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The map label for this gene is hisB

Identifier: 195952751

GI number: 195952751

Start: 328917

End: 329495

Strand: Direct

Name: hisB

Synonym: HY04AAS1_0373

Alternate gene names: 195952751

Gene position: 328917-329495 (Clockwise)

Preceding gene: 195952750

Following gene: 195952752

Centisome position: 21.09

GC content: 34.89

Gene sequence:

>579_bases
ATGAGAAAGGCACATATTTTTAGACAGACAAAAGAAACGGCTATAGATATGGAGATTGACCTAGATGGTTCTGGTGTTTA
TCAAATAGAGACACCTGTAGGTTTTTTAAATCATATGATGGAGAGTTTTTCGAAGCATAGCTTTATAGACATAAAGTTAA
AAGCCGAAGGCGATATCGATGTATCTTACCATCATCTTGTGGAAGATGTAGGTATAGTACTAGGACAAGCTATATCTAAA
GCCTTAGGAGATAAATCTGGTATAAATAGATATGGATTTGCAATTTTACCTATGGACGAAGCTTTGGTGCTATGTTCTCT
TGATTTTTCAGGTAGAGGACTCTTTTTCTACGATAGAAAAGATTTAAGAGGTAAGATTACAGAGTTTGACTTTGAGCTAA
TATGGGAGTTTATAAAAGGGTTTGCATTGGAGTCAAAAGCTACTGTGCATATAAAAATTCTTGATGGGCACATACTTCAC
CATATAGCAGAGTGTAGTATAAAGTCTTTAGCTTTTAGTGTAAGACAAGCTGTAGCAAAACAAGATAAAGGCATCCTTTC
TACAAAAGGGCTTTTATGA

Upstream 100 bases:

>100_bases
TAGGTAGGACGTTGGTGGCTATTATGGAAAATTATCAAACGAAAGATCACAAAATTAGAATACCAAAGGTTTTAAAAGAT
TACATAAAGGGAGAGTGTAT

Downstream 100 bases:

>100_bases
AAGAAAAGTTTAGGGGTATTGTTCTTGGGTCTGCGATAGGAGACGCTATAGGAAAATCTTTTGAGGATTTAGATATTTAT
CAGGTAGAAGAGTTTTATAA

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 192; Mature: 192

Protein sequence:

>192_residues
MRKAHIFRQTKETAIDMEIDLDGSGVYQIETPVGFLNHMMESFSKHSFIDIKLKAEGDIDVSYHHLVEDVGIVLGQAISK
ALGDKSGINRYGFAILPMDEALVLCSLDFSGRGLFFYDRKDLRGKITEFDFELIWEFIKGFALESKATVHIKILDGHILH
HIAECSIKSLAFSVRQAVAKQDKGILSTKGLL

Sequences:

>Translated_192_residues
MRKAHIFRQTKETAIDMEIDLDGSGVYQIETPVGFLNHMMESFSKHSFIDIKLKAEGDIDVSYHHLVEDVGIVLGQAISK
ALGDKSGINRYGFAILPMDEALVLCSLDFSGRGLFFYDRKDLRGKITEFDFELIWEFIKGFALESKATVHIKILDGHILH
HIAECSIKSLAFSVRQAVAKQDKGILSTKGLL
>Mature_192_residues
MRKAHIFRQTKETAIDMEIDLDGSGVYQIETPVGFLNHMMESFSKHSFIDIKLKAEGDIDVSYHHLVEDVGIVLGQAISK
ALGDKSGINRYGFAILPMDEALVLCSLDFSGRGLFFYDRKDLRGKITEFDFELIWEFIKGFALESKATVHIKILDGHILH
HIAECSIKSLAFSVRQAVAKQDKGILSTKGLL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=191, Percent_Identity=38.2198952879581, Blast_Score=137, Evalue=7e-34,
Organism=Saccharomyces cerevisiae, GI6324776, Length=216, Percent_Identity=33.3333333333333, Blast_Score=118, Evalue=6e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_HYDS0 (B4U7F2)

Other databases:

- EMBL:   CP001130
- RefSeq:   YP_002121041.1
- ProteinModelPortal:   B4U7F2
- SMR:   B4U7F2
- GeneID:   6743167
- GenomeReviews:   CP001130_GR
- KEGG:   hya:HY04AAS1_0373
- HOGENOM:   HBG289010
- OMA:   FGWAIIP
- ProtClustDB:   PRK00951
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 21530; Mature: 21530

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKAHIFRQTKETAIDMEIDLDGSGVYQIETPVGFLNHMMESFSKHSFIDIKLKAEGDID
CCCCHHHHHCCCCEEEEEEEECCCCEEEEECCHHHHHHHHHHHCCCCEEEEEEEECCCCC
VSYHHLVEDVGIVLGQAISKALGDKSGINRYGFAILPMDEALVLCSLDFSGRGLFFYDRK
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCEEEEECCCEEEEEEECCCCCEEEEEECC
DLRGKITEFDFELIWEFIKGFALESKATVHIKILDGHILHHIAECSIKSLAFSVRQAVAK
CCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHH
QDKGILSTKGLL
HCCCCCCCCCCC
>Mature Secondary Structure
MRKAHIFRQTKETAIDMEIDLDGSGVYQIETPVGFLNHMMESFSKHSFIDIKLKAEGDID
CCCCHHHHHCCCCEEEEEEEECCCCEEEEECCHHHHHHHHHHHCCCCEEEEEEEECCCCC
VSYHHLVEDVGIVLGQAISKALGDKSGINRYGFAILPMDEALVLCSLDFSGRGLFFYDRK
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCEEEEECCCEEEEEEECCCCCEEEEEECC
DLRGKITEFDFELIWEFIKGFALESKATVHIKILDGHILHHIAECSIKSLAFSVRQAVAK
CCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHH
QDKGILSTKGLL
HCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA