATGTTGCTCCAGGCCAGCTGGAGCTTATTGATCAACCAAAACCAGAGATTCTTGCTCCGACGGA
TGCTGTGGTTCGTTTATTGAAAACAACAATCTGTGGAACAGATTTGCATATTTTAGGTGGAGATGTCCCAGAGACTACTC
ATGGTACCATTTTAGGTCATGAAGGTATTGGTATTGTCGAGTCAGTTGGCTCTGCAGTGAATAATTTTAAGGTAGGTGAT
AAGGTTATTATTTCCTGTATCACAGCCTGCAATACCTGTTATTATTGTAAAAAAGGAATTCCTGCTCATTGTGAAAGCGG
TGGTTGGATTCTAGGGCATTTGATTAATGGGACACAAGCAGAGTATGTTCATATTCCTCAAGCAGATGGCAGCCTTTATC
ATGCTCCTAAAACCGTTGAGGATGATGCCTTGGTTATGCTATCAGACATTTTCCCAACTTCCTATGAAATAGGCGTTCAG
TCTGCAAAGGTAAAACCTGGTGACACAGTGTGTATCGTTGGGGCAGGTCCTATCGGACTAGCAGCTCTTTTAACAGCACA
ATTTTATTCACCAGCTAAGCTGATCATGGTTGACTTATCAGAATCACGTTTAGAAGCGGCTAAGCGCTTTGGAGCGACAG
ATACGATTTGTTCTGGTGACCTTGATGATATTGTTAAAAAAGTCCATGAATTAACTGATGGTCGAGGCGTTGATGTTGCT
ATTGAGTGTGTGGGCTATCCTGCTACCTTTGATATCTGTCAAAAGATTGTTGCTATAGGCGGGCATGTTTCTAACGTTGG
TGTTCATGGAAAACCAGTTAGCTTGGATCTACAGGACCTATGGATCAAAAATATTACGATGTCAACTGGCCTAGTAAATG
CCAATACGACAGAAATGCTATTAAATGTTCTAAAATCAGGTAAGATTGATGCAACTAAGATGGTAACACATCACTTTAAG
CTGTCAGAGGTTGAAAAAGCCTATGAGGTCTTTAAAAATGCCGGCAGTAATAACGCCCTTAAAGTGATTATTGAAAATGA
CATTACAGCCTAA

Upstream 100 bases:

>100_bases
TTTTTCAAAATTGCCTTTTATTAATTGACAAAGAGGGTGTAAAAAATTATACTAAAAATGTAATCGATTACATTTTCTAG
ACTAAATTTGGAGACGTTTT

Downstream 100 bases:

>100_bases
AGGAATAAGATATAAATAGATAAAAGTGACAACAGCATTTGGAATGGTCTAGATGCTGTTTTTTAGCCAACTTAACTGGT
TAAGTTTATTTTCAGAAAAC

Product: Zn-dependent alcohol dehydrogenases and related dehydrogenases

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MKAATYVAPGQLELIDQPKPEILAPTDAVVRLLKTTICGTDLHILGGDVPETTHGTILGHEGIGIVESVGSAVNNFKVGD
KVIISCITACNTCYYCKKGIPAHCESGGWILGHLINGTQAEYVHIPQADGSLYHAPKTVEDDALVMLSDIFPTSYEIGVQ
SAKVKPGDTVCIVGAGPIGLAALLTAQFYSPAKLIMVDLSESRLEAAKRFGATDTICSGDLDDIVKKVHELTDGRGVDVA
IECVGYPATFDICQKIVAIGGHVSNVGVHGKPVSLDLQDLWIKNITMSTGLVNANTTEMLLNVLKSGKIDATKMVTHHFK
LSEVEKAYEVFKNAGSNNALKVIIENDITA

Sequences:

>Translated_350_residues
MKAATYVAPGQLELIDQPKPEILAPTDAVVRLLKTTICGTDLHILGGDVPETTHGTILGHEGIGIVESVGSAVNNFKVGD
KVIISCITACNTCYYCKKGIPAHCESGGWILGHLINGTQAEYVHIPQADGSLYHAPKTVEDDALVMLSDIFPTSYEIGVQ
SAKVKPGDTVCIVGAGPIGLAALLTAQFYSPAKLIMVDLSESRLEAAKRFGATDTICSGDLDDIVKKVHELTDGRGVDVA
IECVGYPATFDICQKIVAIGGHVSNVGVHGKPVSLDLQDLWIKNITMSTGLVNANTTEMLLNVLKSGKIDATKMVTHHFK
LSEVEKAYEVFKNAGSNNALKVIIENDITA
>Mature_350_residues
MKAATYVAPGQLELIDQPKPEILAPTDAVVRLLKTTICGTDLHILGGDVPETTHGTILGHEGIGIVESVGSAVNNFKVGD
KVIISCITACNTCYYCKKGIPAHCESGGWILGHLINGTQAEYVHIPQADGSLYHAPKTVEDDALVMLSDIFPTSYEIGVQ
SAKVKPGDTVCIVGAGPIGLAALLTAQFYSPAKLIMVDLSESRLEAAKRFGATDTICSGDLDDIVKKVHELTDGRGVDVA
IECVGYPATFDICQKIVAIGGHVSNVGVHGKPVSLDLQDLWIKNITMSTGLVNANTTEMLLNVLKSGKIDATKMVTHHFK
LSEVEKAYEVFKNAGSNNALKVIIENDITA

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI71565154, Length=336, Percent_Identity=29.7619047619048, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI156627571, Length=362, Percent_Identity=28.7292817679558, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI4501929, Length=336, Percent_Identity=27.0833333333333, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI71565152, Length=349, Percent_Identity=26.3610315186246, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI4501939, Length=361, Percent_Identity=25.4847645429363, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI156523966, Length=361, Percent_Identity=25.4847645429363, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI34577061, Length=334, Percent_Identity=27.5449101796407, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI4501933, Length=336, Percent_Identity=25.8928571428571, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI71743840, Length=353, Percent_Identity=24.929178470255, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI262073058, Length=353, Percent_Identity=24.929178470255, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI1786825, Length=379, Percent_Identity=29.5514511873351, Blast_Score=172, Evalue=4e-44,
Organism=Escherichia coli, GI1790045, Length=362, Percent_Identity=29.5580110497238, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1787863, Length=338, Percent_Identity=26.6272189349112, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1788075, Length=362, Percent_Identity=26.5193370165746, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI87082125, Length=340, Percent_Identity=28.5294117647059, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1788073, Length=329, Percent_Identity=27.0516717325228, Blast_Score=111, Evalue=7e-26,
Organism=Escherichia coli, GI1786552, Length=366, Percent_Identity=28.4153005464481, Blast_Score=98, Evalue=6e-22,
Organism=Escherichia coli, GI226510992, Length=314, Percent_Identity=28.0254777070064, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI87081918, Length=267, Percent_Identity=31.8352059925094, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788407, Length=270, Percent_Identity=25.9259259259259, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1790718, Length=312, Percent_Identity=22.1153846153846, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17562876, Length=350, Percent_Identity=28.5714285714286, Blast_Score=121, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17562878, Length=349, Percent_Identity=28.6532951289398, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI25146526, Length=362, Percent_Identity=28.1767955801105, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI71997431, Length=362, Percent_Identity=28.1767955801105, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17565904, Length=338, Percent_Identity=28.4023668639053, Blast_Score=108, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI71988145, Length=174, Percent_Identity=30.4597701149425, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17562584, Length=240, Percent_Identity=27.9166666666667, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323099, Length=366, Percent_Identity=27.8688524590164, Blast_Score=116, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6320033, Length=366, Percent_Identity=26.2295081967213, Blast_Score=110, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6322619, Length=357, Percent_Identity=28.0112044817927, Blast_Score=110, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6319955, Length=357, Percent_Identity=28.0112044817927, Blast_Score=110, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6319258, Length=382, Percent_Identity=25.6544502617801, Blast_Score=106, Evalue=6e-24,
Organism=Saccharomyces cerevisiae, GI6319257, Length=355, Percent_Identity=26.4788732394366, Blast_Score=90, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6323729, Length=236, Percent_Identity=27.9661016949153, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6323961, Length=346, Percent_Identity=26.3005780346821, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324486, Length=337, Percent_Identity=26.4094955489614, Blast_Score=66, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6319621, Length=236, Percent_Identity=30.0847457627119, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17737897, Length=349, Percent_Identity=30.3724928366762, Blast_Score=121, Evalue=7e-28,
Organism=Drosophila melanogaster, GI17737895, Length=338, Percent_Identity=29.8816568047337, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI17137530, Length=349, Percent_Identity=30.0859598853868, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI221457811, Length=339, Percent_Identity=22.7138643067847, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI45550770, Length=339, Percent_Identity=22.7138643067847, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI45551930, Length=339, Percent_Identity=22.7138643067847, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 37164; Mature: 37164

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAATYVAPGQLELIDQPKPEILAPTDAVVRLLKTTICGTDLHILGGDVPETTHGTILGH
CCCCEECCCCCEEECCCCCCCEECCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCEEEEC
EGIGIVESVGSAVNNFKVGDKVIISCITACNTCYYCKKGIPAHCESGGWILGHLINGTQA
CCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCE
EYVHIPQADGSLYHAPKTVEDDALVMLSDIFPTSYEIGVQSAKVKPGDTVCIVGAGPIGL
EEEEECCCCCCEEECCCCCCCCCEEEEECCCCCCEECCCEECCCCCCCEEEEEECCHHHH
AALLTAQFYSPAKLIMVDLSESRLEAAKRFGATDTICSGDLDDIVKKVHELTDGRGVDVA
HHHHHHHHCCCEEEEEEECCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEE
IECVGYPATFDICQKIVAIGGHVSNVGVHGKPVSLDLQDLWIKNITMSTGLVNANTTEML
EEEECCCHHHHHHHHHHHHCCCEECCCCCCCCEEECHHHHHHHHEEEECCEECCCHHHHH
LNVLKSGKIDATKMVTHHFKLSEVEKAYEVFKNAGSNNALKVIIENDITA
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCC
>Mature Secondary Structure
MKAATYVAPGQLELIDQPKPEILAPTDAVVRLLKTTICGTDLHILGGDVPETTHGTILGH
CCCCEECCCCCEEECCCCCCCEECCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCEEEEC
EGIGIVESVGSAVNNFKVGDKVIISCITACNTCYYCKKGIPAHCESGGWILGHLINGTQA
CCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCE
EYVHIPQADGSLYHAPKTVEDDALVMLSDIFPTSYEIGVQSAKVKPGDTVCIVGAGPIGL
EEEEECCCCCCEEECCCCCCCCCEEEEECCCCCCEECCCEECCCCCCCEEEEEECCHHHH
AALLTAQFYSPAKLIMVDLSESRLEAAKRFGATDTICSGDLDDIVKKVHELTDGRGVDVA
HHHHHHHHCCCEEEEEEECCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEE
IECVGYPATFDICQKIVAIGGHVSNVGVHGKPVSLDLQDLWIKNITMSTGLVNANTTEML
EEEECCCHHHHHHHHHHHHCCCEECCCCCCCCEEECHHHHHHHHEEEECCEECCCHHHHH
LNVLKSGKIDATKMVTHHFKLSEVEKAYEVFKNAGSNNALKVIIENDITA
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2846513 [H]