Click here to switch to the map view.

The map label for this gene is tyrS [H]

Identifier: 195953012

GI number: 195953012

Start: 571720

End: 572898

Strand: Direct

Name: tyrS [H]

Synonym: HY04AAS1_0637

Alternate gene names: 195953012

Gene position: 571720-572898 (Clockwise)

Preceding gene: 195953011

Following gene: 195953013

Centisome position: 36.66

GC content: 33.42

Gene sequence:

>1179_bases
ATGGATATACAGAAACAATTGGAGATTATACAAAAAGGGACTGTAGAAATTATAGAGAAAGAAGAGCTTATAGAAAAGTT
AAAAAAGGGGAAGCCGCTTGTAGTAAAAGCAGGTTTTGACCCTACAGCAAAAGATTTGCATTTAGGGCACACGGTTTTGC
TTCAAAAATTAAGAGACTTTCAAAATTTAGGGCATGAAATAATATTTTTAATAGGTGATTTTACAGCAATGATAGGAGAC
CCAACCGGCAGAAACGAAACAAGACCCCCTCTTTCTAAAGAAGAAGTTTTAGAAAATGCAAAAACATATCAAGAGCAAGT
TTTTAAGATTTTAGATAAAGATAAAACAAAAATTTTATACAACAGCGAGTGGCTATCCACTATGACAACAAAAGATATAG
TCAACCTTGCTTCAAAATATACAGTAGCAAGAATGTTAGAGCGTGATGATTTTCAAAAGCGCTATAAAGAAGGCTCTCCT
ATACACATTCATGAGTTTTTATATCCACTTTTTCAAGGATACGACTCTGTAATACTAAAAGCAGATATAGAAATAGGAGG
GTCTGATCAAAAGTTTAATTTGCTTGTAGGAAGGGAACTTCAAAAGGATTACGGCTTAGAAAAACAAGTTTGTATTACTA
TGCCGCTTTTAGTGGGAATAGACGGTGTAAAGAAGATGTCAAAAAGCTATGGAAACTATATAGCACTAAAGGATGATCCT
AAGGATATGTTTGGAAAAATTATGAGTATATCTGATGAACTTATGTACGACTATTATACTTTACTCACCGATAAGACCCC
AGATGAGATAGAAAAGATAAAAGCGATGCATCCTATGGAAGCTAAAAAGCAGCTTGCATACATCATTGTATCAAGATTTC
ATTCAGAGGAAAAGGCCAAAGAAGCAAAGGAATTTTTTGAATCTACTTTTTCTCAAAAAGAGTTTCCGAAGGACGCACCA
GTATTTAGCTTTTCTGATAAAGATTCTTTAAAAGCTTACGAACTTATAGTAAAGATAGGTTTTGCAACATCAAACAACGA
AGCAAGAAGGATAATATCTGGTGGAGGATTGAGAATAAACGGAGAAAAGATAACAGATCCAAACAAAGAAATAGTTGTTG
AAAATGAGCTAAGAGTACAAGTAGGTAAAAAACATTTTGCAATAATCAAAAAAGCATGA

Upstream 100 bases:

>100_bases
ACCTTGGGATCCGTAGTCCCATGCTCTATCCAATTGAGCTACCAGGGCTAATAACATATTATAGCATATTAAAAGCCAAA
AACAGGTATAATATATAACC

Downstream 100 bases:

>100_bases
TAAACATAGAAGATTTTATAAACAAACAAGAGTCAATATGCGTAGTAGGGCTTGGATATGTAGGGCTTCCATTGGCTGTA
ACGTTTGCAAAACACTTTAA

Product: tyrosyl-tRNA synthetase

Products: NA

Alternate protein names: Tyrosine--tRNA ligase; TyrRS [H]

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MDIQKQLEIIQKGTVEIIEKEELIEKLKKGKPLVVKAGFDPTAKDLHLGHTVLLQKLRDFQNLGHEIIFLIGDFTAMIGD
PTGRNETRPPLSKEEVLENAKTYQEQVFKILDKDKTKILYNSEWLSTMTTKDIVNLASKYTVARMLERDDFQKRYKEGSP
IHIHEFLYPLFQGYDSVILKADIEIGGSDQKFNLLVGRELQKDYGLEKQVCITMPLLVGIDGVKKMSKSYGNYIALKDDP
KDMFGKIMSISDELMYDYYTLLTDKTPDEIEKIKAMHPMEAKKQLAYIIVSRFHSEEKAKEAKEFFESTFSQKEFPKDAP
VFSFSDKDSLKAYELIVKIGFATSNNEARRIISGGGLRINGEKITDPNKEIVVENELRVQVGKKHFAIIKKA

Sequences:

>Translated_392_residues
MDIQKQLEIIQKGTVEIIEKEELIEKLKKGKPLVVKAGFDPTAKDLHLGHTVLLQKLRDFQNLGHEIIFLIGDFTAMIGD
PTGRNETRPPLSKEEVLENAKTYQEQVFKILDKDKTKILYNSEWLSTMTTKDIVNLASKYTVARMLERDDFQKRYKEGSP
IHIHEFLYPLFQGYDSVILKADIEIGGSDQKFNLLVGRELQKDYGLEKQVCITMPLLVGIDGVKKMSKSYGNYIALKDDP
KDMFGKIMSISDELMYDYYTLLTDKTPDEIEKIKAMHPMEAKKQLAYIIVSRFHSEEKAKEAKEFFESTFSQKEFPKDAP
VFSFSDKDSLKAYELIVKIGFATSNNEARRIISGGGLRINGEKITDPNKEIVVENELRVQVGKKHFAIIKKA
>Mature_392_residues
MDIQKQLEIIQKGTVEIIEKEELIEKLKKGKPLVVKAGFDPTAKDLHLGHTVLLQKLRDFQNLGHEIIFLIGDFTAMIGD
PTGRNETRPPLSKEEVLENAKTYQEQVFKILDKDKTKILYNSEWLSTMTTKDIVNLASKYTVARMLERDDFQKRYKEGSP
IHIHEFLYPLFQGYDSVILKADIEIGGSDQKFNLLVGRELQKDYGLEKQVCITMPLLVGIDGVKKMSKSYGNYIALKDDP
KDMFGKIMSISDELMYDYYTLLTDKTPDEIEKIKAMHPMEAKKQLAYIIVSRFHSEEKAKEAKEFFESTFSQKEFPKDAP
VFSFSDKDSLKAYELIVKIGFATSNNEARRIISGGGLRINGEKITDPNKEIVVENELRVQVGKKHFAIIKKA

Specific function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction:tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) [H]

COG id: COG0162

COG function: function code J; Tyrosyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S4 RNA-binding domain [H]

Homologues:

Organism=Homo sapiens, GI94681057, Length=416, Percent_Identity=27.6442307692308, Blast_Score=134, Evalue=1e-31,
Organism=Escherichia coli, GI1787925, Length=418, Percent_Identity=29.1866028708134, Blast_Score=142, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI25145802, Length=399, Percent_Identity=26.0651629072682, Blast_Score=107, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6325160, Length=439, Percent_Identity=26.4236902050114, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI20130383, Length=405, Percent_Identity=25.9259259259259, Blast_Score=129, Evalue=4e-30,

Paralogues:

None

Copy number: 892 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002942
- InterPro:   IPR002307 [H]

Pfam domain/function: PF01479 S4; PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.1 [H]

Molecular weight: Translated: 44873; Mature: 44873

Theoretical pI: Translated: 7.29; Mature: 7.29

Prosite motif: PS50889 S4 ; PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIQKQLEIIQKGTVEIIEKEELIEKLKKGKPLVVKAGFDPTAKDLHLGHTVLLQKLRDF
CCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHH
QNLGHEIIFLIGDFTAMIGDPTGRNETRPPLSKEEVLENAKTYQEQVFKILDKDKTKILY
HHCCCEEEEEEEHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEE
NSEWLSTMTTKDIVNLASKYTVARMLERDDFQKRYKEGSPIHIHEFLYPLFQGYDSVILK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHCCCCCEEEE
ADIEIGGSDQKFNLLVGRELQKDYGLEKQVCITMPLLVGIDGVKKMSKSYGNYIALKDDP
EEEEECCCCCEEEEEECCHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHCCEEEEECCH
KDMFGKIMSISDELMYDYYTLLTDKTPDEIEKIKAMHPMEAKKQLAYIIVSRFHSEEKAK
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHH
EAKEFFESTFSQKEFPKDAPVFSFSDKDSLKAYELIVKIGFATSNNEARRIISGGGLRIN
HHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHEEHHHEEECCCCCCCHHHEEECCCEEEC
GEKITDPNKEIVVENELRVQVGKKHFAIIKKA
CCCCCCCCCEEEEECCCEEEECCCEEEEEECC
>Mature Secondary Structure
MDIQKQLEIIQKGTVEIIEKEELIEKLKKGKPLVVKAGFDPTAKDLHLGHTVLLQKLRDF
CCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHH
QNLGHEIIFLIGDFTAMIGDPTGRNETRPPLSKEEVLENAKTYQEQVFKILDKDKTKILY
HHCCCEEEEEEEHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEE
NSEWLSTMTTKDIVNLASKYTVARMLERDDFQKRYKEGSPIHIHEFLYPLFQGYDSVILK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHCCCCCEEEE
ADIEIGGSDQKFNLLVGRELQKDYGLEKQVCITMPLLVGIDGVKKMSKSYGNYIALKDDP
EEEEECCCCCEEEEEECCHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHCCEEEEECCH
KDMFGKIMSISDELMYDYYTLLTDKTPDEIEKIKAMHPMEAKKQLAYIIVSRFHSEEKAK
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHH
EAKEFFESTFSQKEFPKDAPVFSFSDKDSLKAYELIVKIGFATSNNEARRIISGGGLRIN
HHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHEEHHHEEECCCCCCCHHHEEECCCEEEC
GEKITDPNKEIVVENELRVQVGKKHFAIIKKA
CCCCCCCCCEEEEECCCEEEECCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]