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The map label for this gene is kbl [C]

Identifier: 195952913

GI number: 195952913

Start: 472112

End: 473230

Strand: Direct

Name: kbl [C]

Synonym: HY04AAS1_0538

Alternate gene names: 195952913

Gene position: 472112-473230 (Clockwise)

Preceding gene: 195952900

Following gene: 195952914

Centisome position: 30.27

GC content: 30.47

Gene sequence:

>1119_bases
ATGAACTTTGAAGAAGAATTAGAATATATTAAAAGCCAAAAACTATACAGGAAAAGAGAAATTATAAAAGATAAAAAAAT
ATTTTGTTCAAACGATTATCTTGGTATGTCTAAAAATAAAGAAGTAATAGATTATATCGTAGAAAAACTAAGGGAAGTAA
ATACTATAGGTGCTACTGCTTCAAGCCTTGTAAATGGATATACAAAATACCATAAAGAGCTAGAGCTTCTACTTAGTAAG
TTAAAATCCAAAGAGGATTGCATAGTTTTTCCCTCTGGATACTCTACAAACATAGGACTTTTTCAAGCGCTTGGAAATGA
AGAAGATGTTTTTTACAGCGATGAATTAAACCATGCATCAATAATAGACGGGATAAGGCTATCAAAAGCTTCAAAATATA
TTTATCAACACAACAACATAAAGCATCTTTTTGAGCTTTTAAAAGCTACAAGACAAAAATATAGAAGGGCTTATATAGTA
TCTGACTCTGTGTTTAGCATGGAAGGAGATTTAGCAAGGTTAAAAGAGTTAATAGATATTTCGAAAGAGTTTGAAGCCTA
TCTTATTCTTGATGAAGCACATGCCACCGGCACTATAGGAAAAGGTATATATGATTATTTTGGGCTTTTACCAGAAGAAA
ATACGATTATAATGGGCACTTTATCAAAAGCAATAGGCTCTCAAGGTGGATTTGTTTGTGCAAAAAAATTAATCATAGAG
TACATAGCAAACAAAGCGAGATCTTACATATTTTCTACCGCTTTAGGACTTCCAATGGTTTTTGCCTCTATAAAAGCCTT
AGAACTTATTGAAAAAAATCTAAACAAATATAAAGAAGAGTTACAACAAAGAACAAAATTTATATTAGATATGATAAAAG
AATTCAATTTTCAACCAAAAGAAGACTTTATCACACCTATAATACCAATAAAAGTAGGTAAAGAAGATGAAGCTCTAAAA
CTAAGAAATAAATTGTTAGAAAATGGCGTATTTATACAAGCTATCAGATACCCAACAGTACCAAAAAACAAAGCCATTCT
AAGGTTAACTGCATCGCTATCTTATTCCAGCGAGGACTTAGAGGTTCTTTATGAAGCTTTTAAAAGCTTGAAAAATTAA

Upstream 100 bases:

>100_bases
ACAATTCCTACACCAAGTTATTTCTGCCCCCGTATATAAGCTTTTAGTAATCATAATAAAATAAATTATATCACTTTTTA
AAAGTTTGTATAATACATTT

Downstream 100 bases:

>100_bases
AGTATCTTCATGTATTTTTCATCAAAAATTAATAAAATATTAACATTAAAAGCGTATATTTAAGATATACTTGAAAGGAG
GTAAGTGTATGAAGTTAAGA

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MNFEEELEYIKSQKLYRKREIIKDKKIFCSNDYLGMSKNKEVIDYIVEKLREVNTIGATASSLVNGYTKYHKELELLLSK
LKSKEDCIVFPSGYSTNIGLFQALGNEEDVFYSDELNHASIIDGIRLSKASKYIYQHNNIKHLFELLKATRQKYRRAYIV
SDSVFSMEGDLARLKELIDISKEFEAYLILDEAHATGTIGKGIYDYFGLLPEENTIIMGTLSKAIGSQGGFVCAKKLIIE
YIANKARSYIFSTALGLPMVFASIKALELIEKNLNKYKEELQQRTKFILDMIKEFNFQPKEDFITPIIPIKVGKEDEALK
LRNKLLENGVFIQAIRYPTVPKNKAILRLTASLSYSSEDLEVLYEAFKSLKN

Sequences:

>Translated_372_residues
MNFEEELEYIKSQKLYRKREIIKDKKIFCSNDYLGMSKNKEVIDYIVEKLREVNTIGATASSLVNGYTKYHKELELLLSK
LKSKEDCIVFPSGYSTNIGLFQALGNEEDVFYSDELNHASIIDGIRLSKASKYIYQHNNIKHLFELLKATRQKYRRAYIV
SDSVFSMEGDLARLKELIDISKEFEAYLILDEAHATGTIGKGIYDYFGLLPEENTIIMGTLSKAIGSQGGFVCAKKLIIE
YIANKARSYIFSTALGLPMVFASIKALELIEKNLNKYKEELQQRTKFILDMIKEFNFQPKEDFITPIIPIKVGKEDEALK
LRNKLLENGVFIQAIRYPTVPKNKAILRLTASLSYSSEDLEVLYEAFKSLKN
>Mature_372_residues
MNFEEELEYIKSQKLYRKREIIKDKKIFCSNDYLGMSKNKEVIDYIVEKLREVNTIGATASSLVNGYTKYHKELELLLSK
LKSKEDCIVFPSGYSTNIGLFQALGNEEDVFYSDELNHASIIDGIRLSKASKYIYQHNNIKHLFELLKATRQKYRRAYIV
SDSVFSMEGDLARLKELIDISKEFEAYLILDEAHATGTIGKGIYDYFGLLPEENTIIMGTLSKAIGSQGGFVCAKKLIIE
YIANKARSYIFSTALGLPMVFASIKALELIEKNLNKYKEELQQRTKFILDMIKEFNFQPKEDFITPIIPIKVGKEDEALK
LRNKLLENGVFIQAIRYPTVPKNKAILRLTASLSYSSEDLEVLYEAFKSLKN

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=383, Percent_Identity=33.9425587467363, Blast_Score=225, Evalue=5e-59,
Organism=Homo sapiens, GI284448556, Length=344, Percent_Identity=36.046511627907, Blast_Score=221, Evalue=7e-58,
Organism=Homo sapiens, GI83977442, Length=353, Percent_Identity=34.2776203966006, Blast_Score=189, Evalue=4e-48,
Organism=Homo sapiens, GI83977444, Length=353, Percent_Identity=34.2776203966006, Blast_Score=189, Evalue=5e-48,
Organism=Homo sapiens, GI83977440, Length=353, Percent_Identity=34.2776203966006, Blast_Score=189, Evalue=5e-48,
Organism=Homo sapiens, GI4502025, Length=355, Percent_Identity=32.112676056338, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI40316939, Length=355, Percent_Identity=32.112676056338, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI4758668, Length=358, Percent_Identity=30.4469273743017, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI119220554, Length=369, Percent_Identity=27.9132791327913, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI5454084, Length=240, Percent_Identity=23.3333333333333, Blast_Score=89, Evalue=7e-18,
Organism=Escherichia coli, GI1790046, Length=384, Percent_Identity=31.7708333333333, Blast_Score=207, Evalue=7e-55,
Organism=Escherichia coli, GI1786993, Length=351, Percent_Identity=27.6353276353276, Blast_Score=149, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI71994529, Length=390, Percent_Identity=33.3333333333333, Blast_Score=208, Evalue=4e-54,
Organism=Caenorhabditis elegans, GI32566772, Length=357, Percent_Identity=26.0504201680672, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17560914, Length=316, Percent_Identity=25.6329113924051, Blast_Score=135, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17560912, Length=316, Percent_Identity=25.6329113924051, Blast_Score=135, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI71982617, Length=233, Percent_Identity=24.0343347639485, Blast_Score=91, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI71982625, Length=233, Percent_Identity=24.0343347639485, Blast_Score=91, Evalue=9e-19,
Organism=Saccharomyces cerevisiae, GI6320267, Length=351, Percent_Identity=27.6353276353276, Blast_Score=160, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6320438, Length=384, Percent_Identity=29.1666666666667, Blast_Score=159, Evalue=6e-40,
Organism=Saccharomyces cerevisiae, GI6323954, Length=275, Percent_Identity=24, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24662918, Length=359, Percent_Identity=32.8690807799443, Blast_Score=205, Evalue=4e-53,
Organism=Drosophila melanogaster, GI17137420, Length=375, Percent_Identity=31.7333333333333, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI17136286, Length=324, Percent_Identity=28.0864197530864, Blast_Score=149, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24653280, Length=371, Percent_Identity=22.6415094339623, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24653276, Length=371, Percent_Identity=22.6415094339623, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24653278, Length=371, Percent_Identity=22.6415094339623, Blast_Score=99, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 42660; Mature: 42660

Theoretical pI: Translated: 8.59; Mature: 8.59

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFEEELEYIKSQKLYRKREIIKDKKIFCSNDYLGMSKNKEVIDYIVEKLREVNTIGATA
CCHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
SSLVNGYTKYHKELELLLSKLKSKEDCIVFPSGYSTNIGLFQALGNEEDVFYSDELNHAS
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHCCCCCCEEECCCCCCHH
IIDGIRLSKASKYIYQHNNIKHLFELLKATRQKYRRAYIVSDSVFSMEGDLARLKELIDI
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHEECCCHHCCCCCHHHHHHHHHH
SKEFEAYLILDEAHATGTIGKGIYDYFGLLPEENTIIMGTLSKAIGSQGGFVCAKKLIIE
HHCCCEEEEEECCCCCCCHHHHHHHHHCCCCCCCEEEEEEHHHHHCCCCCHHHHHHHHHH
YIANKARSYIFSTALGLPMVFASIKALELIEKNLNKYKEELQQRTKFILDMIKEFNFQPK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
EDFITPIIPIKVGKEDEALKLRNKLLENGVFIQAIRYPTVPKNKAILRLTASLSYSSEDL
HHCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEEEEECCCCCHHH
EVLYEAFKSLKN
HHHHHHHHHHCC
>Mature Secondary Structure
MNFEEELEYIKSQKLYRKREIIKDKKIFCSNDYLGMSKNKEVIDYIVEKLREVNTIGATA
CCHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
SSLVNGYTKYHKELELLLSKLKSKEDCIVFPSGYSTNIGLFQALGNEEDVFYSDELNHAS
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHCCCCCCEEECCCCCCHH
IIDGIRLSKASKYIYQHNNIKHLFELLKATRQKYRRAYIVSDSVFSMEGDLARLKELIDI
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHEECCCHHCCCCCHHHHHHHHHH
SKEFEAYLILDEAHATGTIGKGIYDYFGLLPEENTIIMGTLSKAIGSQGGFVCAKKLIIE
HHCCCEEEEEECCCCCCCHHHHHHHHHCCCCCCCEEEEEEHHHHHCCCCCHHHHHHHHHH
YIANKARSYIFSTALGLPMVFASIKALELIEKNLNKYKEELQQRTKFILDMIKEFNFQPK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
EDFITPIIPIKVGKEDEALKLRNKLLENGVFIQAIRYPTVPKNKAILRLTASLSYSSEDL
HHCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEEEEECCCCCHHH
EVLYEAFKSLKN
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]