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The map label for this gene is capL [H]

Identifier: 195953013

GI number: 195953013

Start: 572895

End: 574205

Strand: Direct

Name: capL [H]

Synonym: HY04AAS1_0638

Alternate gene names: 195953013

Gene position: 572895-574205 (Clockwise)

Preceding gene: 195953012

Following gene: 195953014

Centisome position: 36.74

GC content: 32.65

Gene sequence:

>1311_bases
ATGATAAACATAGAAGATTTTATAAACAAACAAGAGTCAATATGCGTAGTAGGGCTTGGATATGTAGGGCTTCCATTGGC
TGTAACGTTTGCAAAACACTTTAACGTAATAGGTTTTGATATAAACCAAATAAGGATAAACGAACTAAAATTAGGTATAG
ACAGAACAAAGGAAACCACTTCTGAAGAACTTCTAAATAGCAACATACTTTTTACGGACAACGAAGAGTATATAAAAAAA
TGTAAATTTATTATCATCACAGTACCAACGCCTATAGATAAACACAAAGTACCAGACCTAAAACCTATATTTAGTGCATC
TGTTATAGTTGGTAGAAATTTACAAAAAGACAGTATAGTGGTGTATGAATCTACAGTATATCCTGGTCTAACGGAAGAAG
AATGTGTACCTATTTTAGAAAAAGAATCAGGGCTTAAATGGAAAAAAGATTTCTTTGTGGGCTATTCACCAGAACGCATA
AATCCTGGTGATAAAATACATAGGTTTGAAAATATAGTAAAAGTAGTTTCTGGAGACAGCGAATATAGCCTTAACATAAT
AAGTGGAATATACTCTAAGGTTGTAAAAGCTGGAATATTTAAAGCAAAATCTATAAAAGTTGCAGAAGCCGCTAAAGTTA
TAGAAAATACTCAACGAGATATAAACATTGCACTTATGAACGAACTATCGATGATCTTTCATAAAATGGGTATAGATACA
AAGGATGTGTTAGAAGCCGCTGCTACCAAATGGAACTTTCTCAAATTTGAACCAGGTTTAGTAGGAGGACACTGTATCAG
CGTAGACCCTTACTATCTAACATTCAAGGCTCAAGAGTTAGGCCACCATCCAGAGGTAATTCTTTCTGGTAGAAGAGTAA
ACGACGACATGCCAAACTTTGTAGTGCAAAACGTTTTAAAGCTTTTAATAAAAGCAAAAAAACAGATAGAATCCTCAAAA
ATAATCATATTTGGGCTCTCTTTTAAAGAAAACATTCCAGACATAAGAAACTCAAAAGTAGTAGATATATACAACGAACT
TAAAGATTTTGGTATAAATACATACATATACGACCCGTACGTATACAGGGATGAAGTTTTTAAAGAATATGGTATAGAAC
TTTTACAAGACCCTTACGAAGAGGCACCTTACGATGCTGTAATTGTAGCGGTAAAACACAACGCTTTTGGGGAATACGAT
ATAAGATTTTACGAAAATATTACTAAAAGCCCAAAAATTTTGATAGACATAAAAAACTTATACAACAAAGATGTTTTCTT
AAAAAATGGCTTTCTTTATTGGAGCTTATAA

Upstream 100 bases:

>100_bases
TAAACGGAGAAAAGATAACAGATCCAAACAAAGAAATAGTTGTTGAAAATGAGCTAAGAGTACAAGTAGGTAAAAAACAT
TTTGCAATAATCAAAAAAGC

Downstream 100 bases:

>100_bases
TGAAAGACATAAGAGCAAGAGCACGAGAAATAGCATTTAGAAGCCTTTACGCTTGGGATATAAGTGGAGGAGAAATATCT
ATTATATCTCAAGAAATTAT

Product: nucleotide sugar dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: NA

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MINIEDFINKQESICVVGLGYVGLPLAVTFAKHFNVIGFDINQIRINELKLGIDRTKETTSEELLNSNILFTDNEEYIKK
CKFIIITVPTPIDKHKVPDLKPIFSASVIVGRNLQKDSIVVYESTVYPGLTEEECVPILEKESGLKWKKDFFVGYSPERI
NPGDKIHRFENIVKVVSGDSEYSLNIISGIYSKVVKAGIFKAKSIKVAEAAKVIENTQRDINIALMNELSMIFHKMGIDT
KDVLEAAATKWNFLKFEPGLVGGHCISVDPYYLTFKAQELGHHPEVILSGRRVNDDMPNFVVQNVLKLLIKAKKQIESSK
IIIFGLSFKENIPDIRNSKVVDIYNELKDFGINTYIYDPYVYRDEVFKEYGIELLQDPYEEAPYDAVIVAVKHNAFGEYD
IRFYENITKSPKILIDIKNLYNKDVFLKNGFLYWSL

Sequences:

>Translated_436_residues
MINIEDFINKQESICVVGLGYVGLPLAVTFAKHFNVIGFDINQIRINELKLGIDRTKETTSEELLNSNILFTDNEEYIKK
CKFIIITVPTPIDKHKVPDLKPIFSASVIVGRNLQKDSIVVYESTVYPGLTEEECVPILEKESGLKWKKDFFVGYSPERI
NPGDKIHRFENIVKVVSGDSEYSLNIISGIYSKVVKAGIFKAKSIKVAEAAKVIENTQRDINIALMNELSMIFHKMGIDT
KDVLEAAATKWNFLKFEPGLVGGHCISVDPYYLTFKAQELGHHPEVILSGRRVNDDMPNFVVQNVLKLLIKAKKQIESSK
IIIFGLSFKENIPDIRNSKVVDIYNELKDFGINTYIYDPYVYRDEVFKEYGIELLQDPYEEAPYDAVIVAVKHNAFGEYD
IRFYENITKSPKILIDIKNLYNKDVFLKNGFLYWSL
>Mature_436_residues
MINIEDFINKQESICVVGLGYVGLPLAVTFAKHFNVIGFDINQIRINELKLGIDRTKETTSEELLNSNILFTDNEEYIKK
CKFIIITVPTPIDKHKVPDLKPIFSASVIVGRNLQKDSIVVYESTVYPGLTEEECVPILEKESGLKWKKDFFVGYSPERI
NPGDKIHRFENIVKVVSGDSEYSLNIISGIYSKVVKAGIFKAKSIKVAEAAKVIENTQRDINIALMNELSMIFHKMGIDT
KDVLEAAATKWNFLKFEPGLVGGHCISVDPYYLTFKAQELGHHPEVILSGRRVNDDMPNFVVQNVLKLLIKAKKQIESSK
IIIFGLSFKENIPDIRNSKVVDIYNELKDFGINTYIYDPYVYRDEVFKEYGIELLQDPYEEAPYDAVIVAVKHNAFGEYD
IRFYENITKSPKILIDIKNLYNKDVFLKNGFLYWSL

Specific function: Required for the biosynthesis of type 1 capsular polysaccharide [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=440, Percent_Identity=25.2272727272727, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI296040438, Length=321, Percent_Identity=24.6105919003115, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI48994968, Length=400, Percent_Identity=29.75, Blast_Score=149, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17560350, Length=466, Percent_Identity=23.6051502145923, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17136908, Length=466, Percent_Identity=23.6051502145923, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 49823; Mature: 49823

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINIEDFINKQESICVVGLGYVGLPLAVTFAKHFNVIGFDINQIRINELKLGIDRTKETT
CCCHHHHHCCCCCEEEEEECHHHHHHHHHHHHHCEEEEEEECEEEEEEEEECCCCCCCHH
SEELLNSNILFTDNEEYIKKCKFIIITVPTPIDKHKVPDLKPIFSASVIVGRNLQKDSIV
HHHHHCCCEEEECCHHHHCCCEEEEEECCCCCCCCCCCCCCHHHHCEEEECCCCCCCCEE
VYESTVYPGLTEEECVPILEKESGLKWKKDFFVGYSPERINPGDKIHRFENIVKVVSGDS
EEEECCCCCCCHHHCCCCEECCCCCCEECCEEECCCCCCCCCCHHHHHHHHHHHHHCCCC
EYSLNIISGIYSKVVKAGIFKAKSIKVAEAAKVIENTQRDINIALMNELSMIFHKMGIDT
CEEHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHCCCH
KDVLEAAATKWNFLKFEPGLVGGHCISVDPYYLTFKAQELGHHPEVILSGRRVNDDMPNF
HHHHHHHHCCCCEEEECCCCCCCEEEEECCEEEEEEHHHCCCCCCEEEECCCCCCCCHHH
VVQNVLKLLIKAKKQIESSKIIIFGLSFKENIPDIRNSKVVDIYNELKDFGINTYIYDPY
HHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCEEHHHHHHHHCCCCEEEECCE
VYRDEVFKEYGIELLQDPYEEAPYDAVIVAVKHNAFGEYDIRFYENITKSPKILIDIKNL
EEHHHHHHHHCHHHHHCCHHHCCCCEEEEEEECCCCCCEEEHHHHCCCCCCEEEEEEHHH
YNKDVFLKNGFLYWSL
CCCCEEEECCEEEEEC
>Mature Secondary Structure
MINIEDFINKQESICVVGLGYVGLPLAVTFAKHFNVIGFDINQIRINELKLGIDRTKETT
CCCHHHHHCCCCCEEEEEECHHHHHHHHHHHHHCEEEEEEECEEEEEEEEECCCCCCCHH
SEELLNSNILFTDNEEYIKKCKFIIITVPTPIDKHKVPDLKPIFSASVIVGRNLQKDSIV
HHHHHCCCEEEECCHHHHCCCEEEEEECCCCCCCCCCCCCCHHHHCEEEECCCCCCCCEE
VYESTVYPGLTEEECVPILEKESGLKWKKDFFVGYSPERINPGDKIHRFENIVKVVSGDS
EEEECCCCCCCHHHCCCCEECCCCCCEECCEEECCCCCCCCCCHHHHHHHHHHHHHCCCC
EYSLNIISGIYSKVVKAGIFKAKSIKVAEAAKVIENTQRDINIALMNELSMIFHKMGIDT
CEEHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHCCCH
KDVLEAAATKWNFLKFEPGLVGGHCISVDPYYLTFKAQELGHHPEVILSGRRVNDDMPNF
HHHHHHHHCCCCEEEECCCCCCCEEEEECCEEEEEEHHHCCCCCCEEEECCCCCCCCHHH
VVQNVLKLLIKAKKQIESSKIIIFGLSFKENIPDIRNSKVVDIYNELKDFGINTYIYDPY
HHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCEEHHHHHHHHCCCCEEEECCE
VYRDEVFKEYGIELLQDPYEEAPYDAVIVAVKHNAFGEYDIRFYENITKSPKILIDIKNL
EEHHHHHHHHCHHHHHCCHHHCCCCEEEEEEECCCCCCEEEHHHHCCCCCCEEEEEEHHH
YNKDVFLKNGFLYWSL
CCCCEEEECCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7961465 [H]