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The map label for this gene is dapL [H]

Identifier: 195952862

GI number: 195952862

Start: 428522

End: 429685

Strand: Direct

Name: dapL [H]

Synonym: HY04AAS1_0487

Alternate gene names: 195952862

Gene position: 428522-429685 (Clockwise)

Preceding gene: 195952851

Following gene: 195952863

Centisome position: 27.48

GC content: 38.66

Gene sequence:

>1164_bases
ATGGAATTTGAGTTTTCTGAAAGGCTAAAGGTTTTACCACCGTATTTGTTTGCGGCTATTGATAAGAAAAAAAGGGAAAA
GGCTGCTCAAGGAGCAGACATAATAGACTTAGGTATAGGCGATCCAGACCTTCCAACTCCAAAGCCTATAGTGGAAGCTG
GAAAAGCGGCTTTAGAAAAACCAGAGCATCATAGGTATCCTTCTTACGAAGGTATGTATGCTTTTAGGAAAGCTGTGGCA
GATTGGTATAAAAAGCGTTTTGGCGTACTGCTAGATCCAGATAAAGAAATTGTGACACTTATAGGTTCTAAAGAAGGGAT
AGCTCATTTTCCACTTGCTTTTGTAAATCCTGGAGATTACGTGCTTTGTCCAGATCCTGGTTATCCGGTTTACAAGATAT
CCACTATCTTTGCTGGTGGCATTCCTTACATGTTGCCCCTAAAAGAAGAAAATGGCTTCTTGCCAGATATAGATTCTATA
CCTCAAAATGTTTTACAAAAAGCCAAAATAATATGGGTAAACTATCCAAACAATCCCACCTCTGCAAAAGCGCCAGATTC
TTTTTATAAAAAGCTTATAGAGTTTGCTCATAAATACGGTATTATAATAGCCTCTGATTTGGCTTATTCTGAGATATACG
CATCAGAACCGCCTCGCTCTATTCTTGAATTTGAAGGAGCTAAAGATGTGGCTATAGAGTTTCACTCTTTATCCAAAACT
TACAACATGACTGGTTGGCGTATTGGTATGGCAGTTGGTAATCCAAGTCTTATAGCTGGTCTTGGCAAGATCAAGACAAA
CGTAGATTCAGGACAGTTTCAAGCCATACAAGAAGCAGGTATAAAGGCCCTTAGCTTAGACGATAGCGTAGTTCAAAATC
TTAGAGATATATATAAAGAAAGAAGAAAAGTTATGACAGAGGCTTTAAAAGCCATAAACCTTGACGTATTCGAATCAGAT
GCCACATTTTACCTTTGGATTAAAGTGCCAAAAGGTTTTACCTCTGCTGGTTTTGCAGAGCTTTTGTTAGATAAACTTGC
CATAGTGGTAACACCGGGTAGTGGTTTTGGTGAAGCGGGAGAAGGTTATTTTAGGATATCTCTTACCGTAGATACAAATA
GACTAAAAGAAGCTGCCGATAGGATAAAAACGCTCACTTTATGA

Upstream 100 bases:

>100_bases
AGTGGGAGAAGATATAGCGTTAATCTTAGCTTATACAAAAAATATAAGCTTACCAATAAGATAATATGTAAAATTTTCAA
AAATATTTTATAATATTCCT

Downstream 100 bases:

>100_bases
TAAACAAAGAACTATTAGATATCATAGCTTGTCCTAAGTGTAAGGGCGGGCTTCTTTACAACGAAAAGAAGGATATATTA
ATTTGTGGTAATTGTAAACT

Product: LL-diaminopimelate aminotransferase

Products: NA

Alternate protein names: DAP-AT; DAP-aminotransferase; LL-DAP-aminotransferase [H]

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MEFEFSERLKVLPPYLFAAIDKKKREKAAQGADIIDLGIGDPDLPTPKPIVEAGKAALEKPEHHRYPSYEGMYAFRKAVA
DWYKKRFGVLLDPDKEIVTLIGSKEGIAHFPLAFVNPGDYVLCPDPGYPVYKISTIFAGGIPYMLPLKEENGFLPDIDSI
PQNVLQKAKIIWVNYPNNPTSAKAPDSFYKKLIEFAHKYGIIIASDLAYSEIYASEPPRSILEFEGAKDVAIEFHSLSKT
YNMTGWRIGMAVGNPSLIAGLGKIKTNVDSGQFQAIQEAGIKALSLDDSVVQNLRDIYKERRKVMTEALKAINLDVFESD
ATFYLWIKVPKGFTSAGFAELLLDKLAIVVTPGSGFGEAGEGYFRISLTVDTNRLKEAADRIKTLTL

Sequences:

>Translated_387_residues
MEFEFSERLKVLPPYLFAAIDKKKREKAAQGADIIDLGIGDPDLPTPKPIVEAGKAALEKPEHHRYPSYEGMYAFRKAVA
DWYKKRFGVLLDPDKEIVTLIGSKEGIAHFPLAFVNPGDYVLCPDPGYPVYKISTIFAGGIPYMLPLKEENGFLPDIDSI
PQNVLQKAKIIWVNYPNNPTSAKAPDSFYKKLIEFAHKYGIIIASDLAYSEIYASEPPRSILEFEGAKDVAIEFHSLSKT
YNMTGWRIGMAVGNPSLIAGLGKIKTNVDSGQFQAIQEAGIKALSLDDSVVQNLRDIYKERRKVMTEALKAINLDVFESD
ATFYLWIKVPKGFTSAGFAELLLDKLAIVVTPGSGFGEAGEGYFRISLTVDTNRLKEAADRIKTLTL
>Mature_387_residues
MEFEFSERLKVLPPYLFAAIDKKKREKAAQGADIIDLGIGDPDLPTPKPIVEAGKAALEKPEHHRYPSYEGMYAFRKAVA
DWYKKRFGVLLDPDKEIVTLIGSKEGIAHFPLAFVNPGDYVLCPDPGYPVYKISTIFAGGIPYMLPLKEENGFLPDIDSI
PQNVLQKAKIIWVNYPNNPTSAKAPDSFYKKLIEFAHKYGIIIASDLAYSEIYASEPPRSILEFEGAKDVAIEFHSLSKT
YNMTGWRIGMAVGNPSLIAGLGKIKTNVDSGQFQAIQEAGIKALSLDDSVVQNLRDIYKERRKVMTEALKAINLDVFESD
ATFYLWIKVPKGFTSAGFAELLLDKLAIVVTPGSGFGEAGEGYFRISLTVDTNRLKEAADRIKTLTL

Specific function: Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate, a reaction that requires three enzymes in E.coli

COG id: COG0436

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI56713256, Length=316, Percent_Identity=23.1012658227848, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI56713254, Length=316, Percent_Identity=23.1012658227848, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI95147551, Length=253, Percent_Identity=24.5059288537549, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI169881279, Length=253, Percent_Identity=24.5059288537549, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI4507369, Length=384, Percent_Identity=22.9166666666667, Blast_Score=73, Evalue=5e-13,
Organism=Escherichia coli, GI1788722, Length=382, Percent_Identity=36.6492146596859, Blast_Score=276, Evalue=1e-75,
Organism=Escherichia coli, GI1786816, Length=368, Percent_Identity=23.9130434782609, Blast_Score=111, Evalue=8e-26,
Organism=Escherichia coli, GI1788627, Length=361, Percent_Identity=24.0997229916898, Blast_Score=88, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI17567369, Length=329, Percent_Identity=24.9240121580547, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI71994472, Length=263, Percent_Identity=27.7566539923954, Blast_Score=100, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI71994476, Length=263, Percent_Identity=27.7566539923954, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17567663, Length=371, Percent_Identity=22.911051212938, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6322401, Length=392, Percent_Identity=21.9387755102041, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI28573069, Length=244, Percent_Identity=26.6393442622951, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24646114, Length=244, Percent_Identity=26.6393442622951, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI28573067, Length=244, Percent_Identity=26.6393442622951, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI28573065, Length=244, Percent_Identity=26.6393442622951, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI18859735, Length=387, Percent_Identity=24.031007751938, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR019881
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.83 [H]

Molecular weight: Translated: 42925; Mature: 42925

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFEFSERLKVLPPYLFAAIDKKKREKAAQGADIIDLGIGDPDLPTPKPIVEAGKAALEK
CCCCHHCHHHHCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHHCC
PEHHRYPSYEGMYAFRKAVADWYKKRFGVLLDPDKEIVTLIGSKEGIAHFPLAFVNPGDY
CCCCCCCCCCHHHHHHHHHHHHHHHHCCEEECCCHHEEEEECCCCCCEECCEEEECCCCE
VLCPDPGYPVYKISTIFAGGIPYMLPLKEENGFLPDIDSIPQNVLQKAKIIWVNYPNNPT
EEECCCCCCEEEEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHCCCEEEEEECCCCCC
SAKAPDSFYKKLIEFAHKYGIIIASDLAYSEIYASEPPRSILEFEGAKDVAIEFHSLSKT
CCCCCHHHHHHHHHHHHHCCEEEECCCHHHHHHCCCCCHHHHHCCCCCEEEEEEEHHCCC
YNMTGWRIGMAVGNPSLIAGLGKIKTNVDSGQFQAIQEAGIKALSLDDSVVQNLRDIYKE
CCCCCEEEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHCCCEEEECCHHHHHHHHHHHHH
RRKVMTEALKAINLDVFESDATFYLWIKVPKGFTSAGFAELLLDKLAIVVTPGSGFGEAG
HHHHHHHHHHHHCCEEEECCCEEEEEEEECCCCCCCCHHHHHHHCEEEEEECCCCCCCCC
EGYFRISLTVDTNRLKEAADRIKTLTL
CCEEEEEEEECHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MEFEFSERLKVLPPYLFAAIDKKKREKAAQGADIIDLGIGDPDLPTPKPIVEAGKAALEK
CCCCHHCHHHHCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHHCC
PEHHRYPSYEGMYAFRKAVADWYKKRFGVLLDPDKEIVTLIGSKEGIAHFPLAFVNPGDY
CCCCCCCCCCHHHHHHHHHHHHHHHHCCEEECCCHHEEEEECCCCCCEECCEEEECCCCE
VLCPDPGYPVYKISTIFAGGIPYMLPLKEENGFLPDIDSIPQNVLQKAKIIWVNYPNNPT
EEECCCCCCEEEEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHCCCEEEEEECCCCCC
SAKAPDSFYKKLIEFAHKYGIIIASDLAYSEIYASEPPRSILEFEGAKDVAIEFHSLSKT
CCCCCHHHHHHHHHHHHHCCEEEECCCHHHHHHCCCCCHHHHHCCCCCEEEEEEEHHCCC
YNMTGWRIGMAVGNPSLIAGLGKIKTNVDSGQFQAIQEAGIKALSLDDSVVQNLRDIYKE
CCCCCEEEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHCCCEEEECCHHHHHHHHHHHHH
RRKVMTEALKAINLDVFESDATFYLWIKVPKGFTSAGFAELLLDKLAIVVTPGSGFGEAG
HHHHHHHHHHHHCCEEEECCCEEEEEEEECCCCCCCCHHHHHHHCEEEEEECCCCCCCCC
EGYFRISLTVDTNRLKEAADRIKTLTL
CCEEEEEEEECHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]