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The map label for this gene is pth [H]

Identifier: 195977162

GI number: 195977162

Start: 4995

End: 5564

Strand: Direct

Name: pth [H]

Synonym: Sez_0006

Alternate gene names: 195977162

Gene position: 4995-5564 (Clockwise)

Preceding gene: 195977161

Following gene: 195977163

Centisome position: 0.25

GC content: 33.16

Gene sequence:

>570_bases
ATGGTAAAAATGATAGTAGGCTTAGGAAATCCAGGCTCAAAATATCAGCAAACAAAGCATAATGTTGGTTTTATGGCAGT
TGACAGACTTGTCAAAGATCTTGACATTAGCTTTACAGAAGATAAAGCCTTCAAGGCTCTTGTTGGAAGTGCTTTTATCA
ATCAAGAAAAGATTTATTTTGTTAAGCCAACTACCTTTATGAATAATAGTGGTCTTGCTGTTAGAGCTTTATTGACCTAT
TACAATATTTCAACTAAAGATTTAATGGTCATCTATGATGATTTAGATATGGCAGTTGGTAAAATTCGTTTGCGTCAAAA
AGGCTCTGCAGGGGGGCATAATGGTATTAAATCCATTATTGCTCATATCGGTACACAGGAATTTGATAGGGTTAAAATTG
GTATTGGAAGACCAAGTCATGGAATGAGTGTTATTAATCATGTTCTAGGAAAATTTGATACAGATGATATGATAACAATC
AATATAGCACTTGATAAGGTTGACAAAGCAATCAACTATTATTTACAGGAAAAAAGCATTGAGAAAACAATGCAGCAATT
TAATGGATAG

Upstream 100 bases:

>100_bases
TCAAAAGCTTAGAAAGGATAAAAATAGTGGGGAAGAAGCTGATAAAGCTTTAATAATGATAGCAGGCTGCTATTATACCT
CATTTCTCTGGTGTATTAGT

Downstream 100 bases:

>100_bases
TTATGGATATTTTAGAATTATTTAATCAAAACAAGTCAATCCAAACCTGGCAATGTGATGTAACAAGCTTAAAACGGCAA
TTAGTCATGGGGTTGTCAGG

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH [H]

Number of amino acids: Translated: 189; Mature: 189

Protein sequence:

>189_residues
MVKMIVGLGNPGSKYQQTKHNVGFMAVDRLVKDLDISFTEDKAFKALVGSAFINQEKIYFVKPTTFMNNSGLAVRALLTY
YNISTKDLMVIYDDLDMAVGKIRLRQKGSAGGHNGIKSIIAHIGTQEFDRVKIGIGRPSHGMSVINHVLGKFDTDDMITI
NIALDKVDKAINYYLQEKSIEKTMQQFNG

Sequences:

>Translated_189_residues
MVKMIVGLGNPGSKYQQTKHNVGFMAVDRLVKDLDISFTEDKAFKALVGSAFINQEKIYFVKPTTFMNNSGLAVRALLTY
YNISTKDLMVIYDDLDMAVGKIRLRQKGSAGGHNGIKSIIAHIGTQEFDRVKIGIGRPSHGMSVINHVLGKFDTDDMITI
NIALDKVDKAINYYLQEKSIEKTMQQFNG
>Mature_189_residues
MVKMIVGLGNPGSKYQQTKHNVGFMAVDRLVKDLDISFTEDKAFKALVGSAFINQEKIYFVKPTTFMNNSGLAVRALLTY
YNISTKDLMVIYDDLDMAVGKIRLRQKGSAGGHNGIKSIIAHIGTQEFDRVKIGIGRPSHGMSVINHVLGKFDTDDMITI
NIALDKVDKAINYYLQEKSIEKTMQQFNG

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis [H]

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family [H]

Homologues:

Organism=Homo sapiens, GI50897284, Length=178, Percent_Identity=30.8988764044944, Blast_Score=117, Evalue=5e-27,
Organism=Escherichia coli, GI1787455, Length=177, Percent_Identity=35.0282485875706, Blast_Score=107, Evalue=6e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001328
- InterPro:   IPR018171 [H]

Pfam domain/function: PF01195 Pept_tRNA_hydro [H]

EC number: =3.1.1.29 [H]

Molecular weight: Translated: 21067; Mature: 21067

Theoretical pI: Translated: 9.81; Mature: 9.81

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1 ; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKMIVGLGNPGSKYQQTKHNVGFMAVDRLVKDLDISFTEDKAFKALVGSAFINQEKIYF
CEEEEEEECCCCHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEE
VKPTTFMNNSGLAVRALLTYYNISTKDLMVIYDDLDMAVGKIRLRQKGSAGGHNGIKSII
ECCCEEECCCCHHHHHHHHHHCCCCCCEEEEEECHHHHHHHHHEECCCCCCCCHHHHHHH
AHIGTQEFDRVKIGIGRPSHGMSVINHVLGKFDTDDMITINIALDKVDKAINYYLQEKSI
HHHCCCCCCEEEEECCCCCCHHHHHHHHHCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHH
EKTMQQFNG
HHHHHHHCC
>Mature Secondary Structure
MVKMIVGLGNPGSKYQQTKHNVGFMAVDRLVKDLDISFTEDKAFKALVGSAFINQEKIYF
CEEEEEEECCCCHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEE
VKPTTFMNNSGLAVRALLTYYNISTKDLMVIYDDLDMAVGKIRLRQKGSAGGHNGIKSII
ECCCEEECCCCHHHHHHHHHHCCCCCCEEEEEECHHHHHHHHHEECCCCCCCCHHHHHHH
AHIGTQEFDRVKIGIGRPSHGMSVINHVLGKFDTDDMITINIALDKVDKAINYYLQEKSI
HHHCCCCCCEEEEECCCCCCHHHHHHHHHCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHH
EKTMQQFNG
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA